{"id":"https://openalex.org/W7208724013","doi":"https://doi.org/10.1158/0008-5472.can-25-5578","title":"Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression","display_name":"Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208724013","doi":"https://doi.org/10.1158/0008-5472.can-25-5578","pmid":"https://pubmed.ncbi.nlm.nih.gov/42696459"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-25-5578","doi":"https://doi.org/10.1158/0008-5472.can-25-5578","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-5578","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/0008-5472.can-25-5578","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002789166","display_name":"Valerio Sabatino","orcid":"https://orcid.org/0000-0002-0424-813X","observed_orcids":["https://orcid.org/0000-0002-0424-813X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Valerio Sabatino","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0424-813X","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065946747","display_name":"Cong Tang","orcid":"https://orcid.org/0000-0003-1661-6793","observed_orcids":["https://orcid.org/0000-0003-1661-6793"]},"institutions":[{"id":"https://openalex.org/I4405252639","display_name":"Gulbenkian Institute for Molecular Medicine","ror":"https://ror.org/0346k0491","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cong Tang","raw_affiliation_strings":["3Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-1661-6793","affiliations":[{"raw_affiliation_string":"3Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405252639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030045958","display_name":"Rita C. Ac\u00farcio","orcid":"https://orcid.org/0000-0003-3412-1903","observed_orcids":["https://orcid.org/0000-0003-3412-1903"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita C. Ac\u00farcio","raw_affiliation_strings":["4Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-3412-1903","affiliations":[{"raw_affiliation_string":"4Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058924195","display_name":"Ana Raquel Coelho","orcid":"https://orcid.org/0000-0002-0965-7573","observed_orcids":["https://orcid.org/0000-0002-0965-7573"]},"institutions":[{"id":"https://openalex.org/I4405252639","display_name":"Gulbenkian Institute for Molecular Medicine","ror":"https://ror.org/0346k0491","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana R. Coelho","raw_affiliation_strings":["3Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-0965-7573","affiliations":[{"raw_affiliation_string":"3Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405252639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035155085","display_name":"Felix M\u00fcller","orcid":"https://orcid.org/0000-0003-2712-8832","observed_orcids":["https://orcid.org/0000-0003-2712-8832"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felix M. M\u00fcller","raw_affiliation_strings":["University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2712-8832","affiliations":[{"raw_affiliation_string":"University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023839658","display_name":"M\u00e1rcia Fontes","orcid":"https://orcid.org/0009-0006-5397-2550","observed_orcids":["https://orcid.org/0009-0006-5397-2550"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M\u00e1rcia Fontes","raw_affiliation_strings":["Champalimaud Foundation 5 Champalimaud Centre for the Unknown, , Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0009-0006-5397-2550","affiliations":[{"raw_affiliation_string":"Champalimaud Foundation 5 Champalimaud Centre for the Unknown, , Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116697134","display_name":"Wei Ting Khaw","orcid":"https://orcid.org/0009-0006-5101-341X","observed_orcids":["https://orcid.org/0009-0006-5101-341X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wei Ting Khaw","raw_affiliation_strings":["University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0006-5101-341X","affiliations":[{"raw_affiliation_string":"University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015729953","display_name":"Carlos Lab\u00e3o\u2010Almeida","orcid":"https://orcid.org/0000-0002-7797-3797","observed_orcids":["https://orcid.org/0000-0002-7797-3797"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]},{"id":"https://openalex.org/I4405252639","display_name":"Gulbenkian Institute for Molecular Medicine","ror":"https://ror.org/0346k0491","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4405252639"]}],"countries":["ES","PT"],"is_corresponding":false,"raw_author_name":"Carlos Lab\u00e3o-Almeida","raw_affiliation_strings":["3Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal","6Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7797-3797","affiliations":[{"raw_affiliation_string":"3Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405252639"]},{"raw_affiliation_string":"6Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045393365","display_name":"Derrick R. Hicks","orcid":"https://orcid.org/0000-0003-2950-1848","observed_orcids":["https://orcid.org/0000-0003-2950-1848"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrick R. Hicks","raw_affiliation_strings":["University of Washington 7 Department of Biochemistry, , Seattle, Washington","University of Washington 8 Institute for Protein Design, , Seattle, Washington"],"raw_orcid":"https://orcid.org/0000-0003-2950-1848","affiliations":[{"raw_affiliation_string":"University of Washington 7 Department of Biochemistry, , Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington 8 Institute for Protein Design, , Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362548","display_name":"Wei Yang","orcid":"https://orcid.org/0000-0003-0637-6327","observed_orcids":["https://orcid.org/0000-0003-0637-6327","https://orcid.org/0009-0008-0585-5362","https://orcid.org/0000-0002-9202-7395"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":["University of Washington 7 Department of Biochemistry, , Seattle, Washington","University of Washington 8 Institute for Protein Design, , Seattle, Washington"],"raw_orcid":"https://orcid.org/0000-0003-0637-6327","affiliations":[{"raw_affiliation_string":"University of Washington 7 Department of Biochemistry, , Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington 8 Institute for Protein Design, , Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019896576","display_name":"Aldrin V. Vasco","orcid":"https://orcid.org/0000-0003-1539-1721","observed_orcids":["https://orcid.org/0000-0003-1539-1721"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Aldrin Vasco Vidal","raw_affiliation_strings":["6Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid, Spain","University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1539-1721","affiliations":[{"raw_affiliation_string":"6Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086293308","display_name":"Irene Sarkar","orcid":"https://orcid.org/0009-0006-7349-9502","observed_orcids":["https://orcid.org/0009-0006-7349-9502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Sarkar","raw_affiliation_strings":["9Lumicks, Amsterdam, Netherlands"],"raw_orcid":"https://orcid.org/0009-0006-7349-9502","affiliations":[{"raw_affiliation_string":"9Lumicks, Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028678545","display_name":"Debarati Shome","orcid":"https://orcid.org/0009-0007-3724-8746","observed_orcids":["https://orcid.org/0009-0007-3724-8746","https://orcid.org/0000-0001-5992-883X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debarati Shome","raw_affiliation_strings":["9Lumicks, Amsterdam, Netherlands"],"raw_orcid":"https://orcid.org/0009-0007-3724-8746","affiliations":[{"raw_affiliation_string":"9Lumicks, Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089159177","display_name":"Mar Cabeza-Cabrerizo","orcid":"https://orcid.org/0000-0001-9061-058X","observed_orcids":["https://orcid.org/0000-0001-9061-058X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mar Cabeza-Cabrerizo","raw_affiliation_strings":["University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9061-058X","affiliations":[{"raw_affiliation_string":"University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009952080","display_name":"Theresa V. Rohm","orcid":"https://orcid.org/0000-0001-8498-1018","observed_orcids":["https://orcid.org/0000-0001-8498-1018"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa V. Rohm","raw_affiliation_strings":["University of California, San Diego 10 Division of Endocrinology and Metabolism, Department of Medicine, , La Jolla, California"],"raw_orcid":"https://orcid.org/0000-0001-8498-1018","affiliations":[{"raw_affiliation_string":"University of California, San Diego 10 Division of Endocrinology and Metabolism, Department of Medicine, , La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116697133","display_name":"Silvan Fleisch","orcid":"https://orcid.org/0009-0005-7946-2340","observed_orcids":["https://orcid.org/0009-0005-7946-2340"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Silvan Fleisch","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0005-7946-2340","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141282123","display_name":"Alexandra Gerber","orcid":"https://orcid.org/0009-0007-1761-0170","observed_orcids":["https://orcid.org/0009-0007-1761-0170"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexandra Gerber","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0007-1761-0170","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083188874","display_name":"Sabrina A. Hogan","orcid":"https://orcid.org/0000-0003-3994-8109","observed_orcids":["https://orcid.org/0000-0003-3994-8109"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sabrina A. Hogan","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3994-8109","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114575157","display_name":"Fiona Gerster","orcid":"https://orcid.org/0009-0000-6975-6517","observed_orcids":["https://orcid.org/0009-0000-6975-6517"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fiona Gerster","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0000-6975-6517","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030354210","display_name":"Deniz Kaymak","orcid":"https://orcid.org/0000-0002-0233-3453","observed_orcids":["https://orcid.org/0000-0002-0233-3453"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Deniz Kaymak","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0233-3453","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030739586","display_name":"Stanislav Pantelyushin","orcid":"https://orcid.org/0000-0002-3490-3860","observed_orcids":["https://orcid.org/0000-0002-3490-3860"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stanislav Pantelyushin","raw_affiliation_strings":["University of Zurich 11 Institute of Laboratory Animal Science, , Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3490-3860","affiliations":[{"raw_affiliation_string":"University of Zurich 11 Institute of Laboratory Animal Science, , Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086786279","display_name":"Johannes vom Berg","orcid":"https://orcid.org/0000-0002-4086-1564","observed_orcids":["https://orcid.org/0000-0002-4086-1564"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johannes vom Berg","raw_affiliation_strings":["University of Zurich 11 Institute of Laboratory Animal Science, , Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-4086-1564","affiliations":[{"raw_affiliation_string":"University of Zurich 11 Institute of Laboratory Animal Science, , Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150029958","display_name":"Lu Li","orcid":"https://orcid.org/0009-0007-7571-4998","observed_orcids":["https://orcid.org/0009-0007-7571-4998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu Li","raw_affiliation_strings":["12Gator Bio, Inc., Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0007-7571-4998","affiliations":[{"raw_affiliation_string":"12Gator Bio, Inc., Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008908090","display_name":"Rogier M. Reijmers","orcid":"https://orcid.org/0000-0001-7471-7715","observed_orcids":["https://orcid.org/0000-0001-7471-7715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rogier M. Reijmers","raw_affiliation_strings":["9Lumicks, Amsterdam, Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7471-7715","affiliations":[{"raw_affiliation_string":"9Lumicks, Amsterdam, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066784159","display_name":"Rita Fior","orcid":"https://orcid.org/0000-0001-5550-2428","observed_orcids":["https://orcid.org/0000-0001-5550-2428"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita Fior","raw_affiliation_strings":["Champalimaud Foundation 5 Champalimaud Centre for the Unknown, , Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5550-2428","affiliations":[{"raw_affiliation_string":"Champalimaud Foundation 5 Champalimaud Centre for the Unknown, , Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053192926","display_name":"David A. Baker","orcid":"https://orcid.org/0000-0001-7896-6217","observed_orcids":["https://orcid.org/0000-0001-7896-6217"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baker","raw_affiliation_strings":["University of Washington 13 Howard Hughes Medical Institute, , Seattle, Washington","University of Washington 7 Department of Biochemistry, , Seattle, Washington","University of Washington 8 Institute for Protein Design, , Seattle, Washington"],"raw_orcid":"https://orcid.org/0000-0001-7896-6217","affiliations":[{"raw_affiliation_string":"University of Washington 13 Howard Hughes Medical Institute, , Seattle, Washington","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington 7 Department of Biochemistry, , Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington 8 Institute for Protein Design, , Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081793497","display_name":"Helena F. Florindo","orcid":"https://orcid.org/0000-0002-4006-5840","observed_orcids":["https://orcid.org/0000-0002-4006-5840"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Helena F. Florindo","raw_affiliation_strings":["4Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-4006-5840","affiliations":[{"raw_affiliation_string":"4Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022950451","display_name":"Gregor H\u00fctter","orcid":"https://orcid.org/0000-0002-7570-3902","observed_orcids":["https://orcid.org/0000-0002-7570-3902"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gregor Hutter","raw_affiliation_strings":["2Department of Biomedicine, Basel University Hospital, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7570-3902","affiliations":[{"raw_affiliation_string":"2Department of Biomedicine, Basel University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050238909","display_name":"Gon\u00e7alo J. L. Bernardes","orcid":"https://orcid.org/0000-0001-6594-8917","observed_orcids":["https://orcid.org/0000-0001-6594-8917"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES","GB"],"is_corresponding":true,"raw_author_name":"Gon\u00e7alo J.L. Bernardes","raw_affiliation_strings":["6Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid, Spain","University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6594-8917","affiliations":[{"raw_affiliation_string":"6Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"University of Cambridge 1 Yusuf Hamied Department of Chemistry, , Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5050238909"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089594"],"apc_list":null,"apc_paid":null,"fwci":2.4016,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82769208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"OF1","last_page":"OF20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.24789999425411224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment-remodeling","display_name":"tumor microenvironment remodeling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7080000042915344},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"neuropilin-1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tuftsin","display_name":"tuftsin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-phagocytosis","display_name":"tumor phagocytosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/macrophage-reprogramming","display_name":"macrophage reprogramming","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.5740000009536743},{"id":"https://openalex.org/keywords/magrolimab","display_name":"magrolimab","score":0.6970000267028809},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/albumin-binding-domain","display_name":"albumin-binding domain","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6266999840736389},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5347999930381775},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4909999966621399},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4894999861717224},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4514000117778778},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4325000047683716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4205999970436096},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4106999933719635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3968999981880188},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.367900013923645},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.33809998631477356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.32429999113082886},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.30059999227523804},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.29989999532699585},{"id":"https://openalex.org/C168261976","wikidata":"https://www.wikidata.org/wiki/Q5347407","display_name":"Efferocytosis","level":4,"score":0.2906999886035919},{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C2779482015","wikidata":"https://www.wikidata.org/wiki/Q17121648","display_name":"Tumor-associated macrophage","level":4,"score":0.2777000069618225},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.2761000096797943},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26489999890327454},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.26179999113082886},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2574000060558319},{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C2778017598","wikidata":"https://www.wikidata.org/wiki/Q7390325","display_name":"SIGLEC","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25450000166893005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-25-5578","doi":"https://doi.org/10.1158/0008-5472.can-25-5578","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-5578","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:42696459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42696459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-25-5578","doi":"https://doi.org/10.1158/0008-5472.can-25-5578","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-5578","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G26688402","display_name":"Phagocytic Synapse Enhancers for the Immunotherapy of Cancer","funder_award_id":"217904","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3999658136","display_name":null,"funder_award_id":"2022.08101.CEECIND","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4747903521","display_name":"Combined Microglia Modulation and Tumor Targeting Against Glioblastoma","funder_award_id":"176974","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4993928010","display_name":"Nano-Immunotherapy Decoding and Targeting Immune Checkpoint-resistant Tumors","funder_award_id":"2023.08262.CEECIND/CP2843/CT0002","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G683472059","display_name":null,"funder_award_id":"KFS\u20104382\u201002\u20102018","funder_id":"https://openalex.org/F4320327941","funder_display_name":"Swiss Cancer Research Foundation"},{"id":"https://openalex.org/G8311708764","display_name":"Reversible PROTACs for Targeted Cancer Therapy","funder_award_id":"202711","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G9001171226","display_name":null,"funder_award_id":"24B120","funder_id":"https://openalex.org/F4320310389","funder_display_name":"Novartis Foundation"},{"id":"https://openalex.org/G9001174636","display_name":null,"funder_award_id":"2023.06183.CEECIND","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G9001174674","display_name":null,"funder_award_id":"LCF/PR/HR24/00968","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G9001175811","display_name":null,"funder_award_id":"KFS 5789-02-2023","funder_id":"https://openalex.org/F4320327941","funder_display_name":"Swiss Cancer Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320310389","display_name":"Novartis Foundation","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320327941","display_name":"Swiss Cancer Research Foundation","ror":"https://ror.org/022wnsy59"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408609530","https://openalex.org/W4416085269","https://openalex.org/W7220417389","https://openalex.org/W7161975425","https://openalex.org/W2972667717","https://openalex.org/W3094427275","https://openalex.org/W4386859687","https://openalex.org/W4401112748","https://openalex.org/W6923496645","https://openalex.org/W2994680571"],"abstract_inverted_index":{"Current":[0],"immunotherapies":[1,202],"often":[2],"fail":[3],"in":[4,22,75,138,162],"immunologically":[5],"\"cold\",":[6],"macrophage-rich":[7],"tumor":[8,56,60,141],"microenvironments":[9],"(TMEs).":[10],"Multi-targeting":[11],"approaches":[12],"that":[13,186],"modulate":[14],"innate-adaptive":[15],"immune":[16,36,191,212],"activation":[17],"represent":[18],"a":[19,32,39,45,107,139,170,197,205,208],"promising":[20],"frontier":[21],"cancer":[23,145],"immunotherapy.":[24],"Here,":[25],"we":[26],"developed":[27],"phagocytic":[28],"synapse":[29],"enhancers":[30],"(PSEs),":[31],"class":[33],"of":[34,86,143,150,172,211],"modular":[35],"engagers":[37,213],"comprising":[38],"high-affinity":[40],"PD-L1":[41,61],"binder":[42],"coupled":[43],"to":[44,62,123],"macrophage-stimulating":[46],"peptide,":[47],"tuftsin.":[48],"PSEs":[49,72,101,182],"strengthened":[50],"effector-target":[51],"cell":[52],"interactions":[53],"and":[54,83,105,111,118,146,165,175,189,203],"enhanced":[55],"phagocytosis":[57],"by":[58,158],"bridging":[59],"macrophage":[63,103,135],"neuropilin-1":[64],"(NRP1),":[65],"bypassing":[66],"the":[67,81,91,95,124,134,156,163],"classical":[68],"Fc\u03b3R-dependent":[69],"pathways.":[70,217],"The":[71,114,193],"also":[73],"acted":[74],"cis":[76],"on":[77],"PD-L1+":[78],"macrophages,":[79],"accelerating":[80],"endocytosis":[82],"lysosomal":[84],"compartmentalization":[85],"surface":[87],"PD-L1,":[88],"therefore":[89],"stripping":[90],"immunosuppressive":[92],"checkpoint":[93],"from":[94],"local":[96],"microenvironment.":[97],"Beyond":[98],"physical":[99],"clearance,":[100],"reprogrammed":[102],"phenotype":[104],"triggered":[106],"robust":[108],"pro-inflammatory":[109],"cytokine":[110],"chemokine":[112],"response.":[113],"lead":[115],"molecule,":[116],"longPSE,":[117,129],"its":[119],"half-life-extended":[120],"variant":[121],"fused":[122],"albumin":[125],"binding":[126],"domain,":[127],"ABD-":[128],"showcased":[130],"superior":[131],"efficacy":[132],"than":[133],"enhancer":[136],"magrolimab":[137],"syngeneic":[140],"model":[142,149],"colorectal":[144],"an":[147],"orthotopic":[148],"pancreatic":[151],"cancer.":[152],"PSE":[153],"treatment":[154],"remodeled":[155],"TME":[157],"inducing":[159],"phenotypic":[160],"changes":[161],"lymphoid":[164],"myeloid":[166],"compartments,":[167],"together":[168],"with":[169],"reduction":[171],"tumor-associated":[173],"macrophages":[174],"regulatory":[176],"T":[177],"cells.":[178],"These":[179],"findings":[180],"establish":[181],"as":[183],"bifunctional":[184,194],"molecules":[185],"complement":[187],"innate":[188],"adaptive":[190],"modulation.":[192],"design":[195],"offers":[196],"versatile":[198],"approach":[199],"for":[200,207],"next-generation":[201],"provides":[204],"blueprint":[206],"plug-and-play":[209],"platform":[210],"targeting":[214],"diverse":[215],"cancer-associated":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-05T00:00:00"}
