{"id":"https://openalex.org/W7207817685","doi":"https://doi.org/10.64898/2026.08.28.747748","title":"A multiscale analysis of liver lobule fibrosis and its impact on drug propagation and metabolism \u2013 a DLA approach","display_name":"A multiscale analysis of liver lobule fibrosis and its impact on drug propagation and metabolism \u2013 a DLA approach","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207817685","doi":"https://doi.org/10.64898/2026.08.28.747748"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747748","doi":"https://doi.org/10.64898/2026.08.28.747748","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747748","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747748.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747748.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090582778","display_name":"Vahid Rezania","orcid":"https://orcid.org/0000-0002-5717-1244","observed_orcids":["https://orcid.org/0000-0002-5717-1244"]},"institutions":[{"id":"https://openalex.org/I924318406","display_name":"MacEwan University","ror":"https://ror.org/003s89n44","country_code":"CA","type":"education","lineage":["https://openalex.org/I924318406"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vahid Rezania","raw_affiliation_strings":["Department of Physical Sciences, MacEwan University, Edmonton, AB T5J 4S2, Canada; rezaniav@macewan.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, MacEwan University, Edmonton, AB T5J 4S2, Canada; rezaniav@macewan.ca","institution_ids":["https://openalex.org/I924318406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136314681","display_name":"Dennis Coombe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272042","display_name":"Computer Modelling Group (Canada)","ror":"https://ror.org/03fjpw289","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405272042"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dennis Coombe","raw_affiliation_strings":["Computer Modelling Group Ltd, Calgary, AB T2L 2A6, Canada; dennis.coombe2@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Modelling Group Ltd, Calgary, AB T2L 2A6, Canada; dennis.coombe2@gmail.com","institution_ids":["https://openalex.org/I4405272042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082024795","display_name":"Jack A. Tuszy\u0144ski","orcid":"https://orcid.org/0000-0001-9976-0429","observed_orcids":["https://orcid.org/0000-0001-9976-0429","https://orcid.org/0009-0009-3421-6399"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I177477856","display_name":"Politecnico di Torino","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["CA","IT","US"],"is_corresponding":true,"raw_author_name":"Jack Tuszynski","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy","Department of Physics and Department of Oncology, University of Alberta, Edmonton, AB T6G 2J1, Canada; jackt@ualberta.ca","The Allen Discovery Center, Tufts University, Medford, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9976-0429","affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy","institution_ids":["https://openalex.org/I177477856"]},{"raw_affiliation_string":"Department of Physics and Department of Oncology, University of Alberta, Edmonton, AB T6G 2J1, Canada; jackt@ualberta.ca","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"The Allen Discovery Center, Tufts University, Medford, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5082024795"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I154425047","https://openalex.org/I177477856"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/liver-lobule","display_name":"liver lobule","score":0.8759999871253967},{"id":"https://openalex.org/keywords/collagen-self-assembly","display_name":"collagen self-assembly","score":0.8379999995231628},{"id":"https://openalex.org/keywords/diffusion-limited-aggregation","display_name":"diffusion-limited aggregation","score":0.949999988079071},{"id":"https://openalex.org/keywords/collagen-microfibrils","display_name":"collagen microfibrils","score":0.7620000243186951},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.7170000076293945},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nanoparticle-delivery","display_name":"nanoparticle delivery","score":0.6610000133514404},{"id":"https://openalex.org/keywords/multiscale-modeling","display_name":"multiscale modeling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sinusoidal-flow","display_name":"sinusoidal flow","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C57322979","wikidata":"https://www.wikidata.org/wiki/Q11611496","display_name":"Lobules of liver","level":2,"score":0.6707000136375427},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.5292999744415283},{"id":"https://openalex.org/C187691185","wikidata":"https://www.wikidata.org/wiki/Q2020720","display_name":"Grid","level":2,"score":0.46389999985694885},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4555000066757202},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.43380001187324524},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.41440001130104065},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C2993866533","wikidata":"https://www.wikidata.org/wiki/Q26868","display_name":"Collagen fiber","level":2,"score":0.4104999899864197},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38999998569488525},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.3653999865055084},{"id":"https://openalex.org/C33676613","wikidata":"https://www.wikidata.org/wiki/Q13415176","display_name":"Dimension (graph theory)","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C116399919","wikidata":"https://www.wikidata.org/wiki/Q1770543","display_name":"Material flow analysis","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30790001153945923},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3068000078201294},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2962999939918518},{"id":"https://openalex.org/C2776418720","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Human liver","level":3,"score":0.2962000072002411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29440000653266907},{"id":"https://openalex.org/C112604564","wikidata":"https://www.wikidata.org/wiki/Q7489226","display_name":"Shape analysis (program analysis)","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2754000127315521},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2644999921321869},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.28.747748","doi":"https://doi.org/10.64898/2026.08.28.747748","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747748","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747748.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747748","doi":"https://doi.org/10.64898/2026.08.28.747748","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747748","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747748.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207817685.pdf","grobid_xml":"https://content.openalex.org/works/W7207817685.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2014630203"],"related_works":["https://openalex.org/W4401808269","https://openalex.org/W2292226965","https://openalex.org/W2923917850","https://openalex.org/W2060924242","https://openalex.org/W2992864763","https://openalex.org/W4298280860","https://openalex.org/W4244883203","https://openalex.org/W2615637577","https://openalex.org/W4391551010","https://openalex.org/W4328025114"],"abstract_inverted_index":{"Abstract":[0],"Employing":[1],"DLA":[2,59,77,127],"methods,":[3],"this":[4,46],"paper":[5],"explores":[6,192],"the":[7,20,32,58,106,193,212,226,234,246],"self-assembly":[8,75,141],"of":[9,22,31,34,51,57,61,86,108,111,133,142,159,172,180,195,206,219,236,256],"collagen":[10,35,73,140,270],"fibers":[11,113],"and":[12,40,42,250,254],"resulting":[13],"fibrosis":[14,196],"at":[15,120],"three":[16,115],"scales":[17],"up":[18],"to":[19,69,104,137,162,210,272],"scale":[21],"regular":[23],"lobule":[24,200,213],"models.":[25],"This":[26,166],"allows":[27],"a":[28,91,121,147,155,169,198,216],"mechanistic":[29],"exploration":[30],"effects":[33,182,235],"on":[36,117,183,225],"drug":[37,252],"transport":[38],"(flow":[39],"diffusion)":[41],"metabolism.":[43],"In":[44],"addition,":[45],"method":[47,60],"permits":[48],"an":[49],"analysis":[50],"fiber":[52,220],"growth":[53],"characteristics.":[54],"First,":[55],"variations":[56],"Parkinson":[62],"et":[63],"al":[64],"(1994)":[65],"will":[66,102],"be":[67,103],"used":[68],"generate":[70],"multiple":[71,203],"explicit":[72,269],"microfibril":[74],"using":[76,82,202],"particles":[78],"in":[79,90,114,129,197,245,263],"one":[80],"dimension":[81],"cubic":[83,130],"grid":[84,97,131,204,238],"blocks":[85,132,205,239],"(4":[87],"mm)":[88],"3":[89,136],"240":[92],"\u00d7":[93,95],"20":[94,96],"model.":[98],"The":[99,230],"second":[100],"stage":[101,191],"assess":[105],"consequences":[107],"various":[109],"densities":[110],"these":[112,160],"dimensions":[116],"flow":[118,152,164,184,242],"reductions":[119],"higher":[122],"scale.":[123],"Here":[124],"we":[125],"utilize":[126],"methods":[128],"(80":[134],"nm)":[135],"mimic":[138],"3D":[139],"fibrils.":[143],"We":[144,248],"then":[145],"apply":[146],"pressure":[148],"gradient":[149],"or":[150],"specified":[151],"rates":[153],"across":[154],"spatially":[156],"gridded":[157],"version":[158],"models":[161,179],"quantify":[163,251],"effects.":[165],"region":[167],"represents":[168],"local":[170],"zone":[171],"liver":[173,199],"tissue":[174],"affected":[175],"by":[176,267],"fibrosis.":[177],"Analytic":[178],"fibrotic":[181,264],"are":[185],"employed":[186],"for":[187],"comparison.":[188],"A":[189],"third":[190],"implications":[194],"model":[201,218,231],"size":[207],"3200":[208],"mm":[209],"represent":[211],"tissue.":[214],"Here,":[215],"continuum":[217],"density":[221],"is":[222],"employed,":[223],"based":[224],"previous":[227],"two":[228],"scales.":[229],"also":[232],"includes":[233],"additional":[237],"representing":[240],"sinusoidal":[241],"paths":[243],"found":[244],"lobule.":[247],"contrast":[249],"propagation":[253],"metabolism":[255],"molecular":[257],"dissolved":[258],"versus":[259],"nanoparticle":[260],"delivery":[261],"vehicles":[262],"media,":[265],"achieved":[266],"upscaling":[268],"distributions":[271],"appropriate":[273],"average":[274],"values.":[275]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-04T00:00:00"}
