{"id":"https://openalex.org/W7208822706","doi":"https://doi.org/10.5281/zenodo.22363319","title":"Genetic Engineering and CAR-T Cell Therapy in Hematological Malignancies: From CD19/BCMA Targeting to CRISPR-Enabled Cellular Engineering","display_name":"Genetic Engineering and CAR-T Cell Therapy in Hematological Malignancies: From CD19/BCMA Targeting to CRISPR-Enabled Cellular Engineering","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208822706","doi":"https://doi.org/10.5281/zenodo.22363319"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22363319","doi":"https://doi.org/10.5281/zenodo.22363319","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22363319","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReview"},"volume":null,"type":"peer-review","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22363319","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094344230","display_name":"Dr.Zeeshan Qaiser","orcid":"https://orcid.org/0000-0003-4535-8519","observed_orcids":["https://orcid.org/0000-0003-4535-8519"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["AU","CH"],"is_corresponding":true,"raw_author_name":"Qaiser, Dr. Zeeshan","raw_affiliation_strings":["Deakin University","World Health Organization","Institute for Cancer Genetics and Precision Oncology (ICGPO)","International Cancer Research Institute (ICRI)","Global Institute for Cancer Research and Innovation (GICRI)","International Institute of Oncology and Cancer Research (IIOCR)","Global Cancer Research and Precision Medicine Institute (GCRPMI)","International Center for Cancer Research and Advanced Therapeutics (ICCRAT)","Global Oncology Research and Innovation Institute (GORII)","International Cancer Genomics and Precision Medicine Institute (ICGPMI)","Center for Advanced Cancer Research and Immunotherapy (CACRI)","nternational Institute for Cancer Prevention and Research (IICPR)"],"raw_orcid":"https://orcid.org/0009-0000-4434-7602","affiliations":[{"raw_affiliation_string":"Deakin University","institution_ids":["https://openalex.org/I149704539"]},{"raw_affiliation_string":"World Health Organization","institution_ids":["https://openalex.org/I4210105654"]},{"raw_affiliation_string":"Institute for Cancer Genetics and Precision Oncology (ICGPO)","institution_ids":[]},{"raw_affiliation_string":"International Cancer Research Institute (ICRI)","institution_ids":[]},{"raw_affiliation_string":"Global Institute for Cancer Research and Innovation (GICRI)","institution_ids":[]},{"raw_affiliation_string":"International Institute of Oncology and Cancer Research (IIOCR)","institution_ids":[]},{"raw_affiliation_string":"Global Cancer Research and Precision Medicine Institute (GCRPMI)","institution_ids":[]},{"raw_affiliation_string":"International Center for Cancer Research and Advanced Therapeutics (ICCRAT)","institution_ids":[]},{"raw_affiliation_string":"Global Oncology Research and Innovation Institute (GORII)","institution_ids":[]},{"raw_affiliation_string":"International Cancer Genomics and Precision Medicine Institute (ICGPMI)","institution_ids":[]},{"raw_affiliation_string":"Center for Advanced Cancer Research and Immunotherapy (CACRI)","institution_ids":[]},{"raw_affiliation_string":"nternational Institute for Cancer Prevention and Research (IICPR)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5094344230"],"corresponding_institution_ids":["https://openalex.org/I149704539","https://openalex.org/I4210105654"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.875},{"id":"https://openalex.org/keywords/b-cell-maturation-antigen","display_name":"BCMA","score":0.9269999861717224},{"id":"https://openalex.org/keywords/crispr-gene-editing","display_name":"CRISPR gene editing","score":0.8320000171661377},{"id":"https://openalex.org/keywords/b-cell-leukemia","display_name":"B-cell leukemia","score":0.6299999952316284},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/allogeneic-car-t-cells","display_name":"allogeneic CAR T cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antigen-escape","display_name":"antigen escape","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/car-t-manufacturing","display_name":"CAR-T manufacturing","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cellular-immunotherapy","display_name":"cellular immunotherapy","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7106000185012817},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.64410001039505},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5458999872207642},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5044999718666077},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4489000141620636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4327999949455261},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43130001425743103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4154999852180481},{"id":"https://openalex.org/C145290725","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome engineering","level":5,"score":0.390500009059906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38429999351501465},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33340001106262207},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.29670000076293945},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2888999879360199},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.2833000123500824},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C110894328","wikidata":"https://www.wikidata.org/wiki/Q4086911","display_name":"Biomedical technology","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2565999925136566}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22363319","doi":"https://doi.org/10.5281/zenodo.22363319","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22363319","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReview"},{"id":"doi:10.5281/zenodo.22363320","doi":"https://doi.org/10.5281/zenodo.22363320","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22363320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReview"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22363319","doi":"https://doi.org/10.5281/zenodo.22363319","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22363319","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReview"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204922620","https://openalex.org/W3195333672","https://openalex.org/W7131777503","https://openalex.org/W3048892129","https://openalex.org/W7124467532","https://openalex.org/W4396866005","https://openalex.org/W7221160892","https://openalex.org/W7160385004","https://openalex.org/W4405332095","https://openalex.org/W4414035837"],"abstract_inverted_index":{"This":[0],"research":[1],"paper":[2,51],"explores":[3],"the":[4,19,41,54,63,91,138],"rapidly":[5],"evolving":[6],"role":[7],"of":[8,21,43,57,70,95,140],"genetic":[9,115],"engineering":[10,60,135],"and":[11,31,36,47,67,89,93,119,132,143],"Chimeric":[12],"Antigen":[13],"Receptor":[14],"T-cell":[15],"(CAR-T)":[16],"therapy":[17],"in":[18,40],"treatment":[20,82],"hematological":[22,147],"malignancies.":[23],"It":[24,73],"examines":[25],"major":[26],"therapeutic":[27,68],"targets,":[28],"particularly":[29],"CD19":[30],"B-cell":[32,44],"maturation":[33],"antigen":[34,110],"(BCMA),":[35],"their":[37],"clinical":[38],"significance":[39],"management":[42],"leukemias,":[45],"lymphomas,":[46],"multiple":[48],"myeloma.":[49],"The":[50,99],"further":[52],"highlights":[53],"emerging":[55],"potential":[56],"CRISPR-enabled":[58],"cellular":[59,141],"to":[61],"improve":[62],"design,":[64],"precision,":[65],"functionality,":[66],"performance":[69],"CAR-T":[71,87],"cells.":[72,98],"discusses":[74],"innovative":[75],"approaches":[76],"for":[77,146],"enhancing":[78],"anti-tumor":[79],"activity,":[80],"overcoming":[81],"resistance,":[83],"developing":[84],"next-generation":[85],"allogeneic":[86],"therapies,":[88],"improving":[90],"safety":[92],"persistence":[94],"engineered":[96],"immune":[97],"study":[100],"also":[101],"addresses":[102],"important":[103],"challenges,":[104],"including":[105],"cytokine":[106],"release":[107],"syndrome,":[108],"neurotoxicity,":[109],"escape,":[111],"tumor":[112],"heterogeneity,":[113],"off-target":[114],"effects,":[116],"manufacturing":[117],"complexity,":[118],"accessibility.":[120],"Overall,":[121],"this":[122],"work":[123],"provides":[124],"an":[125],"integrated":[126],"perspective":[127],"on":[128],"how":[129],"CD19/BCMA":[130],"targeting":[131],"CRISPR-based":[133],"genome":[134],"are":[136],"shaping":[137],"future":[139],"immunotherapy":[142],"precision":[144],"medicine":[145],"cancers.":[148]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-06T00:00:00"}
