{"id":"https://openalex.org/W7210291269","doi":"https://doi.org/10.64898/2026.09.03.749143","title":"Dysregulation of LINGO1 expression in the SOD1(G93A) mutant mice during symptomatic stages of the disease and early postnatal oligodendrogenesis","display_name":"Dysregulation of LINGO1 expression in the SOD1(G93A) mutant mice during symptomatic stages of the disease and early postnatal oligodendrogenesis","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7210291269","doi":"https://doi.org/10.64898/2026.09.03.749143"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.03.749143","doi":"https://doi.org/10.64898/2026.09.03.749143","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749143","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/05/2026.09.03.749143.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/05/2026.09.03.749143.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087070677","display_name":"Amina Zahaf","orcid":"https://orcid.org/0000-0002-4974-7020","observed_orcids":["https://orcid.org/0000-0002-4974-7020"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405254696","display_name":"Maladies et hormones du syst\u00e8me nerveux","ror":"https://ror.org/024c3xj78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4405254696"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amina Zahaf","raw_affiliation_strings":["INSERM-Paris Saclay University, Diseases and Hormones of the Nervous System U1195, 80 Rue du G\u00e9n\u00e9ral Leclerc 94276 Le Kremlin-Bic\u00eatre, France"],"raw_orcid":"https://orcid.org/0000-0002-4974-7020","affiliations":[{"raw_affiliation_string":"INSERM-Paris Saclay University, Diseases and Hormones of the Nervous System U1195, 80 Rue du G\u00e9n\u00e9ral Leclerc 94276 Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405254696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058625130","display_name":"Julie Bourseguin","orcid":"https://orcid.org/0000-0002-3382-225X","observed_orcids":["https://orcid.org/0000-0002-3382-225X"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Bourseguin","raw_affiliation_strings":["Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France"],"raw_orcid":"https://orcid.org/0000-0002-3382-225X","affiliations":[{"raw_affiliation_string":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210118525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019881287","display_name":"Laetitia Cobret","orcid":"https://orcid.org/0000-0002-9217-9954","observed_orcids":["https://orcid.org/0000-0002-9217-9954"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laetitia Cobret","raw_affiliation_strings":["Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France"],"raw_orcid":"https://orcid.org/0000-0002-9217-9954","affiliations":[{"raw_affiliation_string":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210118525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075240293","display_name":"Abdelmoumen Kassoussi","orcid":"https://orcid.org/0000-0002-7082-4764","observed_orcids":["https://orcid.org/0000-0002-7082-4764"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405254696","display_name":"Maladies et hormones du syst\u00e8me nerveux","ror":"https://ror.org/024c3xj78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4405254696"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Abdelmoumen Kassoussi","raw_affiliation_strings":["INSERM-Paris Saclay University, Diseases and Hormones of the Nervous System U1195, 80 Rue du G\u00e9n\u00e9ral Leclerc 94276 Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM-Paris Saclay University, Diseases and Hormones of the Nervous System U1195, 80 Rue du G\u00e9n\u00e9ral Leclerc 94276 Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405254696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038914759","display_name":"Mireille Moussaed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mireille Moussaed","raw_affiliation_strings":["Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210118525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004386868","display_name":"C\u00e9dric Raoul","orcid":"https://orcid.org/0000-0003-0561-6851","observed_orcids":["https://orcid.org/0000-0003-0561-6851"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210134790","display_name":"Institute for Neurosciences of Montpellier","ror":"https://ror.org/0428ctr80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210134790"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Raoul","raw_affiliation_strings":["ALS reference Center, Univ Montpellier, CHU Montpellier, Montpellier, France","INM, Univ Montpellier, INSERM, Montpellier, France"],"raw_orcid":"https://orcid.org/0000-0003-0561-6851","affiliations":[{"raw_affiliation_string":"ALS reference Center, Univ Montpellier, CHU Montpellier, Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"INM, Univ Montpellier, INSERM, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210134790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035314846","display_name":"\u00c9lisabeth Traiffort","orcid":"https://orcid.org/0000-0002-9645-6269","observed_orcids":["https://orcid.org/0000-0002-9645-6269"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405254696","display_name":"Maladies et hormones du syst\u00e8me nerveux","ror":"https://ror.org/024c3xj78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4405254696"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabeth Traiffort","raw_affiliation_strings":["INSERM-Paris Saclay University, Diseases and Hormones of the Nervous System U1195, 80 Rue du G\u00e9n\u00e9ral Leclerc 94276 Le Kremlin-Bic\u00eatre, France"],"raw_orcid":"https://orcid.org/0000-0002-9645-6269","affiliations":[{"raw_affiliation_string":"INSERM-Paris Saclay University, Diseases and Hormones of the Nervous System U1195, 80 Rue du G\u00e9n\u00e9ral Leclerc 94276 Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405254696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075690711","display_name":"S\u00e9verine Morisset\u2010Lopez","orcid":"https://orcid.org/0000-0002-9930-7824","observed_orcids":["https://orcid.org/0000-0002-9930-7824"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"S\u00e9verine Morisset-Lopez","raw_affiliation_strings":["Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France"],"raw_orcid":"https://orcid.org/0000-0002-9930-7824","affiliations":[{"raw_affiliation_string":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, rue Charles Sadron 45071 ORLEANS Cedex 02, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210118525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5075690711"],"corresponding_institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210118525"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lingo-1","display_name":"LINGO-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sod1-g93a-mice","display_name":"SOD1 G93A mice","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mir-138","display_name":"miR-138","score":0.9179999828338623},{"id":"https://openalex.org/keywords/oligodendrogenesis","display_name":"oligodendrogenesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/white-matter-pathology","display_name":"white matter pathology","score":0.7789999842643738},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.8149999976158142},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.5740000009536743},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.6859999895095825},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/presymptomatic-biomarkers","display_name":"presymptomatic biomarkers","score":0.8709999918937683},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7696999907493591},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.730400025844574},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.5737000107765198},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5407000184059143},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49559998512268066},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.46720001101493835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4641000032424927},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.44679999351501465},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.44620001316070557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43459999561309814},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42399999499320984},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.41830000281333923},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4018999934196472},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.38260000944137573},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3603000044822693},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.3386000096797943},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.31209999322891235},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.30799999833106995},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.26980000734329224},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26809999346733093},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.26759999990463257},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.25999999046325684}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.03.749143","doi":"https://doi.org/10.64898/2026.09.03.749143","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749143","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/05/2026.09.03.749143.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.03.749143","doi":"https://doi.org/10.64898/2026.09.03.749143","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749143","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/05/2026.09.03.749143.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3936996224","display_name":null,"funder_award_id":"RAK19097LLP","funder_id":"https://openalex.org/F4320323920","funder_display_name":"Association pour la Recherche sur la Scl\u00e9rose Lat\u00e9rale Amyotrophique et autres Maladies du Motoneurone"}],"funders":[{"id":"https://openalex.org/F4320323920","display_name":"Association pour la Recherche sur la Scl\u00e9rose Lat\u00e9rale Amyotrophique et autres Maladies du Motoneurone","ror":"https://ror.org/054mxgp74"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7210291269.pdf","grobid_xml":"https://content.openalex.org/works/W7210291269.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166043619","https://openalex.org/W2129941454","https://openalex.org/W2756642063","https://openalex.org/W2363036792","https://openalex.org/W1800541863","https://openalex.org/W2064891909","https://openalex.org/W4414007389","https://openalex.org/W2161163550","https://openalex.org/W3180176749","https://openalex.org/W7164350799"],"abstract_inverted_index":{"Abstract":[0],"Oligodendrocytes":[1],"play":[2],"an":[3],"essential":[4],"role":[5],"in":[6,51,69,118,135,156,167,230,266],"axonal":[7,31],"metabolic":[8],"support":[9],"and":[10,12,30,72,84,97,154,216,235,257],"myelination,":[11],"their":[13],"dysfunction":[14],"is":[15,23,66,91],"associated":[16],"with":[17,95],"amyotrophic":[18],"lateral":[19],"sclerosis":[20],"(ALS).":[21],"LINGO1":[22,50,63,90,105,153,227,258],"a":[24,35,138,143,253,260],"major":[25],"inhibitor":[26],"of":[27,49,58,75,87,104,109,126,132,141,152,186,197,201,226,269],"oligodendrocyte":[28,212],"differentiation":[29],"regeneration,":[32],"identified":[33],"as":[34,181,190,192,252,259],"promising":[36],"therapeutic":[37,261],"targeted":[38],"for":[39],"inflammatory":[40],"demyelinating":[41],"diseases.":[42],"Here,":[43],"we":[44],"investigated":[45],"the":[46,52,76,82,88,102,119,124,136,198,243,267],"expression":[47,65,115,151,225],"pattern":[48],"well-established":[53],"SOD1(G93A)":[54],"transgenic":[55],"mouse":[56],"model":[57],"ALS.":[59,270],"We":[60],"show":[61,172],"that":[62,173,188,248],"protein":[64],"significantly":[67],"elevated":[68],"both":[70,81],"grey":[71],"white":[73],"matter":[74],"mutant":[77,120,137],"spinal":[78,121],"cord":[79],"during":[80,164,232],"symptomatic":[83,237],"end":[85],"stages":[86],"disease.":[89],"also":[92],"notably":[93],"co-expressed":[94],"astroglial":[96],"neuronal":[98],"markers.":[99],"However,":[100],"neither":[101],"levels":[103,108],"transcripts,":[106],"nor":[107],"microRNAs":[110,133],"predicted":[111],"to":[112,146,245,263],"regulate":[113],"its":[114],"were":[116],"altered":[117],"cord,":[122],"suggesting":[123],"involvement":[125],"alternative":[127],"regulatory":[128],"mechanisms.":[129,219],"Our":[130],"analysis":[131],"revealed":[134],"significant":[139,184],"downregulation":[140],"miR-138,":[142],"microRNA":[144],"known":[145],"promote":[147,211,264],"myelination.":[148],"The":[149],"differential":[150],"miR-138":[155,207,229,251],"ALS":[157],"mice":[158],"thus":[159],"may":[160,210,249],"drive":[161],"deleterious":[162],"processes":[163],"disease":[165,238],"progression":[166],"adulthood.":[168],"Moreover,":[169],"our":[170,221],"data":[171],"white-matter":[174],"pathology":[175],"arises":[176],"earlier":[177],"than":[178],"initially":[179],"thought,":[180],"evidenced":[182],"by":[183],"alterations":[185],"oligodendrogenesis":[187,234],"manifest":[189],"early":[191,233],"postnatal":[193],"day":[194],"5.":[195],"Study":[196],"molecular":[199],"determinants":[200],"this":[202],"developmental":[203],"defect":[204],"shows":[205],"increased":[206],"expression,":[208],"which":[209],"progenitor":[213],"cell":[214],"maturation":[215],"involve":[217],"compensatory":[218],"Overall,":[220],"work":[222],"identifies":[223],"disrupted":[224],"and/or":[228],"brain":[231],"at":[236],"stages.":[239],"These":[240],"findings":[241],"open":[242],"way":[244],"further":[246],"investigations":[247],"consider":[250],"potential":[254],"presymptomatic":[255],"biomarker":[256],"target":[262],"remyelination":[265],"context":[268]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-07T00:00:00"}
