{"id":"https://openalex.org/W7208838751","doi":"https://doi.org/10.1016/j.bbadis.2026.168451","title":"Circular RNAs and SIRT1 in post-transcriptional regulation and human disease","display_name":"Circular RNAs and SIRT1 in post-transcriptional regulation and human disease","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208838751","doi":"https://doi.org/10.1016/j.bbadis.2026.168451","pmid":"https://pubmed.ncbi.nlm.nih.gov/42700874"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbadis.2026.168451","doi":"https://doi.org/10.1016/j.bbadis.2026.168451","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2026.168451","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbadis.2026.168451","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084984290","display_name":"Omid Vakili","orcid":"https://orcid.org/0000-0002-9103-872X","observed_orcids":["https://orcid.org/0000-0002-9103-872X"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Omid Vakili","raw_affiliation_strings":["Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: o.vakili.isf@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-9103-872X","affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: o.vakili.isf@gmail.com","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039635141","display_name":"Zeynab Yousefi","orcid":"https://orcid.org/0000-0002-7931-5456","observed_orcids":["https://orcid.org/0000-0002-7931-5456"]},"institutions":[{"id":"https://openalex.org/I4405270669","display_name":"Research Institute for Gastroenterology and Liver Diseases","ror":"https://ror.org/014xcbd14","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4405270669"]},{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Zeynab Yousefi","raw_affiliation_strings":["Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: zainabyousefi1991@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: zainabyousefi1991@gmail.com","institution_ids":["https://openalex.org/I4405270669","https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081641438","display_name":"Somayeh Igder","orcid":"https://orcid.org/0000-0002-3096-2660","observed_orcids":["https://orcid.org/0000-0002-3096-2660"]},"institutions":[{"id":"https://openalex.org/I119939603","display_name":"Ahvaz Jundishapur University of Medical Sciences","ror":"https://ror.org/01rws6r75","country_code":"IR","type":"education","lineage":["https://openalex.org/I119939603"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Somayeh Igder","raw_affiliation_strings":["Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: somayeheigder@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: somayeheigder@gmail.com","institution_ids":["https://openalex.org/I119939603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081432304","display_name":"Sahar Yarahmadi","orcid":"https://orcid.org/0000-0002-8171-1650","observed_orcids":["https://orcid.org/0000-0002-8171-1650"]},"institutions":[{"id":"https://openalex.org/I3121602497","display_name":"Lorestan University of Medical Sciences","ror":"https://ror.org/035t7rn63","country_code":"IR","type":"education","lineage":["https://openalex.org/I3121602497"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sahar Yarahmadi","raw_affiliation_strings":["Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: sahar.yarahmadi94@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: sahar.yarahmadi94@yahoo.com","institution_ids":["https://openalex.org/I3121602497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072069760","display_name":"Mobina Gheibi","orcid":"https://orcid.org/0000-0002-4092-8343","observed_orcids":["https://orcid.org/0000-0002-4092-8343"]},"institutions":[{"id":"https://openalex.org/I88085062","display_name":"Mazandaran University of Medical Sciences","ror":"https://ror.org/02wkcrp04","country_code":"IR","type":"education","lineage":["https://openalex.org/I88085062"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mobina Gheibi","raw_affiliation_strings":["Students Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: mobinagheibi78@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Students Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: mobinagheibi78@gmail.com","institution_ids":["https://openalex.org/I88085062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091152853","display_name":"Motahareh Taghizadeh","orcid":"https://orcid.org/0000-0003-0256-4910","observed_orcids":["https://orcid.org/0000-0003-0256-4910"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Motahareh Taghizadeh","raw_affiliation_strings":["Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: taghizadeh.motahare@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: taghizadeh.motahare@gmail.com","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135121631","display_name":"Mahnaz Sadat Moshtaghian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahnaz Sadat Moshtaghian","raw_affiliation_strings":["Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mahnazmoshtaghiyan@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mahnazmoshtaghiyan@gmail.com","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150121599","display_name":"Fatemeh Sartavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Sartavi","raw_affiliation_strings":["Students Research Committee, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: sartavi.sums@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Students Research Committee, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: sartavi.sums@gmail.com","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055661379","display_name":"Sheida Yahyazadeh","orcid":"https://orcid.org/0000-0001-5967-848X","observed_orcids":["https://orcid.org/0000-0001-5967-848X"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sheida Yahyazadeh","raw_affiliation_strings":["Students Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: yahyazadesheida@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Students Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: yahyazadesheida@gmail.com","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053453224","display_name":"Sayed Mohammad Shafiee","orcid":"https://orcid.org/0000-0002-9221-2267","observed_orcids":["https://orcid.org/0000-0002-9221-2267"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sayed Mohammad Shafiee","raw_affiliation_strings":["Autophagy Research Center, Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: shafieem@sums.ac.ir"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autophagy Research Center, Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: shafieem@sums.ac.ir","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059244618","display_name":"Saeid Ghavami","orcid":"https://orcid.org/0000-0001-5948-508X","observed_orcids":["https://orcid.org/0000-0001-5948-508X"]},"institutions":[{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I4210132446","display_name":"Akademia \u015al\u0105ska","ror":"https://ror.org/03dvx1426","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210132446"]},{"id":"https://openalex.org/I4210166742","display_name":"Research Institute in Oncology and Hematology","ror":"https://ror.org/05qer3y84","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210088414","https://openalex.org/I4210166742","https://openalex.org/I46247651"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA","PL"],"is_corresponding":true,"raw_author_name":"Saeid Ghavami","raw_affiliation_strings":["Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada; Academy of Silesia, Faculty of Medicine, Rolna 43, 40-555, Katowice, Poland; Research Institutes of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, MB, R3E 0V9, Canada; Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, R3E 0V9, Canada. Electronic address: saeid.ghavami@umanitoba.ca"],"raw_orcid":"https://orcid.org/0000-0001-5948-508X","affiliations":[{"raw_affiliation_string":"Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada; Academy of Silesia, Faculty of Medicine, Rolna 43, 40-555, Katowice, Poland; Research Institutes of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, MB, R3E 0V9, Canada; Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, R3E 0V9, Canada. Electronic address: saeid.ghavami@umanitoba.ca","institution_ids":["https://openalex.org/I4210091102","https://openalex.org/I4210132446","https://openalex.org/I4210166742","https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5039635141","https://openalex.org/A5059244618","https://openalex.org/A5084984290"],"corresponding_institution_ids":["https://openalex.org/I194604659","https://openalex.org/I4210091102","https://openalex.org/I4210132446","https://openalex.org/I4210166742","https://openalex.org/I4405270669","https://openalex.org/I46247651","https://openalex.org/I48379061","https://openalex.org/I58048189"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":{"value":4010,"currency":"USD","value_usd":4010},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62444582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1873","issue":"1","first_page":"168451","last_page":"168451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/back-splicing","display_name":"back-splicing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mirna-sponge","display_name":"microRNA sponge","score":0.7990000247955322},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.925000011920929},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nad-dependent-deacetylase","display_name":"NAD+-dependent deacetylase","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7806000113487244},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.7264999747276306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7107999920845032},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.6241000294685364},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5824999809265137},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5242000222206116},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.515500009059906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4927000105381012},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4666999876499176},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46129998564720154},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.44429999589920044},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43779999017715454},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4377000033855438},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4336000084877014},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4332999885082245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3862000107765198},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3580000102519989},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.34709998965263367},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33629998564720154},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.33390000462532043},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.3093999922275543},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.3089999854564667},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.30219998955726624},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.27880001068115234},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2761000096797943},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.27399998903274536},{"id":"https://openalex.org/C2775992057","wikidata":"https://www.wikidata.org/wiki/Q16956568","display_name":"Translational efficiency","level":5,"score":0.2678000032901764},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2522999942302704},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000095482","descriptor_name":"RNA, Competitive Endogenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbadis.2026.168451","doi":"https://doi.org/10.1016/j.bbadis.2026.168451","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2026.168451","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},{"id":"pmid:42700874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42700874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. Molecular basis of disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbadis.2026.168451","doi":"https://doi.org/10.1016/j.bbadis.2026.168451","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2026.168451","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.5702193975448608,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":241,"referenced_works":["https://openalex.org/W256883874","https://openalex.org/W1522919673","https://openalex.org/W1531691583","https://openalex.org/W1555023540","https://openalex.org/W1583054722","https://openalex.org/W1585195307","https://openalex.org/W1898338126","https://openalex.org/W1951075546","https://openalex.org/W1963940785","https://openalex.org/W1967791012","https://openalex.org/W1969930226","https://openalex.org/W1971037507","https://openalex.org/W1972556189","https://openalex.org/W1977351943","https://openalex.org/W1979504051","https://openalex.org/W1985211115","https://openalex.org/W1987065605","https://openalex.org/W1988007786","https://openalex.org/W1991746961","https://openalex.org/W1993553259","https://openalex.org/W2001686534","https://openalex.org/W2012085460","https://openalex.org/W2012885541","https://openalex.org/W2017994898","https://openalex.org/W2022970298","https://openalex.org/W2028178274","https://openalex.org/W2035543709","https://openalex.org/W2040576679","https://openalex.org/W2042349286","https://openalex.org/W2044784487","https://openalex.org/W2052210065","https://openalex.org/W2071418897","https://openalex.org/W2071656971","https://openalex.org/W2078015793","https://openalex.org/W2080192652","https://openalex.org/W2088605892","https://openalex.org/W2090466701","https://openalex.org/W2091437677","https://openalex.org/W2092728526","https://openalex.org/W2097487849","https://openalex.org/W2118204731","https://openalex.org/W2118964113","https://openalex.org/W2129931599","https://openalex.org/W2137691989","https://openalex.org/W2138347882","https://openalex.org/W2138610504","https://openalex.org/W2140925956","https://openalex.org/W2147097971","https://openalex.org/W2152025793","https://openalex.org/W2153704476","https://openalex.org/W2154202727","https://openalex.org/W2155837574","https://openalex.org/W2156712995","https://openalex.org/W2158124286","https://openalex.org/W2162306102","https://openalex.org/W2165368743","https://openalex.org/W2166129732","https://openalex.org/W2169259762","https://openalex.org/W2285247593","https://openalex.org/W2511152819","https://openalex.org/W2515158101","https://openalex.org/W2543110461","https://openalex.org/W2559818093","https://openalex.org/W2601018027","https://openalex.org/W2605539210","https://openalex.org/W2726649874","https://openalex.org/W2759546647","https://openalex.org/W2764294957","https://openalex.org/W2770666110","https://openalex.org/W2772086055","https://openalex.org/W2791173369","https://openalex.org/W2903104662","https://openalex.org/W2909189346","https://openalex.org/W2924359561","https://openalex.org/W2953585487","https://openalex.org/W2964331590","https://openalex.org/W2969228284","https://openalex.org/W2978307082","https://openalex.org/W2980877626","https://openalex.org/W2982460893","https://openalex.org/W2993259978","https://openalex.org/W2998319093","https://openalex.org/W3001186791","https://openalex.org/W3003003908","https://openalex.org/W3006346396","https://openalex.org/W3006659944","https://openalex.org/W3006786463","https://openalex.org/W3006891752","https://openalex.org/W3006906459","https://openalex.org/W3010668768","https://openalex.org/W3011571489","https://openalex.org/W3011917394","https://openalex.org/W3015291505","https://openalex.org/W3016029634","https://openalex.org/W3023685759","https://openalex.org/W3028231814","https://openalex.org/W3028471734","https://openalex.org/W3032267617","https://openalex.org/W3032458455","https://openalex.org/W3036257397","https://openalex.org/W3040113149","https://openalex.org/W3043038580","https://openalex.org/W3045566259","https://openalex.org/W3049440353","https://openalex.org/W3081720199","https://openalex.org/W3083695938","https://openalex.org/W3084440612","https://openalex.org/W3086549709","https://openalex.org/W3088785568","https://openalex.org/W3092704961","https://openalex.org/W3096443278","https://openalex.org/W3096703484","https://openalex.org/W3100024563","https://openalex.org/W3112771839","https://openalex.org/W3113893251","https://openalex.org/W3114039364","https://openalex.org/W3127569267","https://openalex.org/W3130780556","https://openalex.org/W3132082876","https://openalex.org/W3134575384","https://openalex.org/W3137196583","https://openalex.org/W3148375483","https://openalex.org/W3155781726","https://openalex.org/W3157241235","https://openalex.org/W3159512579","https://openalex.org/W3162441465","https://openalex.org/W3164216440","https://openalex.org/W3167001555","https://openalex.org/W3173191141","https://openalex.org/W3175562628","https://openalex.org/W3175810491","https://openalex.org/W3178782316","https://openalex.org/W3181136968","https://openalex.org/W3182561264","https://openalex.org/W3185563268","https://openalex.org/W3189795024","https://openalex.org/W3193355465","https://openalex.org/W3193918140","https://openalex.org/W3194821546","https://openalex.org/W3195445061","https://openalex.org/W3195871173","https://openalex.org/W3197198482","https://openalex.org/W3198902824","https://openalex.org/W3201936323","https://openalex.org/W3202653357","https://openalex.org/W3202770922","https://openalex.org/W3205673955","https://openalex.org/W3212494994","https://openalex.org/W3212939343","https://openalex.org/W3212985656","https://openalex.org/W3214092507","https://openalex.org/W3215357760","https://openalex.org/W3217221252","https://openalex.org/W4200037845","https://openalex.org/W4200053202","https://openalex.org/W4200267133","https://openalex.org/W4200391565","https://openalex.org/W4200520781","https://openalex.org/W4205523190","https://openalex.org/W4213445133","https://openalex.org/W4214566256","https://openalex.org/W4214626546","https://openalex.org/W4220753889","https://openalex.org/W4221096450","https://openalex.org/W4223648930","https://openalex.org/W4224230602","https://openalex.org/W4225247750","https://openalex.org/W4225295719","https://openalex.org/W4226101679","https://openalex.org/W4226179888","https://openalex.org/W4226207408","https://openalex.org/W4228999942","https://openalex.org/W4280639447","https://openalex.org/W4281612581","https://openalex.org/W4281690297","https://openalex.org/W4281730292","https://openalex.org/W4281953483","https://openalex.org/W4283033587","https://openalex.org/W4283320458","https://openalex.org/W4283740207","https://openalex.org/W4283772644","https://openalex.org/W4283783103","https://openalex.org/W4284972460","https://openalex.org/W4285034796","https://openalex.org/W4285726602","https://openalex.org/W4288050366","https://openalex.org/W4289521126","https://openalex.org/W4292685595","https://openalex.org/W4295064601","https://openalex.org/W4298641120","https://openalex.org/W4306816457","https://openalex.org/W4307267996","https://openalex.org/W4307468237","https://openalex.org/W4308062299","https://openalex.org/W4309511455","https://openalex.org/W4310289314","https://openalex.org/W4311464397","https://openalex.org/W4319294394","https://openalex.org/W4320732798","https://openalex.org/W4324129633","https://openalex.org/W4366211988","https://openalex.org/W4375844562","https://openalex.org/W4376141999","https://openalex.org/W4377990753","https://openalex.org/W4379384812","https://openalex.org/W4382195795","https://openalex.org/W4382239424","https://openalex.org/W4385230077","https://openalex.org/W4385857806","https://openalex.org/W4386226624","https://openalex.org/W4386575305","https://openalex.org/W4386928921","https://openalex.org/W4387515697","https://openalex.org/W4387576868","https://openalex.org/W4387642559","https://openalex.org/W4387806689","https://openalex.org/W4387837070","https://openalex.org/W4387849356","https://openalex.org/W4388049692","https://openalex.org/W4388695677","https://openalex.org/W4389010000","https://openalex.org/W4389058868","https://openalex.org/W4389373314","https://openalex.org/W4389504097","https://openalex.org/W4390274610","https://openalex.org/W4390743431","https://openalex.org/W4391090885","https://openalex.org/W4392337759","https://openalex.org/W4392593823","https://openalex.org/W4392659348","https://openalex.org/W4393346281","https://openalex.org/W4396232742","https://openalex.org/W4398764758","https://openalex.org/W4399072341","https://openalex.org/W4399691365","https://openalex.org/W4401082680","https://openalex.org/W4402786969","https://openalex.org/W4402926295","https://openalex.org/W4403545903","https://openalex.org/W4405613227","https://openalex.org/W6963131477"],"related_works":[],"abstract_inverted_index":{"Circular":[0],"RNAs":[1],"(circRNAs)":[2],"have":[3,125],"emerged":[4,117],"as":[5,55,118,209,241],"stable":[6],"post-transcriptional":[7,133,212],"regulators":[8],"that":[9,35,71,127],"influence":[10],"gene":[11],"expression,":[12],"cellular":[13,139],"adaptation,":[14,111],"and":[15,27,47,86,104,114,134,145,171,181,222,231,248],"disease":[16,172],"pathogenesis":[17],"through":[18,31,131],"mechanisms":[19],"including":[20],"microRNA":[21],"(miRNA)":[22],"interaction,":[23],"RNA-binding":[24],"protein":[25,58],"modulation,":[26],"signaling-network":[28],"regulation.":[29],"Generated":[30],"the":[32,90,149,185,206,235],"back-splicing":[33],"process":[34],"produce":[36],"covalently":[37],"closed":[38],"RNA":[39,217],"loops,":[40],"circRNAs":[41,128],"exhibit":[42],"remarkable":[43],"stability,":[44],"evolutionary":[45],"conservation,":[46],"tissue-specific":[48],"expression":[49,74],"patterns,":[50],"enabling":[51],"them":[52],"to":[53,76,166,197,220],"function":[54],"miRNA":[56],"sponges,":[57],"scaffolds,":[59],"transcriptional":[60],"modulators,":[61],"and,":[62],"in":[63,142],"some":[64],"cases,":[65],"translational":[66,229],"templates.":[67],"Increasing":[68],"evidence":[69],"indicates":[70],"dysregulated":[72],"circRNA":[73],"contributes":[75],"a":[77,105,119,179,210,242],"broad":[78],"spectrum":[79],"of":[80,107,152,184,237],"human":[81],"diseases,":[82],"highlighting":[83],"their":[84],"diagnostic":[85],"therapeutic":[87,250],"potential.":[88],"Among":[89],"molecular":[91],"pathways":[92],"influenced":[93],"by":[94],"circRNAs,":[95],"Sirtuin":[96],"1":[97],"(SIRT1),":[98],"an":[99],"NAD":[100],"+":[101],"-dependent":[102],"deacetylase":[103],"modulator":[106],"metabolic":[108,169,195],"homeostasis,":[109],"stress":[110],"inflammation,":[112],"autophagy,":[113],"aging,":[115],"has":[116],"particularly":[120],"important":[121],"target.":[122],"Recent":[123],"studies":[124],"revealed":[126],"regulate":[129],"SIRT1":[130,154],"complex":[132],"signaling":[135],"networks,":[136],"thereby":[137],"influencing":[138],"fate":[140],"decisions":[141],"both":[143],"malignant":[144],"non-malignant":[146],"disorders.":[147],"Importantly,":[148],"biological":[150],"consequences":[151],"circRNA-mediated":[153],"modulation":[155],"appear":[156],"highly":[157],"context-dependent,":[158],"with":[159],"protective":[160],"or":[161],"pathogenic":[162],"effects":[163],"varying":[164],"according":[165],"tissue":[167],"type,":[168],"state,":[170],"stage.":[173],"In":[174],"this":[175,238],"review,":[176],"we":[177,204],"provide":[178],"comprehensive":[180],"integrative":[182],"discussion":[183],"circRNA-SIRT1":[186,207],"regulatory":[187,213,239],"axes":[188],"across":[189],"diverse":[190],"pathological":[191],"conditions,":[192],"from":[193],"common":[194],"disorders":[196],"life-threatening":[198],"cancers.":[199],"Beyond":[200],"summarizing":[201],"current":[202],"evidence,":[203],"propose":[205],"network":[208,214],"context-dependent":[211],"linking":[215],"non-coding":[216],"(ncRNA)":[218],"biology":[219],"immunometabolic":[221],"stress-response":[223],"pathways.":[224],"We":[225],"further":[226],"discuss":[227],"emerging":[228],"opportunities":[230],"circRNA-targeted":[232],"therapeutics,":[233],"emphasizing":[234],"potential":[236],"axis":[240],"promising":[243],"platform":[244],"for":[245],"precision":[246],"diagnostics":[247],"disease-specific":[249],"interventions.":[251]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-06T00:00:00"}
