{"id":"https://openalex.org/W7208823688","doi":"https://doi.org/10.64898/2026.09.01.748536","title":"Unifying physical and molecular coordinate systems across modalities in spatial biology","display_name":"Unifying physical and molecular coordinate systems across modalities in spatial biology","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208823688","doi":"https://doi.org/10.64898/2026.09.01.748536"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.748536","doi":"https://doi.org/10.64898/2026.09.01.748536","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748536","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.01.748536","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125373499","display_name":"Bingjie Dai","orcid":"https://orcid.org/0009-0002-6020-6767","observed_orcids":["https://orcid.org/0009-0002-6020-6767"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingjie Dai","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140913587","display_name":"Yunzhi Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunzhi Yan","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121327551","display_name":"Zhikang Wang","orcid":"https://orcid.org/0000-0001-9587-1965","observed_orcids":["https://orcid.org/0000-0001-9587-1965"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhikang Wang","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042256305","display_name":"Yuchao Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchao Liang","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134970768","display_name":"Sijie Li","orcid":"https://orcid.org/0009-0005-0521-0722","observed_orcids":["https://orcid.org/0009-0005-0521-0722"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijie Li","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125371847","display_name":"Pengwei Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengwei Hu","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140757244","display_name":"Xinwang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinwang Yang","raw_affiliation_strings":["Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China","Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081411764","display_name":"Chuyao Wang","orcid":"https://orcid.org/0009-0003-0057-2826","observed_orcids":["https://orcid.org/0009-0003-0057-2826"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4405259713","display_name":"Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University","ror":"https://ror.org/02knk1347","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405259713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuyao Wang","raw_affiliation_strings":["Key Laboratory of Symbolic Computation and Knowledge Engineering of the Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering of the Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4405259713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053445346","display_name":"Litai Yi","orcid":"https://orcid.org/0009-0002-9442-2783","observed_orcids":["https://orcid.org/0009-0002-9442-2783"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Litai Yi","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109380067","display_name":"Chenglong Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152269853","display_name":"Qilu University of Technology","ror":"https://ror.org/04hyzq608","country_code":"CN","type":"education","lineage":["https://openalex.org/I152269853"]},{"id":"https://openalex.org/I4210142748","display_name":"Shandong Academy of Sciences","ror":"https://ror.org/04y8d6y55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenglong Sun","raw_affiliation_strings":["School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China","institution_ids":["https://openalex.org/I152269853","https://openalex.org/I4210142748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049232069","display_name":"Jinhai Huang","orcid":"https://orcid.org/0000-0001-9952-3175","observed_orcids":["https://orcid.org/0000-0001-9952-3175"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhai Huang","raw_affiliation_strings":["Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113418550","display_name":"Xingtao Zhou","orcid":"https://orcid.org/0000-0002-6125-769X","observed_orcids":["https://orcid.org/0000-0002-6125-769X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingtao Zhou","raw_affiliation_strings":["Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I24943067","https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150172006","display_name":"Hebing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hebing Chen","raw_affiliation_strings":["State Key Laboratory of Medical Proteomics, Beijing, 102200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medical Proteomics, Beijing, 102200, China","institution_ids":["https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046409597","display_name":"Daoliang Zhang","orcid":"https://orcid.org/0009-0009-7682-6187","observed_orcids":["https://orcid.org/0009-0009-7682-6187","https://orcid.org/0000-0002-7234-385X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daoliang Zhang","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032177649","display_name":"Qi Zou","orcid":"https://orcid.org/0000-0002-8662-5874","observed_orcids":["https://orcid.org/0000-0002-8662-5874"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zou","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138608082","display_name":"Yixuan Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Du","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102810210","display_name":"Zheqi Hu","orcid":"https://orcid.org/0009-0008-8596-6061","observed_orcids":["https://orcid.org/0009-0008-8596-6061"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheqi Hu","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101018628","display_name":"Yongqiang Xing","orcid":"https://orcid.org/0000-0001-6987-7327","observed_orcids":["https://orcid.org/0000-0001-6987-7327"]},"institutions":[{"id":"https://openalex.org/I31637741","display_name":"Inner Mongolia University of Science and Technology","ror":"https://ror.org/044rgx723","country_code":"CN","type":"education","lineage":["https://openalex.org/I31637741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqiang Xing","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Life Health and Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Life Health and Bioinformatics, School of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China","institution_ids":["https://openalex.org/I31637741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071499238","display_name":"Guifang Cao","orcid":"https://orcid.org/0000-0002-6177-884X","observed_orcids":["https://orcid.org/0000-0002-6177-884X","https://orcid.org/0000-0003-1330-118X"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guifang Cao","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121713009","display_name":"Zhenxing Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55654194","display_name":"Inner Mongolia University of Technology","ror":"https://ror.org/05564e019","country_code":"CN","type":"education","lineage":["https://openalex.org/I55654194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxing Feng","raw_affiliation_strings":["College of Sciences, Inner Mongolia University of Technology, Hohhot, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Sciences, Inner Mongolia University of Technology, Hohhot, China","institution_ids":["https://openalex.org/I55654194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080019095","display_name":"Jianfeng Feng","orcid":"https://orcid.org/0000-0002-9328-5732","observed_orcids":["https://orcid.org/0000-0002-9328-5732"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Feng","raw_affiliation_strings":["Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032774298","display_name":"Shuhua Xu","orcid":"https://orcid.org/0000-0002-1975-1002","observed_orcids":["https://orcid.org/0000-0002-1975-1002"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhua Xu","raw_affiliation_strings":["State Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai 200438, China","State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai 200438, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150406235","display_name":"Wei Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Hu","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001300435","display_name":"Yongchun Zuo","orcid":"https://orcid.org/0000-0002-6065-7835","observed_orcids":["https://orcid.org/0000-0002-6065-7835","https://orcid.org/0000-0002-4953-2337"]},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchun Zuo","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot, 010021, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024701619","display_name":"Bin\u2010Zhi Qian","orcid":"https://orcid.org/0000-0002-5796-1078","observed_orcids":["https://orcid.org/0000-0002-5796-1078"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin-Zhi Qian","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060480375","display_name":"Zhiyuan Yuan","orcid":"https://orcid.org/0000-0002-9367-4236","observed_orcids":["https://orcid.org/0000-0002-9367-4236"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiyuan Yuan","raw_affiliation_strings":["Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China"],"raw_orcid":"https://orcid.org/0000-0002-9367-4236","affiliations":[{"raw_affiliation_string":"Center for Integrative Spatial-Omics Research, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Institute of Science and Technology for Brain-Inspired Intelligence, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai 200003, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5060480375"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405273316"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spatial-biology","display_name":"spatial biology","score":0.8500000238418579},{"id":"https://openalex.org/keywords/multimodal-data-integration","display_name":"multimodal data integration","score":0.9340000152587891},{"id":"https://openalex.org/keywords/coordinate-system-unification","display_name":"coordinate system unification","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mouse-brain-atlas","display_name":"mouse brain atlas","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.5839999914169312},{"id":"https://openalex.org/keywords/spatial-proteomics","display_name":"spatial proteomics","score":0.6430000066757202},{"id":"https://openalex.org/keywords/spatial-genomics","display_name":"spatial genomics","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.7078999876976013},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.6011000275611877},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5641000270843506},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.43880000710487366},{"id":"https://openalex.org/C80551277","wikidata":"https://www.wikidata.org/wiki/Q11210","display_name":"Coordinate system","level":2,"score":0.421999990940094},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4075999855995178},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3905999958515167},{"id":"https://openalex.org/C194226119","wikidata":"https://www.wikidata.org/wiki/Q161779","display_name":"Spatial reference system","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.323199987411499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.323199987411499},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.32170000672340393},{"id":"https://openalex.org/C2781179811","wikidata":"https://www.wikidata.org/wiki/Q28134081","display_name":"Spatial configuration","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C2992918937","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Biological organism","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C164614171","wikidata":"https://www.wikidata.org/wiki/Q5204775","display_name":"DECIPHER","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C158709400","wikidata":"https://www.wikidata.org/wiki/Q3578586","display_name":"Spatial ecology","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C2780977526","wikidata":"https://www.wikidata.org/wiki/Q42417149","display_name":"Data exploration","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.2689000070095062},{"id":"https://openalex.org/C3019692148","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Therapeutic modalities","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C9770341","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Geospatial analysis","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.748536","doi":"https://doi.org/10.64898/2026.09.01.748536","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748536","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.748536","doi":"https://doi.org/10.64898/2026.09.01.748536","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748536","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W1967658333","https://openalex.org/W1973697421","https://openalex.org/W1975389666","https://openalex.org/W1979505297","https://openalex.org/W1996868531","https://openalex.org/W2000011436","https://openalex.org/W2033278243","https://openalex.org/W2035653659","https://openalex.org/W2042789810","https://openalex.org/W2051816002","https://openalex.org/W2078274931","https://openalex.org/W2080293390","https://openalex.org/W2093442991","https://openalex.org/W2102298863","https://openalex.org/W2122805183","https://openalex.org/W2126537932","https://openalex.org/W2145866317","https://openalex.org/W2161092951","https://openalex.org/W2178629455","https://openalex.org/W2317982666","https://openalex.org/W2318567174","https://openalex.org/W2465950095","https://openalex.org/W2582686270","https://openalex.org/W2612519453","https://openalex.org/W2770676323","https://openalex.org/W2785803176","https://openalex.org/W2788975052","https://openalex.org/W2798233554","https://openalex.org/W2800392236","https://openalex.org/W2809368942","https://openalex.org/W2915848182","https://openalex.org/W2916020270","https://openalex.org/W2942939852","https://openalex.org/W2944600762","https://openalex.org/W2949238013","https://openalex.org/W2992768668","https://openalex.org/W3013243617","https://openalex.org/W3016787828","https://openalex.org/W3021105102","https://openalex.org/W3036882247","https://openalex.org/W3040968822","https://openalex.org/W3126958162","https://openalex.org/W3152852090","https://openalex.org/W3166110253","https://openalex.org/W3171692328","https://openalex.org/W3190202966","https://openalex.org/W4212770653","https://openalex.org/W4220765701","https://openalex.org/W4229033508","https://openalex.org/W4233857083","https://openalex.org/W4239026366","https://openalex.org/W4242111955","https://openalex.org/W4280494993","https://openalex.org/W4282030652","https://openalex.org/W4286005528","https://openalex.org/W4292121951","https://openalex.org/W4294710511","https://openalex.org/W4294804925","https://openalex.org/W4300862018","https://openalex.org/W4302362633","https://openalex.org/W4311310228","https://openalex.org/W4313561175","https://openalex.org/W4318982690","https://openalex.org/W4324344255","https://openalex.org/W4367369351","https://openalex.org/W4382520315","https://openalex.org/W4383340946","https://openalex.org/W4385955242","https://openalex.org/W4387095485","https://openalex.org/W4388530027","https://openalex.org/W4388686627","https://openalex.org/W4389481214","https://openalex.org/W4389488172","https://openalex.org/W4389670373","https://openalex.org/W4389670555","https://openalex.org/W4389938094","https://openalex.org/W4390500930","https://openalex.org/W4390918475","https://openalex.org/W4391840598","https://openalex.org/W4392947521","https://openalex.org/W4394752969","https://openalex.org/W4395113935","https://openalex.org/W4396734624","https://openalex.org/W4399256072","https://openalex.org/W4399892951","https://openalex.org/W4400249174","https://openalex.org/W4400294055","https://openalex.org/W4400783289","https://openalex.org/W4401454905","https://openalex.org/W4401757646","https://openalex.org/W4402372460","https://openalex.org/W4402634766","https://openalex.org/W4402902773","https://openalex.org/W4403089181","https://openalex.org/W4403853489","https://openalex.org/W4403920980","https://openalex.org/W4404236873","https://openalex.org/W4404566936","https://openalex.org/W4406401130","https://openalex.org/W4406715779","https://openalex.org/W4406758970","https://openalex.org/W4407415768","https://openalex.org/W4408076145","https://openalex.org/W4408552328","https://openalex.org/W4408758667","https://openalex.org/W4408967910","https://openalex.org/W4409523068","https://openalex.org/W4410866390","https://openalex.org/W4411069266","https://openalex.org/W4412720675","https://openalex.org/W4412871302","https://openalex.org/W4413495230","https://openalex.org/W4414161979","https://openalex.org/W4414183210","https://openalex.org/W4414861707","https://openalex.org/W4415308605","https://openalex.org/W4415846673","https://openalex.org/W4415929055","https://openalex.org/W4416599766","https://openalex.org/W4417319459","https://openalex.org/W4417497709","https://openalex.org/W7114802335","https://openalex.org/W7117668967","https://openalex.org/W7117696677","https://openalex.org/W7127622798","https://openalex.org/W7128298112","https://openalex.org/W7141016961","https://openalex.org/W7148922654","https://openalex.org/W7160505402","https://openalex.org/W7164848671"],"related_works":["https://openalex.org/W7135393790","https://openalex.org/W7170048543","https://openalex.org/W7165478251","https://openalex.org/W4417116812","https://openalex.org/W203742949","https://openalex.org/W7099626501","https://openalex.org/W7116880946","https://openalex.org/W4414370651","https://openalex.org/W7203491230","https://openalex.org/W7125110720"],"abstract_inverted_index":{"Abstract":[0],"Establishing":[1],"a":[2,14,23],"unified":[3],"physical":[4],"and":[5,43,53,75,90,106,146],"molecular":[6],"coordinate":[7],"system":[8],"from":[9,103],"fragmented":[10],"multi-modal":[11,51,81,115,133],"data":[12],"is":[13],"longstanding":[15],"challenge":[16],"in":[17,88],"biology.":[18],"Here,":[19],"we":[20],"present":[21],"MAPS,":[22],"modality-agnostic":[24],"platform":[25],"for":[26,32,40,49,56],"spatial":[27,127,144],"biology":[28],"comprising":[29,99],"(1)":[30],"MAPS-alignment":[31],"ultrafast":[33],"alignment":[34],"of":[35,135,142],"any":[36],"modality,":[37],"(2)":[38],"MAPS-integration":[39],"both":[41],"anchored":[42],"unanchored":[44],"integration":[45],"across":[46,65,84],"orthogonal":[47],"modalities":[48,108],"3D":[50,59,114,132],"reconstruction,":[52],"(3)":[54],"MAPS-Explorer":[55],"large-scale":[57],"interactive":[58],"analysis.":[60],"MAPS":[61,95,123],"outperformed":[62],"existing":[63],"methods":[64],"extensive":[66],"benchmarks":[67],"on":[68],"34":[69],"datasets":[70],"spanning":[71],"16":[72],"technology":[73],"platforms":[74],"6":[76],"modalities,":[77],"while":[78],"delineating":[79],"fine-grained":[80],"tissue":[82],"architectures":[83],"diverse":[85],"biological":[86],"systems":[87],"mouse":[89,116],"human.":[91],"At":[92,119],"cross-consortium":[93],"scale,":[94,122],"integrated":[96],"434":[97],"slices":[98],"21":[100],"million":[101],"cells":[102],"18":[104],"atlases":[105],"5":[107],"to":[109,129],"construct":[110],"the":[111,140],"most":[112],"comprehensive":[113],"brain":[117],"atlas.":[118],"individual":[120],"laboratory":[121],"empowered":[124],"routine":[125],"2D":[126,143],"assays":[128],"reconstruct":[130],"continuous":[131],"landscapes":[134],"human":[136],"hepatocellular":[137],"carcinoma,":[138],"revealing":[139],"limitations":[141],"relationships":[145],"uncovering":[147],"depth-dependent":[148],"immune-state":[149],"transitions.":[150]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-06T00:00:00"}
