{"id":"https://openalex.org/W7211870637","doi":"https://doi.org/10.3390/ijms27209088","title":"Molsidomine Pretreatment Modulates Renal Redox and Endothelial Activation Markers in Experimental Polymicrobial Sepsis","display_name":"Molsidomine Pretreatment Modulates Renal Redox and Endothelial Activation Markers in Experimental Polymicrobial Sepsis","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7211870637","doi":"https://doi.org/10.3390/ijms27209088","pmid":"https://pubmed.ncbi.nlm.nih.gov/42941860","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13705544"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27209088","doi":"https://doi.org/10.3390/ijms27209088","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209088","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27209088","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030362226","display_name":"Adem K\u00f6se","orcid":"https://orcid.org/0000-0002-1853-1243","observed_orcids":["https://orcid.org/0000-0002-1853-1243","https://orcid.org/0000-0002-0570-9241"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adem Kose","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1853-1243","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121985553","display_name":"Zeynep Busra Keser","orcid":"https://orcid.org/0009-0000-4798-8085","observed_orcids":["https://orcid.org/0009-0000-4798-8085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeynep Busra Keser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140966438","display_name":"Mehmet G\u00fcl","orcid":"https://orcid.org/0000-0002-1374-0783","observed_orcids":["https://orcid.org/0000-0002-1374-0783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet G\u00fcl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1374-0783","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030488690","display_name":"\u015eeyma Ya\u015far","orcid":"https://orcid.org/0000-0003-1300-3393","observed_orcids":["https://orcid.org/0000-0003-1300-3393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyma Yasar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1300-3393","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074151447","display_name":"Onural \u00d6zhan","orcid":"https://orcid.org/0000-0001-9018-7849","observed_orcids":["https://orcid.org/0000-0001-9018-7849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Onural Ozhan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9018-7849","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076287743","display_name":"Zeynep Uluta\u015f","orcid":"https://orcid.org/0000-0001-6078-7480","observed_orcids":["https://orcid.org/0000-0001-6078-7480","https://orcid.org/0000-0002-5072-2031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeynep Ulutas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034220613","display_name":"Feyzi Dogru","orcid":"https://orcid.org/0000-0002-7949-9582","observed_orcids":["https://orcid.org/0000-0002-7949-9582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feyzi Dogru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150600117","display_name":"Ezgi Kurucay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ezgi Kurucay","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1865-4937","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137939581","display_name":"AYSE LEVENT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayse Betul Levent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120229474","display_name":"Mehmet Ertugrul Balkar","orcid":"https://orcid.org/0009-0004-0878-5129","observed_orcids":["https://orcid.org/0009-0004-0878-5129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Ertugrul Balkar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-0878-5129","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072192300","display_name":"Hakan Parlakp\u0131nar","orcid":"https://orcid.org/0000-0001-9497-3468","observed_orcids":["https://orcid.org/0000-0001-9497-3468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hakan Parlakpinar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9497-3468","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030362226"],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63912385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"20","first_page":"9088","last_page":"9088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molsidomine","display_name":"molsidomine","score":1.0},{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/sepsis-associated-acute-kidney-injury","display_name":"sepsis-associated acute kidney injury","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7839999794960022},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.796999990940094},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7609999775886536},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8429999947547913},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.8109999895095825},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2780773033","wikidata":"https://www.wikidata.org/wiki/Q408132","display_name":"Molsidomine","level":3,"score":0.9272000193595886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.767799973487854},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5763000249862671},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5479000210762024},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5339000225067139},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5055000185966492},{"id":"https://openalex.org/C2991844318","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"Renal injury","level":3,"score":0.424699991941452},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4032000005245209},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.3926999866962433},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3817000091075897},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C2781087799","wikidata":"https://www.wikidata.org/wiki/Q7312483","display_name":"Renal biopsy","level":3,"score":0.337799996137619},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3034000098705292},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3000999987125397},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2838999927043915},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2540999948978424},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms27209088","doi":"https://doi.org/10.3390/ijms27209088","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209088","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202609.0426.v1","doi":"https://doi.org/10.20944/preprints202609.0426.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202609.0426.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13705544","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705544/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705544/pdf/ijms-27-09088.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42941860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42941860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27209088","doi":"https://doi.org/10.3390/ijms27209088","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209088","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9001247837","display_name":null,"funder_award_id":"TCD-2025-3808","funder_id":"https://openalex.org/F4320327128","funder_display_name":"In\u00f6n\u00fc \u00dcniversitesi"}],"funders":[{"id":"https://openalex.org/F4320327128","display_name":"In\u00f6n\u00fc \u00dcniversitesi","ror":"https://ror.org/04asck240"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7211870637.pdf","grobid_xml":"https://content.openalex.org/works/W7211870637.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W1775749144","https://openalex.org/W1967950800","https://openalex.org/W1976464405","https://openalex.org/W1984793344","https://openalex.org/W1985687390","https://openalex.org/W1990802251","https://openalex.org/W1991209345","https://openalex.org/W2006370393","https://openalex.org/W2018239407","https://openalex.org/W2053054955","https://openalex.org/W2065943558","https://openalex.org/W2068540155","https://openalex.org/W2084715465","https://openalex.org/W2087026897","https://openalex.org/W2159305277","https://openalex.org/W2280404143","https://openalex.org/W2522787346","https://openalex.org/W2526871237","https://openalex.org/W2950273680","https://openalex.org/W2998853022","https://openalex.org/W3008170328","https://openalex.org/W3016688585","https://openalex.org/W3092400338","https://openalex.org/W3195125997","https://openalex.org/W3207163166","https://openalex.org/W4229635174","https://openalex.org/W4236357753","https://openalex.org/W4245743659","https://openalex.org/W4280552865","https://openalex.org/W4283163871","https://openalex.org/W4283713883","https://openalex.org/W4289890883","https://openalex.org/W4321596088","https://openalex.org/W4385620907","https://openalex.org/W4391844328","https://openalex.org/W4392510173","https://openalex.org/W4394684484","https://openalex.org/W4399653576","https://openalex.org/W4408745516","https://openalex.org/W4415470670","https://openalex.org/W7161644696"],"related_works":["https://openalex.org/W2065943558","https://openalex.org/W3197739171","https://openalex.org/W3173090050","https://openalex.org/W41980370","https://openalex.org/W7120340951","https://openalex.org/W1985821466","https://openalex.org/W2889377140","https://openalex.org/W2252282615","https://openalex.org/W2124748423","https://openalex.org/W167687413"],"abstract_inverted_index":{"Sepsis-associated":[0],"renal":[1,12,83,90,97,145,154,212,224,247],"injury":[2,128,214],"involves":[3],"oxidative,":[4],"inflammatory,":[5],"and":[6,21,92,95,110,144,167,171,174,182,185,191,215,242,245],"microvascular":[7],"disturbances.":[8],"This":[9],"study":[10],"evaluated":[11],"changes":[13],"associated":[14,208],"with":[15,149,209],"molsidomine":[16,37,205],"pretreatment":[17,206],"in":[18,65,113,221],"cecal":[19],"ligation":[20],"puncture":[22],"(CLP)-induced":[23],"polymicrobial":[24],"sepsis.":[25],"Forty":[26],"Wistar":[27],"rats":[28],"were":[29,130,137],"randomly":[30],"allocated":[31],"to":[32],"Sham":[33],"(n":[34,43,48],"=":[35,40,44,49],"8),":[36,41],"(MOL;":[38],"n":[39],"CLP":[42,117],"12),":[45],"or":[46],"MOL+CLP":[47,115,151],"12)":[50],"groups.":[51],"Molsidomine":[52],"(10":[53],"mg/kg/day)":[54],"was":[55,81,111,207],"administered":[56],"orally":[57],"for":[58,140],"14":[59],"days":[60],"before":[61,70],"surgery.":[62],"Four":[63],"animals":[64,118],"each":[66],"septic":[67,198],"group":[68],"died":[69],"24":[71],"h,":[72],"leaving":[73],"eight":[74],"survivors":[75],"per":[76],"group.":[77],"The":[78,99],"primary":[79],"outcome":[80],"total":[82,100],"histopathological":[84,101],"damage":[85],"score;":[86],"secondary":[87],"outcomes":[88],"included":[89],"biochemical":[91],"immunohistochemical":[93],"markers":[94],"serum":[96,186,223],"indices.":[98,225],"score":[102],"differed":[103],"across":[104],"groups":[105,199],"(overall":[106],"p":[107],"<":[108],"0.001)":[109],"lower":[112,153,172],"surviving":[114],"than":[116],"(2.22":[119],"\u00b1":[120,124,157,161],"0.97":[121],"vs.":[122,159],"5.38":[123],"1.06).":[125],"All":[126],"four":[127],"components":[129],"numerically":[131],"lower,":[132],"but":[133],"adjusted":[134],"pairwise":[135],"differences":[136,220],"significant":[138,219],"only":[139],"glomerular":[141],"capillary":[142],"collapse":[143],"tubular":[146],"injury.":[147],"Compared":[148],"CLP,":[150],"showed":[152],"malondialdehyde":[155],"(106.41":[156],"9.03":[158],"136.45":[160],"20.27":[162],"nmol/g),":[163],"higher":[164],"superoxide":[165],"dismutase":[166],"glutathione":[168],"peroxidase":[169],"activities,":[170],"VEGF":[173],"P-selectin":[175],"immunoreactivity.":[176],"Renal":[177],"nitric":[178],"oxide,":[179],"other":[180],"redox":[181],"inflammatory":[183],"markers,":[184],"creatinine,":[187],"blood":[188],"urea":[189,192],"nitrogen,":[190],"did":[193],"not":[194],"differ":[195],"significantly":[196],"between":[197],"after":[200,230],"multiplicity":[201],"adjustment.":[202],"Among":[203],"survivors,":[204],"less":[210],"pronounced":[211],"structural":[213],"tissue-level":[216],"abnormalities,":[217],"without":[218],"conventional":[222],"Its":[226],"effects":[227],"when":[228],"initiated":[229],"sepsis":[231],"onset":[232],"remain":[233],"unknown.":[234],"Further":[235],"studies":[236],"should":[237],"evaluate":[238],"post-sepsis":[239],"dosing,":[240],"antimicrobial":[241],"supportive":[243],"care,":[244],"longer-term":[246],"functional":[248],"outcomes.":[249]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-08T00:00:00"}