{"id":"https://openalex.org/W7208716628","doi":"https://doi.org/10.64898/2026.09.01.26359217","title":"PrEgabalin for Treatment Resistant generalised Anxiety disorder","display_name":"PrEgabalin for Treatment Resistant generalised Anxiety disorder","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7208716628","doi":"https://doi.org/10.64898/2026.09.01.26359217"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.26359217","doi":"https://doi.org/10.64898/2026.09.01.26359217","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.26359217","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.01.26359217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055543220","display_name":"Glyn Lewis","orcid":"https://orcid.org/0000-0001-5205-8245","observed_orcids":["https://orcid.org/0000-0001-5205-8245"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Glyn Lewis","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031103837","display_name":"Nick Freemantle","orcid":"https://orcid.org/0000-0001-5807-5740","observed_orcids":["https://orcid.org/0000-0001-5807-5740"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Freemantle","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079928499","display_name":"Hakim\u2010Moulay Dehbi","orcid":"https://orcid.org/0000-0002-0816-0178","observed_orcids":["https://orcid.org/0000-0002-0816-0178"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hakim-Moulay Dehbi","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5126715712","display_name":"Charlotte Clarke","orcid":"https://orcid.org/0000-0002-1296-2229","observed_orcids":["https://orcid.org/0000-0002-1296-2229"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte Clarke","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07819999754428864,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":0.9900000095367432},{"id":"https://openalex.org/keywords/treatment-resistant-anxiety","display_name":"treatment-resistant anxiety","score":0.9549999833106995},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.8050000071525574},{"id":"https://openalex.org/keywords/gad-7","display_name":"GAD-7","score":0.7820000052452087},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.7250000238418579},{"id":"https://openalex.org/keywords/statistical-analysis-plan","display_name":"statistical analysis plan","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.9332000017166138},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.7102000117301941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6906999945640564},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6500999927520752},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.6431999802589417},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6349999904632568},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.5501000285148621},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.48159998655319214},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4092999994754791},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.36000001430511475},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C2994577977","wikidata":"https://www.wikidata.org/wiki/Q1203526","display_name":"Pilot trial","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25459998846054077},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.2515000104904175},{"id":"https://openalex.org/C41260284","wikidata":"https://www.wikidata.org/wiki/Q6956315","display_name":"N of 1 trial","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.26359217","doi":"https://doi.org/10.64898/2026.09.01.26359217","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.26359217","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.26359217","doi":"https://doi.org/10.64898/2026.09.01.26359217","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.26359217","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1968895338","https://openalex.org/W2013564592","https://openalex.org/W2018098567","https://openalex.org/W2027887147","https://openalex.org/W2043705607","https://openalex.org/W2092052931","https://openalex.org/W2102133850","https://openalex.org/W2106203584","https://openalex.org/W2141232381","https://openalex.org/W2151182129","https://openalex.org/W2156104108","https://openalex.org/W2330478546","https://openalex.org/W2747576011","https://openalex.org/W2974841401","https://openalex.org/W3080413193","https://openalex.org/W3084310148","https://openalex.org/W3204219363","https://openalex.org/W4225577030","https://openalex.org/W4409417735","https://openalex.org/W7140217561"],"related_works":["https://openalex.org/W7206190690","https://openalex.org/W2626339997","https://openalex.org/W2145424603","https://openalex.org/W2088812358","https://openalex.org/W2115663250","https://openalex.org/W2333591955","https://openalex.org/W2379828444","https://openalex.org/W938757096","https://openalex.org/W1979125626","https://openalex.org/W2132270420"],"abstract_inverted_index":{"ABSTRACT":[0],"This":[1],"document":[2],"describes":[3],"the":[4,40,44],"Statistical":[5],"Analysis":[6],"Plan":[7],"(SAP)":[8],"for":[9],"PETRA,":[10],"a":[11],"randomised":[12],"controlled":[13],"trial":[14],"in":[15],"people":[16],"with":[17,29,37],"generalised":[18],"anxiety":[19],"disorder":[20],"comparing":[21],"pregabalin":[22],"plus":[23,31],"an":[24,32],"antidepressant":[25,33],"and":[26,34],"standard":[27,35],"care,":[28,36],"placebo":[30],"respect":[38],"to":[39],"primary":[41],"outcome":[42],"of":[43],"GAD-7":[45],"score":[46],"at":[47],"week":[48],"12.":[49]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-05T00:00:00"}