{"id":"https://openalex.org/W7208823631","doi":"https://doi.org/10.2500/aap.2026.47.260054","title":"Hereditary angioedema in women: Hormonal and reproductive influences on disease activity","display_name":"Hereditary angioedema in women: Hormonal and reproductive influences on disease activity","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7208823631","doi":"https://doi.org/10.2500/aap.2026.47.260054","pmid":"https://pubmed.ncbi.nlm.nih.gov/42698169"},"language":"en","primary_location":{"id":"doi:10.2500/aap.2026.47.260054","doi":"https://doi.org/10.2500/aap.2026.47.260054","is_oa":false,"landing_page_url":"https://doi.org/10.2500/aap.2026.47.260054","pdf_url":null,"source":{"id":"https://openalex.org/S49250914","display_name":"Allergy and Asthma Proceedings","issn_l":"1088-5412","issn":["1088-5412","1539-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320401","host_organization_name":"OceanSide Publications, Inc","host_organization_lineage":["https://openalex.org/P4310320401"],"host_organization_lineage_names":["OceanSide Publications, Inc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and Asthma Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116485092","display_name":"Reyhan Sevil Cansunar","orcid":"https://orcid.org/0000-0002-3211-5270","observed_orcids":["https://orcid.org/0000-0002-3211-5270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reyhan S. Cansunar","raw_affiliation_strings":["From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090722278","display_name":"Merve Erko\u00e7","orcid":"https://orcid.org/0000-0001-8147-3181","observed_orcids":["https://orcid.org/0000-0001-8147-3181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merve Erkoc Karaduman","raw_affiliation_strings":["Division of Immunology and Allergy, Prof. Dr. Feriha \u00d6z Emergency Hospital, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Allergy, Prof. Dr. Feriha \u00d6z Emergency Hospital, Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116334817","display_name":"Leyla \u00c7evirme","orcid":"https://orcid.org/0009-0005-8940-0485","observed_orcids":["https://orcid.org/0009-0005-8940-0485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leyla Cevirme","raw_affiliation_strings":["From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092415342","display_name":"Hakan BAS\u0130R","orcid":"https://orcid.org/0000-0002-8180-5059","observed_orcids":["https://orcid.org/0000-0002-8180-5059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hakan Basir","raw_affiliation_strings":["From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019224251","display_name":"G\u00fczin \u00d6zden","orcid":"https://orcid.org/0000-0003-4856-2267","observed_orcids":["https://orcid.org/0000-0003-4856-2267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guzin Ozden","raw_affiliation_strings":["From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8809,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86583757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"47","issue":"5","first_page":"348","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":1.0},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hormonal-effects","display_name":"endocrine effects","score":0.6230000257492065},{"id":"https://openalex.org/keywords/reproductive-factors","display_name":"reproductive factors","score":0.824999988079071},{"id":"https://openalex.org/keywords/menstruation","display_name":"menstruation","score":0.699999988079071},{"id":"https://openalex.org/keywords/oral-contraceptives","display_name":"oral contraceptives","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":1.0},{"id":"https://openalex.org/keywords/attack-frequency","display_name":"attack frequency","score":0.9070000052452087},{"id":"https://openalex.org/keywords/type-i-hereditary-angioedema","display_name":"type I hereditary angioedema","score":0.800000011920929},{"id":"https://openalex.org/keywords/type-ii-hereditary-angioedema","display_name":"type II hereditary angioedema","score":0.9959999918937683},{"id":"https://openalex.org/keywords/delayed-diagnosis","display_name":"delayed diagnosis","score":0.5130000114440918},{"id":"https://openalex.org/keywords/autosomal-dominant-inheritance","display_name":"autosomal dominant inheritance","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9402999877929688},{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.8012999892234802},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6959999799728394},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6065000295639038},{"id":"https://openalex.org/C2779771394","wikidata":"https://www.wikidata.org/wiki/Q12171","display_name":"Menstruation","level":2,"score":0.5823000073432922},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.49900001287460327},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.46860000491142273},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.45649999380111694},{"id":"https://openalex.org/C183021626","wikidata":"https://www.wikidata.org/wiki/Q4620674","display_name":"Sex organ","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4203999936580658},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4115000069141388},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.3944999873638153},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3725999891757965},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.32749998569488525},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C2776172332","wikidata":"https://www.wikidata.org/wiki/Q7292449","display_name":"Hormonal contraception","level":5,"score":0.30979999899864197},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3037000000476837},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29499998688697815},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.29420000314712524},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2840000092983246},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.2572999894618988}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054179","descriptor_name":"Angioedemas, Hereditary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054179","descriptor_name":"Angioedemas, Hereditary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D054179","descriptor_name":"Angioedemas, Hereditary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2500/aap.2026.47.260054","doi":"https://doi.org/10.2500/aap.2026.47.260054","is_oa":false,"landing_page_url":"https://doi.org/10.2500/aap.2026.47.260054","pdf_url":null,"source":{"id":"https://openalex.org/S49250914","display_name":"Allergy and Asthma Proceedings","issn_l":"1088-5412","issn":["1088-5412","1539-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320401","host_organization_name":"OceanSide Publications, Inc","host_organization_lineage":["https://openalex.org/P4310320401"],"host_organization_lineage_names":["OceanSide Publications, Inc"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and Asthma Proceedings","raw_type":"journal-article"},{"id":"pmid:42698169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42698169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and asthma proceedings","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W13804010","https://openalex.org/W1967228366","https://openalex.org/W1972964391","https://openalex.org/W1992005236","https://openalex.org/W1992040596","https://openalex.org/W2052020035","https://openalex.org/W2055547657","https://openalex.org/W2071817071","https://openalex.org/W2121223536","https://openalex.org/W2299483695","https://openalex.org/W2521820355","https://openalex.org/W2894550506","https://openalex.org/W2989863136","https://openalex.org/W2996556119","https://openalex.org/W3083179120","https://openalex.org/W3089461266","https://openalex.org/W3095199063","https://openalex.org/W4206038398","https://openalex.org/W4285394276","https://openalex.org/W4307727141","https://openalex.org/W4398681675"],"related_works":["https://openalex.org/W2985465412","https://openalex.org/W2055547657","https://openalex.org/W2052020035","https://openalex.org/W4243012743","https://openalex.org/W7100323536","https://openalex.org/W2587417110","https://openalex.org/W2121852315","https://openalex.org/W2314599475","https://openalex.org/W3097331515","https://openalex.org/W2472203174"],"abstract_inverted_index":{"Background:":[0],"Hereditary":[1],"angioedema":[2],"(HAE)":[3],"is":[4],"a":[5,144],"rare,":[6],"potentially":[7],"life-threatening":[8],"disorder":[9],"characterized":[10],"by":[11],"recurrent":[12],"edema":[13],"of":[14,55,63,104,148,156,244,270],"the":[15,61,102,157,240],"extremities,":[16],"abdomen,":[17],"face,":[18],"larynx,":[19],"trunk,":[20],"and":[21,31,42,71,78,84,115,120,129,170,190,204,221,228,242,272],"genital":[22],"region.":[23],"It":[24],"follows":[25],"an":[26],"autosomal":[27],"dominant":[28],"inheritance":[29],"pattern":[30],"affects":[32],"both":[33],"sexes":[34],"equally;":[35],"however,":[36],"attacks":[37,68,153,209,214],"may":[38,276],"occur":[39],"more":[40],"frequently":[41],"with":[43,96,143,162,178,237],"greater":[44],"severity":[45],"in":[46,69,154,167,185,188,193,201,216,219,224,235,253,256],"women":[47,70,95,236,262],"due":[48],"to":[49,59,72,100],"hormonal":[50,64,79],"factors.":[51],"Aims:":[52],"The":[53,135,250],"aim":[54],"this":[56,88,257],"study":[57],"was":[58,140,191],"evaluate":[60],"impact":[62],"changes":[65],"on":[66,117],"HAE":[67,97,271],"determine":[73],"how":[74],"different":[75],"reproductive":[76,105,229],"stages":[77,231],"exposures":[80],"affect":[81],"attack":[82,118,182],"frequency":[83,119,183],"course.":[85],"Methods:":[86],"In":[87],"retrospective":[89],"descriptive":[90],"cohort":[91,258],"study,":[92],"36":[93],"postpubertal":[94],"were":[98,222],"evaluated":[99],"assess":[101],"effects":[103,246],"factors,":[106],"including":[107],"menstruation,":[108],"oral":[109],"contraceptive":[110],"use,":[111],"pregnancy,":[112,181],"delivery,":[113],"lactation,":[114],"menopause,":[116,213],"disease":[121,233],"activity.":[122],"Results:":[123],"Thirty":[124],"patients":[125,161,206],"had":[126,131,172],"type":[127,132],"I":[128],"six":[130,202],"II":[133],"HAE.":[134,179],"mean":[136,145],"age":[137],"at":[138,173],"diagnosis":[139,254],"23.5":[141],"years,":[142],"diagnostic":[146],"delay":[147,252],"12.6":[149],"years.":[150],"Menstruation":[151],"triggered":[152],"52.8%":[155],"patients.":[158],"Among":[159],"26":[160],"94":[163],"pregnancies,":[164],"21.2%":[165],"ended":[166],"spontaneous":[168],"abortion,":[169],"73.1%":[171],"least":[174],"one":[175],"child":[176],"diagnosed":[177],"During":[180],"increased":[184,208,215],"30.6%,":[186],"decreased":[187,218],"27.7%,":[189],"unchanged":[192,223],"41.7%.":[194,225],"Attacks":[195],"occurred":[196],"within":[197],"48":[198],"hours":[199],"postpartum":[200],"deliveries,":[203],"three":[205],"reported":[207],"during":[210,279],"lactation.":[211],"After":[212],"25%,":[217],"33.3%,":[220],"Conclusion:":[226],"Hormonal":[227],"life":[230],"influence":[232],"activity":[234],"HAE,":[238],"although":[239],"direction":[241],"magnitude":[243],"these":[245],"vary":[247],"among":[248],"individuals.":[249],"marked":[251],"observed":[255],"suggests":[259],"that":[260],"many":[261],"experience":[263],"pregnancies":[264],"without":[265],"disease-specific":[266],"management.":[267],"Earlier":[268],"recognition":[269],"individualized":[273],"treatment":[274],"approaches":[275],"improve":[277],"care":[278],"hormonally":[280],"dynamic":[281],"periods.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-06T00:00:00"}
