{"id":"https://openalex.org/W7207862001","doi":"https://doi.org/10.64898/2026.09.01.748611","title":"Ribosomal proteins are major substrates of starvation-induced endosomal microautophagy in Drosophila","display_name":"Ribosomal proteins are major substrates of starvation-induced endosomal microautophagy in Drosophila","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207862001","doi":"https://doi.org/10.64898/2026.09.01.748611","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922593","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684643"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.748611","doi":"https://doi.org/10.64898/2026.09.01.748611","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748611","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.01.748611.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.01.748611.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045908536","display_name":"Prasoon Jaya","orcid":"https://orcid.org/0000-0002-2967-1815","observed_orcids":["https://orcid.org/0000-0002-2967-1815"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasoon Jaya","raw_affiliation_strings":["Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2967-1815","affiliations":[{"raw_affiliation_string":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056558578","display_name":"Satya Surabhi","orcid":"https://orcid.org/0000-0002-1888-249X","observed_orcids":["https://orcid.org/0000-0002-1888-249X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satya Surabhi","raw_affiliation_strings":["Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1888-249X","affiliations":[{"raw_affiliation_string":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013713372","display_name":"Jennifer T. Aguilan","orcid":"https://orcid.org/0000-0002-0221-354X","observed_orcids":["https://orcid.org/0000-0002-0221-354X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Aguilan","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0221-354X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060898511","display_name":"Simone Sidoli","orcid":"https://orcid.org/0000-0001-9073-6641","observed_orcids":["https://orcid.org/0000-0001-9073-6641"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simone Sidoli","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9073-6641","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015710789","display_name":"Andreas Jenny","orcid":"https://orcid.org/0000-0001-5989-8212","observed_orcids":["https://orcid.org/0000-0001-5989-8212"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andreas Jenny","raw_affiliation_strings":["Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America","Department of Genetics, Albert Einstein College of Medicine, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5989-8212","affiliations":[{"raw_affiliation_string":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015710789"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.9710000157356262},{"id":"https://openalex.org/keywords/starvation","display_name":"starvation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ribosome-turnover","display_name":"ribosome turnover","score":0.8479999899864197},{"id":"https://openalex.org/keywords/macroautophagy","display_name":"macroautophagy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.5989999771118164},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/translation-biology","display_name":"translation (biology)","score":0.6060000061988831},{"id":"https://openalex.org/keywords/escrt","display_name":"ESCRT","score":0.5019999742507935},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6504999995231628},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.6281999945640564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6274999976158142},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.597100019454956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49889999628067017},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.47620001435279846},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.45570001006126404},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.4212999939918518},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.39239999651908875},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.38089999556541443},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.3752000033855438},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.35420000553131104},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.33480000495910645},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.3179999887943268},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.01.748611","doi":"https://doi.org/10.64898/2026.09.01.748611","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748611","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.01.748611.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42922593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684643","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684643/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.748611","doi":"https://doi.org/10.64898/2026.09.01.748611","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748611","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.01.748611.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1457954493","display_name":null,"funder_award_id":"1S10OD023591-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2533196969","display_name":null,"funder_award_id":"S10-OD030286","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G3687786437","display_name":"Advanced Confocal Microscope in a multi-user facility","funder_award_id":"1s10od023591-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4091541190","display_name":null,"funder_award_id":"1S10 OD021798-01A1","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G6139749373","display_name":"Identification and functional analysis of substrates of starvation- induced eMI in Drosophila","funder_award_id":"915707","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G7219920267","display_name":null,"funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G8754918582","display_name":null,"funder_award_id":"GM119160","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000873724","display_name":"PROVIDENT:  Prepositioning Optimized Strategies for Vaccines and Immunotherapeutics against Diverse Emerging Infectious Threats","funder_award_id":"U19AI181977","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000877850","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000900974","display_name":"NYR-Diabetes Research Center (NYR-DRC)","funder_award_id":"P30DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F1063528218","display_name":"Hevolution Foundation","ror":"https://ror.org/00kgc7526"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207862001.pdf","grobid_xml":"https://content.openalex.org/works/W7207862001.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6902270271","https://openalex.org/W4401984652","https://openalex.org/W3036563505","https://openalex.org/W6977269403","https://openalex.org/W3109389628","https://openalex.org/W7117754656","https://openalex.org/W2609461401","https://openalex.org/W2896565523","https://openalex.org/W2883036698","https://openalex.org/W2560112395"],"abstract_inverted_index":{"ABSTRACT":[0],"Maintenance":[1],"of":[2,20,44,57,121,160,180,194,218,229,235,252,271,280,291],"cellular":[3],"homeostasis":[4],"requires":[5],"tight":[6],"coordination":[7],"between":[8,202],"protein":[9,103,213],"synthesis":[10],"and":[11,17,34,47,49,63,89,109,125,147,187,204,255,268,294],"degradation,":[12],"particularly":[13],"at":[14],"old":[15],"age":[16],"under":[18,106,110,275],"conditions":[19,108],"stress":[21,277],"including":[22,215],"starvation.":[23,240,265],"Autophagy":[24],"contributes":[25],"to":[26,40,50,100,102,144],"sustain":[27],"this":[28],"balance":[29],"by":[30,163,239],"degrading":[31],"cytoplasmic":[32],"proteins":[33,46,78,162,181,286,298],"organelles.":[35],"It":[36],"thus":[37,126],"is":[38,98,115],"essential":[39],"prevent":[41],"the":[42,54,67,70,118,158,166,178,207,232],"accumulation":[43],"damaged":[45],"organelles":[48],"recycle":[51],"nutrients.":[52],"Of":[53],"three":[55],"forms":[56],"autophagy,":[58,62],"macroautophagy,":[59,205],"chaperone":[60],"mediated":[61],"(endosomal)":[64],"microautophagy":[65,282],"(e-MI),":[66],"latter":[68],"remains":[69],"least":[71],"well":[72],"understood.":[73],"During":[74],"e-MI,":[75],"cytosolic":[76],"substrate":[77],"are":[79,287],"captured":[80],"into":[81],"late":[82,93],"endosomes":[83,94],"via":[84],"ESCRT-dependent":[85],"multivesicular":[86],"body":[87,139,274],"formation":[88],"then":[90],"degraded":[91],"in":[92,123,135,183],"or":[95],"lysosomes.":[96],"e-MI":[97,122,155,164,203,230,254,257,293],"thought":[99],"contribute":[101],"quality":[104],"control":[105],"basal":[107],"stress.":[111],"Importantly,":[112,196],"very":[113],"little":[114],"known":[116],"about":[117,127],"endogenous":[119,154],"substrates":[120,156],"flies":[124],"its":[128],"physiological":[129,250],"role.":[130],"Performing":[131],"integrative":[132],"multi-omic":[133],"analyses":[134],"Drosophila":[136,253,272],"larval":[137],"fat":[138,273],"that":[140,175,226],"has":[141],"functions":[142],"similar":[143],"mammalian":[145],"liver":[146],"adipose":[148],"tissue,":[149],"we":[150,173,197],"identified":[151],"153":[152],"high-confidence":[153],"with":[157],"degradation":[159],"ribosomal":[161,188,219,301],"being":[165],"most":[167],"strongly":[168],"affected":[169],"functional":[170],"category.":[171],"Generally,":[172],"found":[174],"starvation":[176,276,304],"caused":[177,238],"depletion":[179],"involved":[182],"translation,":[184],"aminoacyl-tRNA":[185],"synthesis,":[186],"biogenesis,":[189],"without":[190],"affecting":[191],"their":[192],"level":[193],"transcripts.":[195],"observe":[198],"a":[199,248,259,288],"striking":[200],"specificity":[201],"as":[206,247,258],"two":[208],"pathways":[209],"largely":[210],"target":[211,290],"distinct":[212,297],"sets":[214],"different":[216,300],"subsets":[217],"proteins.":[220],"Our":[221],"metabolomic":[222,269],"analysis":[223,270],"further":[224],"shows":[225],"genetic":[227],"inhibition":[228],"reverses":[231],"reduced":[233],"levels":[234],"amino":[236,306],"acid":[237,307],"Together,":[241],"our":[242],"findings":[243],"reveal":[244],"ribosome":[245],"turnover":[246],"central":[249],"function":[251],"establish":[256],"pathway":[260],"driving":[261],"metabolic":[262],"adaptation":[263],"during":[264],"HIGHLIGHTS":[266],"Proteomic":[267],"Systematic":[278],"identification":[279],"endosomal":[281],"(e-MI)":[283],"substrates.":[284],"Ribosomal":[285],"major":[289],"e-MI.":[292],"macroautophagy":[295],"degrade":[296],"incl.":[299],"ones.":[302],"Prolonged":[303],"alters":[305],"levels.":[308]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-04T00:00:00"}