{"id":"https://openalex.org/W7207849596","doi":"https://doi.org/10.32782/2522-9680-2026-2-66","title":"Phytotherapy targeting immunosenescence: mechanistic perspectives for healthy ageing (mini-review)","display_name":"Phytotherapy targeting immunosenescence: mechanistic perspectives for healthy ageing (mini-review)","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207849596","doi":"https://doi.org/10.32782/2522-9680-2026-2-66"},"language":"en","primary_location":{"id":"doi:10.32782/2522-9680-2026-2-66","doi":"https://doi.org/10.32782/2522-9680-2026-2-66","is_oa":true,"landing_page_url":"https://doi.org/10.32782/2522-9680-2026-2-66","pdf_url":"https://doi.org/10.32782/2522-9680-2026-2-66","source":{"id":"https://openalex.org/S4210182665","display_name":"F\u00ectoterap\u00ec\u00e2","issn_l":"2522-9680","issn":["2522-9680"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7207849596"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.32782/2522-9680-2026-2-66","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041424274","display_name":"Sepideh Parchami Ghazaee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3130988169","display_name":"Kyiv Medical University","ror":"https://ror.org/003wdqw68","country_code":"UA","type":"education","lineage":["https://openalex.org/I3130988169"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Sepideh PARCHAMI GHAZAEE","raw_affiliation_strings":["Candidate of Biological Sciences , Associate Professor, Associate Professor at the Department of Pharmacology and Pharmacotherapy , Private higher educational establishment \"Kyiv Medical University\" , Boryspilska str. , 2 , Kyiv , Ukraine, 02099"],"raw_orcid":"https://orcid.org/0000-0002-3829-3270","affiliations":[{"raw_affiliation_string":"Candidate of Biological Sciences , Associate Professor, Associate Professor at the Department of Pharmacology and Pharmacotherapy , Private higher educational establishment \"Kyiv Medical University\" , Boryspilska str. , 2 , Kyiv , Ukraine, 02099","institution_ids":["https://openalex.org/I3130988169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072880993","display_name":"Ella GOROVA","orcid":"https://orcid.org/0000-0003-0259-5469","observed_orcids":["https://orcid.org/0000-0003-0259-5469"]},"institutions":[{"id":"https://openalex.org/I3130988169","display_name":"Kyiv Medical University","ror":"https://ror.org/003wdqw68","country_code":"UA","type":"education","lineage":["https://openalex.org/I3130988169"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Ella GOROVA","raw_affiliation_strings":["Department of Pharmacology and Pharmacotherapy , Private higher educational establishment \"Kyiv Medical University\" , Boryspilska str. , 2 , Kyiv , Ukraine, 02099"],"raw_orcid":"https://orcid.org/0000-0003-0259-5469","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacotherapy , Private higher educational establishment \"Kyiv Medical University\" , Boryspilska str. , 2 , Kyiv , Ukraine, 02099","institution_ids":["https://openalex.org/I3130988169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053988795","display_name":"\u041c\u0430\u0440\u0447\u0435\u043d\u043a\u043e-\u0422\u043e\u043b\u0441\u0442\u0430 \u041a\u0430\u0442\u0435\u0440\u0438\u043d\u0430 \u0421\u0435\u0440\u0433\u0456\u0457\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-7744-5874","observed_orcids":["https://orcid.org/0000-0001-7744-5874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kateryna MARCHENKO-TOLSTA","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7744-5874","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118964014","display_name":"Iryna Tymchenko","orcid":"https://orcid.org/0009-0000-0364-9639","observed_orcids":["https://orcid.org/0009-0000-0364-9639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iryna TYMCHENKO","raw_affiliation_strings":["LLC Smart Medical Center , Kyiv , Ukraine, 02094"],"raw_orcid":"https://orcid.org/0009-0000-0364-9639","affiliations":[{"raw_affiliation_string":"LLC Smart Medical Center , Kyiv , Ukraine, 02094","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050477696","display_name":"\u041d\u043e\u0432\u0438\u043a\u043e\u0432\u0430 \u041b\u0430\u0440\u0438\u0441\u0430 \u0413\u0435\u043e\u0440\u0433\u0456\u0457\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-5103-1016","observed_orcids":["https://orcid.org/0000-0001-5103-1016"]},"institutions":[{"id":"https://openalex.org/I3130988169","display_name":"Kyiv Medical University","ror":"https://ror.org/003wdqw68","country_code":"UA","type":"education","lineage":["https://openalex.org/I3130988169"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Larysa NOVYKOVA","raw_affiliation_strings":["Senior Lecturer at the Department of Chemistry , Drug Technology and Pharmaceutical Management , Private higher educational establishment \"Kyiv Medical University\" , Boryspilska str. , 2 , Kyiv , Ukraine, 02099"],"raw_orcid":"https://orcid.org/0000-0001-5103-1016","affiliations":[{"raw_affiliation_string":"Senior Lecturer at the Department of Chemistry , Drug Technology and Pharmaceutical Management , Private higher educational establishment \"Kyiv Medical University\" , Boryspilska str. , 2 , Kyiv , Ukraine, 02099","institution_ids":["https://openalex.org/I3130988169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149745614","display_name":"Yurii MARCHENKO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yurii MARCHENKO","raw_affiliation_strings":["LLC Smart Medical Center , Kyiv , Ukraine, 02094"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LLC Smart Medical Center , Kyiv , Ukraine, 02094","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5149673331","display_name":"Svitlana VLASENKO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svitlana VLASENKO","raw_affiliation_strings":["LLC Smart Medical Center , Kyiv , Ukraine, 02094"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LLC Smart Medical Center , Kyiv , Ukraine, 02094","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"2","first_page":"66","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.36719998717308044,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.36719998717308044,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1307000070810318,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.0917000025510788,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9980000257492065},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.996999979019165},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.4399999976158142},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cardiovascular-benefits","display_name":"cardiovascular benefits","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6912000179290771},{"id":"https://openalex.org/C3019892597","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy ageing","level":3,"score":0.5139999985694885},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.4544999897480011},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4438999891281128},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.4253000020980835},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3882000148296356},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3077000081539154},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.24869999289512634},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2395000010728836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32782/2522-9680-2026-2-66","doi":"https://doi.org/10.32782/2522-9680-2026-2-66","is_oa":true,"landing_page_url":"https://doi.org/10.32782/2522-9680-2026-2-66","pdf_url":"https://doi.org/10.32782/2522-9680-2026-2-66","source":{"id":"https://openalex.org/S4210182665","display_name":"F\u00ectoterap\u00ec\u00e2","issn_l":"2522-9680","issn":["2522-9680"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32782/2522-9680-2026-2-66","doi":"https://doi.org/10.32782/2522-9680-2026-2-66","is_oa":true,"landing_page_url":"https://doi.org/10.32782/2522-9680-2026-2-66","pdf_url":"https://doi.org/10.32782/2522-9680-2026-2-66","source":{"id":"https://openalex.org/S4210182665","display_name":"F\u00ectoterap\u00ec\u00e2","issn_l":"2522-9680","issn":["2522-9680"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207849596.pdf","grobid_xml":"https://content.openalex.org/works/W7207849596.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W2466333719","https://openalex.org/W2611842385","https://openalex.org/W2923966691","https://openalex.org/W2941673930","https://openalex.org/W2989918141","https://openalex.org/W2999403306","https://openalex.org/W3110946209","https://openalex.org/W3111531956","https://openalex.org/W3209117956","https://openalex.org/W4200621037","https://openalex.org/W4224250685","https://openalex.org/W4281388771","https://openalex.org/W4282827716","https://openalex.org/W4289523692","https://openalex.org/W4291365914","https://openalex.org/W4310040021","https://openalex.org/W4311744984","https://openalex.org/W4313531093","https://openalex.org/W4322744918","https://openalex.org/W4328142021","https://openalex.org/W4361214393","https://openalex.org/W4361282770","https://openalex.org/W4362506713","https://openalex.org/W4380992687","https://openalex.org/W4385245936","https://openalex.org/W4389893698","https://openalex.org/W4391333936","https://openalex.org/W4391824700","https://openalex.org/W4393276557","https://openalex.org/W4396965150","https://openalex.org/W4399698599","https://openalex.org/W4401641937","https://openalex.org/W4401707187","https://openalex.org/W4402096058","https://openalex.org/W4406682328","https://openalex.org/W4408202117","https://openalex.org/W4408924525","https://openalex.org/W4409098938","https://openalex.org/W4409257177","https://openalex.org/W4409301031","https://openalex.org/W4409314042","https://openalex.org/W4410359849","https://openalex.org/W4410510973","https://openalex.org/W4410539574","https://openalex.org/W4412677369","https://openalex.org/W4413023521","https://openalex.org/W4416893204","https://openalex.org/W7134233913"],"related_works":["https://openalex.org/W3049347810","https://openalex.org/W4230701442","https://openalex.org/W4399377438","https://openalex.org/W7204182058","https://openalex.org/W4404959716","https://openalex.org/W4413023521","https://openalex.org/W4411370770","https://openalex.org/W4413440598","https://openalex.org/W4306822659","https://openalex.org/W4399375769"],"abstract_inverted_index":{"Actuality.Aging":[0],"is":[1],"a":[2],"complex":[3],"process":[4],"marked":[5],"by":[6],"molecular":[7],"and":[8,14,24,34,37,51],"cellular":[9],"damage,":[10],"leading":[11],"to":[12],"immunosenescence":[13],"increased":[15],"risk":[16],"of":[17,30],"chronic":[18],"diseases.Phytotherapeutic":[19],"interventions":[20],"are":[21],"widely":[22],"used":[23],"show":[25],"multifunctional":[26],"potential,":[27],"including":[28],"modulation":[29],"signaling":[31],"pathways,":[32,44],"neuroprotective":[33],"cardiovascular":[35],"benefits,":[36],"epigenetic":[38],"regulation.Although":[39],"phytochemicals":[40],"interact":[41],"with":[42],"immune-associated":[43],"their":[45],"effects":[46],"on":[47],"ageing-related":[48],"immune":[49],"dysfunction":[50],"associated":[52],"health":[53],"conditions":[54],"remain":[55],"incompletely":[56],"understood.":[57]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-04T00:00:00"}