{"id":"https://openalex.org/W7208824794","doi":"https://doi.org/10.1016/j.virs.2026.09.003","title":"A HiBiT-Tagged influenza A virus reporter system reveals cytokine-inhibitory micropeptide 53 as a modulator of viral infection and immunopathology","display_name":"A HiBiT-Tagged influenza A virus reporter system reveals cytokine-inhibitory micropeptide 53 as a modulator of viral infection and immunopathology","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208824794","doi":"https://doi.org/10.1016/j.virs.2026.09.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/42700929","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13731426"},"language":"en","primary_location":{"id":"doi:10.1016/j.virs.2026.09.003","doi":"https://doi.org/10.1016/j.virs.2026.09.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virs.2026.09.003","pdf_url":null,"source":{"id":"https://openalex.org/S199072659","display_name":"Virologica Sinica","issn_l":"1995-820X","issn":["1995-820X","1674-0769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virologica Sinica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.virs.2026.09.003","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111251932","display_name":"Shujie Ma","orcid":"https://orcid.org/0009-0002-3087-6356","observed_orcids":["https://orcid.org/0009-0002-3087-6356"]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shujie Ma","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: mashujie@fafu.edu.cn"],"raw_orcid":"https://orcid.org/0009-0002-3087-6356","affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: mashujie@fafu.edu.cn","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150132863","display_name":"Sha Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sha Liu","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110824","display_name":"Conghui Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Conghui Zhao","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112306320","display_name":"Wenjun Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjun Shi","raw_affiliation_strings":["Animal Quarantine Laboratory, Technology Center of Qingdao Customs, Qingdao 266000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Quarantine Laboratory, Technology Center of Qingdao Customs, Qingdao 266000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101524808","display_name":"Chunping Zhang","orcid":"https://orcid.org/0000-0002-1634-9042","observed_orcids":["https://orcid.org/0000-0002-1634-9042"]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunping Zhang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004488211","display_name":"Jiacheng Huang","orcid":"https://orcid.org/0000-0002-6962-7253","observed_orcids":["https://orcid.org/0000-0002-6962-7253"]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiacheng Huang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150061896","display_name":"Yang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712573","display_name":"Xiaoxuan Zhang","orcid":"https://orcid.org/0000-0002-6148-8295","observed_orcids":["https://orcid.org/0000-0002-6148-8295"]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxuan Zhang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150184338","display_name":"Haoxi Qiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoxi Qiang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379136","display_name":"Huanhuan Wang","orcid":"https://orcid.org/0000-0003-4689-5578","observed_orcids":["https://orcid.org/0000-0003-4689-5578"]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanhuan Wang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723444","display_name":"Peilin Li","orcid":"https://orcid.org/0009-0009-6406-5587","observed_orcids":["https://orcid.org/0009-0009-6406-5587","https://orcid.org/0000-0001-7987-2984"]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peilin Li","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158998822","display_name":"Xinhui Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhui Chen","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5150397990","display_name":"Ziyi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Zhang","raw_affiliation_strings":["Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China","institution_ids":["https://openalex.org/I61057504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111251932"],"corresponding_institution_ids":["https://openalex.org/I61057504"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60685561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"5","first_page":"1106","last_page":"1120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reporter-virus","display_name":"reporter virus","score":0.765999972820282},{"id":"https://openalex.org/keywords/micropeptides","display_name":"micropeptides","score":0.7089999914169312},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6809999942779541},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oseltamivir","display_name":"oseltamivir","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.8809999823570251},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/host-directed-therapy","display_name":"host-directed therapy","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7149999737739563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6955000162124634},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.6643000245094299},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6291999816894531},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.6233000159263611},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6104999780654907},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4406999945640564},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4180000126361847},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.37549999356269836},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3619000017642975},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.3296999931335449},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29809999465942383},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2720000147819519}],"mesh":[{"descriptor_ui":"D000096903","descriptor_name":"Micropeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.virs.2026.09.003","doi":"https://doi.org/10.1016/j.virs.2026.09.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virs.2026.09.003","pdf_url":null,"source":{"id":"https://openalex.org/S199072659","display_name":"Virologica Sinica","issn_l":"1995-820X","issn":["1995-820X","1674-0769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virologica Sinica","raw_type":"journal-article"},{"id":"pmid:42700929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42700929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virologica Sinica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13731426","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13731426/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virol Sin","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.virs.2026.09.003","doi":"https://doi.org/10.1016/j.virs.2026.09.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.virs.2026.09.003","pdf_url":null,"source":{"id":"https://openalex.org/S199072659","display_name":"Virologica Sinica","issn_l":"1995-820X","issn":["1995-820X","1674-0769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virologica Sinica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3185917648","display_name":null,"funder_award_id":"2021YFD1800205","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4939383408","display_name":null,"funder_award_id":"2022J05033","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G5347407157","display_name":null,"funder_award_id":"xjq202018","funder_id":"https://openalex.org/F4320325353","funder_display_name":"Fujian Agriculture and Forestry University"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320325353","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84"},{"id":"https://openalex.org/F4320330645","display_name":"General Administration of Customs","ror":"https://ror.org/00s255r43"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1586165122","https://openalex.org/W1967978769","https://openalex.org/W1979882857","https://openalex.org/W1991001144","https://openalex.org/W2000450402","https://openalex.org/W2062364477","https://openalex.org/W2071688420","https://openalex.org/W2076198632","https://openalex.org/W2076216495","https://openalex.org/W2092141595","https://openalex.org/W2101970047","https://openalex.org/W2112982331","https://openalex.org/W2133106116","https://openalex.org/W2150403537","https://openalex.org/W2226712470","https://openalex.org/W2256711589","https://openalex.org/W2295757536","https://openalex.org/W2303243520","https://openalex.org/W2474039476","https://openalex.org/W2625979417","https://openalex.org/W2754886024","https://openalex.org/W2766125601","https://openalex.org/W2781545270","https://openalex.org/W2884524095","https://openalex.org/W2885175320","https://openalex.org/W2890302792","https://openalex.org/W2947612854","https://openalex.org/W2967291924","https://openalex.org/W2987417265","https://openalex.org/W3028463352","https://openalex.org/W3082601821","https://openalex.org/W3086206471","https://openalex.org/W3095238917","https://openalex.org/W3108876173","https://openalex.org/W3112902030","https://openalex.org/W3162651106","https://openalex.org/W3177830510","https://openalex.org/W3199765866","https://openalex.org/W4283368602","https://openalex.org/W4378471642","https://openalex.org/W4382393517","https://openalex.org/W4386416372","https://openalex.org/W4386529963","https://openalex.org/W4386997054","https://openalex.org/W4388337092","https://openalex.org/W4389485678","https://openalex.org/W4392236399","https://openalex.org/W4394869077","https://openalex.org/W4398784834","https://openalex.org/W4400523831","https://openalex.org/W4401537435","https://openalex.org/W4402758517","https://openalex.org/W4403828379","https://openalex.org/W4406348781","https://openalex.org/W4408305872","https://openalex.org/W4408572055","https://openalex.org/W4409119018","https://openalex.org/W4409435525","https://openalex.org/W4412701584","https://openalex.org/W4414183258"],"related_works":["https://openalex.org/W4310082068","https://openalex.org/W7204236320","https://openalex.org/W4394787181","https://openalex.org/W2474039476","https://openalex.org/W2968068165","https://openalex.org/W2781545270","https://openalex.org/W7117363899","https://openalex.org/W2800797190","https://openalex.org/W4206677485","https://openalex.org/W2022206742"],"abstract_inverted_index":{"Influenza":[0],"A":[1],"virus":[2,73],"(IAV)":[3],"remains":[4],"a":[5,48,104,143,190,202],"major":[6],"threat":[7],"to":[8,19,118,129,134,171],"human":[9],"and":[10,23,42,81,92,114,175,198],"animal":[11],"health,":[12],"highlighting":[13],"the":[14,61,67,88,135],"need":[15],"for":[16,30,195,207],"efficient":[17],"approaches":[18],"identify":[20,119],"host":[21,120],"factors":[22],"antivirals.":[24],"Reporter":[25],"viruses":[26],"are":[27],"critical":[28],"tools":[29],"these":[31],"efforts,":[32],"but":[33],"incorporating":[34],"large":[35],"reporter":[36,51,100],"genes":[37],"often":[38],"compromises":[39],"viral":[40,96,165],"fitness":[41],"genetic":[43],"stability.":[44],"Here,":[45],"we":[46,102],"developed":[47],"replication":[49,79,153],"competent":[50],"IAV":[52,123,147,152,209],"by":[53,154],"fusing":[54],"an":[55],"11-amino":[56],"acid":[57],"HiBiT":[58],"tag":[59],"into":[60],"nonstructural":[62],"protein":[63],"1":[64],"(NS1)":[65],"of":[66,95,122,126,137,146],"A/WSN/1933":[68],"(H1N1)":[69],"backbone.":[70],"The":[71],"modified":[72],"retained":[74],"parental":[75],"virion":[76],"morphology,":[77],"comparable":[78],"kinetics,":[80],"in":[82,184],"vivo":[83],"tissue":[84],"tropism,":[85],"while":[86],"enabling":[87],"highly":[89,191],"sensitive,":[90],"rapid,":[91],"quantitative":[93],"detection":[94],"replication.":[97,148],"Using":[98],"this":[99,127],"virus,":[101],"established":[103],"robust":[105],"high-throughput":[106],"screening":[107,193],"(HTS)":[108],"platform":[109,128,194],"with":[110,180],"excellent":[111],"assay":[112],"quality":[113],"validated":[115],"its":[116,167],"capability":[117],"regulators":[121],"infection.":[124,210],"Application":[125],"host-encoded":[130],"micropeptides":[131],"(miPEPs)":[132],"led":[133],"identification":[136],"cytokine-inhibitory":[138],"micropeptide":[139],"53":[140],"(CIM53)":[141],"as":[142,201],"novel":[144],"regulator":[145],"Mechanistically,":[149],"CIM53":[150,163,200],"promoted":[151],"intrinsically":[155],"suppressing":[156],"antiviral":[157],"innate":[158],"immune":[159],"responses.":[160],"Furthermore,":[161],"although":[162],"enhanced":[164],"replication,":[166],"immunomodulatory":[168],"activity":[169],"contributed":[170],"reduced":[172],"lung":[173],"injury":[174],"improved":[176],"survival":[177],"when":[178],"combined":[179],"Oseltamivir":[181],"(OSV)":[182],"treatment":[183],"infected":[185],"mice.":[186],"Our":[187],"study":[188],"establishes":[189],"practical":[192],"virological":[196],"research":[197],"highlights":[199],"potential":[203],"host-directed":[204],"adjunct":[205],"therapy":[206],"severe":[208]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-06T00:00:00"}