{"id":"https://openalex.org/W7208726608","doi":"https://doi.org/10.1016/j.xops.2026.101320","title":"HONU: A Multicenter, Prospective, Observational Study of the Progression of Intermediate Age-Related Macular Degeneration","display_name":"HONU: A Multicenter, Prospective, Observational Study of the Progression of Intermediate Age-Related Macular Degeneration","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208726608","doi":"https://doi.org/10.1016/j.xops.2026.101320","pmid":"https://pubmed.ncbi.nlm.nih.gov/42787462","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13602060"},"language":"en","primary_location":{"id":"doi:10.1016/j.xops.2026.101320","doi":"https://doi.org/10.1016/j.xops.2026.101320","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xops.2026.101320","pdf_url":null,"source":{"id":"https://openalex.org/S4210240620","display_name":"Ophthalmology Science","issn_l":"2666-9145","issn":["2666-9145"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xops.2026.101320","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051997081","display_name":"Robyn H. Guymer","orcid":"https://orcid.org/0000-0002-9441-4356","observed_orcids":["https://orcid.org/0000-0002-9441-4356"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210089625","display_name":"The Royal Victorian Eye & Ear Hospital","ror":"https://ror.org/008q4kt04","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210089625"]},{"id":"https://openalex.org/I4210105949","display_name":"Centre for Eye Research Australia","ror":"https://ror.org/01sqdef20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210105949"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robyn H. Guymer","raw_affiliation_strings":["Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia","Ophthalmology Unit, Department of Surgery, The University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia","institution_ids":["https://openalex.org/I4210089625","https://openalex.org/I4210105949"]},{"raw_affiliation_string":"Ophthalmology Unit, Department of Surgery, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066629372","display_name":"Zhichao Wu","orcid":"https://orcid.org/0000-0002-8623-6684","observed_orcids":["https://orcid.org/0000-0002-8623-6684"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210089625","display_name":"The Royal Victorian Eye & Ear Hospital","ror":"https://ror.org/008q4kt04","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210089625"]},{"id":"https://openalex.org/I4210105949","display_name":"Centre for Eye Research Australia","ror":"https://ror.org/01sqdef20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210105949"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zhichao Wu","raw_affiliation_strings":["Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia","Ophthalmology Unit, Department of Surgery, The University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia","institution_ids":["https://openalex.org/I4210089625","https://openalex.org/I4210105949"]},{"raw_affiliation_string":"Ophthalmology Unit, Department of Surgery, The University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060843606","display_name":"Simon S. Gao","orcid":"https://orcid.org/0000-0002-7020-037X","observed_orcids":["https://orcid.org/0000-0002-7020-037X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon S. Gao","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140387265","display_name":"Miao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miao Zhang","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006688727","display_name":"Verena Steffen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Verena Steffen","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149995538","display_name":"Chen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101452981","display_name":"Jiameng Zhang","orcid":"https://orcid.org/0000-0002-2639-4090","observed_orcids":["https://orcid.org/0000-0002-2639-4090"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiameng Zhang","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077232827","display_name":"Katie M. Litts","orcid":"https://orcid.org/0000-0001-6707-8273","observed_orcids":["https://orcid.org/0000-0001-6707-8273"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie M. Litts","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101827388","display_name":"Michael Chang","orcid":"https://orcid.org/0000-0003-3063-6723","observed_orcids":["https://orcid.org/0000-0003-3063-6723"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Chang","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018725409","display_name":"Justin Elstrott","orcid":"https://orcid.org/0000-0001-6694-5929","observed_orcids":["https://orcid.org/0000-0001-6694-5929"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Elstrott","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135590681","display_name":"Brian Yaspan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Yaspan","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102549912","display_name":"Seema Datta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Datta","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007295289","display_name":"Jeffrey Ryuta Willis","orcid":"https://orcid.org/0000-0002-6712-1144","observed_orcids":["https://orcid.org/0000-0002-6712-1144"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Willis","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150013226","display_name":"Liang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Liu","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5150034092","display_name":"Hao Chen","orcid":"https://orcid.org/0009-0003-1083-1529","observed_orcids":["https://orcid.org/0009-0003-1083-1529"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":"https://orcid.org/0009-0003-1083-1529","affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5150034092"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70010209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"10","first_page":"101320","last_page":"101320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermediate-age-related-macular-degeneration","display_name":"intermediate age-related macular degeneration","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dry-age-related-macular-degeneration","display_name":"dry age-related macular degeneration","score":0.8220000267028809},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8379999995231628},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.843999981880188},{"id":"https://openalex.org/keywords/drusen","display_name":"drusen","score":0.7879999876022339},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ellipsoid-zone-loss","display_name":"ellipsoid zone loss","score":0.9269999861717224},{"id":"https://openalex.org/keywords/visual-function","display_name":"visual function","score":0.6380000114440918},{"id":"https://openalex.org/keywords/patient-enrichment","display_name":"patient enrichment","score":0.4449999928474426},{"id":"https://openalex.org/keywords/clinical-trial-endpoints","display_name":"clinical trial endpoints","score":0.878000020980835},{"id":"https://openalex.org/keywords/multimodal-retinal-imaging","display_name":"multimodal retinal imaging","score":0.8849999904632568},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7523000240325928},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.6729000210762024},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6043000221252441},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.426800012588501},{"id":"https://openalex.org/C2781116099","wikidata":"https://www.wikidata.org/wiki/Q3842207","display_name":"Maculopathy","level":4,"score":0.3407999873161316},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.24809999763965607},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24480000138282776}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xops.2026.101320","doi":"https://doi.org/10.1016/j.xops.2026.101320","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xops.2026.101320","pdf_url":null,"source":{"id":"https://openalex.org/S4210240620","display_name":"Ophthalmology Science","issn_l":"2666-9145","issn":["2666-9145"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13602060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13602060/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13602060/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmol Sci","raw_type":"Text"},{"id":"pmid:42787462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42787462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:21ba19507f1f4589ae8a393e1e6bf59d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/21ba19507f1f4589ae8a393e1e6bf59d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ophthalmology Science, Vol 6, Iss 10, Pp 101320- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xops.2026.101320","doi":"https://doi.org/10.1016/j.xops.2026.101320","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xops.2026.101320","pdf_url":null,"source":{"id":"https://openalex.org/S4210240620","display_name":"Ophthalmology Science","issn_l":"2666-9145","issn":["2666-9145"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1972642682","https://openalex.org/W1976041506","https://openalex.org/W1981111037","https://openalex.org/W2000975660","https://openalex.org/W2004117352","https://openalex.org/W2004808679","https://openalex.org/W2004961129","https://openalex.org/W2019947342","https://openalex.org/W2113404906","https://openalex.org/W2124415048","https://openalex.org/W2150098643","https://openalex.org/W2167414578","https://openalex.org/W2172569937","https://openalex.org/W2179516852","https://openalex.org/W2419255724","https://openalex.org/W2566154985","https://openalex.org/W2748339371","https://openalex.org/W2766820003","https://openalex.org/W2770269548","https://openalex.org/W2807327270","https://openalex.org/W2891443166","https://openalex.org/W2918173802","https://openalex.org/W2939910383","https://openalex.org/W2965133071","https://openalex.org/W2969224153","https://openalex.org/W2978000171","https://openalex.org/W2996572147","https://openalex.org/W3026717122","https://openalex.org/W3037093670","https://openalex.org/W3043154550","https://openalex.org/W3061527321","https://openalex.org/W3083820674","https://openalex.org/W3120919313","https://openalex.org/W3126472925","https://openalex.org/W3126712686","https://openalex.org/W3128947473","https://openalex.org/W3212519697","https://openalex.org/W4206959584","https://openalex.org/W4220655982","https://openalex.org/W4224212640","https://openalex.org/W4236738929","https://openalex.org/W4281484007","https://openalex.org/W4281606368","https://openalex.org/W4281608419","https://openalex.org/W4295185275","https://openalex.org/W4312095044","https://openalex.org/W4313382422","https://openalex.org/W4360871148","https://openalex.org/W4386552811","https://openalex.org/W4387344289","https://openalex.org/W4387784461","https://openalex.org/W4388018304","https://openalex.org/W4388744565","https://openalex.org/W4388975848","https://openalex.org/W4391430774","https://openalex.org/W4392564193","https://openalex.org/W4399038041","https://openalex.org/W4405260236","https://openalex.org/W4407195860","https://openalex.org/W4408535127","https://openalex.org/W4409037622"],"related_works":["https://openalex.org/W7204768852","https://openalex.org/W7214765572","https://openalex.org/W4293773177","https://openalex.org/W2020344616","https://openalex.org/W7128995620","https://openalex.org/W4409183274","https://openalex.org/W2945222800","https://openalex.org/W7143445814","https://openalex.org/W4415285502","https://openalex.org/W1179319101"],"abstract_inverted_index":{"Purpose:":[0],"Large":[1],"and":[2,55,78,94,125,141,155,186,199,249,259,282,296,322],"lengthy":[3],"clinical":[4,53,279],"trials":[5],"are":[6,111,144,152,166],"currently":[7],"required":[8,73,102],"to":[9,16,42,50,74,103,118,180,210,236,303,306],"study":[10,39,44,70,274],"the":[11,18,21,31,187,226,273,320,325],"efficacy":[12],"of":[13,20,24,33,84,107,134,173,189,225,247,298,327],"interventions":[14],"aiming":[15,302],"slow":[17,304],"progression":[19,266,305],"early":[22,299],"stages":[23],"age-related":[25],"macular":[26],"degeneration":[27],"(AMD).":[28],"To":[29],"enable":[30],"design":[32,295],"more":[34,181],"feasible":[35],"trials,":[36],"an":[37],"observational":[38,63],"HONU":[40,255],"aims":[41],"comprehensively":[43],"eyes":[45],"with":[46,121,158,269],"intermediate":[47],"AMD":[48,184,265],"(iAMD)":[49],"explore":[51],"novel":[52,135,277],"endpoints":[54,281],"patient":[56],"enrichment":[57,283],"strategies.":[58],"Design:":[59],"Prospective,":[60],"multicenter,":[61],"international":[62],"study.":[64],"Participants:":[65],"Four":[66],"hundred":[67],"patients,":[68,248],"whose":[69],"eye":[71,100],"is":[72,101,241],"have":[75,104],"large":[76],"drusen":[77],"pigmentary":[79],"change,":[80],"but":[81],"without":[82],"evidence":[83,106],"any":[85],"atrophic":[86,183],"changes":[87,148],"other":[88],"than":[89],"incomplete":[90],"retinal":[91,96,127],"pigment":[92],"epithelium":[93],"outer":[95],"atrophy.":[97,108],"The":[98,171,222,239],"nonstudy":[99],"some":[105],"Methods:":[109],"Patients":[110],"assessed":[112],"every":[113],"12":[114],"weeks":[115],"for":[116,208,285],"up":[117,209,245],"36":[119],"months,":[120],"standard":[122],"opthalmic":[123],"examinations":[124],"multimodal":[126,150],"imaging":[128,151],"as":[129,131,252],"well":[130],"a":[132],"range":[133],"visual":[136,159],"functional":[137],"tests.":[138],"Patient-reported":[139],"outcomes":[140],"biomarker":[142],"samples":[143],"also":[145],"collected.":[146],"Structural":[147],"on":[149,264],"evaluated":[153],"longitudinally":[154],"their":[156],"relationship":[157],"function":[160],"parameters":[161],"analyzed.":[162],"Exploratory":[163],"interim":[164],"analyses":[165],"planned.":[167],"Main":[168],"Outcome":[169],"Measures:":[170],"rates":[172],"conversion":[174],"from":[175,234],"baseline":[176,229],"high":[177],"risk":[178],"iAMD":[179,271],"advanced":[182],"stages,":[185],"rate":[188],"ellipsoid":[190],"zone":[191],"loss.":[192],"Results:":[193],"Recruitment":[194],"commenced":[195],"in":[196,267,272,319],"May":[197],"2022":[198],"400":[200],"patients":[201,227,268,287],"were":[202],"enrolled":[203],"by":[204],"August":[205],"2024,":[206],"allowing":[207],"3":[211],"years":[212],"follow-up.":[213],"Enrollment":[214],"occurred":[215],"at":[216,228,324],"72":[217],"sites":[218],"across":[219],"6":[220],"countries.":[221],"median":[223],"age":[224],"was":[230],"75":[231],"years,":[232],"ranging":[233],"50":[235],"93":[237],"years.":[238],"cohort":[240],"predominantly":[242],"female,":[243],"making":[244],"69%":[246],"95%":[250],"identified":[251],"White.":[253],"Conclusions:":[254],"will":[256,288,293],"provide":[257],"critical":[258],"robust":[260],"natural":[261],"history":[262],"data":[263],"high-risk":[270,286],"eye.":[275],"Potential":[276],"earlier":[278],"trial":[280],"strategy":[284],"be":[289,317],"determined.":[290],"Knowledge":[291],"gained":[292],"inform":[294],"feasibility":[297],"interventional":[300],"studies":[301],"vision-threatening":[307],"late":[308],"AMD.":[309],"Financial":[310],"Disclosures:":[311],"Proprietary":[312],"or":[313],"commercial":[314],"disclosure":[315],"may":[316],"found":[318],"Footnotes":[321],"Disclosures":[323],"end":[326],"this":[328],"article.":[329]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-05T00:00:00"}