{"id":"https://openalex.org/W7210288802","doi":"https://doi.org/10.64898/2026.09.03.749066","title":"HSPD1 promotes neuroblastoma by augmenting MYCN expression","display_name":"HSPD1 promotes neuroblastoma by augmenting MYCN expression","publication_year":2026,"publication_date":"2026-09-06","ids":{"openalex":"https://openalex.org/W7210288802","doi":"https://doi.org/10.64898/2026.09.03.749066"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.03.749066","doi":"https://doi.org/10.64898/2026.09.03.749066","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/06/2026.09.03.749066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/06/2026.09.03.749066.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120028416","display_name":"Shatha S. Alassam","orcid":"https://orcid.org/0009-0006-1068-2983","observed_orcids":["https://orcid.org/0009-0006-1068-2983"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shatha S Alassam","raw_affiliation_strings":["Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":"https://orcid.org/0009-0006-1068-2983","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102762829","display_name":"Dinesh Babu Manikandan","orcid":"https://orcid.org/0000-0003-0605-9946","observed_orcids":["https://orcid.org/0000-0003-0605-9946"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dinesh Babu Manikandan","raw_affiliation_strings":["Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel","The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074001624","display_name":"Hila Ben-David","orcid":"https://orcid.org/0000-0002-6491-2311","observed_orcids":["https://orcid.org/0000-0002-6491-2311"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hila Ben-David","raw_affiliation_strings":["Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":"https://orcid.org/0000-0002-6491-2311","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146654142","display_name":"Linor Cohen","orcid":"https://orcid.org/0009-0006-1736-4400","observed_orcids":["https://orcid.org/0009-0006-1736-4400"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Linor Cohen","raw_affiliation_strings":["Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":"https://orcid.org/0009-0006-1736-4400","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114559171","display_name":"Shai Kaluski-Kopatch","orcid":"https://orcid.org/0000-0002-3457-2299","observed_orcids":["https://orcid.org/0000-0002-3457-2299"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shai Kaluski-Kopatch","raw_affiliation_strings":["Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":"https://orcid.org/0000-0002-3457-2299","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005942429","display_name":"Laura A. Hruby","orcid":"https://orcid.org/0009-0001-1415-6001","observed_orcids":["https://orcid.org/0009-0001-1415-6001"]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Hruby","raw_affiliation_strings":["Institute of Neuropathology, University Hospital D\u00fcsseldorf and Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0009-0001-1415-6001","affiliations":[{"raw_affiliation_string":"Institute of Neuropathology, University Hospital D\u00fcsseldorf and Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006755490","display_name":"Shiran Dror","orcid":"https://orcid.org/0000-0002-2061-4750","observed_orcids":["https://orcid.org/0000-0002-2061-4750"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shiran Dror","raw_affiliation_strings":["Ilse Katz Institute (IKI) for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer Sheva, Israel"],"raw_orcid":"https://orcid.org/0000-0002-2061-4750","affiliations":[{"raw_affiliation_string":"Ilse Katz Institute (IKI) for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083608565","display_name":"Poul H. B. Sorensen","orcid":"https://orcid.org/0000-0001-7447-2199","observed_orcids":["https://orcid.org/0000-0001-7447-2199"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Poul Sorensen","raw_affiliation_strings":["Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0001-7447-2199","affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046393134","display_name":"Alberto Delaidelli","orcid":"https://orcid.org/0000-0001-7416-6503","observed_orcids":["https://orcid.org/0000-0001-7416-6503"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Delaidelli","raw_affiliation_strings":["Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7416-6503","affiliations":[{"raw_affiliation_string":"Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044551982","display_name":"Gabriel Leprivier","orcid":"https://orcid.org/0000-0002-2299-8989","observed_orcids":["https://orcid.org/0000-0002-2299-8989"]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriel Leprivier","raw_affiliation_strings":["Institute of Neuropathology, University Hospital D\u00fcsseldorf and Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2299-8989","affiliations":[{"raw_affiliation_string":"Institute of Neuropathology, University Hospital D\u00fcsseldorf and Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028992290","display_name":"Moshe Elkabets","orcid":"https://orcid.org/0000-0003-3634-9098","observed_orcids":["https://orcid.org/0000-0003-3634-9098"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Moshe Elkabets","raw_affiliation_strings":["Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel","The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel"],"raw_orcid":"https://orcid.org/0000-0003-3634-9098","affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043955991","display_name":"Barak Rotblat","orcid":"https://orcid.org/0000-0003-2985-7115","observed_orcids":["https://orcid.org/0000-0003-2985-7115"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Barak Rotblat","raw_affiliation_strings":["Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"],"raw_orcid":"https://orcid.org/0000-0003-2985-7115","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5043955991"],"corresponding_institution_ids":["https://openalex.org/I124227911"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hspd1","display_name":"HSPD1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitochondrial-hsp60","display_name":"mitochondrial Hsp60","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mycn-amplification","display_name":"MYCN amplification","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-translation","display_name":"mitochondrial translation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/mitochondrial-proteostasis","display_name":"mitochondrial proteostasis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mthfd2","display_name":"MTHFD2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mitochondrial-ribosomal-proteins","display_name":"mitochondrial ribosomal proteins","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5329999923706055},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C111491248","wikidata":"https://www.wikidata.org/wiki/Q18033821","display_name":"DNAJA3","level":5,"score":0.5972999930381775},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5422999858856201},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5008000135421753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49639999866485596},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.4943999946117401},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48500001430511475},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4383000135421753},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.4221999943256378},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4059000015258789},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C146621620","wikidata":"https://www.wikidata.org/wiki/Q24771589","display_name":"HSP60","level":5,"score":0.3720000088214874},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.33730000257492065},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.3368000090122223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.328900009393692},{"id":"https://openalex.org/C2780090675","wikidata":"https://www.wikidata.org/wiki/Q21234507","display_name":"Mitochondrial ribosome","level":5,"score":0.32109999656677246},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.3037000000476837},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.29750001430511475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29649999737739563},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.29490000009536743},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C2779478826","wikidata":"https://www.wikidata.org/wiki/Q24780839","display_name":"Polynucleotide phosphorylase","level":5,"score":0.275299996137619},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C2780102198","wikidata":"https://www.wikidata.org/wiki/Q3054027","display_name":"Endoribonuclease","level":5,"score":0.2700999975204468},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C134792803","wikidata":"https://www.wikidata.org/wiki/Q424886","display_name":"Glyceraldehyde 3-phosphate dehydrogenase","level":4,"score":0.25540000200271606},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.03.749066","doi":"https://doi.org/10.64898/2026.09.03.749066","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/06/2026.09.03.749066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.03.749066","doi":"https://doi.org/10.64898/2026.09.03.749066","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/06/2026.09.03.749066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1601281218","display_name":null,"funder_award_id":"228/25","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7210288802.pdf","grobid_xml":"https://content.openalex.org/works/W7210288802.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W4401573446","https://openalex.org/W4415440497","https://openalex.org/W4415493047"],"related_works":["https://openalex.org/W4391691846","https://openalex.org/W2097055142","https://openalex.org/W2981003839","https://openalex.org/W2002889430","https://openalex.org/W4316372012","https://openalex.org/W2124292178","https://openalex.org/W7118085071","https://openalex.org/W2614951992","https://openalex.org/W2900887066","https://openalex.org/W2811237339"],"abstract_inverted_index":{"Abstract":[0],"MYCN":[1,11,39,54,95,104,121,138],"amplification":[2],"is":[3,46,62],"associated":[4],"with":[5,120],"poor":[6],"outcomes":[7],"in":[8,31,42,94,108,111,123],"neuroblastoma":[9],"(NB).":[10],"encodes":[12],"a":[13,63,131],"transcription":[14],"factor":[15],"that":[16,91],"induces":[17],"the":[18,36,43,68,77,135],"expression":[19,122],"of":[20,38,84,137],"mitochondrial":[21,44,50,65,69,73,85,102],"one-carbon":[22,70,78],"enzymes":[23],"and":[24,29,72,81,106,110,117],"chaperones,":[25],"promoting":[26,67],"metabolic":[27],"reprogramming":[28],"aggressiveness":[30],"NB":[32,97,124],"tumor":[33],"cells.":[34],"While":[35],"contribution":[37],"to":[40,53,100],"changes":[41],"proteome":[45],"well":[47],"established,":[48],"how":[49],"proteostasis":[51],"contributes":[52],"activity":[55],"remains":[56],"poorly":[57],"understood.":[58],"Mitochondrial":[59],"HSP60":[60],"(HSPD1)":[61],"conserved":[64],"chaperone":[66],"pathway":[71],"translation":[74],"by":[75],"folding":[76],"enzyme":[79],"MTHFD2":[80],"preventing":[82],"aggregation":[83],"ribosomal":[86],"proteins.":[87],"Here,":[88],"we":[89],"show":[90],"HSPD1":[92,115,129],"depletion":[93],"-amplified":[96,139],"cells":[98],"led":[99],"reduced":[101],"translation,":[103],"expression,":[105],"tumorigenesis":[107],"vitro":[109],"vivo.":[112],"In":[113],"addition,":[114],"mRNA":[116],"protein":[118],"correlate":[119],"tumors.":[125],"These":[126],"results":[127],"establish":[128],"as":[130],"promising":[132],"target":[133],"for":[134],"treatment":[136],"NB.":[140]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-07T00:00:00"}
