{"id":"https://openalex.org/W7211896561","doi":"https://doi.org/10.64898/2026.09.03.26362182","title":"Socioeconomic disparities in substance use disorder prevalence and severity across the life course","display_name":"Socioeconomic disparities in substance use disorder prevalence and severity across the life course","publication_year":2026,"publication_date":"2026-09-07","ids":{"openalex":"https://openalex.org/W7211896561","doi":"https://doi.org/10.64898/2026.09.03.26362182","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818431","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622718"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.03.26362182","doi":"https://doi.org/10.64898/2026.09.03.26362182","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.26362182","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/07/2026.09.03.26362182.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/07/2026.09.03.26362182.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007591579","display_name":"Peter B. Barr","orcid":"https://orcid.org/0000-0001-9321-657X","observed_orcids":["https://orcid.org/0000-0001-9321-657X"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter B. Barr","raw_affiliation_strings":["Department of Community Health Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0001-9321-657X","affiliations":[{"raw_affiliation_string":"Department of Community Health Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033241043","display_name":"Megan E. Cooke","orcid":"https://orcid.org/0000-0001-9405-367X","observed_orcids":["https://orcid.org/0000-0001-9405-367X"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan E. Cooke","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0001-9405-367X","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064055701","display_name":"Sally I\u2010Chun Kuo","orcid":"https://orcid.org/0000-0002-6192-1001","observed_orcids":["https://orcid.org/0000-0002-6192-1001"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally I-Chun Kuo","raw_affiliation_strings":["Department of Psychiatry, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ"],"raw_orcid":"https://orcid.org/0000-0002-6192-1001","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065634115","display_name":"Henri M. Garrison\u2010Desany","orcid":"https://orcid.org/0000-0003-4164-7065","observed_orcids":["https://orcid.org/0000-0003-4164-7065"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henri M. Garrison-Desany","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0003-4164-7065","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010945910","display_name":"Gayathri Pandey","orcid":"https://orcid.org/0000-0003-0889-3117","observed_orcids":["https://orcid.org/0000-0003-0889-3117"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayathri Pandey","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0003-0889-3117","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034870861","display_name":"Kathleen Keenan Bucholz","orcid":"https://orcid.org/0000-0003-3794-0736","observed_orcids":["https://orcid.org/0000-0003-3794-0736"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen K. Bucholz","raw_affiliation_strings":["Department of Psychiatry, School of Medicine, Washington University in St. Louis, St Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-3794-0736","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, Washington University in St. Louis, St Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044635265","display_name":"Howard J. Edenberg","orcid":"https://orcid.org/0000-0003-0344-9690","observed_orcids":["https://orcid.org/0000-0003-0344-9690"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Edenberg","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN","Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN"],"raw_orcid":"https://orcid.org/0000-0003-0344-9690","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026092513","display_name":"Sivan Kinreich","orcid":"https://orcid.org/0000-0001-6480-1622","observed_orcids":["https://orcid.org/0000-0001-6480-1622"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sivan Kinreich","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0001-6480-1622","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085626269","display_name":"Bernice Porjesz","orcid":"https://orcid.org/0000-0003-2489-0389","observed_orcids":["https://orcid.org/0000-0003-2489-0389"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernice Porjesz","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0003-2489-0389","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000611728","display_name":"Jessica E. Salvatore","orcid":"https://orcid.org/0000-0001-5504-5087","observed_orcids":["https://orcid.org/0000-0001-5504-5087"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica E. Salvatore","raw_affiliation_strings":["Department of Psychiatry, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ"],"raw_orcid":"https://orcid.org/0000-0001-5504-5087","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024112050","display_name":"Jacquelyn Leigh Meyers","orcid":"https://orcid.org/0000-0003-3863-8555","observed_orcids":["https://orcid.org/0000-0003-3863-8555"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacquelyn L. Meyers","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, SUNY Downstate Health Sciences University, Brooklyn, NY","Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY"],"raw_orcid":"https://orcid.org/0000-0003-3863-8555","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY","institution_ids":["https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007591579"],"corresponding_institution_ids":["https://openalex.org/I181697535"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.8579999804496765},{"id":"https://openalex.org/keywords/socioeconomic-status","display_name":"socioeconomic status","score":0.9890000224113464},{"id":"https://openalex.org/keywords/socioeconomic-inequality","display_name":"socioeconomic disparities","score":0.8980000019073486},{"id":"https://openalex.org/keywords/life-course","display_name":"life course","score":0.7179999947547913},{"id":"https://openalex.org/keywords/parental-education","display_name":"parental education","score":0.7789999842643738},{"id":"https://openalex.org/keywords/parental-income","display_name":"parental income","score":0.9710000157356262},{"id":"https://openalex.org/keywords/adult-education","display_name":"adult education","score":0.824999988079071},{"id":"https://openalex.org/keywords/income-mobility","display_name":"income mobility","score":0.6470000147819519},{"id":"https://openalex.org/keywords/tobacco-use-disorder","display_name":"tobacco use disorder","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cannabis-use-disorder","display_name":"cannabis use disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cocaine-dependence","display_name":"cocaine dependence","score":0.9739999771118164},{"id":"https://openalex.org/keywords/familial-risk","display_name":"familial risk","score":0.7670000195503235},{"id":"https://openalex.org/keywords/collaborative-study-on-the-genetics-of-alcoholism","display_name":"Collaborative Study on the Genetics of Alcoholism","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C147077947","wikidata":"https://www.wikidata.org/wiki/Q1515895","display_name":"Socioeconomic status","level":3,"score":0.7627999782562256},{"id":"https://openalex.org/C1691868","wikidata":"https://www.wikidata.org/wiki/Q1811049","display_name":"Life course approach","level":2,"score":0.703499972820282},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.5794000029563904},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.5277000069618225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5213000178337097},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4706000089645386},{"id":"https://openalex.org/C2991912374","wikidata":"https://www.wikidata.org/wiki/Q400711","display_name":"Substance use","level":2,"score":0.4652999937534332},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.45239999890327454},{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.39660000801086426},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C2779297142","wikidata":"https://www.wikidata.org/wiki/Q3276412","display_name":"Educational attainment","level":2,"score":0.38839998841285706},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36419999599456787},{"id":"https://openalex.org/C110888244","wikidata":"https://www.wikidata.org/wiki/Q187588","display_name":"Social class","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.31679999828338623},{"id":"https://openalex.org/C2781354955","wikidata":"https://www.wikidata.org/wiki/Q11920938","display_name":"Marital status","level":3,"score":0.3010999858379364},{"id":"https://openalex.org/C85973986","wikidata":"https://www.wikidata.org/wiki/Q1091731","display_name":"Exploratory research","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C526869908","wikidata":"https://www.wikidata.org/wiki/Q3298118","display_name":"Suicide prevention","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.25290000438690186},{"id":"https://openalex.org/C2776674806","wikidata":"https://www.wikidata.org/wiki/Q12135","display_name":"Mental illness","level":3,"score":0.25}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.03.26362182","doi":"https://doi.org/10.64898/2026.09.03.26362182","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.26362182","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/07/2026.09.03.26362182.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42818431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622718","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622718/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.03.26362182","doi":"https://doi.org/10.64898/2026.09.03.26362182","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.26362182","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/07/2026.09.03.26362182.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9911999702453613,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Reduced inequalities","score":0.7578999996185303,"id":"https://metadata.un.org/sdg/10"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000890121","display_name":"Neighborhood conditions, neural circuits, and substance use behaviors across the early life course.","funder_award_id":"R01DA061850","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320309099","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320309644","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08"},{"id":"https://openalex.org/F4320309650","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332904","display_name":"SUNY Downstate Medical Center","ror":"https://ror.org/0041qmd21"},{"id":"https://openalex.org/F4320333832","display_name":"Roy J. and Lucille A. Carver College of Medicine, University of Iowa","ror":null},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7211896561.pdf","grobid_xml":"https://content.openalex.org/works/W7211896561.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1796993399","https://openalex.org/W1839921965","https://openalex.org/W1919066392","https://openalex.org/W1972056186","https://openalex.org/W1978438556","https://openalex.org/W1987507789","https://openalex.org/W1995692415","https://openalex.org/W1996998435","https://openalex.org/W2009129706","https://openalex.org/W2020028691","https://openalex.org/W2020088825","https://openalex.org/W2043306991","https://openalex.org/W2047040948","https://openalex.org/W2053125924","https://openalex.org/W2055757140","https://openalex.org/W2056359093","https://openalex.org/W2061485803","https://openalex.org/W2071758474","https://openalex.org/W2080060650","https://openalex.org/W2081571050","https://openalex.org/W2085143064","https://openalex.org/W2101374995","https://openalex.org/W2102628581","https://openalex.org/W2107632228","https://openalex.org/W2108566322","https://openalex.org/W2111778050","https://openalex.org/W2117159069","https://openalex.org/W2118061336","https://openalex.org/W2129283428","https://openalex.org/W2131185982","https://openalex.org/W2134291350","https://openalex.org/W2141156752","https://openalex.org/W2142649133","https://openalex.org/W2148520357","https://openalex.org/W2150315800","https://openalex.org/W2155729027","https://openalex.org/W2164184454","https://openalex.org/W2165834902","https://openalex.org/W2400775905","https://openalex.org/W2569396875","https://openalex.org/W2588879699","https://openalex.org/W2743294273","https://openalex.org/W2765468520","https://openalex.org/W2779887333","https://openalex.org/W2804349419","https://openalex.org/W2897097583","https://openalex.org/W2898455876","https://openalex.org/W2906964061","https://openalex.org/W2912799600","https://openalex.org/W2966347682","https://openalex.org/W2970480306","https://openalex.org/W2986974687","https://openalex.org/W3001775073","https://openalex.org/W3012261821","https://openalex.org/W3034339940","https://openalex.org/W3142976211","https://openalex.org/W3177154605","https://openalex.org/W3193815771","https://openalex.org/W3212213613","https://openalex.org/W4200373679","https://openalex.org/W4220754052","https://openalex.org/W4229017078","https://openalex.org/W4245198606","https://openalex.org/W4283805559","https://openalex.org/W4285098606","https://openalex.org/W4292480755","https://openalex.org/W4293179688","https://openalex.org/W4308435067","https://openalex.org/W4376959645","https://openalex.org/W4382812013","https://openalex.org/W4385827455","https://openalex.org/W4386944957","https://openalex.org/W4391277909","https://openalex.org/W4400806027","https://openalex.org/W7083291525","https://openalex.org/W7139071055","https://openalex.org/W7148232735","https://openalex.org/W7166720538"],"related_works":["https://openalex.org/W2148520357","https://openalex.org/W2009129706","https://openalex.org/W2125910289","https://openalex.org/W2336908853","https://openalex.org/W2159790513","https://openalex.org/W6889277815","https://openalex.org/W7117071418","https://openalex.org/W2085509124","https://openalex.org/W2749941107","https://openalex.org/W4414443797"],"abstract_inverted_index":{"Gradients":[0],"across":[1,6,196,233],"socioeconomic":[2],"status":[3],"(SES)":[4],"exist":[5],"most":[7],"health":[8],"conditions.":[9],"While":[10],"there":[11],"has":[12,29],"been":[13],"significant":[14],"attention":[15],"devoted":[16],"to":[17,34,60],"the":[18,40,47,51,55,62,153,187,203],"relationship":[19,63],"between":[20,64],"SES":[21,65,89,175,211],"and":[22,24,69,81,92,102,108,121,148,165,209],"physical":[23],"mental":[25],"health,":[26],"less":[27],"research":[28],"examined":[30],"how":[31],"these":[32],"relate":[33],"substance":[35,73],"use":[36,44,74,111],"disorders":[37,75],"(SUD).":[38],"In":[39,135],"current":[41],"study,":[42],"we":[43],"data":[45],"from":[46],"prospective":[48],"study":[49],"within":[50],"Collaborative":[52],"Study":[53],"on":[54,157],"Genetics":[56],"of":[57,99,146,152,172,205,236],"Alcoholism":[58],"(COGA)":[59],"explore":[61],"(in":[66],"early":[67,87,158,207],"life":[68,88,159,208,216],"adulthood)":[70],"with":[71,96,114,126,143,230],"multiple":[72,197],"(alcohol,":[76],"tobacco,":[77],"cannabis,":[78],"opioid,":[79],"cocaine,":[80],"other":[82],"substances).":[83],"We":[84],"find":[85],"that":[86,177],"(parental":[90],"education":[91,140,227],"income)":[93],"are":[94],"associated":[95,142,229],"lower":[97,103,144],"odds":[98,145],"lifetime":[100],"diagnoses":[101],"severity":[104,149],"for":[105,119,150,168,192,221],"tobacco":[106],"(TUD)":[107],"cannabis":[109],"(CUD)":[110],"disorders.":[112],"Associations":[113],"TUD":[115],"remain":[116],"after":[117,130],"adjusting":[118],"demographic":[120],"familial":[122,132,166],"risk,":[123],"but":[124],"associations":[125],"CUD":[127],"were":[128,180,185],"null":[129],"including":[131],"risk":[133,167,191,232],"factors.":[134],"participants":[136],"aged":[137],"25+,":[138],"adult":[139,161,210,226],"was":[141,228],"diagnosis":[147],"each":[151],"SUD":[154,195,213],"considered,":[155],"conditional":[156],"SES,":[160],"income,":[162],"sociodemographic":[163],"characteristics,":[164],"SUD.":[169],"Exploratory":[170],"analyses":[171],"changes":[173],"in":[174,212],"revealed":[176],"those":[178],"who":[179],"upwardly":[181],"or":[182,189],"downwardly":[183],"mobile":[184],"at":[186],"lowest":[188],"greatest":[190],"more":[193],"severe":[194],"substances,":[198],"respectively.":[199],"Our":[200],"results":[201],"demonstrate":[202],"relevance":[204],"both":[206],"risk.":[214],"Early":[215],"conditions":[217],"seem":[218],"particularly":[219],"relevant":[220],"specific":[222],"substances":[223],"while":[224],"greater":[225],"reduced":[231],"all":[234],"forms":[235],"SUDs.":[237]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-08T00:00:00"}
