{"id":"https://openalex.org/W7208744625","doi":"https://doi.org/10.5281/zenodo.22289824","title":"Dynamic Spatial Tumor\u2013Immune Remodeling Drives Response and Resistance to ICI plus Chemotherapy in Metastatic Gastric Cancer","display_name":"Dynamic Spatial Tumor\u2013Immune Remodeling Drives Response and Resistance to ICI plus Chemotherapy in Metastatic Gastric Cancer","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208744625","doi":"https://doi.org/10.5281/zenodo.22289824"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22289824","doi":"https://doi.org/10.5281/zenodo.22289824","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22289824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22289824","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059232464","display_name":"Seyoung Jung","orcid":"https://orcid.org/0000-0002-0285-5972","observed_orcids":["https://orcid.org/0000-0002-0285-5972"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung, Seyoung","raw_affiliation_strings":["Korea Advanced Institute of Science and Technology"],"raw_orcid":"https://orcid.org/0000-0002-0285-5972","affiliations":[{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124917167","display_name":"Young Soo Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Park, Young Soo","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150013859","display_name":"Ji Young Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ahn, Ji Young","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150039636","display_name":"Jin-hee Noh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Noh, Jin-hee","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kim, Junghee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kim, Junghee","raw_affiliation_strings":["Korea Advanced Institute of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030586134","display_name":"Suho Lee","orcid":"https://orcid.org/0000-0002-5956-9985","observed_orcids":["https://orcid.org/0000-0002-5956-9985"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Lee, Suho","raw_affiliation_strings":["Korea Advanced Institute of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149983676","display_name":"Jaewon Hyung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung, Jaewon","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137144108","display_name":"Changhoon Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoo, Changhoon","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034692104","display_name":"Edward Cha","orcid":"https://orcid.org/0000-0001-8172-0656","observed_orcids":["https://orcid.org/0000-0001-8172-0656"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cha, Edward","raw_affiliation_strings":["Genentech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035922913","display_name":"Rachel Garonce-Hediger","orcid":"https://orcid.org/0009-0004-5061-610X","observed_orcids":["https://orcid.org/0009-0004-5061-610X"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Garonce-Hediger, Rachel","raw_affiliation_strings":["F. Hoffmann-La Roche"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076456783","display_name":"Mark M. Yarchoan","orcid":"https://orcid.org/0000-0003-4401-0748","observed_orcids":["https://orcid.org/0000-0003-4401-0748"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yarchoan, Mark","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0003-4401-0748","affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150003641","display_name":"Min-Hee Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ryu, Min-Hee","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062505942","display_name":"Jeong Seok Lee","orcid":"https://orcid.org/0000-0001-8261-7044","observed_orcids":["https://orcid.org/0000-0001-8261-7044"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Lee, Jeong Seok","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5149986605","display_name":"Hyung-Don Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kim, Hyung-Don","raw_affiliation_strings":["Asan Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Medical Center","institution_ids":["https://openalex.org/I2801680663"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6386487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-gastric-cancer","display_name":"metastatic gastric cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.593999981880188},{"id":"https://openalex.org/keywords/primary-resistance","display_name":"primary resistance","score":0.6610000133514404},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"acquired resistance","score":0.9660000205039978},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ceacam1","display_name":"CEACAM1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.5789999961853027},{"id":"https://openalex.org/keywords/single-nucleus-rna-sequencing","display_name":"single-nucleus RNA sequencing","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6105999946594238},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5888000130653381},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.515999972820282},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5144000053405762},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49779999256134033},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4401000142097473},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41780000925064087},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3962000012397766},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.3736000061035156},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3686999976634979},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3610999882221222},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.3529999852180481},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3472999930381775},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3449999988079071},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3449999988079071},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.3416999876499176},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3400999903678894},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.26899999380111694},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.25609999895095825}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22289824","doi":"https://doi.org/10.5281/zenodo.22289824","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22289824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.22289825","doi":"https://doi.org/10.5281/zenodo.22289825","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22289825","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22289824","doi":"https://doi.org/10.5281/zenodo.22289824","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22289824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416088094","https://openalex.org/W7148795154","https://openalex.org/W4362544134","https://openalex.org/W4362597228","https://openalex.org/W7169852054","https://openalex.org/W7172330613","https://openalex.org/W7162344917","https://openalex.org/W7213471514","https://openalex.org/W7164882917","https://openalex.org/W7117438086"],"abstract_inverted_index":{"Immune":[0],"checkpoint":[1],"inhibitors":[2],"(ICIs)":[3],"improve":[4],"survival":[5],"in":[6,188],"advanced":[7],"gastric":[8,35,189],"cancer,":[9],"but":[10,152],"the":[11,140],"tumor\u2013immune":[12,71,174],"ecosystems":[13,175],"that":[14,77],"determine":[15],"response,":[16],"primary":[17,110],"resistance,":[18],"and":[19,46,54,66,85,91,101,120,130,163,182],"acquired":[20,183],"resistance":[21,111,146,184],"remain":[22],"poorly":[23],"understood.":[24],"We":[25,58,75],"established":[26],"a":[27,177],"prospective":[28],"longitudinal":[29],"cohort":[30],"of":[31,88,115,127,159,173,179],"patients":[32],"with":[33,82],"metastatic":[34],"cancer":[36],"undergoing":[37],"first-line":[38],"ICI":[39],"plus":[40],"chemotherapy,":[41],"collecting":[42],"serial":[43],"tumor":[44,132],"biopsies":[45],"paired":[47],"blood":[48],"samples":[49],"before":[50],"treatment,":[51],"during":[52,73],"therapy,":[53],"at":[55],"disease":[56],"progression.":[57],"integrated":[59],"single-nucleus":[60],"RNA-seq,":[61],"spatial":[62,67,86,113,154,171],"transcriptomics,":[63],"immune":[64],"profiling,":[65],"validation":[68],"to":[69,96,185],"map":[70],"evolution":[72],"treatment.":[74],"find":[76],"clinical":[78],"benefit":[79],"was":[80,134],"associated":[81],"both":[83,180],"enrichment":[84],"aggregation":[87],"lymphoid":[89,128,149],"hubs":[90],"T/B-cell-enriched":[92],"antitumor":[93],"communities":[94],"linked":[95],"CD8\u207a":[97,104],"T":[98,105],"cell-recruiting":[99],"macrophages":[100],"circulating":[102],"GZMK\u207a/proliferating":[103],"cell":[106],"responses.":[107],"By":[108],"contrast,":[109],"featured":[112,147],"niches":[114,162],"SMAD3-high":[116,131],"tumor,":[117],"IL1B\u207a/SPP1\u207a":[118],"myeloid,":[119],"profibrotic":[121],"stromal":[122],"cells.":[123],"The":[124],"predictive":[125],"value":[126],"hub":[129,150],"signatures":[133],"validated":[135],"using":[136],"transcriptomic":[137],"data":[138],"from":[139],"phase":[141],"3":[142],"CheckMate-649":[143],"trial.":[144],"Acquired":[145],"preserved":[148],"abundance":[151],"disrupted":[153],"cohesion,":[155],"accompanied":[156],"by":[157],"infiltration":[158],"inflammatory":[160],"myeloid\u2013stromal":[161],"high":[164],"CEACAM1":[165],"expression.":[166],"These":[167],"findings":[168],"identify":[169],"dynamic":[170],"remodeling":[172],"as":[176],"determinant":[178],"response":[181],"ICI-based":[186],"chemotherapy":[187],"cancer.":[190]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-05T00:00:00"}
