{"id":"https://openalex.org/W7208820274","doi":"https://doi.org/10.64898/2026.09.01.748519","title":"CryoFlex characterizes structural motion between conformations directly from cryo-EM density maps","display_name":"CryoFlex characterizes structural motion between conformations directly from cryo-EM density maps","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208820274","doi":"https://doi.org/10.64898/2026.09.01.748519"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.748519","doi":"https://doi.org/10.64898/2026.09.01.748519","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.01.748519","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074073299","display_name":"Hao Dong","orcid":"https://orcid.org/0000-0001-7280-7506","observed_orcids":["https://orcid.org/0000-0001-7280-7506"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Dong","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018645329","display_name":"Fuwei Li","orcid":"https://orcid.org/0009-0000-1330-9515","observed_orcids":["https://orcid.org/0009-0000-1330-9515"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuwei Li","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018957167","display_name":"\u9648\u5143\u67cf","orcid":"https://orcid.org/0009-0009-1520-5168","observed_orcids":["https://orcid.org/0009-0009-1520-5168"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanbo Chen","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073448968","display_name":"Shuai Tang","orcid":"https://orcid.org/0000-0002-8467-0022","observed_orcids":["https://orcid.org/0000-0002-8467-0022","https://orcid.org/0009-0006-3673-9511"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Tang","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045438179","display_name":"Chenxuan Ji","orcid":"https://orcid.org/0009-0007-9320-7789","observed_orcids":["https://orcid.org/0009-0007-9320-7789","https://orcid.org/0000-0002-5471-1460"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenxuan Ji","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115591573","display_name":"Xinsheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinsheng Wang","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050874957","display_name":"Zhou L\u00fc","orcid":"https://orcid.org/0000-0002-6447-4905","observed_orcids":["https://orcid.org/0000-0002-6447-4905"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Lu","raw_affiliation_strings":["School of Artificial Intelligence, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128744984","display_name":"Bin Hu","orcid":"https://orcid.org/0000-0003-3514-5413","observed_orcids":["https://orcid.org/0000-0003-3514-5413"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Hu","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100731978","display_name":"Fa Zhang","orcid":"https://orcid.org/0000-0002-2081-9369","observed_orcids":["https://orcid.org/0000-0002-2081-9369","https://orcid.org/0000-0003-1939-6677"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fa Zhang","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058683397","display_name":"Xiaohua Wan","orcid":"https://orcid.org/0000-0002-9340-878X","observed_orcids":["https://orcid.org/0000-0002-9340-878X"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohua Wan","raw_affiliation_strings":["Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Brain Health Intelligent Evaluation and Intervention, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]},{"raw_affiliation_string":"School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China","institution_ids":["https://openalex.org/I125839683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058683397"],"corresponding_institution_ids":["https://openalex.org/I125839683"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conformational-states","display_name":"conformational states","score":0.7620000243186951},{"id":"https://openalex.org/keywords/map-registration","display_name":"map registration","score":0.503000020980835},{"id":"https://openalex.org/keywords/protein-flexibility","display_name":"protein flexibility","score":0.5210000276565552},{"id":"https://openalex.org/keywords/cryo-em-maps","display_name":"cryo-EM density maps","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C104114177","wikidata":"https://www.wikidata.org/wiki/Q79782","display_name":"Motion (physics)","level":2,"score":0.6141999959945679},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.5307999849319458},{"id":"https://openalex.org/C146159030","wikidata":"https://www.wikidata.org/wiki/Q7625099","display_name":"Structure from motion","level":3,"score":0.48820000886917114},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.44589999318122864},{"id":"https://openalex.org/C527412718","wikidata":"https://www.wikidata.org/wiki/Q855395","display_name":"Interpretation (philosophy)","level":2,"score":0.43810001015663147},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42149999737739563},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.4108999967575073},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.39489999413490295},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38350000977516174},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.34880000352859497},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32760000228881836},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C10161872","wikidata":"https://www.wikidata.org/wiki/Q557891","display_name":"Motion estimation","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C2777036941","wikidata":"https://www.wikidata.org/wiki/Q6917771","display_name":"Motion analysis","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C126691448","wikidata":"https://www.wikidata.org/wiki/Q2028919","display_name":"Magnitude (astronomy)","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.26260000467300415},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C197055811","wikidata":"https://www.wikidata.org/wiki/Q207522","display_name":"Probability density function","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C123149101","wikidata":"https://www.wikidata.org/wiki/Q1229184","display_name":"Displacement mapping","level":3,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.748519","doi":"https://doi.org/10.64898/2026.09.01.748519","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.748519","doi":"https://doi.org/10.64898/2026.09.01.748519","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2064140868","https://openalex.org/W2067191022","https://openalex.org/W2086812659","https://openalex.org/W2097604487","https://openalex.org/W2100455255","https://openalex.org/W2119851068","https://openalex.org/W2134236847","https://openalex.org/W2141970217","https://openalex.org/W2160643963","https://openalex.org/W2168722300","https://openalex.org/W2253702229","https://openalex.org/W2259134357","https://openalex.org/W2736403501","https://openalex.org/W2884564748","https://openalex.org/W2951611668","https://openalex.org/W2957093526","https://openalex.org/W2979400304","https://openalex.org/W2999597532","https://openalex.org/W3007643904","https://openalex.org/W3083406432","https://openalex.org/W3127326657","https://openalex.org/W3131760520","https://openalex.org/W3149440285","https://openalex.org/W3163847416","https://openalex.org/W4210478976","https://openalex.org/W4220828523","https://openalex.org/W4280519745","https://openalex.org/W4376126459","https://openalex.org/W4392013022","https://openalex.org/W4402753726"],"related_works":["https://openalex.org/W4286471126","https://openalex.org/W4376126459","https://openalex.org/W4385072743","https://openalex.org/W2655649718","https://openalex.org/W4392013022","https://openalex.org/W7097008897","https://openalex.org/W4401461881","https://openalex.org/W4412798618","https://openalex.org/W3209036365","https://openalex.org/W4386875405"],"abstract_inverted_index":{"Summary":[0],"Heterogeneous":[1],"cryo-EM":[2],"reconstruction":[3,141],"methods":[4],"can":[5,31],"resolve":[6],"multiple":[7],"conformational":[8],"states,":[9],"but":[10,34],"understanding":[11],"their":[12,25],"functional":[13,85],"implications":[14],"often":[15,38],"requires":[16],"determining":[17],"which":[18],"regions":[19,36],"move":[20],"between":[21,53,149],"states":[22],"and":[23,50,67,87,94,134],"quantifying":[24],"displacement":[26],"magnitudes.":[27],"Comparing":[28],"atomic":[29],"models":[30],"quantify":[32],"motion,":[33],"flexible":[35],"are":[37],"incompletely":[39],"modeled.":[40],"Direct":[41],"map":[42,48,100],"comparison":[43],"is":[44],"limited":[45],"by":[46],"variable":[47],"quality":[49],"ambiguous":[51],"correspondence":[52],"displaced":[54],"density":[55,75],"features.":[56],"Here,":[57],"we":[58],"present":[59],"CryoFlex,":[60],"a":[61],"method":[62],"that":[63],"estimates":[64],"the":[65],"direction":[66],"magnitude":[68],"of":[69,77,121,146],"structural":[70,96,147],"motion":[71,82,97,148],"directly":[72],"from":[73],"reconstructed":[74,150],"maps":[76],"selected":[78],"states.":[79,151],"The":[80],"resulting":[81],"analysis":[83],"supports":[84],"interpretation":[86],"guides":[88],"downstream":[89],"structure":[90],"processing.":[91],"CryoFlex":[92,116,138],"localized":[93],"quantified":[95],"across":[98],"diverse":[99],"pairs,":[101],"including":[102],"those":[103],"with":[104,143],"incomplete":[105],"atomic-model":[106],"coverage":[107],"or":[108],"weak":[109],"local":[110],"density.":[111],"Against":[112],"C":[113],"\u03b1":[114],"displacements,":[115],"achieved":[117],"an":[118],"endpoint":[119],"error":[120],"about":[122],"1":[123],"\u00c5.":[124],"In":[125],"separate":[126],"benchmarks,":[127],"it":[128],"outperformed":[129],"registration":[130],"baselines":[131],"on":[132],"clean":[133],"noisy":[135],"inputs.":[136],"Thus,":[137],"complements":[139],"heterogeneous":[140],"workflows":[142],"direct":[144],"quantification":[145]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-06T00:00:00"}