{"id":"https://openalex.org/W7211865443","doi":"https://doi.org/10.64898/2026.10.13.758761","title":"Warmth shifts rather than speeds transcriptomic ageing in the malaria mosquito Anopheles gambiae","display_name":"Warmth shifts rather than speeds transcriptomic ageing in the malaria mosquito Anopheles gambiae","publication_year":2026,"publication_date":"2026-10-17","ids":{"openalex":"https://openalex.org/W7211865443","doi":"https://doi.org/10.64898/2026.10.13.758761"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.13.758761","doi":"https://doi.org/10.64898/2026.10.13.758761","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.758761","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/17/2026.10.13.758761.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/17/2026.10.13.758761.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050322243","display_name":"Krishnendu Sinha","orcid":"https://orcid.org/0000-0001-9590-3875","observed_orcids":["https://orcid.org/0000-0001-9590-3875"]},"institutions":[{"id":"https://openalex.org/I130291710","display_name":"Visva-Bharati University","ror":"https://ror.org/02y28sc20","country_code":"IN","type":"education","lineage":["https://openalex.org/I130291710"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Krishnendu Sinha","raw_affiliation_strings":["Department of Zoology, Siksha Bhavana, Visva-Bharati, Santiniketan, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0001-9590-3875","affiliations":[{"raw_affiliation_string":"Department of Zoology, Siksha Bhavana, Visva-Bharati, Santiniketan, West Bengal, India","institution_ids":["https://openalex.org/I130291710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477687","display_name":"Nabanita Ghosh","orcid":"https://orcid.org/0000-0003-1418-0017","observed_orcids":["https://orcid.org/0000-0003-1418-0017"]},"institutions":[{"id":"https://openalex.org/I4405272376","display_name":"Maulana Azad College","ror":"https://ror.org/04334z971","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405272376"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nabanita Ghosh","raw_affiliation_strings":["Department of Zoology, Maulana Azad College, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Maulana Azad College, Kolkata, West Bengal, India","institution_ids":["https://openalex.org/I4405272376"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101663561","display_name":"Sharmistha Banerjee","orcid":"https://orcid.org/0000-0002-8002-0786","observed_orcids":["https://orcid.org/0000-0002-8002-0786"]},"institutions":[{"id":"https://openalex.org/I106826634","display_name":"Jain University","ror":"https://ror.org/01cnqpt53","country_code":"IN","type":"education","lineage":["https://openalex.org/I106826634"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sharmistha Banerjee","raw_affiliation_strings":["Centre for Research in Pure and Applied Sciences, Department of Microbiology and Botany, JAIN (Deemed-to-be University), Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Pure and Applied Sciences, Department of Microbiology and Botany, JAIN (Deemed-to-be University), Karnataka, India","institution_ids":["https://openalex.org/I106826634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050322243"],"corresponding_institution_ids":["https://openalex.org/I130291710"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anopheles-gambiae","display_name":"Anopheles gambiae","score":0.9620000123977661},{"id":"https://openalex.org/keywords/climate-change-and-malaria","display_name":"climate change and malaria","score":0.46700000762939453},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gene-expression-timing","display_name":"gene expression timing","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2776802408","wikidata":"https://www.wikidata.org/wiki/Q135237","display_name":"Anopheles gambiae","level":3,"score":0.8414999842643738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6043999791145325},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5882999897003174},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.460999995470047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45010000467300415},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.44440001249313354},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C2781375639","wikidata":"https://www.wikidata.org/wiki/Q158597","display_name":"Anopheles","level":3,"score":0.35760000348091125},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3059999942779541},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.26980000734329224},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.2554999887943268}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.64898/2026.10.13.758761","doi":"https://doi.org/10.64898/2026.10.13.758761","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.758761","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/17/2026.10.13.758761.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.5281/zenodo.22636319","doi":"https://doi.org/10.5281/zenodo.22636319","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22636319","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.22636320","doi":"https://doi.org/10.5281/zenodo.22636320","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22636320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23337400","doi":"https://doi.org/10.5281/zenodo.23337400","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23337400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.64898/2026.10.13.758761","doi":"https://doi.org/10.64898/2026.10.13.758761","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.758761","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/17/2026.10.13.758761.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7211865443.pdf","grobid_xml":"https://content.openalex.org/works/W7211865443.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1964895626","https://openalex.org/W2048489440","https://openalex.org/W2064326768","https://openalex.org/W2066231767","https://openalex.org/W2081969319","https://openalex.org/W2089023364","https://openalex.org/W2096652998","https://openalex.org/W2101642122","https://openalex.org/W2110065044","https://openalex.org/W2118258530","https://openalex.org/W2122825543","https://openalex.org/W2146512944","https://openalex.org/W2158476711","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2197124664","https://openalex.org/W2413782718","https://openalex.org/W2519975043","https://openalex.org/W2592811885","https://openalex.org/W2744783701","https://openalex.org/W2951912016","https://openalex.org/W4390692436","https://openalex.org/W4417321364"],"related_works":["https://openalex.org/W4417321364","https://openalex.org/W4413927867","https://openalex.org/W4390692436","https://openalex.org/W4402448969","https://openalex.org/W7119750366","https://openalex.org/W7120138837","https://openalex.org/W7120269760","https://openalex.org/W7119934459","https://openalex.org/W4411959335","https://openalex.org/W1960039399"],"abstract_inverted_index":{"Abstract":[0],"Only":[1],"older":[2,88,180],"mosquitoes":[3,21,76,84,95,177],"transmit":[4],"malaria,":[5],"so":[6],"how":[7],"warming":[8],"changes":[9],"mosquito":[10],"ageing":[11,32],"matters":[12],"for":[13],"disease.":[14],"Warmer":[15],"temperatures":[16],"are":[17],"known":[18],"to":[19,126,178],"make":[20],"age":[22],"faster,":[23],"but":[24,152],"\u201cfaster\u201d":[25],"can":[26],"mean":[27],"two":[28],"different":[29],"things:":[30],"the":[31,130,134,156],"clock":[33,71,135],"ticks":[34],"more":[35],"quickly,":[36],"or":[37,60],"it":[38],"is":[39],"simply":[40],"set":[41],"forward.":[42],"We":[43],"distinguished":[44],"these":[45],"by":[46,103],"reanalysing":[47],"115":[48],"whole-body":[49],"RNA-sequencing":[50],"libraries":[51],"from":[52],"female":[53],"Anopheles":[54],"gambiae":[55],"kept":[56],"at":[57,162],"27,":[58],"30":[59,93,163,170],"32":[61,82],"\u00b0C":[62,75,83,94,171],"and":[63,92,106,113,149,165],"sampled":[64],"1\u201315":[65],"days":[66,87,98,111,119],"after":[67],"emergence.":[68],"A":[69],"transcriptomic":[70],"trained":[72],"on":[73],"27":[74],"(error":[77],"\u00b1":[78],"0.9":[79],"days)":[80],"read":[81],"as":[85,96],"2.4":[86],"(95%":[89,122],"CI":[90,123],"1.9\u20132.9)":[91],"1.1":[97],"older.":[99],"The":[100],"gap":[101],"opened":[102],"day":[104,121],"5":[105,112],"then":[107],"stopped":[108],"growing:":[109],"between":[110],"15,":[114],"warmth":[115,139],"added":[116],"0.01":[117],"extra":[118],"per":[120],"\u2212":[124],"0.16":[125],"0.19),":[127],"well":[128],"below":[129],"0.29\u20130.45":[131],"expected":[132],"if":[133],"ran":[136],"faster.":[137],"Genome-wide,":[138],"advanced":[140],"genes":[141,155,167],"that":[142],"change":[143],"late":[144],"in":[145],"life,":[146],"notably":[147],"melanisation":[148],"digestive":[150],"genes,":[151],"moved":[153],"early-maturation":[154],"opposite":[157],"way.":[158],"Many":[159],"responses":[160],"bent":[161],"\u00b0C,":[164],"immune":[166],"held":[168],"until":[169],"before":[172],"falling.":[173],"Warmth":[174],"therefore":[175],"shifts":[176],"an":[179],"transcriptional":[181],"state":[182],"without":[183],"accelerating":[184],"its":[185],"pace.":[186]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-08T00:00:00"}
