{"id":"https://openalex.org/W7208780767","doi":"https://doi.org/10.64898/2026.09.02.748916","title":"Metabolic regulation and structural mechanism of glutamine synthetase AMPylation","display_name":"Metabolic regulation and structural mechanism of glutamine synthetase AMPylation","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7208780767","doi":"https://doi.org/10.64898/2026.09.02.748916"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.02.748916","doi":"https://doi.org/10.64898/2026.09.02.748916","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.748916","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748916.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748916.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119665351","display_name":"Eduardo Sabatine Lopes","orcid":"https://orcid.org/0000-0002-4554-447X","observed_orcids":["https://orcid.org/0000-0002-4554-447X"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]},{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR","DE"],"is_corresponding":false,"raw_author_name":"Eduardo Sabatine Lopes","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil","Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil","Microbial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4554-447X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]},{"raw_affiliation_string":"Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil","institution_ids":["https://openalex.org/I123443094"]},{"raw_affiliation_string":"Microbial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079304513","display_name":"Eijaz Ahmed Bhat","orcid":"https://orcid.org/0000-0002-0372-1511","observed_orcids":["https://orcid.org/0000-0002-0372-1511"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eijaz Ahmed Bhat","raw_affiliation_strings":["Microbial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0372-1511","affiliations":[{"raw_affiliation_string":"Microbial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059538352","display_name":"Larissa Fonseca Tomazini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Larissa Fonseca Tomazini","raw_affiliation_strings":["Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044065673","display_name":"Adriano Alves Stefanello","orcid":"https://orcid.org/0000-0002-8627-2386","observed_orcids":["https://orcid.org/0000-0002-8627-2386"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriano Alves Stefanello","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150036662","display_name":"Lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I4405255904","display_name":"Shenzhen University of Advanced Technology","ror":"https://ror.org/03hz5th67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405255904"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Current address: Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, China","Institute of Biochemistry, Albert-Ludwigs University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, China","institution_ids":["https://openalex.org/I4405255904"]},{"raw_affiliation_string":"Institute of Biochemistry, Albert-Ludwigs University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035927263","display_name":"Paulo S\u00e9rgio Alves Bueno","orcid":"https://orcid.org/0000-0002-6506-4668","observed_orcids":["https://orcid.org/0000-0002-6506-4668"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo S\u00e9rgio Bueno","raw_affiliation_strings":["Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059994322","display_name":"Oliver Einsle","orcid":"https://orcid.org/0000-0001-8722-2893","observed_orcids":["https://orcid.org/0000-0001-8722-2893"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Einsle","raw_affiliation_strings":["Institute of Biochemistry, Albert-Ludwigs University of Freiburg, Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8722-2893","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Albert-Ludwigs University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053013984","display_name":"Emanuel Maltempi de Souza","orcid":"https://orcid.org/0000-0003-1546-9218","observed_orcids":["https://orcid.org/0000-0003-1546-9218"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emanuel Maltempi de Souza","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011414588","display_name":"Edileusa C. M. Gerhardt","orcid":"https://orcid.org/0000-0001-7088-1681","observed_orcids":["https://orcid.org/0000-0001-7088-1681"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edileusa Cristina Marques Gerhardt","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7088-1681","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Universidade Federal do Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073145245","display_name":"Marco Aur\u00e9lio Sch\u00fcler de Oliveira","orcid":"https://orcid.org/0000-0002-1993-7771","observed_orcids":["https://orcid.org/0000-0002-1993-7771"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marco Aurelio Schuler de Oliveira","raw_affiliation_strings":["Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1993-7771","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016948718","display_name":"Khaled A. Selim","orcid":"https://orcid.org/0000-0002-2974-9483","observed_orcids":["https://orcid.org/0000-0002-2974-9483"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Khaled A. Selim","raw_affiliation_strings":["Microbial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2974-9483","affiliations":[{"raw_affiliation_string":"Microbial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016948718"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.4706999957561493,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ampylation","display_name":"AMPylation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/glnb","display_name":"GlnB","score":0.9779999852180481},{"id":"https://openalex.org/keywords/herbaspirillum-seropedicae","display_name":"Herbaspirillum seropedicae","score":0.902999997138977},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5960000157356262},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.8569999933242798},{"id":"https://openalex.org/keywords/uridylation","display_name":"uridylation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/carbon-nitrogen-balance","display_name":"carbon-nitrogen balance","score":0.7559999823570251},{"id":"https://openalex.org/keywords/energy-regulation","display_name":"energy regulation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mgatp","display_name":"MgATP","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C160403918","wikidata":"https://www.wikidata.org/wiki/Q4682322","display_name":"Adenylylation","level":4,"score":0.9740999937057495},{"id":"https://openalex.org/C2779289688","wikidata":"https://www.wikidata.org/wiki/Q418306","display_name":"Glutamine synthetase","level":4,"score":0.641700029373169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5803999900817871},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4560999870300293},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.35589998960494995},{"id":"https://openalex.org/C109549099","wikidata":"https://www.wikidata.org/wiki/Q24773687","display_name":"Glutaminase","level":4,"score":0.34450000524520874},{"id":"https://openalex.org/C2991986269","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic regulation","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.2969000041484833},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.25780001282691956}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.02.748916","doi":"https://doi.org/10.64898/2026.09.02.748916","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.748916","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748916.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.02.748916","doi":"https://doi.org/10.64898/2026.09.02.748916","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.748916","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748916.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208780767.pdf","grobid_xml":"https://content.openalex.org/works/W7208780767.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1499618627","https://openalex.org/W1521871621","https://openalex.org/W1553540128","https://openalex.org/W1594994146","https://openalex.org/W1857343011","https://openalex.org/W1918486354","https://openalex.org/W1964056199","https://openalex.org/W1976620145","https://openalex.org/W1991509434","https://openalex.org/W2003608381","https://openalex.org/W2003920804","https://openalex.org/W2004235182","https://openalex.org/W2022749662","https://openalex.org/W2044489365","https://openalex.org/W2049496165","https://openalex.org/W2087351415","https://openalex.org/W2101845851","https://openalex.org/W2125908827","https://openalex.org/W2127107396","https://openalex.org/W2140944735","https://openalex.org/W2144081223","https://openalex.org/W2145404025","https://openalex.org/W2603089411","https://openalex.org/W2783135910","https://openalex.org/W2886289453","https://openalex.org/W2894804039","https://openalex.org/W2959733893","https://openalex.org/W2973457155","https://openalex.org/W2980534943","https://openalex.org/W2992919883","https://openalex.org/W2995600902","https://openalex.org/W2995806068","https://openalex.org/W4283269097","https://openalex.org/W4385767139","https://openalex.org/W4388701327","https://openalex.org/W4395689596","https://openalex.org/W4399082889","https://openalex.org/W4412522150","https://openalex.org/W4412814542","https://openalex.org/W4414075731","https://openalex.org/W4414322116","https://openalex.org/W4416257412","https://openalex.org/W7164357970","https://openalex.org/W7166650373","https://openalex.org/W7202124450","https://openalex.org/W7202380362"],"related_works":["https://openalex.org/W954505295","https://openalex.org/W179298195","https://openalex.org/W2039883482","https://openalex.org/W2316344308","https://openalex.org/W1585547215","https://openalex.org/W2035778257","https://openalex.org/W1576478358","https://openalex.org/W2323257411","https://openalex.org/W1985465025","https://openalex.org/W473919"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"bacteria,":[2],"glutamine":[3,128,280],"synthetase":[4,229],"(GS)":[5],"is":[6,14,35,100,230],"the":[7,30,38,50,61,88,142,169,172,182,187,214,219,231,257,260,267,275,284,287,295,307],"main":[8],"ammonium":[9],"assimilation":[10,237],"enzyme.":[11],"Its":[12],"activity":[13],"tightly":[15],"regulated":[16],"according":[17],"to":[18,185,198,208],"cellular":[19],"energy":[20,78,138],"status":[21],"and":[22,60,77,86,154,161,212,238,330],"carbon\u2013nitrogen":[23],"balance":[24],"through":[25,114],"reversible":[26,251],"AMPylation":[27,45,68,82,99,110,145,167,211,252,315],"catalyzed":[28],"by":[29,37,67,119,225,250],"bifunctional":[31],"enzyme":[32,92,233,262],"GlnE,":[33],"which":[34],"controlled":[36],"signal":[39,133],"transducer":[40],"GlnB":[41,107],"protein.":[42],"Although":[43,247],"GS":[44,65,81,98,146,156,210,223],"has":[46,239,253,263],"been":[47,240,255],"extensively":[48],"studied,":[49],"GlnB:GlnE:GS":[51],"regulatory":[52],"pathway":[53],"exhibits":[54],"substantial":[55],"plasticity":[56],"among":[57],"bacterial":[58,222,235,327],"groups,":[59],"structural":[62,89,216],"basis":[63,269],"of":[64,102,144,152,171,234,259,270,278,289,297,309],"inhibition":[66,224,271],"remains":[69],"unclear.":[70],"Here,":[71],"we":[72,148],"describe":[73],"how":[74,203],"carbon,":[75],"nitrogen,":[76],"signals":[79,205],"regulate":[80,209],"in":[83,157,181,190,316,326,334],"Herbaspirillum":[84,317],"seropedicae":[85,318],"uncover":[87,331],"mechanism":[90,143,220,313],"underlying":[91,221],"inhibition.":[93],"Our":[94],"data":[95],"reveal":[96,202],"that":[97,124,166,178,283,293],"independent":[101],"unmodified":[103,153],"GlnB,":[104],"whereas":[105],"uridylylated":[106],"(GlnB-UMP)":[108],"inhibits":[109],"under":[111,129],"nitrogen-limiting":[112],"conditions":[113],"a":[115,175,290,298,323],"GlnB-GlnE":[116],"complex":[117,158],"modulated":[118],"2-oxoglutarate.":[120],"We":[121,273],"further":[122],"show":[123],"GlnE":[125],"directly":[126],"senses":[127],"nitrogen-sufficient":[130],"conditions,":[131],"with":[132,159,306],"integration":[134],"depending":[135],"primarily":[136],"on":[137],"availability.":[139],"To":[140],"elucidate":[141],"inhibition,":[147],"solved":[149],"Cryo-EM":[150],"structures":[151,277],"AMPylated":[155,261,279],"MgATP":[160],"MnADP.":[162],"Structural":[163],"comparisons":[164],"revealed":[165],"increases":[168,286],"flexibility":[170,288],"AMP-loop,":[173],"disrupting":[174],"hydrogen-bond":[176],"network":[177],"stabilizes":[179],"Arg342":[180],"orientation":[183],"required":[184,301],"position":[186],"ATP":[188,303],"\u03b3-phosphate":[189],"its":[191,248,335],"catalytic":[192,299],"conformation":[193],"for":[194,242,302],"efficient":[195],"phosphoryl":[196],"transfer":[197],"glutamate.":[199],"These":[200],"findings":[201,321],"metabolic":[204],"are":[206],"integrated":[207],"provide":[213],"first":[215,276],"insights":[217],"into":[218],"AMPylation.":[226],"Importance":[227],"Glutamine":[228],"central":[232],"nitrogen":[236,328],"studied":[241],"more":[243],"than":[244],"six":[245],"decades.":[246],"regulation":[249],"long":[254],"recognized,":[256],"structure":[258],"remained":[264],"unknown,":[265],"leaving":[266],"molecular":[268],"unresolved.":[272],"present":[274],"synthetase,":[281],"revealing":[282],"modification":[285],"surface":[291],"loop":[292],"disrupts":[294],"positioning":[296],"residue":[300],"utilization.":[304],"Together":[305],"identification":[308],"an":[310],"alternative":[311],"signaling":[312],"controlling":[314],",":[319],"these":[320],"resolve":[322],"longstanding":[324],"question":[325],"metabolism":[329],"unexpected":[332],"diversity":[333],"regulation.":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-05T00:00:00"}
