{"id":"https://openalex.org/W7208823369","doi":"https://doi.org/10.1016/j.biopha.2026.119913","title":"Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study","display_name":"Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208823369","doi":"https://doi.org/10.1016/j.biopha.2026.119913","pmid":"https://pubmed.ncbi.nlm.nih.gov/42700616"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2026.119913","doi":"https://doi.org/10.1016/j.biopha.2026.119913","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119913","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332226009492/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0753332226009492/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092372037","display_name":"Rima Salma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I194210350","display_name":"\u00c9cole Nationale Sup\u00e9rieure d'Ing\u00e9nieurs de Caen","ror":"https://ror.org/01fpqqe90","country_code":"FR","type":"education","lineage":["https://openalex.org/I194210350","https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210120813","display_name":"Centre de Recherche sur les Ions, les Mat\u00e9riaux et la Photonique","ror":"https://ror.org/02y0gk295","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I194210350","https://openalex.org/I2738703131","https://openalex.org/I4210098836","https://openalex.org/I4210105918","https://openalex.org/I4210120813","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR","SE"],"is_corresponding":false,"raw_author_name":"Rima Salma","raw_affiliation_strings":["Universit\u00e9 de Caen Normandie, ENSICAEN, CNRS, CEA, Normandie Universit\u00e9, CIMAP, UMR6252, Caen 14000, France; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala SE-75185, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Caen Normandie, ENSICAEN, CNRS, CEA, Normandie Universit\u00e9, CIMAP, UMR6252, Caen 14000, France; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala SE-75185, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1294671590","https://openalex.org/I194210350","https://openalex.org/I2738703131","https://openalex.org/I4210105918","https://openalex.org/I4210120813","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091648901","display_name":"Mira Hammad","orcid":"https://orcid.org/0009-0007-2043-0314","observed_orcids":["https://orcid.org/0009-0007-2043-0314"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210120813","display_name":"Centre de Recherche sur les Ions, les Mat\u00e9riaux et la Photonique","ror":"https://ror.org/02y0gk295","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I194210350","https://openalex.org/I2738703131","https://openalex.org/I4210098836","https://openalex.org/I4210105918","https://openalex.org/I4210120813","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mira Hammad","raw_affiliation_strings":["Universit\u00e9 de Caen Normandie, ENSICAEN, CNRS, CEA, Normandie Universit\u00e9, CIMAP, UMR6252, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Caen Normandie, ENSICAEN, CNRS, CEA, Normandie Universit\u00e9, CIMAP, UMR6252, Caen 14000, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210105918","https://openalex.org/I4210120813","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017163924","display_name":"Mehran Hariri","orcid":"https://orcid.org/0000-0001-9916-6673","observed_orcids":["https://orcid.org/0000-0001-9916-6673"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mehran Hariri","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala SE-75185, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala SE-75185, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008650701","display_name":"Traimate Sangsuwan","orcid":"https://orcid.org/0000-0003-4051-8376","observed_orcids":["https://orcid.org/0000-0003-4051-8376"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR","SE"],"is_corresponding":false,"raw_author_name":"Traimate Sangsuwan","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden; Universit\u00e9 Caen Normandie, Univ Rouen Normandie, Normandie Univ, ABTE UR4651, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden; Universit\u00e9 Caen Normandie, Univ Rouen Normandie, Normandie Univ, ABTE UR4651, Caen, France","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031395513","display_name":"Kave Moloudi","orcid":"https://orcid.org/0000-0003-4982-5946","observed_orcids":["https://orcid.org/0000-0003-4982-5946"]},"institutions":[{"id":"https://openalex.org/I4387156208","display_name":"Aliments Bioproc\u00e9d\u00e9s Toxicologie Environnements","ror":"https://ror.org/04w7xqn11","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210105918","https://openalex.org/I4387156208","https://openalex.org/I62396329","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kave Moloudi","raw_affiliation_strings":["Universit\u00e9 Caen Normandie, Univ Rouen Normandie, Normandie Univ, ABTE UR4651, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Caen Normandie, Univ Rouen Normandie, Normandie Univ, ABTE UR4651, Caen, France","institution_ids":["https://openalex.org/I4387156208","https://openalex.org/I62396329","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056249211","display_name":"Harry Scherthan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4387155235","display_name":"Institut f\u00fcr Radiobiologie der Bundeswehr","ror":"https://ror.org/00j0xy635","country_code":"DE","type":"government","lineage":["https://openalex.org/I4387155235"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harry Scherthan","raw_affiliation_strings":["Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Neuherbergstr, 11, Munich D-80937, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Neuherbergstr, 11, Munich D-80937, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4387155235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109295540","display_name":"Anthony Vela","orcid":"https://orcid.org/0009-0009-9735-5417","observed_orcids":["https://orcid.org/0009-0009-9735-5417"]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anthony Vela","raw_affiliation_strings":["Department of Radiation Oncology, Centre Fran\u00e7ois Baclesse, Caen F-14000, France"],"raw_orcid":"https://orcid.org/0009-0009-9735-5417","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Centre Fran\u00e7ois Baclesse, Caen F-14000, France","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087977092","display_name":"Rute Ces\u00e1rio","orcid":"https://orcid.org/0000-0003-1832-5391","observed_orcids":["https://orcid.org/0000-0003-1832-5391"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rute Ces\u00e1rio","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071820354","display_name":"Paulo R. D. V. Godoy","orcid":"https://orcid.org/0000-0002-4960-6762","observed_orcids":["https://orcid.org/0000-0002-4960-6762"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Paulo Godoy","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4960-6762","affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083672016","display_name":"Jacques Balosso","orcid":"https://orcid.org/0000-0003-0714-9003","observed_orcids":["https://orcid.org/0000-0003-0714-9003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacques Balosso","raw_affiliation_strings":["Advanced Resource Center for HADrontherapy in Europe (ARCHADE), CYCLHAD Hadrontherapy Centre, Caen F-14000, France; Department of Radiation Oncology, Central University Hospital, Grenoble F-38000, France"],"raw_orcid":"https://orcid.org/0000-0003-0714-9003","affiliations":[{"raw_affiliation_string":"Advanced Resource Center for HADrontherapy in Europe (ARCHADE), CYCLHAD Hadrontherapy Centre, Caen F-14000, France; Department of Radiation Oncology, Central University Hospital, Grenoble F-38000, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030761470","display_name":"Bo Stenerl\u00f6w","orcid":"https://orcid.org/0000-0001-8878-8071","observed_orcids":["https://orcid.org/0000-0001-8878-8071"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bo Stenerl\u00f6w","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala SE-75185, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala SE-75185, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013840032","display_name":"Siamak Haghdoost","orcid":"https://orcid.org/0000-0002-2867-4774","observed_orcids":["https://orcid.org/0000-0002-2867-4774"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR","SE"],"is_corresponding":true,"raw_author_name":"Siamak Haghdoost","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden; Universit\u00e9 Caen Normandie, Univ Rouen Normandie, Normandie Univ, ABTE UR4651, Caen, France; Advanced Resource Center for HADrontherapy in Europe (ARCHADE), CYCLHAD Hadrontherapy Centre, Caen F-14000, France. Electronic address: siamak.haghdoost@unicaen.fr"],"raw_orcid":"https://orcid.org/0000-0002-2867-4774","affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm SE-10691, Sweden; Universit\u00e9 Caen Normandie, Univ Rouen Normandie, Normandie Univ, ABTE UR4651, Caen, France; Advanced Resource Center for HADrontherapy in Europe (ARCHADE), CYCLHAD Hadrontherapy Centre, Caen F-14000, France. Electronic address: siamak.haghdoost@unicaen.fr","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I4210105918","https://openalex.org/I62396329","https://openalex.org/I98702875"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5013840032"],"corresponding_institution_ids":["https://openalex.org/I161593684","https://openalex.org/I4210105918","https://openalex.org/I62396329","https://openalex.org/I98702875"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"203","issue":null,"first_page":"119913","last_page":"119913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.1873999983072281,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma-stem-cells","display_name":"glioblastoma stem cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9079999923706055},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.953000009059906},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8270000219345093},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/carbon-ion-radiotherapy","display_name":"carbon ion radiotherapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/photon-irradiation","display_name":"photon irradiation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ml385","display_name":"ML385","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antioxidant-signaling","display_name":"antioxidant signaling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.949999988079071},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/gamma-h2ax-foci","display_name":"\u03b3H2AX foci","score":0.7360000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3889999985694885},{"id":"https://openalex.org/keywords/tumor-spheres","display_name":"tumor spheres","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.90420001745224},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.8264999985694885},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.8082000017166138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6205999851226807},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.5936999917030334},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5867000222206116},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5648999810218811},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5291000008583069},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.37040001153945923},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.34610000252723694},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C2776428644","wikidata":"https://www.wikidata.org/wiki/Q2126468","display_name":"Radiosensitizer","level":3,"score":0.32670000195503235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3154999911785126},{"id":"https://openalex.org/C26114605","wikidata":"https://www.wikidata.org/wiki/Q7280368","display_name":"Radiation sensitivity","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30799999833106995},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.2973000109195709},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27730000019073486},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.2630999982357025},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.25839999318122864},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.2526000142097473}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017785","descriptor_name":"Photons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2026.119913","doi":"https://doi.org/10.1016/j.biopha.2026.119913","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119913","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332226009492/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:42700616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42700616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2026.119913","doi":"https://doi.org/10.1016/j.biopha.2026.119913","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119913","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332226009492/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5900736905","display_name":null,"funder_award_id":"20E06142-00018053","funder_id":"https://openalex.org/F4320329010","funder_display_name":"Universit\u00e9 de Caen Normandie"},{"id":"https://openalex.org/G6437102565","display_name":null,"funder_award_id":"22 2365 Pj","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G766122785","display_name":null,"funder_award_id":"254743 Pj","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G7867113433","display_name":null,"funder_award_id":"20E06142-00018053","funder_id":"https://openalex.org/F4320321778","funder_display_name":"Conseil R\u00e9gional de Haute Normandie"}],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320321778","display_name":"Conseil R\u00e9gional de Haute Normandie","ror":"https://ror.org/03w805n83"},{"id":"https://openalex.org/F4320329010","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16"},{"id":"https://openalex.org/F4320329938","display_name":"R\u00e9gion Normandie","ror":"https://ror.org/03cq89j92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208823369.pdf","grobid_xml":"https://content.openalex.org/works/W7208823369.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1902577542","https://openalex.org/W1994051196","https://openalex.org/W2001544973","https://openalex.org/W2006536535","https://openalex.org/W2014599726","https://openalex.org/W2017611594","https://openalex.org/W2032485712","https://openalex.org/W2035880310","https://openalex.org/W2052481600","https://openalex.org/W2052548231","https://openalex.org/W2054330377","https://openalex.org/W2063767314","https://openalex.org/W2088413560","https://openalex.org/W2103890607","https://openalex.org/W2112704588","https://openalex.org/W2126898119","https://openalex.org/W2127863564","https://openalex.org/W2134565827","https://openalex.org/W2135904268","https://openalex.org/W2148601336","https://openalex.org/W2157313865","https://openalex.org/W2158681922","https://openalex.org/W2170632492","https://openalex.org/W2217757445","https://openalex.org/W2515257966","https://openalex.org/W2548618596","https://openalex.org/W2592950943","https://openalex.org/W2596890243","https://openalex.org/W2597062310","https://openalex.org/W2766048952","https://openalex.org/W2790382909","https://openalex.org/W2805642868","https://openalex.org/W2807838767","https://openalex.org/W2904653870","https://openalex.org/W2929049965","https://openalex.org/W2953749471","https://openalex.org/W2958640546","https://openalex.org/W2972053107","https://openalex.org/W2978851503","https://openalex.org/W2986435328","https://openalex.org/W3009781222","https://openalex.org/W3036199211","https://openalex.org/W3047143964","https://openalex.org/W3084114043","https://openalex.org/W3113445574","https://openalex.org/W3134896677","https://openalex.org/W3148503912","https://openalex.org/W3152778989","https://openalex.org/W3184202385","https://openalex.org/W4220678687","https://openalex.org/W4223577922","https://openalex.org/W4307457805","https://openalex.org/W4310812554","https://openalex.org/W4361212895","https://openalex.org/W4376630057","https://openalex.org/W4377012053","https://openalex.org/W4382753409","https://openalex.org/W4387407919","https://openalex.org/W4401921755","https://openalex.org/W4407372432","https://openalex.org/W4409122367","https://openalex.org/W4412535493"],"related_works":["https://openalex.org/W7112261848","https://openalex.org/W7124398973","https://openalex.org/W2165400661","https://openalex.org/W3036199211","https://openalex.org/W2790382909","https://openalex.org/W2039881995","https://openalex.org/W2103338947","https://openalex.org/W2053722212","https://openalex.org/W7124323453","https://openalex.org/W4387003344"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"exhibits":[3],"strong":[4],"resistance":[5],"to":[6,38,57,75,82,134,150],"radiotherapy,":[7],"partly":[8],"driven":[9],"by":[10],"glioblastoma":[11],"stem-like":[12],"cells":[13],"(GSCs)":[14],"with":[15,92,169,174,215,234,268],"enhanced":[16,148],"redox":[17],"homeostasis":[18],"and":[19,31,61,79,98,108,126,142,152,154,171,176,205,247,255],"DNA":[20,33,217,241],"repair":[21,34,238],"capacity.":[22],"This":[23],"study":[24],"evaluated":[25],"whether":[26],"targeting":[27,265],"Nrf2-mediated":[28],"antioxidant":[29,203],"signaling":[30],"PARP1-dependent":[32],"enhances":[35],"GSC":[36,253],"radiosensitivity":[37,149],"different":[39],"radiation":[40,186],"modalities.":[41],"Pharmacological":[42],"inhibition":[43,200,212,221],"of":[44,65,84,95,115,137,239,252,262],"Nrf2":[45,103,199,246],"(ML385,":[46],"6":[47],"\u00b5mol/L)":[48,53],"or":[49,236],"PARP1":[50,211,248],"(olaparib,":[51],"5":[52],"reduced":[54,73,201],"tumorsphere":[55],"formation":[56,74],"74.5":[58],"\u00b1":[59,63,77,117,122,128,140,144],"10%":[60],"58.56":[62],"14.5%":[64],"control":[66],"levels,":[67],"respectively,":[68],"while":[69,210],"combined":[70],"treatment":[71,180],"further":[72,222,260],"51":[76],"11%":[78],"sphere":[80],"size":[81],"29%":[83],"control.":[85],"Western":[86],"blotting":[87],"confirmed":[88],"effective":[89],"pathway":[90],"inhibition,":[91],"complete":[93],"suppression":[94],"PARP":[96],"activity":[97],"approximately":[99],"30%":[100],"reduction":[101,184],"in":[102,185,266],"downstream":[104,202],"proteins":[105,204],"(SOD1,":[106],"PRDX2,":[107],"NQO1).":[109],"Dose-response":[110],"analysis":[111],"showed":[112,155,165],"D\u2085\u2080":[113],"values":[114,136],"5.03":[116],"0.09":[118],"Gy":[119,124,130],"(photons),":[120],"2.96":[121],"0.91":[123],"(protons),":[125],"2.04":[127],"0.47":[129],"(carbon":[131],"ions),":[132],"corresponding":[133],"RBE\u2085\u2080":[135],"1,":[138],"1.70":[139],"0.55,":[141],"2.46":[143],"0.57,":[145],"respectively.":[146],"ML385":[147],"photons":[151,170],"protons":[153,175],"a":[156,182,257],"similar":[157],"radiosensitizing":[158],"trend":[159],"following":[160,196,230],"carbon-ion":[161],"irradiation,":[162,232],"whereas":[163],"olaparib":[164],"its":[166],"strongest":[167],"effect":[168],"limited":[172],"effects":[173],"carbon":[177],"ions.":[178],"Combined":[179,220],"produced":[181],"greater":[183],"survival":[187],"than":[188],"either":[189],"inhibitor":[190],"alone":[191],"under":[192],"selected":[193,227],"conditions,":[194],"particularly":[195],"photon":[197],"irradiation.":[198],"increased":[206,223],"late":[207],"apoptotic/necrotic":[208],"fraction,":[209],"was":[213],"associated":[214],"altered":[216],"damage":[218],"persistence.":[219],"\u03b3-H2AX":[224],"foci":[225],"at":[226],"time":[228],"points":[229],"proton":[231],"consistent":[233],"delayed":[235],"incomplete":[237],"radiation-induced":[240],"damage.":[242],"These":[243],"findings":[244],"support":[245],"as":[249],"potential":[250],"regulators":[251],"radioresistance":[254],"provide":[256],"rationale":[258],"for":[259],"investigation":[261],"their":[263],"therapeutic":[264],"combination":[267],"radiotherapy.":[269]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-06T00:00:00"}