{"id":"https://openalex.org/W7208820867","doi":"https://doi.org/10.1016/j.aohep.2026.102433","title":"CD38 in hepatic pathobiology: mechanisms, disease association and therapeutic implications","display_name":"CD38 in hepatic pathobiology: mechanisms, disease association and therapeutic implications","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208820867","doi":"https://doi.org/10.1016/j.aohep.2026.102433","pmid":"https://pubmed.ncbi.nlm.nih.gov/42700796"},"language":"en","primary_location":{"id":"doi:10.1016/j.aohep.2026.102433","doi":"https://doi.org/10.1016/j.aohep.2026.102433","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aohep.2026.102433","pdf_url":"https://www.sciencedirect.com/science/article/pii/S166526812600253X/pdf","source":{"id":"https://openalex.org/S32516778","display_name":"Annals of Hepatology","issn_l":"1665-2681","issn":["1665-2681","2659-5982"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S166526812600253X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066978332","display_name":"Jason W.\u2010L. Eng","orcid":"https://orcid.org/0000-0002-8219-2290","observed_orcids":["https://orcid.org/0000-0002-8219-2290"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason W. Eng","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. Electronic address: Jason.Eng@osumc.edu"],"raw_orcid":"https://orcid.org/0000-0002-8219-2290","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. Electronic address: Jason.Eng@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040465204","display_name":"Blake R. Peterson","orcid":"https://orcid.org/0000-0001-8251-3579","observed_orcids":["https://orcid.org/0000-0001-8251-3579"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake R. Peterson","raw_affiliation_strings":["Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA"],"raw_orcid":"https://orcid.org/0000-0001-8251-3579","affiliations":[{"raw_affiliation_string":"Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134553000","display_name":"Sylvester Black","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvester Black","raw_affiliation_strings":["Division of Transplant Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066978332"],"corresponding_institution_ids":["https://openalex.org/I2802841970"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47773973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"1","first_page":"102433","last_page":"102433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.12700000405311584,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":1.0},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.49000000953674316},{"id":"https://openalex.org/keywords/nad-metabolism","display_name":"NAD+ metabolism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7319999933242798},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6299999952316284},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/end-stage-liver-failure","display_name":"end-stage liver failure","score":0.902999997138977},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ischemic-injury","display_name":"ischemic injury","score":0.7689999938011169},{"id":"https://openalex.org/keywords/acute-cellular-rejection","display_name":"acute cellular rejection","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9900000095367432},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.9106000065803528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.753000020980835},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6919999718666077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.47760000824928284},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4433000087738037},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.43369999527931213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4235000014305115},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.4074999988079071},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3968999981880188},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3718999922275543},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.32429999113082886},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3240000009536743},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2849000096321106},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2578999996185303},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.2547000050544739}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.aohep.2026.102433","doi":"https://doi.org/10.1016/j.aohep.2026.102433","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aohep.2026.102433","pdf_url":"https://www.sciencedirect.com/science/article/pii/S166526812600253X/pdf","source":{"id":"https://openalex.org/S32516778","display_name":"Annals of Hepatology","issn_l":"1665-2681","issn":["1665-2681","2659-5982"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hepatology","raw_type":"journal-article"},{"id":"pmid:42700796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42700796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6d9fdb5aa05546298c68d48082773cf9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6d9fdb5aa05546298c68d48082773cf9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annals of Hepatology, Vol 32, Iss 1, Pp 102433- (2027)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.aohep.2026.102433","doi":"https://doi.org/10.1016/j.aohep.2026.102433","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aohep.2026.102433","pdf_url":"https://www.sciencedirect.com/science/article/pii/S166526812600253X/pdf","source":{"id":"https://openalex.org/S32516778","display_name":"Annals of Hepatology","issn_l":"1665-2681","issn":["1665-2681","2659-5982"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208820867.pdf","grobid_xml":"https://content.openalex.org/works/W7208820867.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W1847534405","https://openalex.org/W1902692042","https://openalex.org/W1959183711","https://openalex.org/W1983001605","https://openalex.org/W1985223527","https://openalex.org/W1987171087","https://openalex.org/W1991791243","https://openalex.org/W1992913613","https://openalex.org/W1993513350","https://openalex.org/W1996764611","https://openalex.org/W2010932585","https://openalex.org/W2013209378","https://openalex.org/W2014552382","https://openalex.org/W2028092699","https://openalex.org/W2029205502","https://openalex.org/W2046205800","https://openalex.org/W2046451707","https://openalex.org/W2052284473","https://openalex.org/W2052661726","https://openalex.org/W2057770806","https://openalex.org/W2063588399","https://openalex.org/W2111204875","https://openalex.org/W2112850316","https://openalex.org/W2118270110","https://openalex.org/W2153207398","https://openalex.org/W2158509187","https://openalex.org/W2160411012","https://openalex.org/W2160838704","https://openalex.org/W2168333087","https://openalex.org/W2178843624","https://openalex.org/W2333241266","https://openalex.org/W2427895239","https://openalex.org/W2492830844","https://openalex.org/W2547963687","https://openalex.org/W2605212331","https://openalex.org/W2738253488","https://openalex.org/W2749542756","https://openalex.org/W2760844181","https://openalex.org/W2769944289","https://openalex.org/W2798162147","https://openalex.org/W2800027563","https://openalex.org/W2800314655","https://openalex.org/W2884608802","https://openalex.org/W2901672881","https://openalex.org/W2911503452","https://openalex.org/W2914566915","https://openalex.org/W2924802726","https://openalex.org/W2940573123","https://openalex.org/W2984726907","https://openalex.org/W3006192922","https://openalex.org/W3011037324","https://openalex.org/W3011373710","https://openalex.org/W3041013637","https://openalex.org/W3044819494","https://openalex.org/W3080269113","https://openalex.org/W3084174900","https://openalex.org/W3090691936","https://openalex.org/W3102558410","https://openalex.org/W3108023649","https://openalex.org/W3112023046","https://openalex.org/W3115974950","https://openalex.org/W3130316624","https://openalex.org/W3168999471","https://openalex.org/W3184651442","https://openalex.org/W3185476603","https://openalex.org/W3199230924","https://openalex.org/W3208238109","https://openalex.org/W3214875229","https://openalex.org/W4200469052","https://openalex.org/W4210851083","https://openalex.org/W4220708949","https://openalex.org/W4224228879","https://openalex.org/W4292411599","https://openalex.org/W4296241157","https://openalex.org/W4310291390","https://openalex.org/W4313418340","https://openalex.org/W4317214128","https://openalex.org/W4323350903","https://openalex.org/W4367181411","https://openalex.org/W4377095051","https://openalex.org/W4380264539","https://openalex.org/W4381429253","https://openalex.org/W4382894970","https://openalex.org/W4385295635","https://openalex.org/W4386811088","https://openalex.org/W4388106682","https://openalex.org/W4388945789","https://openalex.org/W4389243010","https://openalex.org/W4389744379","https://openalex.org/W4391091208","https://openalex.org/W4391994115","https://openalex.org/W4392520395","https://openalex.org/W4394721014","https://openalex.org/W4395029924","https://openalex.org/W4396559736","https://openalex.org/W4399012950","https://openalex.org/W4399352323","https://openalex.org/W4399830708","https://openalex.org/W4401568975","https://openalex.org/W4402653629","https://openalex.org/W4405038846","https://openalex.org/W4405141639","https://openalex.org/W4406798193","https://openalex.org/W4406882620","https://openalex.org/W4406903796","https://openalex.org/W4407419609","https://openalex.org/W4407753667","https://openalex.org/W4408722363","https://openalex.org/W4409952312","https://openalex.org/W4410198197","https://openalex.org/W4410230067","https://openalex.org/W4410568314","https://openalex.org/W4411619205","https://openalex.org/W4417016506"],"related_works":["https://openalex.org/W4410198197","https://openalex.org/W4406135325","https://openalex.org/W2038807667","https://openalex.org/W4318831169","https://openalex.org/W7042317968","https://openalex.org/W2398847960","https://openalex.org/W4403105913","https://openalex.org/W1970209641","https://openalex.org/W2054439577","https://openalex.org/W2162797083"],"abstract_inverted_index":{"CD38":[0,31,42,50,66,87,146,158,179],"is":[1,43],"a":[2,27,150],"highly":[3],"conserved":[4],"multifunctional":[5],"enzyme":[6],"that":[7,65],"regulates":[8],"intracellular":[9,77,144],"calcium":[10],"signaling":[11,111],"and":[12,20,35,58,79,92,102,115,135,166,183],"NAD\u207a":[13,78,161],"metabolism.":[14],"Although":[15],"extensively":[16],"studied":[17],"in":[18,32,88,96,125,170,180],"cancer":[19],"autoimmune":[21],"diseases,":[22,101],"growing":[23],"evidence":[24],"points":[25],"to":[26,53,112],"critical":[28],"role":[29,85,124],"for":[30,178],"both":[33],"normal":[34],"diseased":[36],"liver":[37,97,100,117,126,181],"physiology.":[38],"In":[39],"hepatic":[40,90,113],"tissue,":[41],"expressed":[44],"on":[45,142],"multiple":[46,143],"cell":[47],"types.":[48],"Aberrant":[49],"activity":[51],"contributes":[52],"increased":[54],"oxidative":[55],"stress,":[56],"inflammation,":[57],"diminished":[59],"tissue":[60,164],"repair.":[61],"Recent":[62],"studies":[63],"suggest":[64],"may":[67],"also":[68,105],"promote":[69],"cellular":[70,137],"senescence":[71],"partly":[72],"through":[73],"its":[74,94,122,140],"regulation":[75],"of":[76,86,109,186],"calcium.":[80],"This":[81],"review":[82],"examines":[83],"the":[84,107,171,184],"maintaining":[89],"homeostasis":[91],"explores":[93],"involvement":[95],"injury,":[98],"chronic":[99],"carcinogenesis.":[103],"We":[104],"highlight":[106],"contribution":[108],"CD38-mediated":[110],"fibrogenesis":[114],"end-stage":[116],"failure":[118],"as":[119,121,149],"well":[120],"potential":[123],"transplantation,":[127],"particularly":[128],"post-transplant":[129],"related":[130],"conditions":[131],"including":[132],"ischemic":[133],"injury":[134],"acute":[136],"rejection.":[138],"Given":[139],"impact":[141],"processes,":[145],"has":[147],"emerged":[148],"promising":[151],"therapeutic":[152,188],"target.":[153],"New":[154],"findings":[155],"describe":[156],"how":[157],"inhibition":[159],"preserves":[160],"levels,":[162],"supports":[163],"recovery,":[165],"mitigates":[167],"disease":[168],"progression":[169],"liver.":[172],"Finally,":[173],"we":[174],"outline":[175],"new":[176],"frontiers":[177],"biology":[182],"advancement":[185],"CD38-targeted":[187],"strategies.":[189]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-09-06T00:00:00"}