{"id":"https://openalex.org/W7208819745","doi":"https://doi.org/10.21203/rs.3.rs-10829503/v1","title":"Mas Receptor Agonism Attenuates Seizures in a Pentylenetetrazole Kindling Model of Experimental Epilepsy in Mice","display_name":"Mas Receptor Agonism Attenuates Seizures in a Pentylenetetrazole Kindling Model of Experimental Epilepsy in Mice","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208819745","doi":"https://doi.org/10.21203/rs.3.rs-10829503/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10829503/v1","doi":"https://doi.org/10.21203/rs.3.rs-10829503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10829503/v1","pdf_url":"https://www.researchsquare.com/article/rs-10829503/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7208819745"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10829503/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108965880","display_name":"B\u00fc\u015fra Okuyucu","orcid":"https://orcid.org/0000-0002-0183-3798","observed_orcids":["https://orcid.org/0000-0002-0183-3798"]},"institutions":[{"id":"https://openalex.org/I227306068","display_name":"Ondokuz May\u0131s University","ror":"https://ror.org/028k5qw24","country_code":"TR","type":"education","lineage":["https://openalex.org/I227306068"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B\u00fc\u015fra Okuyucu","raw_affiliation_strings":["University of Ondokuz May\u0131s"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ondokuz May\u0131s","institution_ids":["https://openalex.org/I227306068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067074772","display_name":"Elif T\u00dcRKD\u00d6NMEZ","orcid":"https://orcid.org/0000-0001-9609-3624","observed_orcids":["https://orcid.org/0000-0001-9609-3624"]},"institutions":[{"id":"https://openalex.org/I64957398","display_name":"Ordu University","ror":"https://ror.org/04r0hn449","country_code":"TR","type":"education","lineage":["https://openalex.org/I64957398"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif T\u00fcrkd\u00f6nmez Ak","raw_affiliation_strings":["University of Ordu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ordu","institution_ids":["https://openalex.org/I64957398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080405609","display_name":"Emre Soner Tiryaki","orcid":"https://orcid.org/0000-0002-4253-2705","observed_orcids":["https://orcid.org/0000-0002-4253-2705"]},"institutions":[{"id":"https://openalex.org/I227306068","display_name":"Ondokuz May\u0131s University","ror":"https://ror.org/028k5qw24","country_code":"TR","type":"education","lineage":["https://openalex.org/I227306068"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emre Soner Tiryaki","raw_affiliation_strings":["University of Ondokuz May\u0131s"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ondokuz May\u0131s","institution_ids":["https://openalex.org/I227306068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000253049","display_name":"Mustafa Ayy\u0131ld\u0131z","orcid":"https://orcid.org/0000-0002-6594-3080","observed_orcids":["https://orcid.org/0000-0002-6594-3080"]},"institutions":[{"id":"https://openalex.org/I227306068","display_name":"Ondokuz May\u0131s University","ror":"https://ror.org/028k5qw24","country_code":"TR","type":"education","lineage":["https://openalex.org/I227306068"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Ayy\u0131ld\u0131z","raw_affiliation_strings":["University of Ondokuz May\u0131s"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ondokuz May\u0131s","institution_ids":["https://openalex.org/I227306068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094138425","display_name":"Erdal A\u011far","orcid":"https://orcid.org/0000-0001-8450-5791","observed_orcids":["https://orcid.org/0000-0001-8450-5791"]},"institutions":[{"id":"https://openalex.org/I227306068","display_name":"Ondokuz May\u0131s University","ror":"https://ror.org/028k5qw24","country_code":"TR","type":"education","lineage":["https://openalex.org/I227306068"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erdal A\u011far","raw_affiliation_strings":["University of Ondokuz May\u0131s"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ondokuz May\u0131s","institution_ids":["https://openalex.org/I227306068"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011714698","display_name":"G\u00f6khan Arslan","orcid":"https://orcid.org/0000-0003-4186-2478","observed_orcids":["https://orcid.org/0000-0003-4186-2478"]},"institutions":[{"id":"https://openalex.org/I227306068","display_name":"Ondokuz May\u0131s University","ror":"https://ror.org/028k5qw24","country_code":"TR","type":"education","lineage":["https://openalex.org/I227306068"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"G\u00f6khan Arslan","raw_affiliation_strings":["University of Ondokuz May\u0131s"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ondokuz May\u0131s","institution_ids":["https://openalex.org/I227306068"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011714698"],"corresponding_institution_ids":["https://openalex.org/I227306068"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mas-receptor","display_name":"Mas receptor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pentylenetetrazole-kindling","display_name":"pentylenetetrazole kindling","score":0.925000011920929},{"id":"https://openalex.org/keywords/experimental-epilepsy","display_name":"experimental epilepsy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.875},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nr2b","display_name":"NR2B","score":0.9390000104904175},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.8169999718666077},{"id":"https://openalex.org/keywords/myoclonic-seizures","display_name":"myoclonic seizures","score":0.5789999961853027},{"id":"https://openalex.org/keywords/anticonvulsant-therapy","display_name":"anticonvulsant therapy","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.6984000205993652},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6869000196456909},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C2778302826","wikidata":"https://www.wikidata.org/wiki/Q1741970","display_name":"Kindling model","level":4,"score":0.642300009727478},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5726000070571899},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.5342000126838684},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4916999936103821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4449000060558319},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.4381999969482422},{"id":"https://openalex.org/C2779994606","wikidata":"https://www.wikidata.org/wiki/Q1424895","display_name":"Clonus","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4165000021457672},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.4142000079154968},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4009999930858612},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.39820000529289246},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.37959998846054077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37770000100135803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3610000014305115},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.3513000011444092},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.3476000130176544},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C2777010014","wikidata":"https://www.wikidata.org/wiki/Q852376","display_name":"Convulsion","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.2612999975681305}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10829503/v1","doi":"https://doi.org/10.21203/rs.3.rs-10829503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10829503/v1","pdf_url":"https://www.researchsquare.com/article/rs-10829503/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10829503/v1","doi":"https://doi.org/10.21203/rs.3.rs-10829503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10829503/v1","pdf_url":"https://www.researchsquare.com/article/rs-10829503/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208819745.pdf","grobid_xml":"https://content.openalex.org/works/W7208819745.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1512110535","https://openalex.org/W1875008998","https://openalex.org/W1983294571","https://openalex.org/W2006580899","https://openalex.org/W2007244994","https://openalex.org/W2020962059","https://openalex.org/W2063665693","https://openalex.org/W2069527370","https://openalex.org/W2081070804","https://openalex.org/W2085912953","https://openalex.org/W2090468125","https://openalex.org/W2100798750","https://openalex.org/W2114712219","https://openalex.org/W2122639201","https://openalex.org/W2125008708","https://openalex.org/W2131747794","https://openalex.org/W2132224038","https://openalex.org/W2162445261","https://openalex.org/W2228495115","https://openalex.org/W2309165118","https://openalex.org/W2401152555","https://openalex.org/W2512987830","https://openalex.org/W2792200090","https://openalex.org/W2794280748","https://openalex.org/W2799718839","https://openalex.org/W2892604754","https://openalex.org/W2940794125","https://openalex.org/W2996019109","https://openalex.org/W2998717532","https://openalex.org/W3022558790","https://openalex.org/W3035511928","https://openalex.org/W3068798970","https://openalex.org/W3105081831","https://openalex.org/W3122968061","https://openalex.org/W3130306976","https://openalex.org/W3157641855","https://openalex.org/W3205909460","https://openalex.org/W3206120919","https://openalex.org/W3207501658","https://openalex.org/W4200074103","https://openalex.org/W4211147755","https://openalex.org/W4285090375","https://openalex.org/W4306294898","https://openalex.org/W4319656123","https://openalex.org/W4320516612","https://openalex.org/W4389726466","https://openalex.org/W4389937751","https://openalex.org/W4396618272","https://openalex.org/W4401636148","https://openalex.org/W4403872289","https://openalex.org/W4403979695","https://openalex.org/W4404454162","https://openalex.org/W4405095779","https://openalex.org/W4406054855","https://openalex.org/W4409300606","https://openalex.org/W4409904976","https://openalex.org/W4414222350","https://openalex.org/W4414292539"],"related_works":["https://openalex.org/W2531040213","https://openalex.org/W3196024351","https://openalex.org/W1986875378","https://openalex.org/W1540498747","https://openalex.org/W1972506687","https://openalex.org/W1970397197","https://openalex.org/W3013140475","https://openalex.org/W2369116133","https://openalex.org/W2807928577","https://openalex.org/W4401983542"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"investigate":[2],"the":[3,6,61,139,213,219],"effects":[4],"of":[5,158,169,223],"Mas":[7],"receptor":[8],"(MasR)":[9],"agonist":[10],"AVE":[11,76,89,170,178,206],"0991":[12,77,90,171,179,207],"on":[13,34],"seizure":[14,116,175,184,191],"parameters,":[15,176],"anxiety-like":[16,197],"behavior,":[17],"and":[18,37,75,88,118,125,146,150,161,186,189,199,215,217,225],"learning-memory":[19],"functions":[20],"in":[21,27,212,239],"a":[22,97],"pentylenetetrazole":[23],"(PTZ)-induced":[24],"epilepsy":[25],"model":[26,52],"mice,":[28],"as":[29,31,96],"well":[30],"its":[32],"impact":[33],"MasR,":[35,159],"NR2B,":[36,160],"BDNF":[38,162,226],"mRNA":[39,163,210,227],"expression":[40,211],"levels.":[41],"Seventy-one":[42],"male":[43],"Swiss":[44],"albino":[45],"mice":[46],"were":[47,65,86,129,136,153],"used.":[48],"A":[49],"chronic":[50],"kindling":[51,62],"was":[53,93],"induced":[54],"with":[55],"PTZ":[56,72],"(37":[57],"mg/kg,":[58],"i.p.).":[59],"Following":[60],"procedure,":[63],"animals":[64],"assigned":[66],"to":[67,173],"four":[68],"groups:":[69],"na\u00efve":[70],"control,":[71],"control":[73],"(saline),":[74],"at":[78],"3":[79],"mg/kg":[80],"or":[81,91,104],"10":[82],"mg/kg.":[83],"ECoG":[84],"electrodes":[85],"implanted,":[87],"saline":[92],"administered":[94],"either":[95],"single":[98],"dose":[99],"(30":[100],"min":[101],"before":[102],"PTZ)":[103],"daily":[105],"for":[106,155],"14":[107],"days.":[108],"Seizure":[109],"severity,":[110],"first":[111],"myoclonic":[112],"jerk":[113],"latency,":[114],"generalized":[115,123],"latency":[117],"duration,":[119],"spike":[120,127,187],"count":[121],"during":[122],"seizures,":[124],"total":[126],"number":[128],"assessed.":[130],"After":[131],"long-term":[132,177],"administrations,":[133],"behavioral":[134],"evaluations":[135],"conducted":[137],"using":[138],"open":[140],"field":[141],"test,":[142],"elevated":[143],"plus":[144],"maze,":[145],"Y-maze":[147],"test.":[148],"Cortical":[149],"hippocampal":[151],"tissues":[152],"collected":[154],"qPCR":[156],"analysis":[157],"expression.":[164,228],"While":[165],"acute":[166],"single-dose":[167],"administration":[168,182],"failed":[172],"alter":[174],"(10":[180],"mg/kg)":[181],"reduced":[183],"severity":[185],"activity,":[188],"prolonged":[190],"latencies.":[192],"It":[193,229],"also":[194],"attenuated":[195],"PTZ-induced":[196,220],"behavior":[198],"cognitive":[200],"impairment.":[201],"Molecular":[202],"analyses":[203],"showed":[204],"that":[205,232],"increased":[208],"MasR":[209],"cortex":[214],"hippocampus":[216],"suppressed":[218],"pathological":[221],"upregulation":[222],"NR2B":[224],"is":[230],"suggested":[231],"MasR-targeted":[233],"therapies":[234],"may":[235],"hold":[236],"therapeutic":[237],"potential":[238],"epilepsy,":[240],"warranting":[241],"further":[242],"investigation.":[243]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-06T00:00:00"}
