{"id":"https://openalex.org/W7208420271","doi":null,"title":"Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1","display_name":"Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W7208420271"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:07557:0007269714","doi":null,"is_oa":true,"landing_page_url":"https://kyu-dent.repo.nii.ac.jp/records/2000055","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In Vivo","raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kyu-dent.repo.nii.ac.jp/records/2000055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132238898","display_name":"Miyawaki Aki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MIYAWAKI AKI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078375091","display_name":"Thira Rojasawasthien","orcid":"https://orcid.org/0000-0002-6449-7664","observed_orcids":["https://orcid.org/0000-0002-6449-7664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ROJASAWASTHIEN THIRA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131828100","display_name":"Hitomi Suzuro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HITOMI SUZURO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149962050","display_name":"AOKI YOSHINORI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AOKI YOSHINORI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131912454","display_name":"Urata Mariko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"URATA MARIKO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082396827","display_name":"Inoue Asako","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"INOUE ASAKO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090220419","display_name":"Matsubara Takuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MATSUBARA TAKUMA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149617998","display_name":"MORIKAWA KAZUMASA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MORIKAWA KAZUMASA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149886025","display_name":"Habu Manabu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HABU MANABU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149883909","display_name":"TOMINAGA KAZUHIRO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TOMINAGA KAZUHIRO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5149766533","display_name":"KOKABU Shoichiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KOKABU SHOICHIRO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"5","first_page":"2345","last_page":"2351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/geranylgeraniol","display_name":"geranylgeraniol","score":0.996999979019165},{"id":"https://openalex.org/keywords/atrogin-1","display_name":"atrogin-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6480000019073486},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.8650000095367432},{"id":"https://openalex.org/keywords/muscle-fiber-cross-sectional-area","display_name":"muscle fiber cross-sectional area","score":0.859000027179718},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2778359262","wikidata":"https://www.wikidata.org/wiki/Q3123708","display_name":"Geranylgeraniol","level":3,"score":0.940500020980835},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.8066999912261963},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6661999821662903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6565999984741211},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5985000133514404},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5860000252723694},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.5400000214576721},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5146999955177307},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3815999925136566},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.37560001015663147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3458999991416931},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28610000014305115},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2597000002861023}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:07557:0007269714","doi":null,"is_oa":true,"landing_page_url":"https://kyu-dent.repo.nii.ac.jp/records/2000055","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In Vivo","raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:07557:0007269714","doi":null,"is_oa":true,"landing_page_url":"https://kyu-dent.repo.nii.ac.jp/records/2000055","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In Vivo","raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2802977116","https://openalex.org/W4391621617","https://openalex.org/W2793707404","https://openalex.org/W2151917785","https://openalex.org/W2353885556","https://openalex.org/W2772188588","https://openalex.org/W4414159414","https://openalex.org/W2120168239","https://openalex.org/W2347034027","https://openalex.org/W7204134820"],"abstract_inverted_index":{"Background/aim:":[0],"Geranylgeraniol":[1],"(GGOH),":[2],"a":[3],"C20":[4],"isoprenoid":[5],"naturally":[6],"occurs":[7],"in":[8,26,48,84,99,115,122],"several":[9],"foods.":[10],"We":[11],"previously":[12],"reported":[13],"that":[14],"GGOH":[15,42,80,105,128],"treatment":[16,106],"reduced":[17,81],"the":[18,32,39,82,85,94,108,113],"expression":[19,63,95,109],"levels":[20,64,96],"of":[21,35,41,65,79,88,97,110,127,135],"Atrogin-1":[22,66,98,111],"which":[23],"is":[24,50],"involved":[25],"skeletal":[27,45,116,140],"muscle":[28,46,56,89,102,117,131,141],"degradation":[29],"and":[30,53,91,112],"stimulates":[31],"myogenic":[33],"differentiation":[34],"C2C12":[36],"myoblasts.":[37],"However,":[38],"effect":[40],"supplementation":[43],"on":[44],"metabolism":[47],"vivo":[49],"unknown.":[51],"Materials":[52],"methods:":[54],"Skeletal":[55],"atrophy":[57,132],"was":[58],"induced":[59,101],"by":[60,69,120],"denervation.":[61],"The":[62],"were":[67],"assessed":[68],"western":[70],"blotting":[71],"or":[72],"real":[73],"time":[74],"PCR.":[75],"Results:":[76],"Intraoral":[77,125],"administration":[78,126],"decrease":[83,114],"cross-sectional":[86],"area":[87],"fibers":[90],"also":[92],"suppressed":[93,107],"denervation":[100],"atrophy.":[103,142],"Also,":[104],"fiber":[118],"size":[119],"glucocorticoid":[121],"vitro.":[123],"Conclusion:":[124],"rescues":[129],"denervation-induced":[130],"via":[133],"suppression":[134],"Atrogin-1.":[136],"Keywords:":[137],"Atrogin-1;":[138],"Geranylgeraniol;":[139]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-04T00:00:00"}
