{"id":"https://openalex.org/W7208070073","doi":null,"title":"\u98df\u9053\u6241\u5e73\u4e0a\u76ae\u764c\u65e9\u671f\u75c5\u5909\u306ep53\u907a\u4f1d\u5b50\u5909\u7570\u306b\u95a2\u3059\u308b\u7814\u7a76","display_name":"\u98df\u9053\u6241\u5e73\u4e0a\u76ae\u764c\u65e9\u671f\u75c5\u5909\u306ep53\u907a\u4f1d\u5b50\u5909\u7570\u306b\u95a2\u3059\u308b\u7814\u7a76","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W7208070073"},"language":"ja","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01100:0003328444","doi":null,"is_oa":true,"landing_page_url":"https://niigata-u.repo.nii.ac.jp/records/10262","pdf_url":"https://niigata-u.repo.nii.ac.jp/record/10262/files/124(11)_627-637.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","raw_type":"departmental bulletin paper"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://niigata-u.repo.nii.ac.jp/record/10262/files/124(11)_627-637.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049035518","display_name":"\u6e05\u5b5d \u576a\u4e95","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u576a\u4e95, \u6e05\u5b5d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049035518"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"11","first_page":"627","last_page":"637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/early-esophageal-cancer","display_name":"early esophageal cancer","score":0.5960000157356262},{"id":"https://openalex.org/keywords/dysplasia","display_name":"dysplasia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"carcinoma in situ","score":0.8830000162124634},{"id":"https://openalex.org/keywords/low-grade-dysplasia","display_name":"low-grade dysplasia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/high-grade-dysplasia","display_name":"high-grade dysplasia","score":1.0},{"id":"https://openalex.org/keywords/esophageal-intraepithelial-neoplasia","display_name":"esophageal intraepithelial neoplasia","score":0.699999988079071},{"id":"https://openalex.org/keywords/p53-overexpression","display_name":"p53 overexpression","score":0.7310000061988831},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6190000176429749},{"id":"https://openalex.org/keywords/histogenesis","display_name":"histogenesis","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.19869999587535858},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.19509999454021454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19110000133514404},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.18619999289512634},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.1842000037431717},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.1688999980688095},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.16599999368190765},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.16449999809265137},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.1615999937057495},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.15880000591278076}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01100:0003328444","doi":null,"is_oa":true,"landing_page_url":"https://niigata-u.repo.nii.ac.jp/records/10262","pdf_url":"https://niigata-u.repo.nii.ac.jp/record/10262/files/124(11)_627-637.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","raw_type":"departmental bulletin paper"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01100:0003328444","doi":null,"is_oa":true,"landing_page_url":"https://niigata-u.repo.nii.ac.jp/records/10262","pdf_url":"https://niigata-u.repo.nii.ac.jp/record/10262/files/124(11)_627-637.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","raw_type":"departmental bulletin paper"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7208070073.pdf","grobid_xml":"https://content.openalex.org/works/W7208070073.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W408579175","https://openalex.org/W579939847","https://openalex.org/W585488271","https://openalex.org/W351810538","https://openalex.org/W573157880","https://openalex.org/W352135141","https://openalex.org/W437302787","https://openalex.org/W340740127","https://openalex.org/W572724990","https://openalex.org/W7144841925"],"abstract_inverted_index":{"\u98df\u9053\u6247\u5e73\u4e0a\u76ae\u764c\u306f\u7570\u5f62\u6210":[0],"(dysplasia)":[1],"\u3068\u547c\u3070\u308c\u308b\u7570\u578b\u6247\u5e73\u4e0a\u76ae\u3092\u524d\u764c\u75c5\u5909\u3068\u3057,":[2],"\u305d\u308c\u304c\u4e0a\u76ae\u5185\u764c":[3],"(carcinoma":[4],"in":[5],"situ:":[6],"CIS)":[7,25],"\u3092\u7d4c\u3066\u6d78\u6f64\u764c\u306b\u9032\u884c\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b.":[8],"Dysplasia\u306f\u8efd(low-grade":[9],"dysplasia:":[10,14],"LGD)":[11],"\u3068\u9ad8\u5ea6":[12],"(high-grade":[13],"HGD)":[15],"\u306b\u5927\u5225\u3055\u308c\u308b\u304c,":[16],"\u305d\u306e\u3044\u305a\u308c\u304c,":[17],"\u98df\u9053\u6247\u5e73\u4e0a\u76ae\u306e\u767a\u764c\u65e9\u671f\u6bb5\u968e\u304b\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u3044.":[18],"\u3053\u306e\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081,":[19],"\u672c\u7814\u7a76\u3067\u306f,":[20],"\u98df\u9053\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u9ad8\u983b\u5ea6\u306b\u307f\u3089\u308c\u308bp53\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u7740\u76ee\u3057,":[21],"\u6241\u5e73\u4e0a\u76ae\u764c\u3068\u305d\u308c\u306b\u4f75\u5b58\u3059\u308b\u4e0a\u76ae\u5185\u816b\u760d":[22],"(LGD,":[23],"HGD,":[24,34],"\u306ep53\u907a\u4f1d\u5b50\u5909\u7570\u304a\u3088\u3073\u540c\u86cb\u767d\u904e\u5270\u767a\u73fe\u3092\u691c\u8a0e\u3057\u305f.":[26],"\u5185\u8996\u93e1\u7684\u6458\u9664\u30db\u30eb\u30de\u30ea\u30f3\u56fa\u5b9a\u98df\u9053\u6247\u5e73\u4e0a\u76ae\u764c10\u4f8b":[27],"(\u7c98\u819c\u56fa\u6709\u5c64\u6d78\u6f64\u764c:":[28],"M\u764c4\u4f8b,":[29],"\u7c98\u819c\u4e0b\u5c64\u6d78\u6f64\u764c:":[30],"SM\u764c6\u4f8b)":[31],"\u3092\u5bfe\u8c61\u3068\u3057,":[32],"LGD,":[33],"CIS,":[35],"M\u764c\u90e8,":[36],"SM\u764c\u7fa4\u5225\u306bp53\u514d\u75ab\u67d3\u8272\u3092\u8a55\u4fa1\u3057,":[37],"\u305d\u308c\u305e\u308c\u306e\u9818\u57df\u304b\u3089\u30de\u30a4\u30af\u30ed\u30c0\u30a4\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u3088\u308aDNA\u3092\u62bd\u51fa\u3057,":[38],"p53\u907a\u4f1d\u5b50\u306e\u30a8\u30af\u30bd\u30f35\uff5e8\u3092PCR\u3067\u5897\u5e45\u3057,":[39],"\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790\u306b\u3088\u308a\u540c\u907a\u4f1d\u5b50\u5909\u7570\u3092\u691c\u7d22\u3057\u305f.":[40],"p53\u907a\u4f1d\u5b50\u5909\u7570\u306fLGD\u306e83.3%,":[41],"HGD\u306e50.0%,":[42],"CIS\u306e71.4%,":[43],"\u6d78\u6f64\u764c\u90e8\u306e50.0-75.0%\u306b\u8a8d\u3081\u3089\u308c\u305f.":[44],"LGD\u3068HGD\u3067\u306f,":[45],"1\u4f8b\u3092\u9664\u304d,":[46],"\u540c\u4e00\u75c5\u5909\u5185\u306b\u4f75\u5b58\u3059\u308bCIS\u304a\u3088\u3073\u6d78\u6f64\u764c\u90e8\u3068\u5909\u7570\u30b3\u30c9\u30f3\u304c\u5171\u901a\u3059\u308b\u304b,":[47],"\u3082\u3057\u304f\u306f\u4e21\u8005\u3068\u3082":[48],"wild-type":[49],"\u3067\u3042\u3063\u305f.":[50],"\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089,p53\u907a\u4f1d\u5b50\u5909\u7570\u306e\u89b3\u70b9\u304b\u3089\u307f\u305f\u9650\u308a\u306f,":[51],"LGD\u304a\u3088\u3073HGD\u306f\u540c\u4e00\u75c5\u5909\u5185\u306eCIS\u3084\u6d78\u6f64\u764c\u90e8\u3068\u7d44\u7e54\u767a\u751f\u5b66\u7684\u9023\u7d9a\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u63a8\u5b9a\u3055\u308c\u305f.":[52],"\u540c\u4e00\u75c5\u5909\u5185\u306eCIS\u3068\u6d78\u6f64\u764c\u90e8\u3067\u306f\u907a\u4f1d\u5b50\u5909\u7570\u306f\u5358\u4e00\u306e\u5909\u7570\u30b3\u30c9\u30f3\u306b\u751f\u3058\u3066\u3044\u305f\u304c,":[53],"LGD\u3068HGD\u3067\u306f\u5909\u7570\u30b3\u30c9\u30f3\u306b\u591a\u69d8\u6027":[54],"(\u8907\u6570\u306e\u5909\u7570\u30b3\u30c9\u30f3\u304c\u5b58\u5728)":[55],"\u304c\u307f\u3089\u308c\u305f.":[56],"LGD\u3068HGD\u306f\u7570\u306a\u308bp53\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u8907\u6570\u306e\u7d30\u80de\u96c6\u56e3\u304b\u3089\u69cb\u6210\u3055\u308c,":[57],"\u305d\u308c\u3089\u304c\u30af\u30ed\u30fc\u30f3\u9078\u629e\u3092\u7d4c\u3066\u5747\u4e00\u306ap53\u907a\u4f1d\u5b50\u5909\u7570\u30d1\u30bf-\u30f3\u3092\u6301\u3064CIS\u3068\u306a\u308a,":[58],"\u7c98\u819c\u56fa\u6709\u5c64\u3078\u6d78\u6f64\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f.":[59],"\u672c\u7814\u7a76\u7d50\u679c\u304b\u3089,":[60],"LGD\u306e\u6bb5\u968e\u3067\u65e2\u306bCIS\u3084\u6d78\u6f64\u764c\u3068\u5171\u901a\u3059\u308bp53\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6765\u3057\u305f\u7d30\u80de\u96c6\u56e3\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u63a8\u5b9a\u3055\u308c,":[61],"LGD\u3092\u98df\u9053\u504f\u5e73\u4e0a\u76ae\u306e\u767a\u764c\u65e9\u671f\u6bb5\u968e\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a,":[62],"LGD\u306b\u5bfe\u3057\u3066\u306f\u7a4d\u6975\u7684\u306a\u81e8\u5e8a\u5bfe\u5fdc\u304c\u5fc5\u8981\u3068\u8003\u3048\u3089\u308c\u305f.":[63]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-09-04T00:00:00"}