{"id":"https://openalex.org/W7210281609","doi":"https://doi.org/10.64898/2026.09.01.26361892","title":"Baseline intratumoral TCR\u03b2 and TCR\u03b3 repertoires predict response to immune checkpoint inhibitors in advanced renal cell carcinoma","display_name":"Baseline intratumoral TCR\u03b2 and TCR\u03b3 repertoires predict response to immune checkpoint inhibitors in advanced renal cell carcinoma","publication_year":2026,"publication_date":"2026-09-06","ids":{"openalex":"https://openalex.org/W7210281609","doi":"https://doi.org/10.64898/2026.09.01.26361892"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.26361892","doi":"https://doi.org/10.64898/2026.09.01.26361892","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.26361892","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/04/2026.09.01.26361892.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/04/2026.09.01.26361892.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106250970","display_name":"Manuel Pino-Gonz\u00e1lez","orcid":"https://orcid.org/0009-0006-0385-1021","observed_orcids":["https://orcid.org/0009-0006-0385-1021"]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Pino-Gonz\u00e1lez","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":"https://orcid.org/0009-0006-0385-1021","affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023835682","display_name":"Mart\u00edn Emilio L\u00e1zaro Quintela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mart\u00edn L\u00e1zaro-Quintela","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146962029","display_name":"Guillermo de Velasco Oria de Rueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guillermo de Velasco","raw_affiliation_strings":["Department of Medical Oncology, Biomedical Research Institute I+12, Hospital Universitario \u201c12 de Octubre\u201d, 28041 (Madrid), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Biomedical Research Institute I+12, Hospital Universitario \u201c12 de Octubre\u201d, 28041 (Madrid), Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063969801","display_name":"Marta Due\u00f1as Porto","orcid":"https://orcid.org/0000-0003-0857-9726","observed_orcids":["https://orcid.org/0000-0003-0857-9726"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Due\u00f1as","raw_affiliation_strings":["Molecular and Traslational Oncology Division, Biomedical Innovation Unit, CIEMAT, 28040 (Madrid), Spain. Cellular and Molecular Oncology and Genitourinary Tumor Group, Biomedical Research Institute Imas12, Hospital Universitario \u201c12 de Octubre\u201d, 28041 (Madrid), Spain. Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer, 28029 (Madrid), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Traslational Oncology Division, Biomedical Innovation Unit, CIEMAT, 28040 (Madrid), Spain. Cellular and Molecular Oncology and Genitourinary Tumor Group, Biomedical Research Institute Imas12, Hospital Universitario \u201c12 de Octubre\u201d, 28041 (Madrid), Spain. Centro de Investigaci\u00f3n Biom\u00e9dica en Red C\u00e1ncer, 28029 (Madrid), Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691","https://openalex.org/I4210115082","https://openalex.org/I4210158561","https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049802668","display_name":"Irene Alonso \u00c1lvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Irene Alonso-\u00c1lvarez","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102617609","display_name":"Alejandro Francisco Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Francisco-Fern\u00e1ndez","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055043876","display_name":"Pilar San Miguel-Fraile","orcid":"https://orcid.org/0000-0001-5408-7752","observed_orcids":["https://orcid.org/0000-0001-5408-7752"]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar San Fraile","raw_affiliation_strings":["Department of Pathology, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain. Uropathology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain. Uropathology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024476379","display_name":"Jos\u00e9 Antonio Ortiz Rey","orcid":"https://orcid.org/0000-0003-1280-1115","observed_orcids":["https://orcid.org/0000-0003-1280-1115"]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Antonio Ortiz","raw_affiliation_strings":["Department of Pathology, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain. Uropathology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain. Uropathology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027627986","display_name":"Mar\u00eda Gallardo\u2010G\u00f3mez","orcid":"https://orcid.org/0000-0002-4856-9322","observed_orcids":["https://orcid.org/0000-0002-4856-9322"]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Gallardo-G\u00f3mez","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150503969","display_name":"Laura Carracedo Videira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Carracedo-Videira","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086975017","display_name":"Sandra Gallach","orcid":"https://orcid.org/0000-0002-6721-1211","observed_orcids":["https://orcid.org/0000-0002-6721-1211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Gallach","raw_affiliation_strings":["Molecular Oncology Laboratory, General University Hospital of Valencia Research Foundation, 46014 (Valencia), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Laboratory, General University Hospital of Valencia Research Foundation, 46014 (Valencia), Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051426336","display_name":"Eloisa Jantus Lewintre","orcid":"https://orcid.org/0000-0001-7395-4380","observed_orcids":["https://orcid.org/0000-0001-7395-4380"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eloisa Jantus-Lewintre","raw_affiliation_strings":["Instituto Interuniversitario de Investigacii\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia - Universitat de Val\u00e8ncia, Valencia, Spain y Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia - Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Department of Biotechnology. Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 (Valencia), Spain","Molecular Oncology Laboratory, General University Hospital of Valencia Research Foundation, 46014 (Valencia), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Interuniversitario de Investigacii\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM), Universitat Polit\u00e8cnica de Val\u00e8ncia - Universitat de Val\u00e8ncia, Valencia, Spain y Unidad Mixta UPV-CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina, Universitat Polit\u00e8cnica de Val\u00e8ncia - Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Department of Biotechnology. Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 (Valencia), Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I4210165109","https://openalex.org/I60053951"]},{"raw_affiliation_string":"Molecular Oncology Laboratory, General University Hospital of Valencia Research Foundation, 46014 (Valencia), Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033985975","display_name":"M\u00f3nica Mart\u00ednez Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M\u00f3nica Mart\u00ednez-Fern\u00e1ndez","raw_affiliation_strings":["Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Hospital \u00c1lvaro Cunqueiro, Carretera Clara Campoamor, 341, 36213 (Vigo), Spain","institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5033985975"],"corresponding_institution_ids":["https://openalex.org/I4210158352","https://openalex.org/I6289922"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.9300000071525574},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7829999923706055},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6029999852180481},{"id":"https://openalex.org/keywords/clonal-dominance","display_name":"clonal dominance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.6069999933242798},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.796999990940094},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6470000147819519},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6815999746322632},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.6044999957084656},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5795999765396118},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5773000121116638},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5446000099182129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5335000157356262},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5322999954223633},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.504800021648407},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.49540001153945923},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4772999882698059},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4580000042915344},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.39419999718666077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38850000500679016},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3605000078678131},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3391999900341034},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.3197999894618988},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.30550000071525574},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30239999294281006},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2897999882698059},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2565999925136566},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.26361892","doi":"https://doi.org/10.64898/2026.09.01.26361892","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.26361892","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/04/2026.09.01.26361892.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.26361892","doi":"https://doi.org/10.64898/2026.09.01.26361892","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.26361892","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/04/2026.09.01.26361892.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G113891353","display_name":null,"funder_award_id":"IN606B","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G3889575626","display_name":null,"funder_award_id":"IN606B-2024/014","funder_id":"https://openalex.org/F4320326633","funder_display_name":"Axencia Galega de Innovaci\u00f3n"},{"id":"https://openalex.org/G5117529824","display_name":"UNA PERSPECTIVA EPIGENETICA EN LA ERA DE LA INMUNO-ONCOLOGIA","funder_award_id":"PI21/00348","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7153136221","display_name":null,"funder_award_id":"CP20/00188","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7256145014","display_name":null,"funder_award_id":"CP20/00188","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G8150804867","display_name":null,"funder_award_id":"IN606B-2024/014","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320326633","display_name":"Axencia Galega de Innovaci\u00f3n","ror":"https://ror.org/02vcxyt85"},{"id":"https://openalex.org/F4320326655","display_name":"Xunta de Galicia","ror":"https://ror.org/0181xnw06"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7210281609.pdf","grobid_xml":"https://content.openalex.org/works/W7210281609.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1978029914","https://openalex.org/W2019607817","https://openalex.org/W2028433016","https://openalex.org/W2071507149","https://openalex.org/W2101637500","https://openalex.org/W2109916620","https://openalex.org/W2152575748","https://openalex.org/W2154330708","https://openalex.org/W2163544987","https://openalex.org/W2222086386","https://openalex.org/W2593493913","https://openalex.org/W2761575992","https://openalex.org/W2783304102","https://openalex.org/W2787894218","https://openalex.org/W2792937256","https://openalex.org/W2804742579","https://openalex.org/W2805302875","https://openalex.org/W2888593931","https://openalex.org/W2900841241","https://openalex.org/W2901601525","https://openalex.org/W2906815954","https://openalex.org/W2911812451","https://openalex.org/W2966465234","https://openalex.org/W2985693568","https://openalex.org/W2997606761","https://openalex.org/W3004928071","https://openalex.org/W3006739116","https://openalex.org/W3007632958","https://openalex.org/W3029490475","https://openalex.org/W3083058958","https://openalex.org/W3104068360","https://openalex.org/W3125723584","https://openalex.org/W3125831681","https://openalex.org/W3134486851","https://openalex.org/W3157161120","https://openalex.org/W3165019442","https://openalex.org/W3189520376","https://openalex.org/W3210762887","https://openalex.org/W4286268688","https://openalex.org/W4294358748","https://openalex.org/W4295587459","https://openalex.org/W4311570783","https://openalex.org/W4313888795","https://openalex.org/W4319065859","https://openalex.org/W4386774808","https://openalex.org/W4387499185","https://openalex.org/W4388880158","https://openalex.org/W4388925666","https://openalex.org/W4399010807","https://openalex.org/W4400763614","https://openalex.org/W4401536442","https://openalex.org/W4401948805","https://openalex.org/W4416402643","https://openalex.org/W7133310319"],"related_works":["https://openalex.org/W4388531148","https://openalex.org/W4403400566","https://openalex.org/W7171666673","https://openalex.org/W4386090594","https://openalex.org/W3006739116","https://openalex.org/W4286268688","https://openalex.org/W3125723584","https://openalex.org/W3022137648","https://openalex.org/W2982796219","https://openalex.org/W4379282200"],"abstract_inverted_index":{"Abstract":[0],"Immune":[1],"checkpoint":[2,90,211],"inhibitors":[3],"(ICIs)":[4],"have":[5,31],"transformed":[6],"the":[7,50,65,69,118,148,165,182,190,234],"treatment":[8],"landscape":[9],"of":[10,20,49,68,80,121,147,170,237,244],"advanced":[11,83,205],"renal":[12],"cell":[13],"carcinoma":[14],"(RCC),":[15],"yet":[16],"only":[17],"a":[18,77,95,156,231,242],"subset":[19],"patients":[21,81,203],"derives":[22],"durable":[23],"clinical":[24,36,136],"benefit":[25,246],"and":[26,73,106,130,138,152,178,199,229],"no":[27],"robust":[28],"predictive":[29,66],"biomarkers":[30,224],"been":[32],"implemented":[33],"in":[34,76,172,202,247],"routine":[35],"practice.":[37],"As":[38],"T-cell":[39],"receptor":[40],"(TCR)-mediated":[41],"antigen":[42],"recognition":[43],"underlies":[44],"effective":[45],"antitumor":[46],"immunity,":[47],"characterization":[48],"intratumoral":[51,71,197,217],"TCR":[52,218,238],"repertoire":[53,100,219,239],"may":[54],"provide":[55,230],"clinically":[56],"relevant":[57],"information":[58],"for":[59,225,233],"patient":[60,227],"stratification.":[61],"Here,":[62],"we":[63],"evaluated":[64],"value":[67],"baseline":[70,196,216],"TCR\u03b2":[72,99,151,198],"TCR\u03b3":[74,104,113,153,200],"repertoires":[75,201],"real-world":[78],"cohort":[79],"with":[82,87,102,135,175,204],"RCC":[84,206],"treated":[85],"predominantly":[86,207],"first-line":[88,209],"immune":[89,210],"inhibitor-based":[91],"regimens.":[92],"Responders":[93],"exhibited":[94],"significantly":[96],"more":[97],"even":[98],"together":[101],"increased":[103],"diversity":[105],"clonal":[107,114],"richness,":[108],"whereas":[109],"non-responders":[110],"showed":[111],"greater":[112],"dominance.":[115],"In":[116,142],"addition,":[117],"preferential":[119],"usage":[120],"specific":[122],"TRBV":[123],"genes,":[124],"including":[125],"TRBV5.7":[126],",":[127,129,132],"TRBV7.1":[128],"TRBV18":[131],"was":[133],"associated":[134],"response":[137],"longer":[139],"progression-free":[140],"survival.":[141],"this":[143,188],"exploratory":[144],"cohort,":[145],"integration":[146],"most":[149],"informative":[150],"variables":[154],"into":[155],"combined":[157],"random":[158],"forest":[159],"model":[160],"yielded":[161],"an":[162],"area":[163],"under":[164],"receiver":[166],"operating":[167],"characteristic":[168],"curve":[169],"0.90":[171],"leave-one-out":[173],"cross-validation,":[174],"100%":[176],"sensitivity":[177],"81.8%":[179],"specificity":[180],"at":[181],"selected":[183],"threshold.":[184],"To":[185],"our":[186],"knowledge,":[187],"is":[189],"first":[191],"study":[192],"to":[193],"simultaneously":[194],"characterize":[195],"receiving":[208],"blockade.":[212],"These":[213],"findings":[214],"support":[215],"features":[220],"as":[221,241],"candidate":[222],"tissue":[223],"pretreatment":[226],"stratification":[228],"rationale":[232],"prospective":[235],"validation":[236],"profiling":[240],"predictor":[243],"immunotherapy":[245],"RCC.":[248]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-07T00:00:00"}