{"id":"https://openalex.org/W7208786273","doi":"https://doi.org/10.64898/2026.08.28.747903","title":"The ultrastructure of subarachnoid trabeculae in non-human primates varies by tissue region within the central nervous system","display_name":"The ultrastructure of subarachnoid trabeculae in non-human primates varies by tissue region within the central nervous system","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7208786273","doi":"https://doi.org/10.64898/2026.08.28.747903"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747903","doi":"https://doi.org/10.64898/2026.08.28.747903","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747903","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747903.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747903.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022328191","display_name":"Colin O. Riley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin Riley","raw_affiliation_strings":["Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099076518","display_name":"Olivia Mihalek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Mihalek","raw_affiliation_strings":["Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066035154","display_name":"Rrita Daci","orcid":"https://orcid.org/0000-0003-3767-2284","observed_orcids":["https://orcid.org/0000-0003-3767-2284"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rrita Daci","raw_affiliation_strings":["Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098812770","display_name":"Lily Bigelow","orcid":"https://orcid.org/0009-0003-3201-3076","observed_orcids":["https://orcid.org/0009-0003-3201-3076"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Bigelow","raw_affiliation_strings":["University of Massachusetts Amherst, Department of Biomedical Engineering, Amherst, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst, Department of Biomedical Engineering, Amherst, MA, United States of America","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036469723","display_name":"Martha Fowler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Fowler","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, United States of America","Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015150415","display_name":"David I. Sandberg","orcid":"https://orcid.org/0000-0002-0245-6461","observed_orcids":["https://orcid.org/0000-0002-0245-6461"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David I. Sandberg","raw_affiliation_strings":["Department of Pediatric Surgery, McGovern Medical School, UTHealth, Houston, TX, United States of America","Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, McGovern Medical School, UTHealth, Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060773187","display_name":"Christopher F. Janssen","orcid":"https://orcid.org/0000-0002-6698-6023","observed_orcids":["https://orcid.org/0000-0002-6698-6023"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher F. Janssen","raw_affiliation_strings":["Center for Laboratory Animal Medicine and Care, McGovern Medical School, UTHealth, Houston, TX, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Laboratory Animal Medicine and Care, McGovern Medical School, UTHealth, Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041870859","display_name":"Rachael W. Sirianni","orcid":"https://orcid.org/0000-0002-9196-0239","observed_orcids":["https://orcid.org/0000-0002-9196-0239","https://orcid.org/0009-0002-3570-2857"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachael W. Sirianni","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, United States of America","Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America","Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA, United States of America","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States of America","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041870859"],"corresponding_institution_ids":["https://openalex.org/I166722992","https://openalex.org/I74775410","https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14134","display_name":"Classical Anatomy and Histology","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2702","display_name":"Anatomy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subarachnoid-space","display_name":"subarachnoid space","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8059999942779541},{"id":"https://openalex.org/keywords/collagen-fibers","display_name":"collagen fibers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/fiber-diameter","display_name":"fiber diameter","score":0.578000009059906},{"id":"https://openalex.org/keywords/fiber-density","display_name":"fiber density","score":0.7630000114440918},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.6430000066757202},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cauda-equina","display_name":"cauda equina","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nerve-roots","display_name":"nerve roots","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.7939000129699707},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6718000173568726},{"id":"https://openalex.org/C2780813603","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Subarachnoid space","level":3,"score":0.6696000099182129},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6571000218391418},{"id":"https://openalex.org/C2993925342","wikidata":"https://www.wikidata.org/wiki/Q28457374","display_name":"Fiber tract","level":4,"score":0.52920001745224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.498199999332428},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.46149998903274536},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4068000018596649},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.39730000495910645},{"id":"https://openalex.org/C2776823239","wikidata":"https://www.wikidata.org/wiki/Q48834737","display_name":"Nerve fiber","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.36579999327659607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3467999994754791},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33469998836517334},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C3020251336","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Cell bodies","level":3,"score":0.3222000002861023},{"id":"https://openalex.org/C178409289","wikidata":"https://www.wikidata.org/wiki/Q674696","display_name":"Nerve root","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C2777921445","wikidata":"https://www.wikidata.org/wiki/Q203850","display_name":"Nervous tissue","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C100776233","wikidata":"https://www.wikidata.org/wiki/Q2532492","display_name":"Bridge (graph theory)","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.2590999901294708}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.28.747903","doi":"https://doi.org/10.64898/2026.08.28.747903","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747903","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747903.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747903","doi":"https://doi.org/10.64898/2026.08.28.747903","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747903","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747903.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208786273.pdf","grobid_xml":"https://content.openalex.org/works/W7208786273.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1845098379","https://openalex.org/W3033580743","https://openalex.org/W168380197","https://openalex.org/W2187337962","https://openalex.org/W2046088413","https://openalex.org/W4413959404","https://openalex.org/W6947479834","https://openalex.org/W2045756435","https://openalex.org/W2150850052","https://openalex.org/W2145249424"],"abstract_inverted_index":{"Abstract":[0,224],"The":[1,29],"subarachnoid":[2,41,50],"space":[3,51],"(SAS)":[4],"plays":[5],"an":[6,33],"important":[7],"role":[8],"in":[9,63,78,108,156,202,220],"central":[10],"nervous":[11],"system":[12],"(CNS)":[13],"physiology,":[14],"housing":[15],"cerebrospinal":[16],"fluid":[17],"(CSF),":[18],"providing":[19],"nutrients,":[20],"clearing":[21],"waste,":[22],"and":[23,52,65,98,122,160,177,196],"protecting":[24],"CNS":[25],"tissues":[26],"from":[27,113],"injury.":[28],"SAS":[30],"also":[31],"contains":[32],"intricate":[34],"arrangement":[35],"of":[36,56,61,69,87,116,129,133,136,146,166,189,205,216],"collagenous":[37],"fibers,":[38,192],"known":[39],"as":[40,45],"trabeculae,":[42],"which":[43],"serve":[44],"biomechanical":[46],"support":[47],"for":[48,148],"the":[49,54,67,88,117,130,167,206],"modulate":[53],"flow":[55],"CSF.":[57],"Despite":[58],"their":[59],"myriad":[60],"roles":[62],"health":[64],"disease,":[66],"ultrastructure":[68],"trabeculae":[70,109,170],"is":[71],"incompletely":[72],"described,":[73],"with":[74],"a":[75,144,185,212],"specific":[76,218],"gap":[77],"understanding":[79,215],"how":[80],"fiber":[81,137,149,157],"structure":[82],"varies":[83],"across":[84],"different":[85,114,134,164],"regions":[86,115,165,204],"CNS.":[89,168,207],"In":[90],"this":[91],"work,":[92],"we":[93],"used":[94],"optimized":[95],"fixation":[96],"techniques":[97],"scanning":[99],"electron":[100],"microscopy":[101],"(SEM)":[102],"imaging":[103],"to":[104,143,183,211],"study":[105],"ultrastructural":[106],"differences":[107,155,219],"that":[110],"were":[111,181,200],"obtained":[112],"nonhuman":[118],"primate":[119],"(NHP)":[120],"brain":[121],"spinal":[123,175],"cord.":[124],"Qualitative":[125],"assessments":[126],"included":[127],"evaluation":[128],"relative":[131],"prevalence":[132],"kinds":[135],"networks":[138],"by":[139],"region,":[140],"leading":[141],"us":[142],"redefinition":[145],"terminology":[147],"morphology.":[150],"Quantitative":[151],"measurements":[152],"yielded":[153],"dramatic":[154],"diameter,":[158],"density,":[159],"network":[161],"porosity":[162],"between":[163],"Broadly,":[169],"supporting":[171],"cauda":[172],"equina,":[173],"cervical":[174],"cord,":[176],"exiting":[178],"nerve":[179],"roots":[180],"observed":[182,201],"have":[184],"very":[186],"high":[187],"density":[188],"small":[190],"diameter":[191],"whereas":[193],"larger":[194],"fibers":[195],"more":[197],"complex":[198],"arrangements":[199],"other":[203],"These":[208],"data":[209],"contribute":[210],"growing":[213],"field":[214],"CNS-region":[217],"tissue":[221],"ultrastructure.":[222],"Graphical":[223]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-05T00:00:00"}
