{"id":"https://openalex.org/W7208770712","doi":"https://doi.org/10.1038/s41467-026-77428-w","title":"HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity","display_name":"HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208770712","doi":"https://doi.org/10.1038/s41467-026-77428-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42697879","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13545280"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-77428-w","doi":"https://doi.org/10.1038/s41467-026-77428-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77428-w","pdf_url":"https://www.nature.com/articles/s41467-026-77428-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-77428-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080839777","display_name":"Benay Eksi","orcid":"https://orcid.org/0009-0000-3168-0588","observed_orcids":["https://orcid.org/0009-0000-3168-0588"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benay Eksi","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0009-0000-3168-0588","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004096317","display_name":"Daniel Finke","orcid":"https://orcid.org/0000-0002-0536-7536","observed_orcids":["https://orcid.org/0000-0002-0536-7536"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Finke","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102626363","display_name":"Synje Michel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Synje Michel","raw_affiliation_strings":["German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032884556","display_name":"Jannek Brauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jannek Brauer","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037170307","display_name":"Markus B. Heckmann","orcid":"https://orcid.org/0000-0002-3085-1282","observed_orcids":["https://orcid.org/0000-0002-3085-1282"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus B. Heckmann","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3085-1282","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058644693","display_name":"Mohsen Valadan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohsen Valadan","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054192998","display_name":"Leonard M. Schanze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leonard M. Schanze","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122856535","display_name":"Vighnesh Sunder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vighnesh Sunder","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083022383","display_name":"Kevin Steimel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kevin Steimel","raw_affiliation_strings":["Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Medical Faculty Heidelberg/Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Medical Faculty Heidelberg/Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018056534","display_name":"J\u00fcrgen Burhenne","orcid":"https://orcid.org/0000-0002-2190-1698","observed_orcids":["https://orcid.org/0000-0002-2190-1698"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Burhenne","raw_affiliation_strings":["Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Medical Faculty Heidelberg/Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2190-1698","affiliations":[{"raw_affiliation_string":"Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Medical Faculty Heidelberg/Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077959685","display_name":"Timon Seeger","orcid":"https://orcid.org/0009-0000-3102-2374","observed_orcids":["https://orcid.org/0009-0000-3102-2374"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timon Seeger","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049262839","display_name":"Hugo Albert Katus","orcid":"https://orcid.org/0000-0002-2293-2314","observed_orcids":["https://orcid.org/0000-0002-2293-2314"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hugo A. Katus","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008704300","display_name":"Norbert Frey","orcid":"https://orcid.org/0000-0001-7611-378X","observed_orcids":["https://orcid.org/0000-0001-7611-378X"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Frey","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7611-378X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070951638","display_name":"Johannes Backs","orcid":"https://orcid.org/0000-0002-2322-2699","observed_orcids":["https://orcid.org/0000-0002-2322-2699"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Backs","raw_affiliation_strings":["Department of Internal Medicine VIII, Heidelberg University Hospital, Heidelberg, Germany","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","Heidelberg University, Heidelberg, Germany","Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany","Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany","Molecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2322-2699","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine VIII, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Molecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014033391","display_name":"Lorenz Lehmann","orcid":"https://orcid.org/0000-0001-5077-8580","observed_orcids":["https://orcid.org/0000-0001-5077-8580"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lorenz H. Lehmann","raw_affiliation_strings":["Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. Lorenz.Lehmann@med.uni-heidelberg.de","German Cancer Research Center (DKFZ), Heidelberg, Germany. Lorenz.Lehmann@med.uni-heidelberg.de","German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany. Lorenz.Lehmann@med.uni-heidelberg.de"],"raw_orcid":"https://orcid.org/0000-0001-5077-8580","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. Lorenz.Lehmann@med.uni-heidelberg.de","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"German Cancer Research Center (DKFZ), Heidelberg, Germany. Lorenz.Lehmann@med.uni-heidelberg.de","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim, Heidelberg, Germany. Lorenz.Lehmann@med.uni-heidelberg.de","institution_ids":["https://openalex.org/I4210127591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5014033391"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2802164966","https://openalex.org/I4210127591"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":4.0135,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95265332,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9549999833106995},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mef2","display_name":"MEF2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9269999861717224},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8539999723434448},{"id":"https://openalex.org/keywords/actc1","display_name":"ACTC1","score":0.746999979019165},{"id":"https://openalex.org/keywords/myosin-light-chain-2","display_name":"myosin light chain 2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/myh7","display_name":"MYH7","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7059999704360962},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.6244000196456909},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.6189000010490417},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5699999928474426},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.49540001153945923},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.489300012588501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47780001163482666},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.43149998784065247},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4251999855041504},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.421999990940094},{"id":"https://openalex.org/C2776281265","wikidata":"https://www.wikidata.org/wiki/Q420327","display_name":"Hydroxamic acid","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C58793620","wikidata":"https://www.wikidata.org/wiki/Q21173206","display_name":"HDAC4","level":5,"score":0.41350001096725464},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4068000018596649},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.3978999853134155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3968000113964081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3953000009059906},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3837999999523163},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.37059998512268066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C51183755","wikidata":"https://www.wikidata.org/wiki/Q83166919","display_name":"Mef2","level":5,"score":0.30090001225471497},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3000999987125397},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.262800008058548},{"id":"https://openalex.org/C116186050","wikidata":"https://www.wikidata.org/wiki/Q4039110","display_name":"GATA4","level":4,"score":0.25540000200271606}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064326","descriptor_name":"MEF2 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064326","descriptor_name":"MEF2 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-026-77428-w","doi":"https://doi.org/10.1038/s41467-026-77428-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77428-w","pdf_url":"https://www.nature.com/articles/s41467-026-77428-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13545280","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13545280/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13545280/pdf/41467_2026_Article_77428.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:42697879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42697879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:26897","doi":null,"is_oa":true,"landing_page_url":"https://edoc.mdc-berlin.de/id/eprint/26897/2/26897suppl.zip","pdf_url":"https://edoc.mdc-berlin.de/id/eprint/26897/1/26897oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:bea9c6f7f2af4a0a99312f47dfd86bb3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bea9c6f7f2af4a0a99312f47dfd86bb3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-77428-w","doi":"https://doi.org/10.1038/s41467-026-77428-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77428-w","pdf_url":"https://www.nature.com/articles/s41467-026-77428-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G236772470","display_name":null,"funder_award_id":"CRC1550","funder_id":"https://openalex.org/F4320312069","funder_display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung"}],"funders":[{"id":"https://openalex.org/F4320312069","display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","ror":"https://ror.org/031t5w623"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320338011","display_name":"Stanford Cardiovascular Institute, School of Medicine, Stanford University","ror":"https://ror.org/03kk52s14"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208770712.pdf","grobid_xml":"https://content.openalex.org/works/W7208770712.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1671254148","https://openalex.org/W1975073933","https://openalex.org/W1997883674","https://openalex.org/W2009826707","https://openalex.org/W2019830818","https://openalex.org/W2021860877","https://openalex.org/W2052373759","https://openalex.org/W2054848045","https://openalex.org/W2060511004","https://openalex.org/W2061072091","https://openalex.org/W2085539609","https://openalex.org/W2090139913","https://openalex.org/W2099262276","https://openalex.org/W2105517676","https://openalex.org/W2108116956","https://openalex.org/W2113111385","https://openalex.org/W2114815592","https://openalex.org/W2121055805","https://openalex.org/W2126839598","https://openalex.org/W2131438908","https://openalex.org/W2135830745","https://openalex.org/W2141882676","https://openalex.org/W2142491779","https://openalex.org/W2145860233","https://openalex.org/W2156613731","https://openalex.org/W2166305181","https://openalex.org/W2296878578","https://openalex.org/W2346631874","https://openalex.org/W2472687861","https://openalex.org/W2625038588","https://openalex.org/W2774777951","https://openalex.org/W2895168260","https://openalex.org/W2994884492","https://openalex.org/W2995188062","https://openalex.org/W3004664745","https://openalex.org/W3198154012","https://openalex.org/W4200092526","https://openalex.org/W4386782554"],"related_works":["https://openalex.org/W7172278350","https://openalex.org/W4412805570","https://openalex.org/W2726024713","https://openalex.org/W3190750739","https://openalex.org/W4407983559","https://openalex.org/W2777848148","https://openalex.org/W4400701324","https://openalex.org/W2736135258","https://openalex.org/W4385660764","https://openalex.org/W2979202252"],"abstract_inverted_index":{"Anthracycline-induced":[0],"cardiotoxicity":[1],"remains":[2],"a":[3,21,144,150],"major":[4],"limitation":[5],"of":[6,24,96,107],"cancer":[7],"therapy,":[8],"and":[9,54,63,120,148,156],"effective":[10],"preventive":[11],"strategies":[12],"are":[13],"lacking.":[14],"Topoisomerase":[15],"IIb":[16,45],"has":[17],"been":[18],"implicated":[19],"as":[20,93,143],"central":[22],"driver":[23],"this":[25],"toxicity,":[26],"suggesting":[27],"that":[28,41],"epigenetic":[29,154],"regulators":[30],"may":[31],"interfere":[32],"with":[33,114],"the":[34,76,108],"pathological":[35],"cardiac":[36],"response.":[37],"Here,":[38],"we":[39],"show":[40],"doxorubicin":[42],"promotes":[43],"topoisomerase":[44],"accumulation":[46],"at":[47],"cardiomyocyte-specific":[48],"gene":[49],"promoters":[50],"(e.g.,":[51],"Actc1,":[52],"Myl2,":[53],"Myh7)":[55],"overlapping":[56],"myocyte":[57,65,122],"enhancer":[58,66,123],"factor":[59,67,124],"2":[60,68,125],"binding":[61],"sites":[62],"enhances":[64],"-dependent":[69],"transcription.":[70,128],"This":[71],"response":[72],"is":[73],"attenuated":[74],"by":[75],"pan-histone":[77],"deacetylase":[78,141],"inhibitor":[79],"suberoylanilide":[80,102,131],"hydroxamic":[81,84,103,132],"acid.":[82],"Suberoylanilide":[83],"acid":[85,104,133],"-mediated":[86],"cardioprotection":[87],"requires":[88],"class":[89],"IIa":[90],"histone":[91,140],"deacetylases,":[92],"genetic":[94],"loss":[95],"HDAC4":[97],"abolishes":[98],"its":[99,112],"effect.":[100],"Mechanistically,":[101],"induces":[105],"acetylation":[106],"chaperone":[109],"14-3-3,":[110],"disrupting":[111],"interaction":[113],"HDAC4/5,":[115],"promoting":[116],"their":[117],"nuclear":[118],"accumulation,":[119],"repressing":[121],"-":[126],"driven":[127],"In":[129],"vivo,":[130],"mitigates":[134],"doxorubicin-induced":[135],"cardiotoxicity.":[136,158],"These":[137],"findings":[138],"identify":[139],"inhibition":[142],"cardioprotective":[145],"repurposing":[146],"strategy":[147],"reveal":[149],"mechanistic":[151],"link":[152],"between":[153],"regulation":[155],"anthracycline-associated":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-05T00:00:00"}
