{"id":"https://openalex.org/W7208665693","doi":null,"title":"TGF-beta\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u8131\u5206\u5316\u306b\u3088\u308b\u764c\u5e79\u7d30\u80de\u6027\u306e\u7372\u5f97","display_name":"TGF-beta\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u8131\u5206\u5316\u306b\u3088\u308b\u764c\u5e79\u7d30\u80de\u6027\u306e\u7372\u5f97","publication_year":2019,"publication_date":"2019-03-31","ids":{"openalex":"https://openalex.org/W7208665693"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005981701","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2324/2236122","pdf_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/2236122/med3238_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/2236122/med3238_abstract.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019459271","display_name":"Michitaka Nakano","orcid":"https://orcid.org/0000-0003-1049-5791","observed_orcids":["https://orcid.org/0000-0003-1049-5791"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nakano, Michitaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019459271"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.968999981880188},{"id":"https://openalex.org/keywords/dedifferentiation","display_name":"dedifferentiation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3467000126838684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32269999384880066},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2515999972820282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24300000071525574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22910000383853912},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22259999811649323}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005981701","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2324/2236122","pdf_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/2236122/med3238_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005981701","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2324/2236122","pdf_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/2236122/med3238_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208665693.pdf","grobid_xml":"https://content.openalex.org/works/W7208665693.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3184261806","https://openalex.org/W2312450511","https://openalex.org/W7208697285","https://openalex.org/W7146370071","https://openalex.org/W2752213732","https://openalex.org/W7029580935","https://openalex.org/W3007259991","https://openalex.org/W3210501634","https://openalex.org/W2516572548","https://openalex.org/W7207762582"],"abstract_inverted_index":{"Dedifferentiation":[0],"process":[1],"driven":[2],"by":[3],"TGF-beta":[4],"signaling":[5],"enhances":[6],"stem":[7],"cell":[8],"properties":[9],"in":[10],"human":[11],"colorectal":[12],"cancer":[13]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2026-09-04T00:00:00"}