{"id":"https://openalex.org/W7208835166","doi":"https://doi.org/10.1007/s11064-026-04883-8","title":"Lactobacillus rhamnosus and Saccharomyces boulardii Attenuate LPS-Induced Cognitive and Affective Dysfunction Associated with Hippocampal Neuroinflammatory and Neurochemical Alterations","display_name":"Lactobacillus rhamnosus and Saccharomyces boulardii Attenuate LPS-Induced Cognitive and Affective Dysfunction Associated with Hippocampal Neuroinflammatory and Neurochemical Alterations","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208835166","doi":"https://doi.org/10.1007/s11064-026-04883-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42700187"},"language":"en","primary_location":{"id":"doi:10.1007/s11064-026-04883-8","doi":"https://doi.org/10.1007/s11064-026-04883-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11064-026-04883-8","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038027347","display_name":"Durmu\u015f Ali Aslanlar","orcid":"https://orcid.org/0000-0002-6932-2767","observed_orcids":["https://orcid.org/0000-0002-6932-2767"]},"institutions":[{"id":"https://openalex.org/I4210107659","display_name":"Necmettin Erbakan University","ror":"https://ror.org/013s3zh21","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210107659"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Durmu\u015f Ali Aslanlar","raw_affiliation_strings":["Faculty of Medicine, Department of Medical Pharmacology, Necmettin Erbakan University, 42080, Konya, Turkey. daliaslanlar@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-6932-2767","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Medical Pharmacology, Necmettin Erbakan University, 42080, Konya, Turkey. daliaslanlar@gmail.com","institution_ids":["https://openalex.org/I4210107659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068623011","display_name":"K\u0131smet Esra Nurullaho\u011flu Atal\u0131k","orcid":"https://orcid.org/0000-0003-2301-7887","observed_orcids":["https://orcid.org/0000-0003-2301-7887"]},"institutions":[{"id":"https://openalex.org/I4210107659","display_name":"Necmettin Erbakan University","ror":"https://ror.org/013s3zh21","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210107659"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"K. Esra Nurullahoglu Atal\u0131k","raw_affiliation_strings":["Faculty of Medicine, Department of Medical Pharmacology, Necmettin Erbakan University, 42080, Konya, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-2301-7887","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Medical Pharmacology, Necmettin Erbakan University, 42080, Konya, Turkey","institution_ids":["https://openalex.org/I4210107659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074573320","display_name":"Mehmet \u00d6z","orcid":"https://orcid.org/0000-0003-4167-2623","observed_orcids":["https://orcid.org/0000-0003-4167-2623"]},"institutions":[{"id":"https://openalex.org/I121596126","display_name":"Aksaray University","ror":"https://ror.org/026db3d50","country_code":"TR","type":"education","lineage":["https://openalex.org/I121596126"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet \u00d6z","raw_affiliation_strings":["Faculty of Medicine, Department of Physiology, Aksaray University, 68100, Aksaray, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4167-2623","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Physiology, Aksaray University, 68100, Aksaray, Turkey","institution_ids":["https://openalex.org/I121596126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150075548","display_name":"\u0130brahim Y\u0131ld\u0131z","orcid":"https://orcid.org/0000-0002-8983-9501","observed_orcids":["https://orcid.org/0000-0002-8983-9501"]},"institutions":[{"id":"https://openalex.org/I4210107659","display_name":"Necmettin Erbakan University","ror":"https://ror.org/013s3zh21","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210107659"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130brahim Y\u0131ld\u0131z","raw_affiliation_strings":["College of Health Services, Necmettin Erbakan University, 42080, Konya, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8983-9501","affiliations":[{"raw_affiliation_string":"College of Health Services, Necmettin Erbakan University, 42080, Konya, Turkey","institution_ids":["https://openalex.org/I4210107659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006024193","display_name":"Mehmet Tu\u011frul Y\u0131lmaz","orcid":"https://orcid.org/0000-0001-5744-0902","observed_orcids":["https://orcid.org/0000-0001-5744-0902"]},"institutions":[{"id":"https://openalex.org/I4210107659","display_name":"Necmettin Erbakan University","ror":"https://ror.org/013s3zh21","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210107659"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Tu\u011frul Y\u0131lmaz","raw_affiliation_strings":["Faculty of Medicine, Department of Anatomy, Necmettin Erbakan University, 42080, Konya, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-5744-0902","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Anatomy, Necmettin Erbakan University, 42080, Konya, Turkey","institution_ids":["https://openalex.org/I4210107659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038027347"],"corresponding_institution_ids":["https://openalex.org/I4210107659"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.11999999731779099,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lacticaseibacillus-rhamnosus","display_name":"Lactobacillus rhamnosus","score":0.9769999980926514},{"id":"https://openalex.org/keywords/saccharomyces-boulardii","display_name":"Saccharomyces boulardii","score":1.0},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9769999980926514},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.972000002861023},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9240000247955322},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.8479999899864197},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.8389999866485596},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9779999852180481},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8019999861717224},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cholinergic-system","display_name":"cholinergic system","score":0.8640000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2778489779","wikidata":"https://www.wikidata.org/wiki/Q135368","display_name":"Saccharomyces boulardii","level":4,"score":0.916700005531311},{"id":"https://openalex.org/C2776651480","wikidata":"https://www.wikidata.org/wiki/Q1607640","display_name":"Lactobacillus rhamnosus","level":4,"score":0.8302000164985657},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.7663999795913696},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5873000025749207},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5464000105857849},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.5365999937057495},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4912000000476837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4657000005245209},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.4226999878883362},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4171000123023987},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3986999988555908},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.3788999915122986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3544999957084656},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.3352999985218048},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.32339999079704285},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.323199987411499},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.32120001316070557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3068000078201294},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30320000648498535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29159998893737793},{"id":"https://openalex.org/C2776119998","wikidata":"https://www.wikidata.org/wiki/Q1070023","display_name":"Orexin-A","level":5,"score":0.2883000075817108},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.27250000834465027},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.26190000772476196}],"mesh":[{"descriptor_ui":"D000069983","descriptor_name":"Saccharomyces boulardii","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052201","descriptor_name":"Lacticaseibacillus rhamnosus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11064-026-04883-8","doi":"https://doi.org/10.1007/s11064-026-04883-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11064-026-04883-8","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},{"id":"pmid:42700187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42700187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329599","display_name":"Necmettin Erbakan \u00dcniversitesi","ror":"https://ror.org/013s3zh21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1973386992","https://openalex.org/W1994017777","https://openalex.org/W2041561931","https://openalex.org/W2072441360","https://openalex.org/W2905645620","https://openalex.org/W3040358866","https://openalex.org/W3096640405","https://openalex.org/W3146049580","https://openalex.org/W4200120934","https://openalex.org/W4221080243","https://openalex.org/W4307971376","https://openalex.org/W4317566608","https://openalex.org/W4367053288","https://openalex.org/W4384626401","https://openalex.org/W4385330162","https://openalex.org/W4385657721","https://openalex.org/W4386070895","https://openalex.org/W4388343528","https://openalex.org/W4390463473","https://openalex.org/W4391685884","https://openalex.org/W4392553212","https://openalex.org/W4394617808","https://openalex.org/W4396532444","https://openalex.org/W4399039922","https://openalex.org/W4399352917","https://openalex.org/W4399666710","https://openalex.org/W4399903426","https://openalex.org/W4400451014","https://openalex.org/W4401164724","https://openalex.org/W4401581588","https://openalex.org/W4401995645","https://openalex.org/W4402741149","https://openalex.org/W4402910435","https://openalex.org/W4403240294","https://openalex.org/W4403590283","https://openalex.org/W4404520233","https://openalex.org/W4405187546","https://openalex.org/W4405890485","https://openalex.org/W4407635987","https://openalex.org/W4407924571","https://openalex.org/W4410132222","https://openalex.org/W4412178075","https://openalex.org/W4412459529","https://openalex.org/W4412573841","https://openalex.org/W4412808308","https://openalex.org/W4413025598","https://openalex.org/W4413452792","https://openalex.org/W4414133452","https://openalex.org/W4414135727","https://openalex.org/W4415147262","https://openalex.org/W4415177499","https://openalex.org/W4416096320","https://openalex.org/W4416773320","https://openalex.org/W4417410441","https://openalex.org/W7128724437","https://openalex.org/W7130507442","https://openalex.org/W7131254117","https://openalex.org/W7135135362"],"related_works":["https://openalex.org/W4416754228","https://openalex.org/W4406225091","https://openalex.org/W4307971376","https://openalex.org/W3214739052","https://openalex.org/W2904727441","https://openalex.org/W4384941022","https://openalex.org/W4404289546","https://openalex.org/W2935539797","https://openalex.org/W3096640405","https://openalex.org/W2088787792"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-06T00:00:00"}
