{"id":"https://openalex.org/W7208819646","doi":"https://doi.org/10.64898/2026.09.02.747634","title":"Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4 + T H 17 Cells","display_name":"Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4 + T H 17 Cells","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208819646","doi":"https://doi.org/10.64898/2026.09.02.747634","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922550","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684497"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.02.747634","doi":"https://doi.org/10.64898/2026.09.02.747634","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.747634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.02.747634","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062857034","display_name":"Priyadarshini Chatterjee","orcid":"https://orcid.org/0000-0001-5602-4683","observed_orcids":["https://orcid.org/0000-0001-5602-4683","https://orcid.org/0009-0008-2002-8218"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyadarshini Chatterjee","raw_affiliation_strings":["Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0009-0008-2002-8218","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150131860","display_name":"Keishla S\u00e1nchez Ortiz","orcid":"https://orcid.org/0000-0002-4537-3252","observed_orcids":["https://orcid.org/0000-0002-4537-3252"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keishla S\u00e1nchez Ortiz","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0002-4537-3252","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051137075","display_name":"Stanislav Dikiy","orcid":"https://orcid.org/0000-0002-8287-6561","observed_orcids":["https://orcid.org/0000-0002-8287-6561"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Dikiy","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0002-8287-6561","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009038754","display_name":"Michael J. Bollong","orcid":"https://orcid.org/0000-0001-9439-1476","observed_orcids":["https://orcid.org/0000-0001-9439-1476"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Bollong","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-9439-1476","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091728889","display_name":"Jessica E. Thaxton","orcid":"https://orcid.org/0000-0003-1759-5576","observed_orcids":["https://orcid.org/0000-0003-1759-5576"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica E. Thaxton","raw_affiliation_strings":["Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA"],"raw_orcid":"https://orcid.org/0000-0003-1759-5576","affiliations":[{"raw_affiliation_string":"Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064328407","display_name":"Alejandra Mendoza","orcid":"https://orcid.org/0000-0001-9116-5465","observed_orcids":["https://orcid.org/0000-0001-9116-5465"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Mendoza","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-9116-5465","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083999892","display_name":"R. Luke Wiseman","orcid":"https://orcid.org/0000-0001-9287-6840","observed_orcids":["https://orcid.org/0000-0001-9287-6840"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Luke Wiseman","raw_affiliation_strings":["Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-9287-6840","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.24709999561309814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.6669999957084656},{"id":"https://openalex.org/keywords/oxidative-stress-response","display_name":"oxidative stress response","score":0.828000009059906},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.8199999928474426},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8450000286102295},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cd4-t-cell-subsets","display_name":"CD4+ T cell subsets","score":0.7409999966621399},{"id":"https://openalex.org/keywords/effector-cytokines","display_name":"effector cytokines","score":0.7789999842643738},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.8859999775886536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7961000204086304},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7085000276565552},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6862000226974487},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5187000036239624},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.499099999666214},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4880000054836273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4684999883174896},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.43479999899864197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40959998965263367},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3361999988555908},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C2778997996","wikidata":"https://www.wikidata.org/wiki/Q18036598","display_name":"ATF6","level":4,"score":0.3052000105381012},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.28209999203681946},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.27399998903274536},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.25940001010894775},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.02.747634","doi":"https://doi.org/10.64898/2026.09.02.747634","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.747634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42922550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684497","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684497/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.02.747634","doi":"https://doi.org/10.64898/2026.09.02.747634","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.747634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4780588658","display_name":"Discovering Small Molecule Activators of Stress-responsive Signaling","funder_award_id":"R01AG046495","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7148600706","display_name":"Discovering Small Molecule Activators of Stress-Responsive Signaling","funder_award_id":"RF1AG046495","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000185148","display_name":null,"funder_award_id":"AG046495","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856413","display_name":"Methods and approaches to expand the pharmacological toolset","funder_award_id":"R35GM146865","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F279999757","display_name":"Conrad Prebys Foundation","ror":"https://ror.org/00x8e3847"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W229616345","https://openalex.org/W1582225030","https://openalex.org/W1973603971","https://openalex.org/W1974835124","https://openalex.org/W1994772574","https://openalex.org/W2021340905","https://openalex.org/W2046278771","https://openalex.org/W2048086508","https://openalex.org/W2058487327","https://openalex.org/W2059737466","https://openalex.org/W2064811354","https://openalex.org/W2067040999","https://openalex.org/W2068894470","https://openalex.org/W2074660641","https://openalex.org/W2084765237","https://openalex.org/W2092599092","https://openalex.org/W2102049218","https://openalex.org/W2104527627","https://openalex.org/W2116289946","https://openalex.org/W2117800935","https://openalex.org/W2121699385","https://openalex.org/W2131933701","https://openalex.org/W2141982524","https://openalex.org/W2152014155","https://openalex.org/W2476887811","https://openalex.org/W2492190774","https://openalex.org/W2495220859","https://openalex.org/W2500692493","https://openalex.org/W2534725153","https://openalex.org/W2563891010","https://openalex.org/W2576351276","https://openalex.org/W2887731941","https://openalex.org/W2903993983","https://openalex.org/W2908615024","https://openalex.org/W2921191661","https://openalex.org/W2947250947","https://openalex.org/W3000418621","https://openalex.org/W3048887029","https://openalex.org/W3157566098","https://openalex.org/W3201225423","https://openalex.org/W3213596431","https://openalex.org/W4224935505","https://openalex.org/W4309714585","https://openalex.org/W4310211651","https://openalex.org/W4313528847","https://openalex.org/W4315475070","https://openalex.org/W4367626396","https://openalex.org/W4377138692","https://openalex.org/W4378219846","https://openalex.org/W4382281109","https://openalex.org/W4383956733","https://openalex.org/W4385410374","https://openalex.org/W4394623035","https://openalex.org/W4398205548","https://openalex.org/W4400742564","https://openalex.org/W4403355378","https://openalex.org/W4404058074","https://openalex.org/W4404870543","https://openalex.org/W4406189376","https://openalex.org/W4407348784","https://openalex.org/W4408156770","https://openalex.org/W4413964752","https://openalex.org/W4414652772","https://openalex.org/W4416339463","https://openalex.org/W4416422274","https://openalex.org/W7135088977","https://openalex.org/W7161557638"],"related_works":["https://openalex.org/W2947844033","https://openalex.org/W4313353106","https://openalex.org/W1994252478","https://openalex.org/W67580575","https://openalex.org/W2285776298","https://openalex.org/W2092599092","https://openalex.org/W2770082188","https://openalex.org/W1990895784","https://openalex.org/W2118773711","https://openalex.org/W2080205611"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1],"differentiation":[2,48,97,153,190],"of":[3,52,98,123,134,154,163,174,193,218,226,244],"na\u00efve":[4],"CD4":[5,176],"+":[6,177],"T":[7,11,16,19,22,26,38,78,101,156,178,187,232,247,266,279],"cells":[8,28,159],"into":[9],"effector":[10,228,231,274,278],"cell":[12,39,79,102,129,179,248,269,280],"subsets":[13],"such":[14,56,260],"as":[15,57,109,261],"H":[17,20,23,157,188,267],"1,":[18],"2,":[21],"17":[24,158,189,268],"and":[25,44,63,200],"REG":[27],"is":[29,191],"governed":[30],"by":[31,160],"tightly":[32],"coordinated":[33],"activation":[34,195,199],"programmes":[35],"dependent":[36],"on":[37],"receptor":[40],"(TCR)":[41],"engagement,":[42],"co-stimulation,":[43],"cytokine":[45,275],"signalling.":[46],"This":[47,82],"process":[49],"involves":[50,197],"regulation":[51],"stress-responsive":[53,87],"signalling":[54,121],"pathways":[55,88],"the":[58,64,72,96,119,124,131,135,164,171,219,242,253],"unfolded":[59],"protein":[60],"response":[61,67],"(UPR)":[62],"oxidative":[65],"stress":[66],"(OSR)":[68],"to":[69,71,76,93,263],"adapt":[70],"physiologic":[73],"demands":[74],"specific":[75],"distinct":[77],"subset":[80],"functions.":[81],"suggests":[83],"that":[84,115,147,183,214],"pharmacologically":[85],"targeting":[86],"offers":[89],"a":[90,110],"unique":[91],"opportunity":[92],"selectively":[94,151,264],"remodel":[95],"these":[99,245],"different":[100],"subsets.":[103,180,249,281],"We":[104,181],"previously":[105],"identified":[106],"compound":[107,240],"AA147":[108,150,215,262],"metabolically":[111,256],"activated":[112,257],"proteostasis":[113,258],"regulator":[114],"can":[116],"induce":[117],"both":[118],"ATF6":[120,194],"arm":[122,133],"UPR":[125],"and,":[126],"in":[127,186,202,237],"certain":[128],"types,":[130],"NRF2-regulated":[132],"OSR.(Paxman":[136],"et":[137,141],"al.,":[138,142],"2018;":[139],"Plate":[140],"2016)":[143],"Here,":[144],"we":[145,211],"show":[146,213],"treatment":[148],"with":[149],"reduces":[152],"pro-inflammatory":[155],"promoting":[161],"degradation":[162],"lineage-specifying":[165],"transcription":[166,172],"factor":[167,221],"ROR\u03b3t,":[168,210],"without":[169],"impacting":[170],"factors":[173],"other":[175],"find":[182],"AA147-dependent":[184],"reduction":[185],"independent":[192],"but":[196],"NRF2":[198],"reductions":[201],"intracellular":[203],"reactive":[204],"oxygen":[205],"species":[206],"(ROS).":[207],"Apart":[208],"from":[209],"further":[212],"decreases":[216],"expression":[217],"TCR-responsive":[220],"IRF4,":[222],"thus":[223],"suppressing":[224],"production":[225],"select":[227],"cytokines":[229],"across":[230,277],"cells,":[233],"revealing":[234],"additional":[235],"ways":[236],"which":[238],"this":[239],"reshapes":[241],"activities":[243],"essential":[246],"Our":[250],"results":[251],"demonstrate":[252],"potential":[254],"for":[255],"regulators":[259],"reshape":[265],"identity":[270],"while":[271],"broadly":[272],"dampening":[273],"responses":[276]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-09-06T00:00:00"}