{"id":"https://openalex.org/W7207834705","doi":"https://doi.org/10.1002/pul2.70391","title":"Observed Weight Gain in Patients With Pulmonary Arterial Hypertension Treated With Sotatercept","display_name":"Observed Weight Gain in Patients With Pulmonary Arterial Hypertension Treated With Sotatercept","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7207834705","doi":"https://doi.org/10.1002/pul2.70391","pmid":"https://pubmed.ncbi.nlm.nih.gov/42694650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13540266"},"language":"en","primary_location":{"id":"doi:10.1002/pul2.70391","doi":"https://doi.org/10.1002/pul2.70391","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pul2.70391","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.70391","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.70391","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054686636","display_name":"Rebecca A. Greene","orcid":"https://orcid.org/0000-0002-3108-3019","observed_orcids":["https://orcid.org/0000-0002-3108-3019"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca A. Greene","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Brown University Health Specialty Pharmacy Providence Rhode Island USA"],"raw_orcid":"https://orcid.org/0000-0002-3108-3019","affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Brown University Health Specialty Pharmacy Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146861750","display_name":"Darlene Tat","orcid":"https://orcid.org/0009-0002-6404-9199","observed_orcids":["https://orcid.org/0009-0002-6404-9199"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darlene Tat","raw_affiliation_strings":["Rhode Island Hospital Brown University Health Providence Rhode Island USA"],"raw_orcid":"https://orcid.org/0009-0002-6404-9199","affiliations":[{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136201609","display_name":"Allyson Sherman\u2010Roe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allyson Sherman\u2010Roe","raw_affiliation_strings":["Rhode Island Hospital Brown University Health Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119861789","display_name":"Tiffaney Cayton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffaney Cayton","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000460687","display_name":"Jacqueline Lopes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Lopes","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Brown University Health Specialty Pharmacy Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Brown University Health Specialty Pharmacy Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027126272","display_name":"Alexander T. Jorrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Jorrin","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071223454","display_name":"James R. Klinger","orcid":"https://orcid.org/0000-0003-2997-5955","observed_orcids":["https://orcid.org/0000-0003-2997-5955"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Klinger","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Rhode Island Hospital Brown University Health Providence Rhode Island USA","The Warren Alpert Medical School of Brown University Providence Rhode Island USA"],"raw_orcid":"https://orcid.org/0000-0003-2997-5955","affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"The Warren Alpert Medical School of Brown University Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032813950","display_name":"Christopher J. Mullin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Mullin","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Rhode Island Hospital Brown University Health Providence Rhode Island USA","The Warren Alpert Medical School of Brown University Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"The Warren Alpert Medical School of Brown University Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149864119","display_name":"Kathryn Needle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Needle","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081916285","display_name":"William M. Oldham","orcid":"https://orcid.org/0000-0003-3029-4866","observed_orcids":["https://orcid.org/0000-0003-3029-4866"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Oldham","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Rhode Island Hospital Brown University Health Providence Rhode Island USA","The Warren Alpert Medical School of Brown University Providence Rhode Island USA"],"raw_orcid":"https://orcid.org/0000-0003-3029-4866","affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"The Warren Alpert Medical School of Brown University Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149932252","display_name":"Crossandra Osgood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crossandra Osgood","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101810402","display_name":"Navneet Singh","orcid":"https://orcid.org/0000-0001-8058-3004","observed_orcids":["https://orcid.org/0000-0001-8058-3004"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navneet Singh","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Rhode Island Hospital Brown University Health Providence Rhode Island USA","The Warren Alpert Medical School of Brown University Providence Rhode Island USA"],"raw_orcid":"https://orcid.org/0000-0001-8058-3004","affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"The Warren Alpert Medical School of Brown University Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069966002","display_name":"Corey E. Ventetuolo","orcid":"https://orcid.org/0000-0002-4223-4775","observed_orcids":["https://orcid.org/0000-0002-4223-4775"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey E. Ventetuolo","raw_affiliation_strings":["Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","Rhode Island Hospital Brown University Health Providence Rhode Island USA","The Warren Alpert Medical School of Brown University Providence Rhode Island USA"],"raw_orcid":"https://orcid.org/0000-0002-4223-4775","affiliations":[{"raw_affiliation_string":"Brown University Health Center for Advanced Lung Care Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Rhode Island Hospital Brown University Health Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]},{"raw_affiliation_string":"The Warren Alpert Medical School of Brown University Providence Rhode Island USA","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054686636"],"corresponding_institution_ids":["https://openalex.org/I27804330"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":{"value":2310,"currency":"USD","value_usd":2310},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65935147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"3","first_page":"e70391","last_page":"e70391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sotatercept","display_name":"sotatercept","score":0.996999979019165},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9980000257492065},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.9829999804496765},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.8169999718666077},{"id":"https://openalex.org/keywords/weight-monitoring","display_name":"weight monitoring","score":0.5680000185966492},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.675000011920929},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9490000009536743},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.808899998664856},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.532800018787384},{"id":"https://openalex.org/C3017894415","wikidata":"https://www.wikidata.org/wiki/Q7979883","display_name":"Weight change","level":4,"score":0.5231999754905701},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5095000267028809},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49799999594688416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47380000352859497},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.4503999948501587},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.44999998807907104},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4275999963283539},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41929998993873596},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.41749998927116394},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C2777501473","wikidata":"https://www.wikidata.org/wiki/Q1796666","display_name":"Body surface area","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.3912000060081482},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3662000000476837},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.3619999885559082},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.3490999937057495},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3479999899864197},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25589999556541443},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/pul2.70391","doi":"https://doi.org/10.1002/pul2.70391","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pul2.70391","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.70391","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13540266","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13540266/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13540266/pdf/PUL2-16-e70391.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulm Circ","raw_type":"Text"},{"id":"pmid:42694650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42694650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary circulation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ac4609883f6d4cb1b656ca1d7cd36117","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ac4609883f6d4cb1b656ca1d7cd36117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pulmonary Circulation, Vol 16, Iss 3, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/pul2.70391","doi":"https://doi.org/10.1002/pul2.70391","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pul2.70391","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.70391","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207834705.pdf","grobid_xml":"https://content.openalex.org/works/W7207834705.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1989923772","https://openalex.org/W2013322454","https://openalex.org/W2054320127","https://openalex.org/W2161607413","https://openalex.org/W2181990243","https://openalex.org/W2193966792","https://openalex.org/W2593996379","https://openalex.org/W2609075277","https://openalex.org/W2731310808","https://openalex.org/W2809966069","https://openalex.org/W2943371017","https://openalex.org/W3045169849","https://openalex.org/W3082697358","https://openalex.org/W3083711036","https://openalex.org/W3092694780","https://openalex.org/W3120336759","https://openalex.org/W3152050105","https://openalex.org/W4214906582","https://openalex.org/W4281492356","https://openalex.org/W4291448167","https://openalex.org/W4323293924","https://openalex.org/W4386602680","https://openalex.org/W4389735954","https://openalex.org/W4400180535","https://openalex.org/W4402349387","https://openalex.org/W4407768531","https://openalex.org/W4409087259","https://openalex.org/W4414598667","https://openalex.org/W4414623555","https://openalex.org/W4416295437","https://openalex.org/W4416943640","https://openalex.org/W4417520712","https://openalex.org/W7117156280","https://openalex.org/W7133195341","https://openalex.org/W7133219817"],"related_works":["https://openalex.org/W7161596502","https://openalex.org/W4410277011","https://openalex.org/W4407850043","https://openalex.org/W7161590322","https://openalex.org/W7161547570","https://openalex.org/W4414623555","https://openalex.org/W3152050105","https://openalex.org/W4389944636","https://openalex.org/W4323293924","https://openalex.org/W4413791885"],"abstract_inverted_index":{"ABSTRACT":[0],"Sotatercept,":[1],"an":[2,24,209],"activin":[3],"signaling":[4],"inhibitor":[5],"for":[6,26,45,102],"pulmonary":[7],"arterial":[8],"hypertension":[9],"(PAH),":[10],"has":[11],"demonstrated":[12],"significant":[13,119,164],"improvements":[14],"in":[15,30,58,66,141,169,244],"clinical":[16,245],"outcomes":[17],"though":[18],"its":[19],"off\u2010target":[20],"effects":[21],"are":[22],"still":[23],"area":[25],"discovery.":[27],"Anecdotal":[28],"increases":[29,65],"total":[31],"body":[32,49,68,142,224],"weight":[33,46,56,120,153,165,181,202,225,231],"not":[34,239],"attributable":[35],"to":[36,139,148,247],"fluid":[37],"retention":[38],"have":[39],"been":[40],"observed.":[41],"Understanding":[42],"the":[43,59,112,131,189,218],"potential":[44,150],"gain":[47,57,121,166,232],"and":[48,155,188,229],"composition":[50],"changes":[51,140,203],"is":[52,62,233],"important":[53],"as":[54],"excessive":[55],"PAH":[60,88],"population":[61],"deleterious":[63],"whereas":[64],"lean":[67],"mass":[69],"may":[70],"favorably":[71],"affect":[72],"exercise":[73],"capacity.":[74],"Therefore,":[75],"we":[76],"conducted":[77,147],"a":[78,92,103],"single\u2010center":[79],"retrospective":[80],"observational":[81],"cohort":[82],"study":[83],"of":[84,105,114,122,133,157,211,220,223],"adult":[85],"Group":[86],"1":[87],"patients":[89,115,161],"seen":[90],"at":[91,208],"Pulmonary":[93],"Hypertension":[94],"Association\u2010accredited":[95],"Comprehensive":[96],"Care":[97],"Center":[98],"treated":[99],"with":[100,125,236],"sotatercept":[101,126,134,227],"minimum":[104],"12":[106],"weeks.":[107],"The":[108,175],"primary":[109],"endpoint":[110],"was":[111,167,182,193],"proportion":[113],"who":[116],"experienced":[117],"clinically":[118,163],"\u2265":[123],"5%":[124],"treatment.":[127],"Secondary":[128],"endpoints":[129],"were":[130,146],"frequency":[132],"dose":[135],"adjustments":[136,198],"required":[137],"due":[138],"weight.":[143],"Exploratory":[144],"analyses":[145],"identify":[149],"relationships":[151],"between":[152],"change":[154,178,192],"covariates":[156],"interest.":[158],"Of":[159],"23":[160],"included,":[162],"observed":[168,241],"43.5%":[170],"(":[171],"n":[172],"=":[173],"10).":[174],"median":[176,190],"absolute":[177],"from":[179],"baseline":[180],"3.18":[183],"kg":[184],"(Q1\u2013Q3,":[185,195],"\u22120.80\u20137.43":[186],"kg),":[187],"percent":[191],"4.43":[194],"\u22120.78\u20139.01).":[196],"Dosage":[197],"based":[199],"on":[200],"dosing":[201],"(increase":[204],"or":[205,242],"decrease)":[206],"occurred":[207],"incidence":[210],"1.56":[212],"per":[213],"patient\u2010year.":[214],"These":[215],"results":[216],"suggest":[217],"importance":[219],"ongoing":[221],"monitoring":[222],"throughout":[226],"treatment":[228],"that":[230],"commonly":[234],"associated":[235],"treatment,":[237],"although":[238],"previously":[240],"evaluated":[243],"trials":[246],"date.":[248]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-04T00:00:00"}
