{"id":"https://openalex.org/W7207826194","doi":"https://doi.org/10.64898/2026.09.02.748911","title":"Multiscale spatial analysis implicates chromosomal metaloops in gene patterning across the Drosophila brain","display_name":"Multiscale spatial analysis implicates chromosomal metaloops in gene patterning across the Drosophila brain","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207826194","doi":"https://doi.org/10.64898/2026.09.02.748911","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922523","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684528"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.02.748911","doi":"https://doi.org/10.64898/2026.09.02.748911","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.748911","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748911.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748911.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014238624","display_name":"Aleena L. Patel","orcid":"https://orcid.org/0000-0003-4765-0468","observed_orcids":["https://orcid.org/0000-0003-4765-0468"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleena L. Patel","raw_affiliation_strings":["Department of Developmental Biology, Stanford University"],"raw_orcid":"https://orcid.org/0000-0003-4765-0468","affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078749005","display_name":"Achuthan Raja Venkatesh","orcid":"https://orcid.org/0009-0003-1868-4068","observed_orcids":["https://orcid.org/0009-0003-1868-4068"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Achuthan Raja Venkatesh","raw_affiliation_strings":["Department of Developmental Biology, Stanford University","Program in Biophysics, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Program in Biophysics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116077842","display_name":"Tohn Borjigin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tohn Borjigin","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Princeton University","Lewis-Sigler Institute for Integrative Genomics, Princeton University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103621198","display_name":"Xiao Li","orcid":"https://orcid.org/0009-0005-0922-5913","observed_orcids":["https://orcid.org/0009-0005-0922-5913"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao Li","raw_affiliation_strings":["Department of Molecular Biology, Princeton University","Lewis-Sigler Institute for Integrative Genomics, Princeton University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126330205","display_name":"Michael S. Levine","orcid":"https://orcid.org/0000-0001-7629-0081","observed_orcids":["https://orcid.org/0000-0001-7629-0081"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Levine","raw_affiliation_strings":["Department of Molecular Biology, Princeton University","Lewis-Sigler Institute for Integrative Genomics, Princeton University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079862746","display_name":"Alistair\u00a0Nicol Boettiger","orcid":"https://orcid.org/0000-0002-3554-5196","observed_orcids":["https://orcid.org/0000-0002-3554-5196"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alistair N. Boettiger","raw_affiliation_strings":["Department of Developmental Biology, Stanford University","Program in Biophysics, Stanford University"],"raw_orcid":"https://orcid.org/0000-0002-3554-5196","affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Program in Biophysics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079862746","https://openalex.org/A5126330205"],"corresponding_institution_ids":["https://openalex.org/I20089843","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-genome-organization","display_name":"3D genome organization","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drosophila-brain","display_name":"Drosophila brain","score":0.8500000238418579},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7466999888420105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7164999842643738},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6209999918937683},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.6162999868392944},{"id":"https://openalex.org/C175779824","wikidata":"https://www.wikidata.org/wiki/Q7574078","display_name":"Spatial organization","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4431999921798706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4406000077724457},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43700000643730164},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.43070000410079956},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.40689998865127563},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39559999108314514},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.3840999901294708},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.37959998846054077},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3763999938964844},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3711000084877014},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.36239999532699585},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.35899999737739563},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.3125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3043999969959259},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C93946551","wikidata":"https://www.wikidata.org/wiki/Q5113914","display_name":"Chromosome conformation capture","level":5,"score":0.25920000672340393},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.25459998846054077},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.2538999915122986}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.02.748911","doi":"https://doi.org/10.64898/2026.09.02.748911","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.748911","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748911.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42922523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684528","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684528/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.02.748911","doi":"https://doi.org/10.64898/2026.09.02.748911","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.748911","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.02.748911.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5462171940","display_name":"URoL: Epigenetics 2: Connecting cell fate and epigenome drift through physical models of chromatin structure and dynamics","funder_award_id":"2022182","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000881406","display_name":"Visualization of gene activity in the Drosophila embryo","funder_award_id":"R35GM118147","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000920059","display_name":"Mapping 3D-genome motion with next generation tracking technology to distinguish molecular drivers of cis-regulatory control","funder_award_id":"1r01gm157292-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207826194.pdf","grobid_xml":"https://content.openalex.org/works/W7207826194.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W2008227324","https://openalex.org/W2021644221","https://openalex.org/W2022984394","https://openalex.org/W2039309132","https://openalex.org/W2092098765","https://openalex.org/W2161851632","https://openalex.org/W2172277209","https://openalex.org/W2175556166","https://openalex.org/W2292452666","https://openalex.org/W2616198309","https://openalex.org/W2619724512","https://openalex.org/W2765567136","https://openalex.org/W2807884764","https://openalex.org/W2894289085","https://openalex.org/W2900480723","https://openalex.org/W2908798728","https://openalex.org/W2921773684","https://openalex.org/W2945510241","https://openalex.org/W2952706635","https://openalex.org/W2971956617","https://openalex.org/W2990575494","https://openalex.org/W3009515669","https://openalex.org/W3012382205","https://openalex.org/W3013167866","https://openalex.org/W3022888162","https://openalex.org/W3095762353","https://openalex.org/W3107849053","https://openalex.org/W3124454906","https://openalex.org/W3128774108","https://openalex.org/W3133042336","https://openalex.org/W3133363356","https://openalex.org/W3144036649","https://openalex.org/W3157597006","https://openalex.org/W4210718579","https://openalex.org/W4225392266","https://openalex.org/W4225647574","https://openalex.org/W4226350022","https://openalex.org/W4229004838","https://openalex.org/W4280531272","https://openalex.org/W4295907576","https://openalex.org/W4318486619","https://openalex.org/W4319069365","https://openalex.org/W4368363438","https://openalex.org/W4379095375","https://openalex.org/W4381613305","https://openalex.org/W4385497786","https://openalex.org/W4386258242","https://openalex.org/W4390350688","https://openalex.org/W4392671698","https://openalex.org/W4394887657","https://openalex.org/W4395010433","https://openalex.org/W4400974411","https://openalex.org/W4402911908","https://openalex.org/W4404628417","https://openalex.org/W4409487739","https://openalex.org/W4411023364","https://openalex.org/W4411178170","https://openalex.org/W4414692721","https://openalex.org/W7116090574","https://openalex.org/W7130409125","https://openalex.org/W7159833308","https://openalex.org/W7203642328"],"related_works":["https://openalex.org/W4385497786","https://openalex.org/W7025165713","https://openalex.org/W4414454239","https://openalex.org/W2093431562","https://openalex.org/W4411178170","https://openalex.org/W2521908250","https://openalex.org/W3165123931","https://openalex.org/W2336112669","https://openalex.org/W2463019898","https://openalex.org/W1998665601"],"abstract_inverted_index":{"Abstract":[0],"Scores":[1],"of":[2,31,41,45,47,62,70,76,125,152,200,203,209,212],"chromosome-scale":[3],"loops,":[4],"or":[5,108,120,177],"metaloops,":[6],"arise":[7,89],"in":[8,43,58,97],"the":[9,37,59,63,68,74,83,91,98,126,143,183,186,190,197,207],"Drosophila":[10,51],"brain,":[11,64],"but":[12],"their":[13],"spatial":[14,39],"organization":[15,40],"and":[16,49,94,157,189],"relationship":[17],"to":[18,35,88,104],"neural":[19],"gene":[20,172,188],"expression":[21,208],"patterns":[22],"remain":[23],"unclear.":[24],"Here,":[25],"we":[26],"used":[27],"multiplexed":[28],"Optical":[29],"Reconstruction":[30],"Chromatin":[32],"Architecture":[33],"(ORCA)":[34],"examine":[36],"multiscale":[38],"metaloops":[42,55,86,96],"cross-sections":[44],"100s":[46],"larval":[48],"adult":[50],"brains.":[52],"We":[53,194],"find":[54],"form":[56,105],"preferentially":[57],"central":[60],"regions":[61],"where":[65],"they":[66],"nucleate":[67],"formation":[69,199],"metadomains,":[71],"characterized":[72],"by":[73],"intermingling":[75],"distal":[77,147],"topologically":[78],"associating":[79],"domains":[80],"(TADs).":[81],"At":[82],"sub-cellular":[84],"scale,":[85],"tend":[87],"towards":[90],"nuclear":[92],"center,":[93],"multiple":[95],"same":[99],"cell":[100],"have":[101],"a":[102,117,132,137,146,150,158],"preference":[103],"hubs":[106],"(3":[107],"more":[109],"contacts).":[110],"Each":[111],"brain":[112,218],"nucleus":[113],"generally":[114],"harbors":[115],"only":[116],"few":[118],"loops":[119],"hubs.":[121],"An":[122],"in-depth":[123],"analysis":[124],"hub":[127],"centered":[128],"on":[129,171],"DIP-epsilon":[130,144,153,176],",":[131,154],"synaptic":[133,213],"wiring":[134,214],"gene,":[135],"identified":[136],"three-way":[138],"metadomain":[139,166],"that":[140,196],"brings":[141],"together":[142],"TAD;":[145],"TAD":[148,184],"carrying":[149,185],"paralog":[151],"DIP-zeta":[155,178],";":[156],"putative":[159,191],"regulatory":[160,192],"TAD,":[161],"across":[162],"3":[163],"Mb.":[164],"This":[165],"adopts":[167],"distinct":[168],"conformations":[169],"depending":[170],"expression;":[173],"cells":[174],"expressing":[175],"show":[179],"preferential":[180],"interactions":[181],"between":[182],"corresponding":[187],"TAD.":[193],"posit":[195],"neuron-specific":[198],"different":[201],"subsets":[202],"metadomains":[204],"might":[205],"coordinate":[206],"diverse":[210],"combinations":[211],"genes":[215],"underlying":[216],"complex":[217],"architecture.":[219]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-09-04T00:00:00"}