{"id":"https://openalex.org/W7211875388","doi":"https://doi.org/10.1002/psp4.70336","title":"Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data","display_name":"Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7211875388","doi":"https://doi.org/10.1002/psp4.70336","pmid":"https://pubmed.ncbi.nlm.nih.gov/42704118","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733373"},"language":"en","primary_location":{"id":"doi:10.1002/psp4.70336","doi":"https://doi.org/10.1002/psp4.70336","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.70336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.70336","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.70336","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030886085","display_name":"Toshiaki Tsuchitani","orcid":"https://orcid.org/0000-0002-7257-3196","observed_orcids":["https://orcid.org/0000-0002-7257-3196"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiaki Tsuchitani","raw_affiliation_strings":["Faculty of Pharmacy Keio University  Tokyo Japan"],"raw_orcid":"https://orcid.org/0000-0002-7257-3196","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy Keio University  Tokyo Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022660345","display_name":"Masatoshi Tomi","orcid":"https://orcid.org/0000-0002-9829-8436","observed_orcids":["https://orcid.org/0000-0002-9829-8436"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatoshi Tomi","raw_affiliation_strings":["Faculty of Pharmacy Keio University  Tokyo Japan"],"raw_orcid":"https://orcid.org/0000-0002-9829-8436","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy Keio University  Tokyo Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027984186","display_name":"Yuichi Sugiyama","orcid":"https://orcid.org/0000-0002-8452-8835","observed_orcids":["https://orcid.org/0000-0002-8452-8835"]},"institutions":[{"id":"https://openalex.org/I2802864159","display_name":"Genome Canada","ror":"https://ror.org/029s29983","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2802864159"]},{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]},{"id":"https://openalex.org/I4405274089","display_name":"Nippon GENE Co., Ltd. (Japan)","ror":"https://ror.org/011zx6172","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274089"]}],"countries":["CA","CN","JP"],"is_corresponding":true,"raw_author_name":"Yuichi Sugiyama","raw_affiliation_strings":["Genomembrane Co. Ltd  Yokohama Kanagawa Japan","iHuman Institute ShanghaiTech University  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomembrane Co. Ltd  Yokohama Kanagawa Japan","institution_ids":["https://openalex.org/I2802864159","https://openalex.org/I4405274089"]},{"raw_affiliation_string":"iHuman Institute ShanghaiTech University  Shanghai China","institution_ids":["https://openalex.org/I30809798"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027984186","https://openalex.org/A5030886085"],"corresponding_institution_ids":["https://openalex.org/I203951103","https://openalex.org/I2802864159","https://openalex.org/I30809798","https://openalex.org/I4405274089"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":{"value":4140,"currency":"USD","value_usd":4140},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62465747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"9","first_page":"e70336","last_page":"e70336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/clearance-ratio","display_name":"clearance ratio","score":0.5260000228881836},{"id":"https://openalex.org/keywords/drug-reabsorption","display_name":"drug reabsorption","score":0.7049999833106995},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7350000143051147},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-extrapolation","display_name":"in vitro-in vivo extrapolation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.6876000165939331},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.652899980545044},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6126999855041504},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5590000152587891},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.5328999757766724},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5263000130653381},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5212000012397766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49390000104904175},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4212000072002411},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3671000003814697},{"id":"https://openalex.org/C2909587778","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Kidney tubules","level":3,"score":0.3490999937057495},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3431999981403351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3197999894618988},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2651999890804291},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.2590999901294708}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/psp4.70336","doi":"https://doi.org/10.1002/psp4.70336","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.70336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.70336","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},{"id":"pmid:42704118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42704118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: pharmacometrics & systems pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733373","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13733373/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT Pharmacometrics Syst Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7028d2b46b01475da20c2689f21e0938","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7028d2b46b01475da20c2689f21e0938","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology, Vol 15, Iss 9, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/psp4.70336","doi":"https://doi.org/10.1002/psp4.70336","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.70336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.70336","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G484937687","display_name":null,"funder_award_id":"JP22H02789","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8600107370","display_name":"Integrated modeling of drugs and endogenous ligands based on physiologically based pharmacokinetic models","funder_award_id":"25K18661","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320327675","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7211875388.pdf","grobid_xml":"https://content.openalex.org/works/W7211875388.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1894928914","https://openalex.org/W1968025310","https://openalex.org/W1990738536","https://openalex.org/W1999103336","https://openalex.org/W2008834586","https://openalex.org/W2036846365","https://openalex.org/W2043191275","https://openalex.org/W2048147728","https://openalex.org/W2067808501","https://openalex.org/W2076998806","https://openalex.org/W2094110689","https://openalex.org/W2115861330","https://openalex.org/W2222653645","https://openalex.org/W2313644778","https://openalex.org/W2411619353","https://openalex.org/W2491156638","https://openalex.org/W2521008236","https://openalex.org/W2568910280","https://openalex.org/W2586437282","https://openalex.org/W2610183145","https://openalex.org/W2750915311","https://openalex.org/W2884215650","https://openalex.org/W2899997184","https://openalex.org/W2919263543","https://openalex.org/W2946799139","https://openalex.org/W2967339111","https://openalex.org/W2972575346","https://openalex.org/W2997954936","https://openalex.org/W3088557102","https://openalex.org/W3174476055","https://openalex.org/W3191157818","https://openalex.org/W3209508323","https://openalex.org/W3210303808","https://openalex.org/W4280504736","https://openalex.org/W4282930798","https://openalex.org/W4295765232","https://openalex.org/W4361004392","https://openalex.org/W4382517145","https://openalex.org/W4384816663","https://openalex.org/W4401711061","https://openalex.org/W4401733994","https://openalex.org/W4404081446","https://openalex.org/W4404775598","https://openalex.org/W4406662741","https://openalex.org/W4407095592","https://openalex.org/W4409885969"],"related_works":["https://openalex.org/W2214815552","https://openalex.org/W3151377281","https://openalex.org/W2588066480","https://openalex.org/W1980819440","https://openalex.org/W2478266090","https://openalex.org/W2324377885","https://openalex.org/W2167026096","https://openalex.org/W2154165320","https://openalex.org/W3036880023","https://openalex.org/W7211927839"],"abstract_inverted_index":{"ABSTRACT":[0],"Renal":[1],"clearance":[2,30],"(CL":[3,43],"r":[4,42,172],")":[5,45,173],"is":[6,216],"the":[7,18,94,100,129,138,213],"net":[8,22,126,220],"outcome":[9],"of":[10,62,195,208],"glomerular":[11,101],"filtration,":[12],"secretion,":[13],"and":[14,52,57,91,99,154,183,234],"reabsorption,":[15,123],"which":[16],"makes":[17],"quantitative":[19,142],"requirements":[20],"for":[21,46,164,218],"renal":[23,73,221,232],"secretion":[24,74,117,233],"difficult":[25],"to":[26,158,198,230],"infer":[27],"from":[28],"simple":[29],"models.":[31],"Using":[32],"a":[33],"mechanistic":[34],"kidney":[35],"model":[36],"(MechKiM),":[37],"we":[38],"simulated":[39],"blood\u2010referenced":[40],"CL":[41,79,168,171],"r,b":[44,80],"30,000":[47],"virtual":[48],"drugs":[49],"(neutral,":[50],"monoanionic,":[51],"monocationic)":[53],"under":[54],"continuous":[55],"infusion":[56],"across":[58],"all":[59,132],"eight":[60],"combinations":[61],"three":[63,133],"proximal\u2010tubule":[64],"transporters":[65,134,211],"(basal":[66],"uptake,":[67],"basal":[68,107,148,160,196,209],"efflux,":[69],"apical":[70,112],"efflux).":[71],"Net":[72],"(clearance":[75],"ratio":[76],"CR":[77],"=":[78,181,189],"/(":[81],"f":[82,89],"u,b":[83,90],"\u00d7":[84],"GFR)":[85],">":[86,193],"1.5,":[87],"where":[88,131],"GFR":[92],"are":[93],"unbound":[95],"fraction":[96],"in":[97,175,212,227],"blood":[98],"filtration":[102],"rate)":[103],"occurred":[104],"only":[105],"when":[106],"uptake":[108,150,161,197,210],"transport":[109],"was":[110,119],"present;":[111],"efflux":[113],"alone":[114],"produced":[115],"proximal":[116,214],"that":[118],"offset":[120],"by":[121],"downstream":[122],"yielding":[124],"no":[125],"secretion.":[127,222],"In":[128],"scenario":[130],"were":[135,200],"present":[136],"within":[137],"MechKiM":[139],"framework,":[140],"five":[141],"criteria":[143,229],"distinguished":[144],"secretion\u2010type":[145],"drugs,":[146],"including":[147],"transporter\u2010mediated":[149,235],"(>":[151,162],"4.2":[152],"L/h)":[153],"its":[155],"fractional":[156],"contribution":[157,207],"total":[159],"94%":[163],"non\u2010cationic":[165],"compounds).":[166],"Clinical":[167],"r,p":[169],"(plasma\u2010referenced":[170],"versus":[174],"vitro":[176],"uptake\u2010transporter":[177],"data":[178],"(":[179,187],"n":[180,188],"217)":[182],"published":[184],"MechKiM\u2010PBPK":[185],"models":[186],"19,":[190],"typically":[191],"assigning":[192],"99%":[194],"transporters)":[199],"consistent":[201],"with":[202],"these":[203],"findings.":[204],"A":[205],"sufficient":[206],"tubule":[215],"essential":[217],"observing":[219],"This":[223],"study":[224],"provides":[225],"quantitative,":[226],"vitro\u2010translatable":[228],"anticipate":[231],"drug\u2013drug":[236],"interaction":[237],"liability.":[238]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-08T00:00:00"}