{"id":"https://openalex.org/W7208465366","doi":null,"title":"\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u304a\u3051\u308b\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u5408\u4f75\u306e\u81e8\u5e8a\u7684\u91cd\u8981\u6027 : \u30b3\u30ea\u30f3\u6b20\u4e4f\u304c\u30de\u30a6\u30b9\u5b9f\u9a13\u8178\u708e\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308b\u57fa\u790e\u7684\u691c\u8a0e\u3092\u542b\u3081\u3066 1.\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u304a\u3051\u308bNAFLD\u5408\u4f75\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u306b\u95a2\u3059\u308b\u691c\u8a0e 2.\u30b3\u30ea\u30f3\u6b20\u4e4f\u304c\u30de\u30a6\u30b9\u5b9f\u9a13\u8178\u708e\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308b\u691c\u8a0e","display_name":"\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u304a\u3051\u308b\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u5408\u4f75\u306e\u81e8\u5e8a\u7684\u91cd\u8981\u6027 : \u30b3\u30ea\u30f3\u6b20\u4e4f\u304c\u30de\u30a6\u30b9\u5b9f\u9a13\u8178\u708e\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308b\u57fa\u790e\u7684\u691c\u8a0e\u3092\u542b\u3081\u3066 1.\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u304a\u3051\u308bNAFLD\u5408\u4f75\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u306b\u95a2\u3059\u308b\u691c\u8a0e 2.\u30b3\u30ea\u30f3\u6b20\u4e4f\u304c\u30de\u30a6\u30b9\u5b9f\u9a13\u8178\u708e\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308b\u691c\u8a0e","publication_year":2017,"publication_date":"2017-03-23","ids":{"openalex":"https://openalex.org/W7208465366"},"language":"en","primary_location":{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02004341","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2004341","pdf_url":"https://hiroshima.repo.nii.ac.jp/record/2004341/files/k7264_1.pdf","source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hiroshima.repo.nii.ac.jp/record/2004341/files/k7264_1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014935303","display_name":"Shintaro Sagami","orcid":"https://orcid.org/0000-0002-1202-8161","observed_orcids":["https://orcid.org/0000-0002-1202-8161"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"\u4f50\u4e0a, \u664b\u592a\u90ce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014935303"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/choline-deficiency","display_name":"choline deficiency","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/methionine-and-choline-deficient-diet","display_name":"methionine-choline-deficient diet","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cxcr6","display_name":"CXCR6","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8309999704360962},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.7419999837875366},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7229999899864197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5511000156402588},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5396999716758728},{"id":"https://openalex.org/C2780941987","wikidata":"https://www.wikidata.org/wiki/Q3796380","display_name":"Ileitis","level":4,"score":0.4505000114440918},{"id":"https://openalex.org/C2779237934","wikidata":"https://www.wikidata.org/wiki/Q7643652","display_name":"Mesenteric lymph nodes","level":3,"score":0.4462999999523163},{"id":"https://openalex.org/C2778607024","wikidata":"https://www.wikidata.org/wiki/Q4216825","display_name":"CD1D","level":5,"score":0.4406000077724457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.423799991607666},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3391000032424927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31779998540878296},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30570000410079956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29840001463890076},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.2912999987602234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28209999203681946},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.2597000002861023},{"id":"https://openalex.org/C94205230","wikidata":"https://www.wikidata.org/wiki/Q5005868","display_name":"C-C chemokine receptor type 6","level":5,"score":0.25940001010894775},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.2590000033378601}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02004341","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2004341","pdf_url":"https://hiroshima.repo.nii.ac.jp/record/2004341/files/k7264_1.pdf","source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"pmh:oai:irdb.nii.ac.jp:01372:0006658196","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2004341","pdf_url":"https://hiroshima.repo.nii.ac.jp/record/2004341/files/k7264_3-2.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02004341","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2004341","pdf_url":"https://hiroshima.repo.nii.ac.jp/record/2004341/files/k7264_1.pdf","source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208465366.pdf","grobid_xml":"https://content.openalex.org/works/W7208465366.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W73649259","https://openalex.org/W1768853402","https://openalex.org/W1966525151","https://openalex.org/W1966916901","https://openalex.org/W1969201936","https://openalex.org/W1972416270","https://openalex.org/W1974374532","https://openalex.org/W1977340713","https://openalex.org/W1979217507","https://openalex.org/W1981005478","https://openalex.org/W1988706813","https://openalex.org/W1992791066","https://openalex.org/W1997831022","https://openalex.org/W2014562911","https://openalex.org/W2027234413","https://openalex.org/W2035588804","https://openalex.org/W2038904723","https://openalex.org/W2040148868","https://openalex.org/W2047733598","https://openalex.org/W2056908987","https://openalex.org/W2066203385","https://openalex.org/W2067740038","https://openalex.org/W2073343574","https://openalex.org/W2075988234","https://openalex.org/W2077417036","https://openalex.org/W2077724247","https://openalex.org/W2078621117","https://openalex.org/W2081536518","https://openalex.org/W2106322659","https://openalex.org/W2108389937","https://openalex.org/W2110385952","https://openalex.org/W2110758916","https://openalex.org/W2116375475","https://openalex.org/W2121756640","https://openalex.org/W2123625556","https://openalex.org/W2131254788","https://openalex.org/W2135810789","https://openalex.org/W2136589770","https://openalex.org/W2139464173","https://openalex.org/W2147163488","https://openalex.org/W2155808278","https://openalex.org/W2289068089","https://openalex.org/W2334542234","https://openalex.org/W2339286393"],"related_works":["https://openalex.org/W2576359618","https://openalex.org/W2336443963","https://openalex.org/W3049074705","https://openalex.org/W2217922687","https://openalex.org/W2724919434","https://openalex.org/W7029072941","https://openalex.org/W3182065708","https://openalex.org/W1974374532","https://openalex.org/W2548496569","https://openalex.org/W4396220593"],"abstract_inverted_index":{"Serum":[0],"levels":[1,56,79],"of":[2,22,28,41,57,80,88,105,137,151,183,199,215],"choline":[3,23,42,234,252],"and":[4,72,76,118,164,189,193,201,243,268],"its":[5],"derivatives":[6],"are":[7],"lower":[8],"in":[9,17,44,50,65,85,95,120,127,142,154,186,196,205,210,225,248],"patients":[10],"with":[11,93,217,228],"inflammatory":[12],"bowel":[13],"disease":[14],"(IBD)":[15],"than":[16],"healthy":[18],"individuals.However,":[19],"the":[20,26,34,39,55,66,78,86,106,125,128,135,149,173,197],"effect":[21],"deficiency":[24,43,235,253],"on":[25,124],"severity":[27,150],"colitis":[29,49,143,153,224,250],"has":[30],"not":[31,209],"been":[32],"investigated.In":[33],"present":[35],"study,":[36],"we":[37,147],"investigated":[38],"role":[40,136],"dextran":[45],"sulfate":[46],"sodium":[47],"(DSS)-induced":[48],"mice.Methionine-choline-deficient":[51],"(MCD)":[52],"diet":[53,179],"lowered":[54],"type":[58,81,129,138,155,162,165,218,238,257,264],"II":[59,82,130,139,166,219,239,258,265],"natural":[60],"killer":[61],"T":[62],"(NKT)":[63],"cells":[64,84,141,204,221],"colonic":[67],"lamina":[68],"propria,":[69],"peritoneal":[70],"cavity,":[71],"mesenteric":[73],"lymph":[74],"nodes,":[75],"increased":[77],"NKT":[83,112,131,140,157,167,203,220,240,259,266],"livers":[87],"wild-type":[89],"B6":[90],"mice":[91,96,171],"compared":[92],"that":[94,233],"fed":[97,172],"a":[98,121,194],"control":[99],"(CTR)":[100],"diet.The":[101],"gene":[102],"expression":[103],"pattern":[104],"chemokine":[107],"receptor":[108],"CXCR6,":[109],"which":[110],"promotes":[111],"cell":[113,132,241,267],"accumulation,":[114],"varied":[115],"between":[116],"colon":[117],"liver":[119],"manner":[122],"dependent":[123],"changes":[126],"levels.To":[133],"examine":[134],"under":[144,251],"choline-deficient":[145],"conditions,":[146],"assessed":[148],"DSS-induced":[152,223,245,249],"I":[156,163],"cell-deficient":[158,168],"(J\u03b118":[159],"-/-)":[160,170],"or":[161,175],"(CD1d":[169],"MCD":[174,178,229],"CTR":[176],"diets.The":[177],"led":[180],"to":[181],"amelioration":[182],"inflammation,":[184],"decreases":[185],"interferon":[187],"(IFN)-\u03b3":[188],"interleukin":[190],"(IL)-4":[191],"secretion,":[192],"decrease":[195],"number":[198],"IFN-\u03b3":[200],"IL-4-producing":[202],"J\u03b118":[206,226],"-/-mice":[207,227],"but":[208],"CD1d":[211],"-/-mice.Finally,":[212],"adaptive":[213],"transfer":[214],"lymphocytes":[216],"exacerbated":[222],"diet.These":[230],"results":[231],"suggest":[232],"causes":[236],"proinflammatory":[237,269],"loss":[242],"alleviates":[244],"colitis.Thus,":[246],"inflammation":[247],"is":[254],"caused":[255],"by":[256],"cell-dependent":[260],"mechanisms,":[261],"including":[262],"decreased":[263],"cytokine":[270],"levels.":[271]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-09-04T00:00:00"}