{"id":"https://openalex.org/W72097699","doi":null,"title":"Partial pressure of NH\u2083 in cirrhotic patients with and without hepatic encephalopathy.","display_name":"Partial pressure of NH\u2083 in cirrhotic patients with and without hepatic encephalopathy.","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W72097699","mag":"72097699","pmid":"https://pubmed.ncbi.nlm.nih.gov/21725514"},"language":"en","primary_location":{"id":"pmid:21725514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21725514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087937660","display_name":"Yong He","orcid":"https://orcid.org/0000-0003-1877-316X","observed_orcids":["https://orcid.org/0000-0003-1877-316X","https://orcid.org/0009-0009-5057-1147"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong He","raw_affiliation_strings":["Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067046366","display_name":"Guixing Li","orcid":"https://orcid.org/0000-0003-0107-213X","observed_orcids":["https://orcid.org/0000-0003-0107-213X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guixing Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101177704","display_name":"Hao-Lan Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haolan Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112081603","display_name":"Tong-Xing Luo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tongxing Luo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060004850","display_name":"Bao-Xiu Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baoxiu Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5104083623","display_name":"Jin Xu","orcid":"https://orcid.org/0009-0003-8319-2748","observed_orcids":["https://orcid.org/0009-0003-8319-2748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1166,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78161589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"2","first_page":"169","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ammonia","display_name":"ammonia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/blood-ph","display_name":"blood pH","score":0.6690000295639038},{"id":"https://openalex.org/keywords/alkalosis","display_name":"alkalosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/venous-ammonia","display_name":"venous ammonia","score":0.824999988079071},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7059999704360962},{"id":"https://openalex.org/keywords/encephalopathy-severity","display_name":"encephalopathy severity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.9569001197814941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7943753004074097},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7798377275466919},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.6996780633926392},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6790976524353027},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.5608169436454773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5539292693138123},{"id":"https://openalex.org/C2781099255","wikidata":"https://www.wikidata.org/wiki/Q1640868","display_name":"Hyperammonemia","level":2,"score":0.539695680141449},{"id":"https://openalex.org/C2777068682","wikidata":"https://www.wikidata.org/wiki/Q512654","display_name":"Alkalosis","level":3,"score":0.466016560792923},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.4491797983646393},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.11609923839569092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07392874360084534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05013084411621094}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006501","descriptor_name":"Hepatic Encephalopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006501","descriptor_name":"Hepatic Encephalopathy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008603","descriptor_name":"Mental Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21725514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21725514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},{"id":"mag:72097699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21725514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W155384573","https://openalex.org/W1964632652","https://openalex.org/W1965059326","https://openalex.org/W1977666668","https://openalex.org/W1982049192","https://openalex.org/W1985697148","https://openalex.org/W1992788998","https://openalex.org/W1997466270","https://openalex.org/W2002322884","https://openalex.org/W2003045986","https://openalex.org/W2008583357","https://openalex.org/W2018406010","https://openalex.org/W2041296742","https://openalex.org/W2043045730","https://openalex.org/W2103708381","https://openalex.org/W2104703549","https://openalex.org/W2127244067","https://openalex.org/W2132135875","https://openalex.org/W2466223576","https://openalex.org/W2474455978","https://openalex.org/W2499299949","https://openalex.org/W2601648899","https://openalex.org/W4292028675"],"related_works":["https://openalex.org/W2103708381","https://openalex.org/W2127244067","https://openalex.org/W1993089591","https://openalex.org/W1970596289","https://openalex.org/W2076939844","https://openalex.org/W2334647181","https://openalex.org/W2042649946","https://openalex.org/W2170468921","https://openalex.org/W3019110099","https://openalex.org/W2186365101"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Although":[3],"the":[4,19,28,33,46,58,67,77,172,179,197],"exact":[5],"pathogenetic":[6],"factor":[7],"in":[8,117,158,214,238],"hepatic":[9,36,80,89,136,151,161,176,220,242],"encephalopathy":[10,37,90,128],"is":[11,15,45,52,74],"still":[12],"unknown,":[13],"ammonia":[14,31,44,50,73,141,165,185,205,208],"considered":[16],"to":[17,54,171],"be":[18,232],"major":[20],"cause":[21,62],"of":[22,35,49,71,79,113,175,192,200,219],"neurotoxicity.":[23],"However,":[24],"previous":[25],"studies":[26],"on":[27],"relationship":[29],"between":[30],"and":[32,61,91,96,100,105,121,126,140,153,166,187,203,229,235],"severity":[34,78],"have":[38],"yielded":[39],"variable":[40],"results.":[41],"Since":[42],"unionized":[43,72],"only":[47],"form":[48],"that":[51,69,196,226],"able":[53],"freely":[55],"spread":[56],"through":[57],"blood-brain":[59],"barrier":[60],"cerebral":[63],"dysfunction,":[64],"we":[65],"tested":[66],"hypothesis":[68],"concentration":[70],"correlated":[75,170],"with":[76,85,88,125,135,160,241],"encephalopathy.":[81,162,221,243],"METHODS:":[82],"156":[83],"patients":[84,124,134,149,159,194,216,240],"cirrhosis":[86],"(74":[87],"82":[92],"without)":[93],"were":[94,108,129,143,168,210],"enrolled,":[95],"underwent":[97],"clinical":[98,173],"examination":[99],"blood":[101],"testing.":[102],"Ammonia,":[103],"pNH3":[104,139,167,188,202,228],"pH":[106,122,230],"determinations":[107],"repeated":[109],"after":[110,217],"two":[111],"days":[112],"treatment.":[114],"The":[115,190],"differences":[116],"venous":[118,164,184,204,207],"ammonia,":[119],"pNH3,":[120],"among":[123,148],"without":[127,150],"analyzed.":[130],"RESULTS:":[131],"Among":[132],"cirrhotic":[133,239],"encephalopathy,":[137,152],"pH,":[138,201],"levels":[142,199,209],"all":[144],"higher":[145,213],"than":[146],"those":[147],"alkalosis":[154],"was":[155,181],"more":[156],"common":[157],"Both":[163],"significantly":[169],"grade":[174],"encephalopathy;":[177],"however,":[178],"r":[180],"similar":[182],"for":[183],"(r=0.63)":[186],"(r=0.68).":[189],"follow-up":[191],"20":[193],"showed":[195],"median":[198],"decreased;":[206],"unchanged":[211],"or":[212],"some":[215],"resolution":[218],"CONCLUSION:":[222],"This":[223],"study":[224],"supports":[225],"pH-dependant":[227],"could":[231],"useful":[233],"diagnostic":[234],"prognostic":[236],"tools":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}