{"id":"https://openalex.org/W7210281130","doi":"https://doi.org/10.2139/ssrn.7403077","title":"Determinants of Lassa virus resistance to the antiviral nucleoside 4\u2032-fluorouridine","display_name":"Determinants of Lassa virus resistance to the antiviral nucleoside 4\u2032-fluorouridine","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7210281130","doi":"https://doi.org/10.2139/ssrn.7403077"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.7403077","doi":"https://doi.org/10.2139/ssrn.7403077","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7403077","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.7403077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046216083","display_name":"Jamie A. Kelly","orcid":"https://orcid.org/0000-0003-2416-2496","observed_orcids":["https://orcid.org/0000-0003-2416-2496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamie  A. Kelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114693676","display_name":"Virginia Aida-Ficken","orcid":"https://orcid.org/0000-0001-9450-0142","observed_orcids":["https://orcid.org/0000-0001-9450-0142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virginia Aida-Ficken","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9450-0142","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324231","display_name":"Payel Chatterjee","orcid":"https://orcid.org/0000-0001-6714-7232","observed_orcids":["https://orcid.org/0000-0001-6714-7232","https://orcid.org/0009-0004-7474-9740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Payel Chatterjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6714-7232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064113837","display_name":"Laura K. McMullan","orcid":"https://orcid.org/0000-0003-2748-5151","observed_orcids":["https://orcid.org/0000-0003-2748-5151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura McMullan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2748-5151","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086546231","display_name":"M. Harley Jenks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.  Harley Jenks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031547878","display_name":"George R. Painter","orcid":"https://orcid.org/0000-0002-9803-8095","observed_orcids":["https://orcid.org/0000-0002-9803-8095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George  R. Painter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086245832","display_name":"Joel M. Montgomery","orcid":"https://orcid.org/0000-0003-0523-4431","observed_orcids":["https://orcid.org/0000-0003-0523-4431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel  M. Montgomery","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0523-4431","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034664089","display_name":"Christina F. Spiropoulou","orcid":"https://orcid.org/0000-0001-8406-3161","observed_orcids":["https://orcid.org/0000-0001-8406-3161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina  F. Spiropoulou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8406-3161","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051176579","display_name":"Mike Flint","orcid":"https://orcid.org/0000-0002-5373-787X","observed_orcids":["https://orcid.org/0000-0002-5373-787X","https://orcid.org/0000-0002-9784-5530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike Flint","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lassa-virus","display_name":"Lassa virus","score":1.0},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.8109999895095825},{"id":"https://openalex.org/keywords/rna-polymerase","display_name":"RNA polymerase","score":0.628000020980835},{"id":"https://openalex.org/keywords/replicative-fitness","display_name":"replicative fitness","score":0.7269999980926514},{"id":"https://openalex.org/keywords/polymerase-inhibitors","display_name":"polymerase inhibitors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.6990000009536743},{"id":"https://openalex.org/keywords/ec50","display_name":"EC50","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8396000266075134},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.7516999840736389},{"id":"https://openalex.org/C2777427142","wikidata":"https://www.wikidata.org/wiki/Q24719561","display_name":"Lassa virus","level":3,"score":0.6413999795913696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6378999948501587},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5910000205039978},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5692999958992004},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.4702000021934509},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.45100000500679016},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.40790000557899475},{"id":"https://openalex.org/C3020505244","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral treatment","level":4,"score":0.3452000021934509},{"id":"https://openalex.org/C2776352584","wikidata":"https://www.wikidata.org/wiki/Q418533","display_name":"Nucleoside triphosphate","level":4,"score":0.34290000796318054},{"id":"https://openalex.org/C153574943","wikidata":"https://www.wikidata.org/wiki/Q408939","display_name":"Nucleotidyltransferase","level":4,"score":0.3208000063896179},{"id":"https://openalex.org/C2780023225","wikidata":"https://www.wikidata.org/wiki/Q706845","display_name":"Lassa fever","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.29159998893737793},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.2874999940395355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C2779574689","wikidata":"https://www.wikidata.org/wiki/Q2368907","display_name":"Arenavirus","level":5,"score":0.2615000009536743},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.25940001010894775},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C2779772310","wikidata":"https://www.wikidata.org/wiki/Q16934561","display_name":"Favipiravir","level":5,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.7403077","doi":"https://doi.org/10.2139/ssrn.7403077","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7403077","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.7403077","doi":"https://doi.org/10.2139/ssrn.7403077","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7403077","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7160691653","https://openalex.org/W4391428428","https://openalex.org/W7167461020","https://openalex.org/W7134251825","https://openalex.org/W2611397933","https://openalex.org/W4396514528","https://openalex.org/W7131079792","https://openalex.org/W4310214315","https://openalex.org/W7122744613","https://openalex.org/W4399358511"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-07T00:00:00"}