{"id":"https://openalex.org/W7208825515","doi":"https://doi.org/10.65329/wjeb.v14.02.02","title":"Carbapenem Resistance is Associated with Biofilm formation in Clinical isolates of Klebsiella pneumoniae","display_name":"Carbapenem Resistance is Associated with Biofilm formation in Clinical isolates of Klebsiella pneumoniae","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208825515","doi":"https://doi.org/10.65329/wjeb.v14.02.02"},"language":"en","primary_location":{"id":"doi:10.65329/wjeb.v14.02.02","doi":"https://doi.org/10.65329/wjeb.v14.02.02","is_oa":true,"landing_page_url":"https://doi.org/10.65329/wjeb.v14.02.02","pdf_url":"https://journals.uniscipub.com/index.php/Wjebs/article/download/204/225","source":{"id":"https://openalex.org/S7407053622","display_name":"World Journal of Experimental Biosciences","issn_l":"2313-3937","issn":["2313-3937","3070-0647"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Experimental Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.uniscipub.com/index.php/Wjebs/article/download/204/225","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064925958","display_name":"Sura I.A. Jabuk","orcid":"https://orcid.org/0000-0002-7106-3768","observed_orcids":["https://orcid.org/0000-0002-7106-3768"]},"institutions":[{"id":"https://openalex.org/I166455938","display_name":"University of Babylon","ror":"https://ror.org/0170edc15","country_code":"IQ","type":"education","lineage":["https://openalex.org/I166455938"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Sura Jabuk","raw_affiliation_strings":["Department of Biology, College of Science, University of Babylon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, University of Babylon","institution_ids":["https://openalex.org/I166455938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048393935","display_name":"Mehdi Meskini Heydarlou","orcid":"https://orcid.org/0000-0001-5858-8079","observed_orcids":["https://orcid.org/0000-0001-5858-8079"]},"institutions":[{"id":"https://openalex.org/I96268669","display_name":"Okan University","ror":"https://ror.org/054d5vq03","country_code":"TR","type":"education","lineage":["https://openalex.org/I96268669"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehdi Meskini Heydarlou","raw_affiliation_strings":["Istanbul Okan University Faculty of Medicine, Department of Basic Medical Sciences, Medical Microbiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istanbul Okan University Faculty of Medicine, Department of Basic Medical Sciences, Medical Microbiology","institution_ids":["https://openalex.org/I96268669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000443479","display_name":"Muhammad Shawal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172324550","display_name":"Gomal University","ror":"https://ror.org/0241b8f19","country_code":"PK","type":"education","lineage":["https://openalex.org/I172324550"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Shawal","raw_affiliation_strings":["Drug Delivery & Cosmetics Lab, GCPS, Faculty of Pharmacy, Gomal University DI Khan, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery & Cosmetics Lab, GCPS, Faculty of Pharmacy, Gomal University DI Khan, Pakistan","institution_ids":["https://openalex.org/I172324550"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024822204","display_name":"Ata Ur Rehman","orcid":"https://orcid.org/0000-0002-8227-5352","observed_orcids":["https://orcid.org/0000-0002-8227-5352"]},"institutions":[{"id":"https://openalex.org/I172324550","display_name":"Gomal University","ror":"https://ror.org/0241b8f19","country_code":"PK","type":"education","lineage":["https://openalex.org/I172324550"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ata Ur Rehman","raw_affiliation_strings":["Institute of Biological Sciences, Gomal University DI Khan, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Sciences, Gomal University DI Khan, Pakistan","institution_ids":["https://openalex.org/I172324550"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.354,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79112382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"73","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9539999961853027},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":1.0},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.734000027179718},{"id":"https://openalex.org/keywords/imipenem","display_name":"imipenem","score":0.753000020980835},{"id":"https://openalex.org/keywords/doripenem","display_name":"doripenem","score":0.968999981880188},{"id":"https://openalex.org/keywords/ertapenem","display_name":"ertapenem","score":0.9729999899864197},{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.7900000214576721},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.7839999794960022},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7540000081062317},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.746999979019165},{"id":"https://openalex.org/keywords/virulence-genes","display_name":"virulence genes","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9569000005722046},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8533999919891357},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.784500002861023},{"id":"https://openalex.org/C2776685102","wikidata":"https://www.wikidata.org/wiki/Q410897","display_name":"Carbapenem","level":3,"score":0.5138999819755554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4796999990940094},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.42989999055862427},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.2946000099182129},{"id":"https://openalex.org/C2775992322","wikidata":"https://www.wikidata.org/wiki/Q5037837","display_name":"Carbapenem-resistant enterobacteriaceae","level":5,"score":0.2865999937057495},{"id":"https://openalex.org/C2779116282","wikidata":"https://www.wikidata.org/wiki/Q131854","display_name":"Klebsiella","level":4,"score":0.28200000524520874},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.27090001106262207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26980000734329224},{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.2583000063896179},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.257099986076355}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.65329/wjeb.v14.02.02","doi":"https://doi.org/10.65329/wjeb.v14.02.02","is_oa":true,"landing_page_url":"https://doi.org/10.65329/wjeb.v14.02.02","pdf_url":"https://journals.uniscipub.com/index.php/Wjebs/article/download/204/225","source":{"id":"https://openalex.org/S7407053622","display_name":"World Journal of Experimental Biosciences","issn_l":"2313-3937","issn":["2313-3937","3070-0647"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Experimental Biosciences","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.journals.uniscipub.com:article/204","doi":null,"is_oa":true,"landing_page_url":"https://journals.uniscipub.com/index.php/index/article/view/204","pdf_url":null,"source":{"id":"https://openalex.org/S7407053622","display_name":"World Journal of Experimental Biosciences","issn_l":"2313-3937","issn":["2313-3937","3070-0647"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2313-3937","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:803bdb153c20420c893931d59742fa4a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/803bdb153c20420c893931d59742fa4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Experimental Biosciences, Vol 14, Iss 02, Pp 73-78 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.65329/wjeb.v14.02.02","doi":"https://doi.org/10.65329/wjeb.v14.02.02","is_oa":true,"landing_page_url":"https://doi.org/10.65329/wjeb.v14.02.02","pdf_url":"https://journals.uniscipub.com/index.php/Wjebs/article/download/204/225","source":{"id":"https://openalex.org/S7407053622","display_name":"World Journal of Experimental Biosciences","issn_l":"2313-3937","issn":["2313-3937","3070-0647"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Experimental Biosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208825515.pdf","grobid_xml":"https://content.openalex.org/works/W7208825515.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2101996554","https://openalex.org/W2107372863","https://openalex.org/W2965299294","https://openalex.org/W2991574077","https://openalex.org/W3122080139","https://openalex.org/W4280610801","https://openalex.org/W4308593019","https://openalex.org/W4315647491","https://openalex.org/W4317518145","https://openalex.org/W4321255202","https://openalex.org/W4385665781","https://openalex.org/W4392109538","https://openalex.org/W4396769532","https://openalex.org/W4403303732","https://openalex.org/W4407255029","https://openalex.org/W4408312246","https://openalex.org/W4409430637","https://openalex.org/W4417328524","https://openalex.org/W7130647657","https://openalex.org/W7132834911","https://openalex.org/W7166796619"],"related_works":["https://openalex.org/W4404433003","https://openalex.org/W2991574077","https://openalex.org/W7214886550","https://openalex.org/W7204648756","https://openalex.org/W2999584905","https://openalex.org/W3213124138","https://openalex.org/W4416214909","https://openalex.org/W3039134432","https://openalex.org/W6977541379","https://openalex.org/W3213979763"],"abstract_inverted_index":{"Carbapenem-resistant":[0],"Klebsiella":[1],"pneumoniae":[2],"(CRKP)":[3],"and":[4,12,20,32,42,66,103,115,123,162,241,255],"biofilm-producing":[5],"nosocomial":[6],"pathogenic":[7],"bacteria":[8],"may":[9],"complicate":[10],"treatment":[11],"infection":[13],"control.":[14],"The":[15,54,106,126,168],"relationship":[16],"between":[17],"carbapenem":[18,91,136,237],"resistance":[19,92,238],"biofilm":[21,84,145,155,160,166,171,197,209,248],"formation":[22,172,198,210],"remains":[23],"poorly":[24],"characterized.":[25],"Susceptibility":[26],"to":[27,75,82,134,191],"imipenem,":[28,118],"doripenem,":[29,119],"ertapenem,":[30,121],"amikacin,":[31,122],"levofloxacin":[33],"was":[34,67,73,147,173,193,225,239],"assessed":[35],"using":[36],"the":[37,60,77,80,89,94,144,151,223],"Kirby-Bauer":[38],"disk":[39],"diffusion":[40],"assay":[41],"CLSI":[43],"M100":[44],"breakpoints":[45],"for":[46,117],"ninety-five":[47],"non-duplicate":[48],"clinical":[49],"isolates":[50,81,95,152,178,182],"of":[51,79,150,170],"K.":[52],"pneumoniae.":[53],"crystal-violet":[55],"microtiter":[56],"assay,":[57],"which":[58],"measured":[59],"optical":[61],"density":[62],"at":[63],"570":[64],"nm":[65],"categorised":[68],"based":[69],"on":[70,88],"Stepanovic":[71],"criteria,":[72],"used":[74],"measure":[76],"ability":[78],"produce":[83],"in":[85,176,180,214,217,247],"vitro.":[86],"Based":[87],"isolates'":[90],"results,":[93],"were":[96,109,132,141,153,158,164,211],"classified":[97],"as":[98],"carbapenem-resistant":[99],"(CR),":[100],"carbapenem-intermediate":[101],"(CIN),":[102],"carbapenem-susceptible":[104],"(CS).":[105],"susceptibility":[107],"rates":[108],"74.0%,":[110],"68.8%,":[111],"63.5%,":[112],"46.0%,":[113],"73.1%,":[114],"68.4%":[116],"meropenem,":[120],"levofloxacin,":[124],"respectively.":[125],"results":[127],"showed":[128],"that":[129,236],"43.2%":[130],"(41/95)":[131],"resistant":[133],"a":[135,244],"antibiotic,":[137],"while":[138],"16.8%":[139],"(16/95)":[140],"multidrug-resistant.":[142],"When":[143],"product":[146],"assessed,":[148],"35.4%":[149],"moderate":[154,245],"producers,":[156,161],"43.8%":[157],"strong":[159,208],"20.8%":[163],"weak":[165],"producers.":[167],"OD570":[169],"significantly":[174,194],"higher":[175],"CR":[177],"than":[179,216],"CS":[181],"(0.59":[183],"vs.":[184,220],"0.424;":[185],"Mann-Whitney":[186],"U=976.5,":[187],"p=":[188],"0.03).":[189],"Resistance":[190],"carbapenems":[192],"correlated":[195],"with":[196,207,243],"(Spearman":[199],"\u03c1":[200],"=":[201,204],"0.224,":[202],"p":[203,230],"0.028).":[205],"Isolates":[206],"more":[212],"frequent":[213],"CR-KP":[215,218],"(53.7%":[219],"36.4%),":[221],"but":[222],"distribution":[224],"not":[226],"significant":[227],"(\u03c7\u00b2":[228],"=3.16,":[229],"=0.206).":[231],"It":[232],"can":[233],"be":[234],"concluded":[235],"common":[240],"associated":[242],"increase":[246],"production.":[249],"This":[250],"study":[251],"recommends":[252],"continued":[253],"surveillance,":[254],"large":[256],"genotypic":[257],"studies":[258],"are":[259],"warranted.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-06T00:00:00"}