{"id":"https://openalex.org/W7208752298","doi":"https://doi.org/10.64898/2026.08.31.748147","title":"Antibodies with Engineered Fc Domains Having Absolute Binding Selectivity to either Fc\u03b3RIIa or Fc\u03b3RI Delineate the Respective Effector Phenotypes by Human Monocytes and Macrophages","display_name":"Antibodies with Engineered Fc Domains Having Absolute Binding Selectivity to either Fc\u03b3RIIa or Fc\u03b3RI Delineate the Respective Effector Phenotypes by Human Monocytes and Macrophages","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208752298","doi":"https://doi.org/10.64898/2026.08.31.748147","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922493","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684468"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.31.748147","doi":"https://doi.org/10.64898/2026.08.31.748147","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748147","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.08.31.748147.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.08.31.748147.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032517655","display_name":"Katia George","orcid":"https://orcid.org/0000-0001-8511-7918","observed_orcids":["https://orcid.org/0000-0001-8511-7918"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katia George","raw_affiliation_strings":["Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-8511-7918","affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082846960","display_name":"Sanghwan Ko","orcid":"https://orcid.org/0000-0002-2950-4937","observed_orcids":["https://orcid.org/0000-0002-2950-4937"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanghwan Ko","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-2950-4937","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063336135","display_name":"Seema Irani","orcid":"https://orcid.org/0000-0001-5159-3473","observed_orcids":["https://orcid.org/0000-0001-5159-3473"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Irani","raw_affiliation_strings":["Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013595637","display_name":"George Delidakis","orcid":"https://orcid.org/0000-0002-4330-9476","observed_orcids":["https://orcid.org/0000-0002-4330-9476"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Delidakis","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588373","display_name":"Chang\u2010Han Lee","orcid":"https://orcid.org/0000-0002-7156-4423","observed_orcids":["https://orcid.org/0000-0002-7156-4423"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Han Lee","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-7156-4423","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040327327","display_name":"Prashant S. Menon","orcid":"https://orcid.org/0000-0001-6415-5202","observed_orcids":["https://orcid.org/0000-0001-6415-5202"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashant Menon","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048900614","display_name":"Jin Eyun Kim","orcid":"https://orcid.org/0000-0002-6297-3292","observed_orcids":["https://orcid.org/0000-0002-6297-3292"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Eyun Kim","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-6297-3292","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041971377","display_name":"Bart M. Herpers","orcid":"https://orcid.org/0009-0009-6771-4810","observed_orcids":["https://orcid.org/0009-0009-6771-4810"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bart M. Herpers","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0009-0009-6771-4810","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150045974","display_name":"Evelyn Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn Rocha","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149992600","display_name":"Gabriel Soto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Soto","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150044744","display_name":"Akhil Majmudar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akhil Majmudar","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041553722","display_name":"Navin Varadarajan","orcid":"https://orcid.org/0000-0001-7524-8228","observed_orcids":["https://orcid.org/0000-0001-7524-8228"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navin Varadarajan","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134173569","display_name":"Y Jessie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Jessie Zhang","raw_affiliation_strings":["Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047788420","display_name":"George Georgiou","orcid":"https://orcid.org/0000-0002-8823-3073","observed_orcids":["https://orcid.org/0000-0002-8823-3073"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George Georgiou","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA","Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047788420"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.8090000152587891},{"id":"https://openalex.org/keywords/fcgammariia","display_name":"Fc\u03b3RIIa","score":0.9639999866485596},{"id":"https://openalex.org/keywords/fcgammari","display_name":"Fc\u03b3RI","score":0.996999979019165},{"id":"https://openalex.org/keywords/fc-engineered-antibody","display_name":"Fc-engineered antibody","score":0.7419999837875366},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.699999988079071},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-phagocytosis","display_name":"antibody-dependent cellular phagocytosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6380000114440918},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gm-csf-secretion","display_name":"GM-CSF secretion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9240000247955322},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/trogocytosis","display_name":"trogocytosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/fc-effector-functions","display_name":"Fc effector functions","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7741000056266785},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6462000012397766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5702000260353088},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5554999709129333},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.5130000114440918},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.4918999969959259},{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.4860999882221222},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.47510001063346863},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45509999990463257},{"id":"https://openalex.org/C2909900342","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Immunoglobulin Fc Fragments","level":4,"score":0.44530001282691956},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4438999891281128},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42730000615119934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42410001158714294},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C125823703","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Fragment crystallizable region","level":3,"score":0.39100000262260437},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.3862999975681305},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.37560001015663147},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.36079999804496765},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3346000015735626},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.31850001215934753},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2888000011444092},{"id":"https://openalex.org/C2779931124","wikidata":"https://www.wikidata.org/wiki/Q417823","display_name":"Fc receptor","level":3,"score":0.28690001368522644},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27720001339912415},{"id":"https://openalex.org/C2777066959","wikidata":"https://www.wikidata.org/wiki/Q869711","display_name":"Cricetulus","level":4,"score":0.27619999647140503},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.26100000739097595},{"id":"https://openalex.org/C168507396","wikidata":"https://www.wikidata.org/wiki/Q14859847","display_name":"Antibody opsonization","level":4,"score":0.26080000400543213}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.31.748147","doi":"https://doi.org/10.64898/2026.08.31.748147","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748147","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.08.31.748147.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684468","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684468/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684468/pdf/nihpp-2026.08.31.748147v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42922493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.31.748147","doi":"https://doi.org/10.64898/2026.08.31.748147","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748147","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/04/2026.08.31.748147.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G102163711","display_name":null,"funder_award_id":"DE\u2010 AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4836344180","display_name":"Systematic, molecular level analysis of the Fc receptor ligation on antibody effector functions","funder_award_id":"U01AI148118","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000887531","display_name":"Deciphering the phosphorylation pattern of RNA polymerase II for eukaryotic transcription","funder_award_id":"R35GM148356","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000898044","display_name":"Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules","funder_award_id":"R35GM139658","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320310620","display_name":"University of Texas at Austin","ror":"https://ror.org/00hj54h04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208752298.pdf","grobid_xml":"https://content.openalex.org/works/W7208752298.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2925727197","https://openalex.org/W2005519719","https://openalex.org/W1608459222","https://openalex.org/W1559033760","https://openalex.org/W1973746851","https://openalex.org/W2622901432","https://openalex.org/W2076072317","https://openalex.org/W2531610726","https://openalex.org/W2168313542","https://openalex.org/W2157661876"],"abstract_inverted_index":{"Abstract":[0],"IgG1":[1,42,166],"immune":[2],"complexes":[3],"bind":[4],"to":[5,18,51,57,137,192,209],"all":[6,174],"the":[7,20,33,64,71,76,79,138,178,214,227],"Fc\u03b3":[8],"receptors":[9],"(Fc\u03b3R)":[10],"expressed":[11],"on":[12,26],"myeloid":[13],"cells,":[14],"making":[15],"it":[16],"challenging":[17],"determine":[19],"precise":[21,215],"role":[22],"of":[23,35,67,78,155,181,194,229],"each":[24],"Fc\u03b3R":[25],"Fc":[27,43,72,105],"effector":[28,216],"phenotypes.":[29],"Here":[30],"we":[31,90,145],"report":[32],"engineering":[34],"Fc2":[36,100,148,169],"KG":[37,101,149,170],",":[38],"an":[39,104],"aglycosylated":[40],"human":[41,128,160,220],"domain":[44,73,106],"that":[45,92,107,123,147],"binds":[46,108],"with":[47,53,95,99,103,117,124,164,168],"near":[48,118],"physiological":[49],"affinity":[50],"Fc\u03b3RIIa/b":[52],"no":[54],"detectable":[55],"binding":[56],"any":[58],"other":[59],"Fc\u03b3Rs.":[60],"Crystallographic":[61],"analysis":[62],"elucidated":[63],"structural":[65],"basis":[66],"how":[68,201],"mutations":[69],"in":[70,177],"compensate":[74],"for":[75,226],"absence":[77],"N297":[80],"glycan":[81],"and":[82],"enable":[83],"selective":[84,130],"binding.":[85],"Using":[86],"single-cell":[87],"phagocytosis":[88],"assays,":[89],"show":[91],"particles":[93],"opsonized":[94,182],"Fc-engineered":[96,204],"antibodies":[97,151,205],"formatted":[98,150,163],"or":[102,171],"only":[109,188],"Fc\u03b3RI":[110,189],"(Fc5),":[111],"are":[112],"ingested":[113],"by":[114,141,219],"THP-1":[115],"cells":[116,186],"identical":[119],"kinetics.":[120],"We":[121],"find":[122],"CD16":[125],"+":[126,185],"primary":[127],"monocytes,":[129],"Fc\u03b3RII":[131],"engagement":[132,190],"is":[133,224],"a":[134],"major":[135],"contributor":[136],"ADCP":[139],"mediated":[140,218],"wild-type":[142,165],"IgG1.":[143],"Additionally,":[144],"showed":[146],"induce":[152],"high":[153],"levels":[154],"GM-CSF.":[156],"With":[157],"M1-like":[158],"monocyte-derived":[159],"macrophages,":[161],"trastuzumab":[162],"Fc,":[167],"Fc5":[172],"were":[173],"equally":[175],"proficient":[176],"trogocytotic":[179],"killing":[180],"SK-BR-3":[183],"HER2":[184],"but":[187],"led":[191],"secretion":[193],"proinflammatory":[195],"cytokines.":[196],"Collectively,":[197],"our":[198],"results":[199],"highlight":[200],"precisely":[202],"tuned,":[203],"can":[206],"be":[207],"deployed":[208],"answer":[210],"long-standing":[211],"questions":[212],"regarding":[213],"functions":[217],"Fc\u03b3Rs,":[221],"information":[222],"which":[223],"key":[225],"optimization":[228],"therapeutic":[230],"antibodies.":[231]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-05T00:00:00"}
