{"id":"https://openalex.org/W7211893979","doi":"https://doi.org/10.64898/2026.09.03.749222","title":"Pannexin 1 inhibition reduces tumorigenic properties of patient-derived glioblastoma cells through the HIPPO and Wnt signalling pathways","display_name":"Pannexin 1 inhibition reduces tumorigenic properties of patient-derived glioblastoma cells through the HIPPO and Wnt signalling pathways","publication_year":2026,"publication_date":"2026-09-07","ids":{"openalex":"https://openalex.org/W7211893979","doi":"https://doi.org/10.64898/2026.09.03.749222"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.03.749222","doi":"https://doi.org/10.64898/2026.09.03.749222","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749222","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011542293","display_name":"Danielle E. Johnston","orcid":"https://orcid.org/0000-0001-7491-1518","observed_orcids":["https://orcid.org/0000-0001-7491-1518"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danielle Johnston","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107015697","display_name":"Matthew S. Huver","orcid":"https://orcid.org/0009-0001-8687-7115","observed_orcids":["https://orcid.org/0009-0001-8687-7115"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Huver","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072037534","display_name":"Rehanna Kanji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rehanna Kanji","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150656177","display_name":"Carlijn Van Kessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carlijn Van Kessel","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025060388","display_name":"John Joseph Kelly","orcid":"https://orcid.org/0000-0002-3626-8629","observed_orcids":["https://orcid.org/0000-0002-3626-8629"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Kelly","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043346076","display_name":"Rafael E. Sanchez\u2010Pupo","orcid":"https://orcid.org/0000-0002-6970-2137","observed_orcids":["https://orcid.org/0000-0002-6970-2137"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rafael E Sanchez Pupo","raw_affiliation_strings":["Western University;"],"raw_orcid":"https://orcid.org/0000-0002-6970-2137","affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150571818","display_name":"Brooke O'Donnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brooke O'Donnell","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010072548","display_name":"Norah Defamie","orcid":"https://orcid.org/0000-0002-7504-7538","observed_orcids":["https://orcid.org/0000-0002-7504-7538"]},"institutions":[{"id":"https://openalex.org/I32881790","display_name":"Universit\u00e9 de Poitiers","ror":"https://ror.org/04xhy8q59","country_code":"FR","type":"education","lineage":["https://openalex.org/I32881790"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Norah Defamie","raw_affiliation_strings":["University of Poitiers;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Poitiers;","institution_ids":["https://openalex.org/I32881790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150620437","display_name":"Rebecca Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rebecca Lau","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107865873","display_name":"Carolina Herrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carolina Herrera","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067752656","display_name":"Andrew M. Deweyert","orcid":"https://orcid.org/0009-0004-9404-0659","observed_orcids":["https://orcid.org/0009-0004-9404-0659"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Deweyert","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082849305","display_name":"Marc Mesnil","orcid":"https://orcid.org/0000-0003-4922-0365","observed_orcids":["https://orcid.org/0000-0003-4922-0365"]},"institutions":[{"id":"https://openalex.org/I32881790","display_name":"Universit\u00e9 de Poitiers","ror":"https://ror.org/04xhy8q59","country_code":"FR","type":"education","lineage":["https://openalex.org/I32881790"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Mesnil","raw_affiliation_strings":["University of Poitiers;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Poitiers;","institution_ids":["https://openalex.org/I32881790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037728175","display_name":"John Andrew Ronald","orcid":"https://orcid.org/0000-0003-3665-173X","observed_orcids":["https://orcid.org/0000-0003-3665-173X"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Ronald","raw_affiliation_strings":["The University of Western Ontario;"],"raw_orcid":"https://orcid.org/0000-0001-6025-8300","affiliations":[{"raw_affiliation_string":"The University of Western Ontario;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050923743","display_name":"Matthew O. Hebb","orcid":"https://orcid.org/0000-0002-9582-4314","observed_orcids":["https://orcid.org/0000-0002-9582-4314"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Hebb","raw_affiliation_strings":["Western University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western University;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091829028","display_name":"Silvia Pe\u00f1uela","orcid":"https://orcid.org/0000-0003-4829-5517","observed_orcids":["https://orcid.org/0000-0003-4829-5517"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Silvia Penuela","raw_affiliation_strings":["University of Western Ontario"],"raw_orcid":"https://orcid.org/0000-0003-4829-5517","affiliations":[{"raw_affiliation_string":"University of Western Ontario","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091829028"],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.12849999964237213,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pannexin-1","display_name":"pannexin 1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.7400000095367432},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9139999747276306},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.8740000128746033},{"id":"https://openalex.org/keywords/spironolactone","display_name":"spironolactone","score":1.0},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.607200026512146},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5756999850273132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5670999884605408},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5479000210762024},{"id":"https://openalex.org/C127992366","wikidata":"https://www.wikidata.org/wiki/Q410332","display_name":"Pannexin","level":5,"score":0.5407999753952026},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5041999816894531},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4650000035762787},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44839999079704285},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.4401000142097473},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3955000042915344},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C2778735756","wikidata":"https://www.wikidata.org/wiki/Q18028523","display_name":"Galectin-1","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.34940001368522644},{"id":"https://openalex.org/C128473837","wikidata":"https://www.wikidata.org/wiki/Q7863603","display_name":"U87","level":3,"score":0.34779998660087585},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.3447999954223633},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.33820000290870667},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3082999885082245},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.29339998960494995},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2745000123977661},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.03.749222","doi":"https://doi.org/10.64898/2026.09.03.749222","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749222","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6982584424","https://openalex.org/W4247510452","https://openalex.org/W2016224591","https://openalex.org/W7124436856","https://openalex.org/W2314360422","https://openalex.org/W2062426202","https://openalex.org/W2133505501","https://openalex.org/W4409201412","https://openalex.org/W1150630736","https://openalex.org/W7135388146"],"abstract_inverted_index":{"Glioblastoma":[0],"(GBM)":[1],"is":[2,36],"the":[3,77,116,130,142,188],"most":[4],"common":[5],"primary":[6,64],"brain":[7,68],"tumour,":[8],"with":[9,161,218],"a":[10,17,29,139,146,168,203,229],"median":[11],"survival":[12],"of":[13,52,80,84,129,135,141,156,191,226],"12-18":[14],"months,":[15],"highlighting":[16],"need":[18],"for":[19],"new":[20,221],"treatment":[21],"targets.":[22],"We":[23],"observed":[24],"that":[25,242],"pannexin":[26],"1":[27],"(PANX1),":[28],"channel-forming":[30],"glycoprotein":[31],"important":[32],"in":[33,38,62,102,119,138,149,158,171,205,237],"purinergic":[34],"signalling,":[35],"upregulated":[37],"GBM":[39,54,81,103,159,200,231],"compared":[40,66,76,90,196],"to":[41,67,91,121,197],"normal":[42],"tissue":[43,69],"and":[44,70,95,108,113,126,145,151,164,175,187,212,234],"expressed":[45],"throughout":[46],"patient":[47],"tumours.":[48],"Western":[49],"blot":[50],"analysis":[51],"patient-derived":[53],"cell":[55,106,109,152,173,207],"lines":[56,65],"revealed":[57,100],"significantly":[58],"increased":[59],"PANX1":[60,85,136,157,227],"expression":[61,79],"these":[63],"control":[71],"glial":[72],"cells.":[73],"Bulk":[74],"RNA-sequencing":[75],"gene":[78,97],"cells":[82,104,160],"devoid":[83],"via":[86,177],"CRISPR/Cas9":[87],"deletion":[88,134],"(PANX1-KO)":[89],"controls.":[92,198],"Gene":[93],"Ontology":[94],"KEGG":[96],"set":[98],"analyses":[99],"PANX1-KO":[101],"affects":[105],"surface":[107],"junction":[110],"components,":[111],"processes,":[112],"pathways,":[114],"including":[115],"HIPPO":[117],"pathway,":[118],"addition":[120],"critically":[122],"downregulating":[123],"\u03b2-catenin":[124,143],"mRNA":[125],"other":[127],"components":[128],"Wnt":[131],"pathway.":[132],"The":[133],"resulted":[137],"disruption":[140],"protein":[144],"dramatic":[147],"reduction":[148,170,204],"migration":[150,176],"growth.":[153],"Pharmacological":[154],"inhibition":[155],"Probenecid":[162],"(PBN)":[163],"Spironolactone":[165],"(SPIR)":[166],"demonstrated":[167],"significant":[169],"live":[172],"numbers":[174],"scratch":[178],"assay.":[179],"Both":[180],"blockers":[181],"dramatically":[182],"decreased":[183],"F-actin":[184],"filament":[185],"formation,":[186],"cellular":[189],"localization":[190],"beta-catenin":[192],"became":[193],"more":[194],"intracellular":[195],"Xenografted":[199],"tumours":[201],"showed":[202],"tumour":[206],"viability":[208],"by":[209],"bioluminescent":[210],"imaging":[211],"reduced":[213],"hemorrhaging":[214],"incidence":[215],"when":[216],"treated":[217],"PBN.":[219],"These":[220],"insights":[222],"support":[223],"further":[224],"investigation":[225],"as":[228],"potential":[230],"therapeutic":[232],"target":[233],"its":[235],"role":[236],"multiple":[238],"cancer":[239],"signaling":[240],"pathways":[241],"regulate":[243],"this":[244],"devastating":[245],"disease.":[246]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-08T00:00:00"}