{"id":"https://openalex.org/W7208814671","doi":"https://doi.org/10.18203/2349-3933.ijam20263254","title":"Real-world evidence study evaluating the effectiveness, tolerability and utilization patterns of Vonoprazan in routine clinical practice across out-patient clinical setting in India","display_name":"Real-world evidence study evaluating the effectiveness, tolerability and utilization patterns of Vonoprazan in routine clinical practice across out-patient clinical setting in India","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7208814671","doi":"https://doi.org/10.18203/2349-3933.ijam20263254"},"language":"en","primary_location":{"id":"doi:10.18203/2349-3933.ijam20263254","doi":"https://doi.org/10.18203/2349-3933.ijam20263254","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2349-3933.ijam20263254","pdf_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4520/2949","source":{"id":"https://openalex.org/S2764699550","display_name":"International Journal of Advances in Medicine","issn_l":"2349-3925","issn":["2349-3925","2349-3933"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advances in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4520/2949","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5150318306","display_name":"Arka Banerjee","orcid":"https://orcid.org/0000-0003-0177-0050","observed_orcids":["https://orcid.org/0000-0003-0177-0050"]},"institutions":[{"id":"https://openalex.org/I4210100047","display_name":"Institute of Post Graduate Medical Education and Research","ror":"https://ror.org/00ysvbp68","country_code":"IN","type":"education","lineage":["https://openalex.org/I226431899","https://openalex.org/I4210100047"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arka Banerjee","raw_affiliation_strings":["Department of Gastroenterology, IPGME and SSKM Hospital, Acharya Jagadish, Kolkata, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0003-0177-0050","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, IPGME and SSKM Hospital, Acharya Jagadish, Kolkata, West Bengal, India","institution_ids":["https://openalex.org/I4210100047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102766833","display_name":"Tanvi Shetty","orcid":"https://orcid.org/0009-0000-8369-4420","observed_orcids":["https://orcid.org/0009-0000-8369-4420"]},"institutions":[{"id":"https://openalex.org/I4210150536","display_name":"Alkem (India)","ror":"https://ror.org/04kwy9224","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210150536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tanvi Shetty","raw_affiliation_strings":["Department of Medical, Alkem Laboratories Limited, Alkem House, Lower Parel, Mumbai, Maharashtra India"],"raw_orcid":"https://orcid.org/0009-0000-8369-4420","affiliations":[{"raw_affiliation_string":"Department of Medical, Alkem Laboratories Limited, Alkem House, Lower Parel, Mumbai, Maharashtra India","institution_ids":["https://openalex.org/I4210150536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109194586","display_name":"Kushal Sarda","orcid":"https://orcid.org/0000-0002-1715-2428","observed_orcids":["https://orcid.org/0000-0002-1715-2428"]},"institutions":[{"id":"https://openalex.org/I4210150536","display_name":"Alkem (India)","ror":"https://ror.org/04kwy9224","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210150536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kushal Sarda","raw_affiliation_strings":["Department of Medical, Alkem Laboratories Limited, Alkem House, Lower Parel, Mumbai, Maharashtra India"],"raw_orcid":"https://orcid.org/0000-0002-1715-2428","affiliations":[{"raw_affiliation_string":"Department of Medical, Alkem Laboratories Limited, Alkem House, Lower Parel, Mumbai, Maharashtra India","institution_ids":["https://openalex.org/I4210150536"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140053961","display_name":"Akhilesh Sharma","orcid":"https://orcid.org/0000-0001-6863-4729","observed_orcids":["https://orcid.org/0000-0001-6863-4729"]},"institutions":[{"id":"https://openalex.org/I4210150536","display_name":"Alkem (India)","ror":"https://ror.org/04kwy9224","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210150536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akhilesh Sharma","raw_affiliation_strings":["Department of Medical, Alkem Laboratories Limited, Alkem House, Lower Parel, Mumbai, Maharashtra India"],"raw_orcid":"https://orcid.org/0000-0001-6863-4729","affiliations":[{"raw_affiliation_string":"Department of Medical, Alkem Laboratories Limited, Alkem House, Lower Parel, Mumbai, Maharashtra India","institution_ids":["https://openalex.org/I4210150536"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vonoprazan","display_name":"vonoprazan","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/acid-related-disorders","display_name":"acid-related diseases","score":0.7990000247955322},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/acid-suppression","display_name":"acid suppression","score":0.6359999775886536},{"id":"https://openalex.org/keywords/heartburn","display_name":"heartburn","score":0.7369999885559082},{"id":"https://openalex.org/keywords/acid-regurgitation","display_name":"acid regurgitation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-satisfaction","display_name":"treatment satisfaction","score":0.7429999709129333},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.8560000061988831},{"id":"https://openalex.org/keywords/indian-patients","display_name":"Indian patients","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.984499990940094},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7824000120162964},{"id":"https://openalex.org/C2776462128","wikidata":"https://www.wikidata.org/wiki/Q537297","display_name":"Heartburn","level":4,"score":0.7548999786376953},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.6805999875068665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.512499988079071},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5055999755859375},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4900999963283539},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4867999851703644},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.4560999870300293},{"id":"https://openalex.org/C2779390736","wikidata":"https://www.wikidata.org/wiki/Q17095243","display_name":"Peptic","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.30820000171661377},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C2780656511","wikidata":"https://www.wikidata.org/wiki/Q172941","display_name":"Peptic ulcer","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2780168065","wikidata":"https://www.wikidata.org/wiki/Q1930043","display_name":"Regurgitation (circulation)","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2349-3933.ijam20263254","doi":"https://doi.org/10.18203/2349-3933.ijam20263254","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2349-3933.ijam20263254","pdf_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4520/2949","source":{"id":"https://openalex.org/S2764699550","display_name":"International Journal of Advances in Medicine","issn_l":"2349-3925","issn":["2349-3925","2349-3933"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advances in Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2349-3933.ijam20263254","doi":"https://doi.org/10.18203/2349-3933.ijam20263254","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2349-3933.ijam20263254","pdf_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4520/2949","source":{"id":"https://openalex.org/S2764699550","display_name":"International Journal of Advances in Medicine","issn_l":"2349-3925","issn":["2349-3925","2349-3933"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advances in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208814671.pdf","grobid_xml":"https://content.openalex.org/works/W7208814671.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1984257229","https://openalex.org/W2080700808","https://openalex.org/W2087446127","https://openalex.org/W2114442699","https://openalex.org/W2115870674","https://openalex.org/W2125790751","https://openalex.org/W2145047720","https://openalex.org/W2298103311","https://openalex.org/W2543818161","https://openalex.org/W2554833894","https://openalex.org/W2564438499","https://openalex.org/W2588681870","https://openalex.org/W2783553238","https://openalex.org/W2790151975","https://openalex.org/W2795983009","https://openalex.org/W2797397035","https://openalex.org/W2801245286","https://openalex.org/W2906739385","https://openalex.org/W2945579399","https://openalex.org/W2945598651","https://openalex.org/W2968018058","https://openalex.org/W3195940931","https://openalex.org/W4214617140","https://openalex.org/W4304014277","https://openalex.org/W4383500880","https://openalex.org/W4385654266","https://openalex.org/W4392805841","https://openalex.org/W4393976542","https://openalex.org/W4399862237","https://openalex.org/W4405108305","https://openalex.org/W4407348524","https://openalex.org/W4411412007"],"related_works":["https://openalex.org/W7164372173","https://openalex.org/W7162124051","https://openalex.org/W7167207670","https://openalex.org/W4388796180","https://openalex.org/W4415695912","https://openalex.org/W2987027580","https://openalex.org/W4389237151","https://openalex.org/W2591623136","https://openalex.org/W2883707795","https://openalex.org/W2744536355"],"abstract_inverted_index":{"Background:":[0],"Gastroesophageal":[1],"reflux":[2],"disease":[3,8],"(GERD)":[4],"and":[5,27,40,43,60,99,106,113,156,209,218],"peptic":[6,115],"ulcer":[7],"(PUD)":[9],"are":[10,22],"two":[11],"of":[12,30,53,135,141,154,190],"the":[13,122,126],"most":[14,127],"common":[15,128],"acid-related":[16,220],"gastrointestinal":[17],"conditions":[18],"in":[19,37,62,81,152,160,204,213,230],"India.":[20],"They":[21],"associated":[23],"with":[24,148,188,216],"significant":[25],"morbidity":[26],"impaired":[28],"quality":[29],"life.":[31],"Vonoprazan":[32,80,131,142,197],"has":[33],"demonstrated":[34,198],"clinical":[35,38,232],"efficacy":[36,61],"trials":[39],"offers":[41],"rapid":[42],"sustained":[44],"acid":[45,114,157,175],"suppression.":[46],"However,":[47],"there":[48],"is":[49],"still":[50],"a":[51,87],"dearth":[52],"empirical":[54],"data":[55],"on":[56],"its":[57,223],"therapeutic":[58,228],"application":[59],"Indian":[63,214],"patients.":[64],"Methods:":[65],"This":[66],"multicentre,":[67],"retrospective,":[68],"observational":[69],"real-world":[70,201],"evidence":[71],"study":[72],"examined":[73],"medical":[74],"records":[75],"from":[76,165,178],"8,325":[77],"patients":[78,136,155,191,215],"prescribed":[79],"outpatient":[82],"settings":[83],"across":[84],"India":[85],"during":[86],"6-month":[88],"period.":[89],"Demographic":[90],"details,":[91],"indications,":[92],"dose":[93],"patterns,":[94],"symptom":[95,205],"improvement,":[96],"treatment":[97,172,184],"satisfaction,":[98],"safety":[100],"outcomes":[101],"were":[102,125],"assessed":[103],"using":[104],"descriptive":[105],"comparative":[107],"statistical":[108],"methods.":[109],"Results:":[110],"GERD":[111,217],"(55.98%)":[112],"disorders":[116],"(APD;":[117],"33.07%)":[118],"as":[119,225],"diagnosed":[120],"by":[121],"treating":[123],"physicians":[124],"indicators":[129],"for":[130],"treatment.":[132],"The":[133],"majority":[134],"(93.14%)":[137],"received":[138],"20":[139],"mg":[140],"once":[143],"daily.":[144],"Symptoms":[145],"improved":[146],"significantly,":[147],"heartburn":[149,163],"relief":[150],"reported":[151],"97.53%":[153],"regurgitation":[158,176],"improvement":[159,203],"91.80%.":[161],"Severe":[162],"dropped":[164],"44.06%":[166],"at":[167],"baseline":[168],"to":[169,180],"1.93%":[170],"after":[171],"(p<0.05),":[173],"while":[174],"decreased":[177],"31.95%":[179],"6.56%":[181],"(p<0.05).":[182],"Overall":[183],"satisfaction":[185,212],"was":[186],"high,":[187],"73.44%":[189],"reporting":[192],"being":[193],"extremely":[194],"satisfied.":[195],"Conclusions:":[196],"clinically":[199],"meaningful":[200],"effectiveness,":[202],"control,":[206],"favourable":[207],"tolerability,":[208],"high":[210],"patient":[211],"other":[219],"disorders,":[221],"supporting":[222],"role":[224],"an":[226],"effective":[227],"option":[229],"routine":[231],"practice.":[233]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-06T00:00:00"}