{"id":"https://openalex.org/W7208739414","doi":"https://doi.org/10.1016/j.bpj.2026.09.001","title":"Hypoxia-responsive HIF-1\u03b1-dependent RhoA signaling promotes motility and aerotaxis in polyaneuploid PC3 cancer cells with increased nuclear rounding","display_name":"Hypoxia-responsive HIF-1\u03b1-dependent RhoA signaling promotes motility and aerotaxis in polyaneuploid PC3 cancer cells with increased nuclear rounding","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208739414","doi":"https://doi.org/10.1016/j.bpj.2026.09.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/42693642"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2026.09.001","doi":"https://doi.org/10.1016/j.bpj.2026.09.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2026.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bpj.2026.09.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116885687","display_name":"Noreen Hosny","orcid":"https://orcid.org/0009-0001-1804-252X","observed_orcids":["https://orcid.org/0009-0001-1804-252X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Noreen Hosny","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ, USA. Electronic address: nh7663@alumni.princeton.edu"],"raw_orcid":"https://orcid.org/0009-0001-1804-252X","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ, USA. Electronic address: nh7663@alumni.princeton.edu","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132857954","display_name":"Shengkai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengkai Li","raw_affiliation_strings":["Department of Physics, Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032533490","display_name":"Robert A. Gatenby","orcid":"https://orcid.org/0000-0002-1621-1510","observed_orcids":["https://orcid.org/0000-0002-1621-1510"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Gatenby","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124967827","display_name":"Kenneth J Pienta","orcid":"https://orcid.org/0000-0002-4138-2186","observed_orcids":["https://orcid.org/0000-0002-4138-2186"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth J. Pienta","raw_affiliation_strings":["Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150008073","display_name":"Joel S. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel S. Brown","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057442795","display_name":"Emma U. Hammarlund","orcid":"https://orcid.org/0000-0001-7625-4793","observed_orcids":["https://orcid.org/0000-0001-7625-4793"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Emma U. Hammarlund","raw_affiliation_strings":["Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150014355","display_name":"Chen Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038645053","display_name":"Junle Qu","orcid":"https://orcid.org/0000-0001-7833-4711","observed_orcids":["https://orcid.org/0000-0001-7833-4711"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junle Qu","raw_affiliation_strings":["College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081117311","display_name":"Robert H. Austin","orcid":"https://orcid.org/0000-0002-4269-6793","observed_orcids":["https://orcid.org/0000-0002-4269-6793"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Austin","raw_affiliation_strings":["Department of Physics, Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002629506","display_name":"Sarah R. Amend","orcid":"https://orcid.org/0000-0002-5606-1262","observed_orcids":["https://orcid.org/0000-0002-5606-1262"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah R. Amend","raw_affiliation_strings":["Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. Electronic address: samend2@jhmi.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA. Electronic address: samend2@jhmi.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002629506","https://openalex.org/A5116885687"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I20089843","https://openalex.org/I4210164401"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63882444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"19","first_page":"5718","last_page":"5738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoreplication","display_name":"endoreplication","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rhoa-signaling","display_name":"RhoA signaling","score":1.0},{"id":"https://openalex.org/keywords/aerotaxis","display_name":"aerotaxis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-cell-motility","display_name":"tumor cell motility","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nuclear-morphology","display_name":"nuclear morphology","score":0.9269999861717224},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8159999847412109},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/intravasation","display_name":"intravasation","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.9772999882698059},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6004999876022339},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5845999717712402},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5602999925613403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5443000197410583},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45649999380111694},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3544999957084656},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.3310000002384186},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3303999900817871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3125999867916107},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2542000114917755}],"mesh":[{"descriptor_ui":"D000078722","descriptor_name":"PC-3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053144","descriptor_name":"Cell Nucleus Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bpj.2026.09.001","doi":"https://doi.org/10.1016/j.bpj.2026.09.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2026.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmid:42693642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42693642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2026.09.001","doi":"https://doi.org/10.1016/j.bpj.2026.09.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2026.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6567022204399109,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3241809954","display_name":"PFC: Center for the Physics of Biological Function","funder_award_id":"1734030","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3487841166","display_name":null,"funder_award_id":"62127819","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3899842762","display_name":null,"funder_award_id":"2421003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5687007761","display_name":"Evolution Game Theory Modeling of Tumor Dormancy","funder_award_id":"1659940","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309292","display_name":"Princeton University","ror":"https://ror.org/00hx57361"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W782467378","https://openalex.org/W1038585844","https://openalex.org/W1495945591","https://openalex.org/W1599671876","https://openalex.org/W2010394923","https://openalex.org/W2016496152","https://openalex.org/W2019319762","https://openalex.org/W2030694827","https://openalex.org/W2043946666","https://openalex.org/W2060631540","https://openalex.org/W2063328565","https://openalex.org/W2063756151","https://openalex.org/W2064647932","https://openalex.org/W2069518226","https://openalex.org/W2087214757","https://openalex.org/W2134481788","https://openalex.org/W2142021578","https://openalex.org/W2151404354","https://openalex.org/W2163069245","https://openalex.org/W2196607495","https://openalex.org/W2323751645","https://openalex.org/W2555040012","https://openalex.org/W2580610149","https://openalex.org/W2605549867","https://openalex.org/W2605772872","https://openalex.org/W2803387836","https://openalex.org/W2810253525","https://openalex.org/W2885710012","https://openalex.org/W2887895233","https://openalex.org/W2891843147","https://openalex.org/W2943883981","https://openalex.org/W2971267238","https://openalex.org/W2979930460","https://openalex.org/W3082714059","https://openalex.org/W3107418969","https://openalex.org/W3111521801","https://openalex.org/W3122336120","https://openalex.org/W3160987595","https://openalex.org/W4224254765","https://openalex.org/W4281665512","https://openalex.org/W4281791847","https://openalex.org/W4291283009","https://openalex.org/W4308957828","https://openalex.org/W4309103031","https://openalex.org/W4311079783","https://openalex.org/W4319659370","https://openalex.org/W4376608926","https://openalex.org/W4380871251","https://openalex.org/W4389179040","https://openalex.org/W4391585716","https://openalex.org/W4403397640","https://openalex.org/W4404041787","https://openalex.org/W4405205568","https://openalex.org/W4409112141","https://openalex.org/W4414938868","https://openalex.org/W4415614574"],"related_works":["https://openalex.org/W4414011051","https://openalex.org/W7167100851","https://openalex.org/W7148848038","https://openalex.org/W2170634721","https://openalex.org/W2010843529","https://openalex.org/W1996326339","https://openalex.org/W2090194662","https://openalex.org/W3001569083","https://openalex.org/W2612102682","https://openalex.org/W1985869934"],"abstract_inverted_index":{"Most":[0],"cancer":[1,18,57],"deaths":[2],"result":[3],"from":[4,230],"metastasis,":[5],"yet":[6],"only":[7],"a":[8,60,69,83,137,212,255,277],"subset":[9,53],"of":[10,54,72,80,104,122,150,197,203,263],"tumor":[11,106,232],"cells":[12,19,58],"can":[13],"complete":[14],"this":[15,39],"process.":[16],"Polyaneuploid":[17],"(PACCs),":[20],"which":[21,88,225],"arise":[22],"via":[23],"endoreplication":[24],"under":[25,47,205],"stressors":[26],"such":[27],"as":[28,32,95,276],"hypoxia,":[29,50],"are":[30],"implicated":[31],"metastatic":[33],"drivers,":[34],"but":[35],"how":[36],"they":[37],"acquire":[38],"capacity":[40],"remains":[41],"unclear.":[42],"Here,":[43],"we":[44],"show":[45],"that":[46,66,155],"extreme":[48,206],"self-generated":[49,90],"the":[51,105,145,178,198,240,268],"polyaneuploid":[52],"PC3":[55],"prostate":[56],"upregulates":[59],"hypoxia-responsive,":[61],"HIF-1\u03b1-dependent":[62,139,217],"RhoA":[63,116,126,130,140,218,244],"signaling":[64,219,245],"axis":[65],"promotes":[67],"aerotaxis,":[68,128],"behavior":[70],"predictive":[71],"intravasation":[73],"during":[74],"metastasis.":[75],"We":[76],"observe":[77],"an":[78],"enrichment":[79],"PACCs":[81,111,204,275],"using":[82],"membrane-based":[84],"culture":[85],"system":[86],"in":[87,144,220,223,267],"extreme,":[89],"radial":[91],"oxygen":[92,97],"gradients":[93],"emerge":[94],"cellular":[96],"demand":[98],"exceeds":[99],"supply,":[100],"recapitulating":[101],"key":[102],"features":[103],"microenvironment.":[107],"Under":[108],"these":[109,209,272],"conditions,":[110],"exhibited":[112],"elevated":[113,243],"HIF-1\u03b1":[114,124,134],"and":[115,158,166,171,187,195,234,246,261],"expression":[117,131],"relative":[118],"to":[119],"non-PACCs.":[120],"Disruption":[121],"either":[123],"or":[125],"attenuates":[127],"with":[129,163,170,190,280],"suppressed":[132],"upon":[133],"inhibition,":[135],"suggesting":[136,192],"functional":[138,214],"pathway":[141],"selectively":[142],"enhanced":[143],"PACC":[146,180,269],"state.":[147,270],"Quantitative":[148],"analysis":[149],"nuclear":[151,156,164,175,185,200,248,252,265],"morphology":[152,160],"further":[153],"reveals":[154],"circularity":[157,186,249],"solidity,":[159],"metrics":[161],"associated":[162],"rounding":[165,194],"boundary":[167],"organization,":[168],"increase":[169],"saturate":[172],"at":[173,250],"high":[174],"area.":[176],"Notably,":[177],"hypoxic":[179,231],"population":[181],"exhibits":[182],"significantly":[183],"greater":[184],"solidity":[188],"compared":[189],"non-PACCs,":[191],"increased":[193,247],"stabilization":[196],"enlarged":[199,264],"architecture":[201,266],"characteristic":[202],"hypoxia.":[207],"Together,":[208],"findings":[210],"reveal":[211],"new":[213],"role":[215],"for":[216,282],"regulating":[221],"aerotaxis":[222],"PACCs,":[224],"may":[226],"enable":[227],"aerotactic":[228],"escape":[229],"cores":[233],"entry":[235],"into":[236],"oxygen-rich":[237],"vasculature.":[238],"Additionally,":[239],"association":[241],"between":[242,258],"larger":[251],"area":[253],"suggests":[254],"potential":[256],"link":[257],"hypoxia-responsive":[259],"migration":[260],"maintenance":[262],"Collectively,":[271],"characteristics":[273],"highlight":[274],"hypoxia-adapted":[278],"subpopulation":[279],"relevance":[281],"anti-metastatic":[283],"therapeutic":[284],"strategies.":[285]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-09-05T00:00:00"}
