{"id":"https://openalex.org/W72106338","doi":null,"title":"Assessment of oral ascorbate in three children with chronic granulomatous disease and defective neutrophil motility over a 2-year period.","display_name":"Assessment of oral ascorbate in three children with chronic granulomatous disease and defective neutrophil motility over a 2-year period.","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W72106338","mag":"72106338","pmid":"https://pubmed.ncbi.nlm.nih.gov/6265123","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537134"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537134","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537134","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030988903","display_name":"Ronald Anderson","orcid":"https://orcid.org/0000-0002-5925-6452","observed_orcids":["https://orcid.org/0000-0002-5925-6452"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"R Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030988903"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9047,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.8536036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"43","issue":"1","first_page":"180","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-granulomatous-disease","display_name":"chronic granulomatous disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sodium-ascorbate","display_name":"sodium ascorbate","score":0.875},{"id":"https://openalex.org/keywords/neutrophil-motility","display_name":"neutrophil motility","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neutrophil-function","display_name":"neutrophil function","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9240000247955322},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.7260000109672546},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.7419999837875366},{"id":"https://openalex.org/keywords/elevated-ige","display_name":"elevated IgE","score":0.6019999980926514},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5479999780654907},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.658993124961853},{"id":"https://openalex.org/C2778175462","wikidata":"https://www.wikidata.org/wiki/Q2165663","display_name":"Chronic granulomatous disease","level":2,"score":0.6502757668495178},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5600893497467041},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.549502968788147},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.516523540019989},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.5006709098815918},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.49709466099739075},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.4890459477901459},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.45612776279449463},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.4358028173446655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42827287316322327},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4263710379600525},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33181649446487427},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.26629316806793213},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2502376437187195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20708534121513367},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16794532537460327},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.1396346092224121},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001770","descriptor_name":"Blood Bactericidal Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006105","descriptor_name":"Granulomatous Disease, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006105","descriptor_name":"Granulomatous Disease, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006105","descriptor_name":"Granulomatous Disease, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1537134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537134","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:6265123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6265123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:72106338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6265123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537134","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1571192763","https://openalex.org/W1835370745","https://openalex.org/W1839735542","https://openalex.org/W1988101228","https://openalex.org/W2043402438","https://openalex.org/W2048098540","https://openalex.org/W2082782581","https://openalex.org/W2089813543","https://openalex.org/W2090428109","https://openalex.org/W2096795975","https://openalex.org/W2097620608","https://openalex.org/W2100422822","https://openalex.org/W2113842973","https://openalex.org/W2151634273","https://openalex.org/W2161523807","https://openalex.org/W2224792910","https://openalex.org/W2315608135","https://openalex.org/W2333247981","https://openalex.org/W2342046504","https://openalex.org/W2401566563","https://openalex.org/W2435633064","https://openalex.org/W3001715983"],"related_works":["https://openalex.org/W2435633064","https://openalex.org/W2474332741","https://openalex.org/W42538725","https://openalex.org/W2407929538","https://openalex.org/W2407151370","https://openalex.org/W2427044623","https://openalex.org/W1835370745","https://openalex.org/W2411683071","https://openalex.org/W2020226014","https://openalex.org/W2107673518"],"abstract_inverted_index":{"Two":[0],"brothers":[1],"and":[2,14,52,60,83,86,118,160],"their":[3,141,144],"sister":[4,145],"with":[5,20,157],"chronic":[6],"granulomatous":[7],"disease,":[8],"elevated":[9],"levels":[10],"of":[11,26,43,66,89,106,123],"serum":[12,109],"IgE":[13],"defective":[15],"neutrophil":[16,44,78,90,107],"motility":[17,91],"were":[18,46],"treated":[19],"a":[21,32,153],"single":[22],"oral":[23],"daily":[24],"dose":[25],"1":[27],"g":[28],"sodium":[29],"ascorbate":[30,50,67,137,161],"as":[31],"supplement":[33],"to":[34,49,68,103,113,140],"prophylactic":[35,158],"trimethoprim--sulphamethoxazole":[36],"therapy":[37,51],"for":[38,57],"2":[39],"years.":[40],"Laboratory":[41],"tests":[42],"functions":[45],"performed":[47],"prior":[48],"repeated":[53],"at":[54,61],"1-monthly":[55],"intervals":[56,63],"6":[58],"months":[59],"6-monthly":[62],"thereafter.":[64],"Introduction":[65],"the":[69,124],"therapeutic":[70,142],"regimen":[71],"was":[72,100,138,162],"accompanied":[73],"by":[74],"slight":[75],"increases":[76,115],"in":[77,92,116],"hexose":[79],"monophosphate":[80],"shunt":[81],"activity":[82,85,99,122],"staphylocidal":[84,98],"good":[87],"improvement":[88],"all":[93],"three":[94,166],"children.":[95],"The":[96],"improved":[97],"not":[101],"due":[102],"ascorbate-mediated":[104],"inhibition":[105],"or":[108,112,121],"catalase":[110],"activities":[111],"detectable":[114],"superoxide":[117],"H2O2":[119],"production":[120],"MPO/H2O2/halide":[125],"system.":[126],"Both":[127],"male":[128],"children":[129,167],"have":[130,168],"remained":[131],"free":[132],"from":[133],"obvious":[134],"infection":[135,151],"since":[136],"added":[139],"regimen;":[143],"has":[146],"experienced":[147],"one":[148],"urinary":[149],"tract":[150],"during":[152],"period":[154],"when":[155],"treatment":[156],"co-trimoxazole":[159],"inadvertently":[163],"stopped.":[164],"All":[165],"gained":[169],"weight.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
