{"id":"https://openalex.org/W7208717922","doi":"https://doi.org/10.48550/arxiv.2609.04029","title":"Mechanistic Framework for Multicomponent Nanoparticle Assembly: Predicting RNA-lipid and PEI-DNA nanoparticle assembly","display_name":"Mechanistic Framework for Multicomponent Nanoparticle Assembly: Predicting RNA-lipid and PEI-DNA nanoparticle assembly","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7208717922","doi":"https://doi.org/10.48550/arxiv.2609.04029"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2609.04029","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.04029","pdf_url":"https://arxiv.org/pdf/2609.04029","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2609.04029","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006146560","display_name":"Turash Haque Pial","orcid":"https://orcid.org/0000-0002-6038-7900","observed_orcids":["https://orcid.org/0000-0002-6038-7900"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pial, Turash Haque","raw_affiliation_strings":[") Department of Materials Science and Engineering , Johns Hopkins University , Baltimore , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":") Department of Materials Science and Engineering , Johns Hopkins University , Baltimore , USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083901218","display_name":"Tine Curk","orcid":"https://orcid.org/0000-0002-2167-5336","observed_orcids":["https://orcid.org/0000-0002-2167-5336"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curk, Tine","raw_affiliation_strings":[") Department of Materials Science and Engineering , Johns Hopkins University , Baltimore , USA",") Department of Physics and Astronomy , Johns Hopkins University , Baltimore , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":") Department of Materials Science and Engineering , Johns Hopkins University , Baltimore , USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":") Department of Physics and Astronomy , Johns Hopkins University , Baltimore , USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12274","display_name":"Electrostatics and Colloid Interactions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetic-monte-carlo","display_name":"kinetic Monte Carlo","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mrna-lipid-nanoparticles","display_name":"mRNA lipid nanoparticles","score":0.8799999952316284},{"id":"https://openalex.org/keywords/particle-coalescence","display_name":"particle coalescence","score":0.625},{"id":"https://openalex.org/keywords/solvent-exchange","display_name":"solvent exchange","score":0.6940000057220459},{"id":"https://openalex.org/keywords/nucleation-and-growth","display_name":"nucleation and growth","score":0.7250000238418579},{"id":"https://openalex.org/keywords/log-normal-size-distribution","display_name":"log-normal size distribution","score":0.6499999761581421},{"id":"https://openalex.org/keywords/payload-distribution","display_name":"payload distribution","score":0.621999979019165},{"id":"https://openalex.org/keywords/compositional-heterogeneity","display_name":"compositional heterogeneity","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6478000283241272},{"id":"https://openalex.org/C149792144","wikidata":"https://www.wikidata.org/wiki/Q2071902","display_name":"Coalescence (physics)","level":2,"score":0.569100022315979},{"id":"https://openalex.org/C45786274","wikidata":"https://www.wikidata.org/wiki/Q3333611","display_name":"Kinetic Monte Carlo","level":3,"score":0.5630000233650208},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4625999927520752},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.4499000012874603},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4244999885559082},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.38749998807907104},{"id":"https://openalex.org/C114466953","wikidata":"https://www.wikidata.org/wiki/Q6034165","display_name":"Initialization","level":2,"score":0.3781999945640564},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.37720000743865967},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3752000033855438},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.35600000619888306},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3449999988079071},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.33230000734329224},{"id":"https://openalex.org/C42747912","wikidata":"https://www.wikidata.org/wiki/Q1048447","display_name":"Multiplicative function","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C138777275","wikidata":"https://www.wikidata.org/wiki/Q6884054","display_name":"Mixing (physics)","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30079999566078186},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C134066672","wikidata":"https://www.wikidata.org/wiki/Q1424639","display_name":"Payload (computing)","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C144082473","wikidata":"https://www.wikidata.org/wiki/Q213185","display_name":"Stoichiometry","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2609.04029","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.04029","pdf_url":"https://arxiv.org/pdf/2609.04029","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2609.04029","doi":"https://doi.org/10.48550/arxiv.2609.04029","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2609.04029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2609.04029","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.04029","pdf_url":"https://arxiv.org/pdf/2609.04029","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5945091033","display_name":"MRI: Acquisition of an Advanced Computing Instrument to Integrate Data-Driven Research and Data intensive computing at Johns Hopkins University","funder_award_id":"1920103","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208717922.pdf","grobid_xml":"https://content.openalex.org/works/W7208717922.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W7124586033","https://openalex.org/W7155915432"],"related_works":["https://openalex.org/W1971149274","https://openalex.org/W2093024669","https://openalex.org/W4296700373","https://openalex.org/W3006623820","https://openalex.org/W2301137214","https://openalex.org/W7124586033","https://openalex.org/W2952051444","https://openalex.org/W4416867094","https://openalex.org/W7220737832","https://openalex.org/W7155915432"],"abstract_inverted_index":{"The":[0,61,115,137,152],"assembly":[1,108],"of":[2,89,127,174],"multicomponent":[3,175],"nanoparticles":[4],"is":[5,140],"often":[6],"kinetically":[7],"controlled":[8],"and":[9,18,51,71,73,84,102,130,154,165],"exhibits":[10],"strong":[11],"pathway":[12],"dependence.":[13],"Transport,":[14],"solvent":[15],"exchange,":[16],"nucleation/growth,":[17],"collision-driven":[19],"coalescence":[20],"together":[21],"determine":[22],"not":[23],"only":[24],"ensemble-averaged":[25],"properties":[26],"but":[27],"also":[28,141],"particle-to-particle":[29],"compositional":[30],"heterogeneity.":[31],"Here,":[32],"we":[33],"present":[34],"a":[35,160,171],"computational":[36],"modeling":[37],"framework":[38,62,139,153],"for":[39],"predicting":[40,164],"nanoparticle":[41,176],"property":[42,168],"distributions":[43,132,169],"by":[44],"coupling":[45],"processing":[46],"conditions,":[47],"early-stage":[48],"self-assembly":[49],"physics,":[50],"molecular":[52],"chemical":[53],"details":[54],"with":[55,67],"kinetic":[56],"Monte":[57],"Carlo":[58],"(kMC)":[59],"simulations.":[60],"combines":[63],"(i)":[64],"mixing":[65],"conditions":[66],"solvent-exchange-mediated":[68],"particle":[69],"initialization":[70],"growth,":[72],"(ii)":[74],"kMC":[75,116],"simulations":[76,117],"that":[77],"resolve":[78],"stochastic":[79],"collision":[80],"histories,":[81,122],"electrostatics-controlled":[82],"coalescence,":[83],"composition":[85],"at":[86],"the":[87,97,125],"level":[88],"individual":[90],"particles.":[91],"Applied":[92],"to":[93,111,143,163],"mRNA":[94],"lipid":[95],"nanoparticles,":[96],"model":[98],"predicts":[99],"size-loading":[100],"correlations":[101],"provides":[103],"insight":[104],"into":[105],"how":[106],"processing-dependent":[107],"pathways":[109],"lead":[110],"heterogeneous":[112],"payload":[113,131],"distributions.":[114,151],"further":[118],"provide":[119,159],"merging":[120],"lineage":[121],"which":[123],"explain":[124],"emergence":[126],"log-normal":[128],"volume":[129],"through":[133],"multiplicative":[134],"particle-growth":[135],"pathways.":[136],"same":[138],"applied":[142],"PEI-DNA":[144],"polyelectrolytic":[145],"complexation,":[146],"yielding":[147],"single-particle-resolved":[148],"DNA-PEI":[149],"stoichiometry":[150],"its":[155],"open-source":[156],"implementation,":[157],"FormLNP,":[158],"process-aware":[161],"route":[162],"controlling":[166],"single-particle":[167],"across":[170],"broad":[172],"range":[173],"systems.":[177]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-05T00:00:00"}