{"id":"https://openalex.org/W7208812346","doi":"https://doi.org/10.64898/2026.09.01.748595","title":"Widespread cryptic RAG-mediated recombination in developing T lymphocytes","display_name":"Widespread cryptic RAG-mediated recombination in developing T lymphocytes","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208812346","doi":"https://doi.org/10.64898/2026.09.01.748595"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.748595","doi":"https://doi.org/10.64898/2026.09.01.748595","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748595","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.09.01.748595.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.09.01.748595.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073270719","display_name":"Daniel Sobral","orcid":"https://orcid.org/0000-0003-3955-0117","observed_orcids":["https://orcid.org/0000-0003-3955-0117"]},"institutions":[{"id":"https://openalex.org/I4210142220","display_name":"National Institute of Health Dr. Ricardo Jorge","ror":"https://ror.org/03mx8d427","country_code":"PT","type":"other","lineage":["https://openalex.org/I4210117458","https://openalex.org/I4210142220","https://openalex.org/I4210157859"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"D. Sobral","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","National Institute of Health Doutor Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"National Institute of Health Doutor Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210142220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403868","display_name":"Joana Silva","orcid":"https://orcid.org/0000-0003-3977-7418","observed_orcids":["https://orcid.org/0000-0003-3977-7418"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J. Silva","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150373745","display_name":"Diogo Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"D. Santos","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051946710","display_name":"Jos\u00e9 B\u00e1rtholo Pereira Leal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J. Perreira Leal","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","Universidade NOVA de Lisboa, Campus de Campolide, 1099-085 Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Universidade NOVA de Lisboa, Campus de Campolide, 1099-085 Lisbon, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091488339","display_name":"Salvatore Spicuglia","orcid":"https://orcid.org/0000-0002-8101-7108","observed_orcids":["https://orcid.org/0000-0002-8101-7108"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Spicuglia","raw_affiliation_strings":["Aix-Marseille University, Inserm, TAGC, UMR1090, Marseille, France","Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, Inserm, TAGC, UMR1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Marseille, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054364052","display_name":"Jocelyne Demengeot","orcid":"https://orcid.org/0000-0002-4761-614X","observed_orcids":["https://orcid.org/0000-0002-4761-614X"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J. Demengeot","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107828928","display_name":"Marie Bonnet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["GB","PT"],"is_corresponding":true,"raw_author_name":"M. Bonnet-Di Placido","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","The Pirbright Institute, Ash Road, Pirbright GU24 0NF, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"The Pirbright Institute, Ash Road, Pirbright GU24 0NF, United Kingdom","institution_ids":["https://openalex.org/I1287548271"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5107828928"],"corresponding_institution_ids":["https://openalex.org/I1287548271","https://openalex.org/I48057805"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.41499999165534973,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.6690000295639038},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tcr-beta-locus","display_name":"TCR beta locus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pseudogenes","display_name":"pseudogenes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/recombination-fraction","display_name":"recombination frequency","score":0.5479999780654907},{"id":"https://openalex.org/keywords/chromatin-context","display_name":"chromatin context","score":0.5979999899864197},{"id":"https://openalex.org/keywords/z-dna","display_name":"Z-DNA","score":0.6800000071525574},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/antigen-receptor-diversity","display_name":"antigen receptor diversity","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8149999976158142},{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.7872999906539917},{"id":"https://openalex.org/C157402786","wikidata":"https://www.wikidata.org/wiki/Q7302710","display_name":"Recombination signal sequences","level":5,"score":0.6704999804496765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.659500002861023},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5940999984741211},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.5728999972343445},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5557000041007996},{"id":"https://openalex.org/C113646796","wikidata":"https://www.wikidata.org/wiki/Q50263283","display_name":"Recombination-activating gene","level":4,"score":0.5407000184059143},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.47690001130104065},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4625000059604645},{"id":"https://openalex.org/C2780254951","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"V(D)J recombination","level":4,"score":0.44679999351501465},{"id":"https://openalex.org/C125390029","wikidata":"https://www.wikidata.org/wiki/Q1297859","display_name":"Species complex","level":4,"score":0.4413999915122986},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.3919999897480011},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.35589998960494995},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.34209999442100525},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.32339999079704285},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C1547928","wikidata":"https://www.wikidata.org/wiki/Q1660177","display_name":"Immunogenetics","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C195139083","wikidata":"https://www.wikidata.org/wiki/Q3463539","display_name":"Intergenic region","level":4,"score":0.29499998688697815},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.29109999537467957},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2833000123500824},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.2750999927520752},{"id":"https://openalex.org/C82040048","wikidata":"https://www.wikidata.org/wiki/Q7049125","display_name":"Non-allelic homologous recombination","level":5,"score":0.27489998936653137},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C86546924","wikidata":"https://www.wikidata.org/wiki/Q3454460","display_name":"Chromosomal rearrangement","level":5,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.748595","doi":"https://doi.org/10.64898/2026.09.01.748595","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748595","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.09.01.748595.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.748595","doi":"https://doi.org/10.64898/2026.09.01.748595","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748595","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.09.01.748595.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208812346.pdf","grobid_xml":"https://content.openalex.org/works/W7208812346.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4397356","https://openalex.org/W2513771944","https://openalex.org/W1996314558","https://openalex.org/W2116232221","https://openalex.org/W1985161890","https://openalex.org/W2124344664","https://openalex.org/W2005796886","https://openalex.org/W2169704715","https://openalex.org/W2122161903","https://openalex.org/W2117707303"],"abstract_inverted_index":{"ABSTRACT":[0],"V(D)J":[1],"recombination":[2,88,121,150,155],"generates":[3],"antigen":[4,178],"receptor":[5,179],"diversity":[6],"through":[7],"the":[8,12,16,53,75,81,102,106,167,209],"targeted":[9,37],"activity":[10],"of":[11,60,74,120,189],"RAG1/2":[13],"recombinase,":[14],"but":[15],"extent":[17],"to":[18,40,177],"which":[19,154],"RAG":[20],"also":[21],"engages":[22],"cryptic":[23,87,114,163,201],"genomic":[24],"targets":[25],"during":[26],"normal":[27],"lymphocyte":[28],"development":[29],"remains":[30],"poorly":[31],"defined.":[32],"Here,":[33],"we":[34],"developed":[35],"a":[36,117],"PCR-sequencing":[38],"approach":[39],"detect":[41],"and":[42,56,105,130,198,212],"quantify":[43],"rare":[44],"RAG-mediated":[45,164,191],"rearrangements":[46,93,165],"in":[47,67,91,128,194],"mouse":[48],"thymocytes.":[49],"We":[50,159],"first":[51],"examined":[52,215],"TCR\u03b2":[54],"locus":[55,82],"found":[57],"that":[58,171,200],"four":[59],"its":[61],"twelve":[62],"pseudogenes":[63],"undergo":[64],"detectable":[65,149],"rearrangement":[66,193],"vivo,":[68],"despite":[69],"being":[70],"considered":[71],"non-functional":[72,92],"components":[73],"repertoire.":[76],"Extending":[77],"this":[78],"analysis":[79],"across":[80,100],"revealed":[83],"33":[84],"previously":[85],"uncharacterized":[86],"sites":[89,115,124,147],"involved":[90],"with":[94,112,148],"DJ\u03b2":[95],"segments.":[96],"These":[97],"events":[98,173],"occurred":[99],"both":[101],"V\u03b2":[103],"region":[104],"largely":[107],"inaccessible":[108],"V\u03b230\u2013D\u03b21":[109],"intergenic":[110],"region,":[111],"individual":[113],"spanning":[116],"broad":[118,187],"range":[119],"frequencies.":[122],"Cryptic":[123],"were":[125],"highly":[126],"heterogeneous":[127],"sequence":[129],"chromatin":[131],"context:":[132],"neither":[133],"RSS":[134],"resemblance,":[135],"predicted":[136],"Z-DNA":[137],"formation,":[138],"local":[139,210],"epigenetic":[140,213],"features,":[141],"nor":[142],"chromosomal":[143],"interactions":[144],"reliably":[145],"distinguished":[146],"from":[151],"those":[152],"at":[153,166],"was":[156],"not":[157,175],"detected.":[158],"further":[160],"identified":[161],"additional":[162],"Bcl11b":[168],"locus,":[169],"demonstrating":[170],"such":[172],"are":[174],"restricted":[176],"loci.":[180],"Together,":[181],"these":[182],"findings":[183],"reveal":[184],"an":[185],"unexpectedly":[186],"landscape":[188],"low-frequency":[190],"DNA":[192],"developing":[195],"T":[196],"lymphocytes":[197],"suggest":[199],"target":[202],"selection":[203],"cannot":[204],"be":[205],"explained":[206],"solely":[207],"by":[208],"genetic":[211],"features":[214],"here.":[216]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-06T00:00:00"}