{"id":"https://openalex.org/W7207760650","doi":"https://doi.org/10.64898/2026.09.01.748751","title":"Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits","display_name":"Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207760650","doi":"https://doi.org/10.64898/2026.09.01.748751"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.748751","doi":"https://doi.org/10.64898/2026.09.01.748751","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748751","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.09.01.748751.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.09.01.748751.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056628690","display_name":"Zeyu Mike Lu","orcid":"https://orcid.org/0000-0001-6536-6407","observed_orcids":["https://orcid.org/0000-0001-6536-6407"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zeyu Lu","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026705465","display_name":"Craig P. Barry","orcid":"https://orcid.org/0000-0001-8964-8118","observed_orcids":["https://orcid.org/0000-0001-8964-8118"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Craig Barry","raw_affiliation_strings":["The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086688311","display_name":"Masahiro Tominaga","orcid":"https://orcid.org/0000-0001-9691-0428","observed_orcids":["https://orcid.org/0000-0001-9691-0428"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Tominaga","raw_affiliation_strings":["Kobe University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kobe University;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149609995","display_name":"Anh Phan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anh Phan","raw_affiliation_strings":["The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008687199","display_name":"Ali Jahanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ali Jahanian","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103241725","display_name":"Thomas Collier","orcid":"https://orcid.org/0000-0001-8613-3290","observed_orcids":["https://orcid.org/0000-0001-8613-3290","https://orcid.org/0009-0006-0537-445X"]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Thomas R Collier","raw_affiliation_strings":["Macquarie University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macquarie University;","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077575193","display_name":"Nicholas A. Wendrick","orcid":"https://orcid.org/0009-0001-2110-244X","observed_orcids":["https://orcid.org/0009-0001-2110-244X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A Wendrick","raw_affiliation_strings":["University of Florida;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Samuel Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Samuel Evans","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103255931","display_name":"Liam McDonnell","orcid":"https://orcid.org/0009-0006-1572-8549","observed_orcids":["https://orcid.org/0009-0006-1572-8549"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Liam McDonnell","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008932030","display_name":"Gabriele A. Netzel","orcid":"https://orcid.org/0000-0003-1581-4851","observed_orcids":["https://orcid.org/0000-0003-1581-4851"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gabriele Netzel","raw_affiliation_strings":["The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032284909","display_name":"Tim McCubbin","orcid":"https://orcid.org/0000-0002-9707-6532","observed_orcids":["https://orcid.org/0000-0002-9707-6532"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tim McCubbin","raw_affiliation_strings":["The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025823138","display_name":"Shana Sunny Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shana Jacob","raw_affiliation_strings":["The University of Queensland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066266218","display_name":"Patrick A. da Roza","orcid":"https://orcid.org/0009-0003-9945-2620","observed_orcids":["https://orcid.org/0009-0003-9945-2620"]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Patrick A da Roza","raw_affiliation_strings":["Macquarie University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macquarie University;","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009440227","display_name":"Xin Xu","orcid":"https://orcid.org/0000-0002-5644-5397","observed_orcids":["https://orcid.org/0000-0002-5644-5397"]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Macquarie University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macquarie University;","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683295","display_name":"Chengqiang Wang","orcid":"https://orcid.org/0000-0003-0222-4094","observed_orcids":["https://orcid.org/0000-0003-0222-4094"]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengqiang Wang","raw_affiliation_strings":["Shandong Agricultural University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Agricultural University;","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055378566","display_name":"Jun Ishii","orcid":"https://orcid.org/0000-0003-2568-515X","observed_orcids":["https://orcid.org/0000-0003-2568-515X"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Ishii","raw_affiliation_strings":["Kobe University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kobe University;","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071783725","display_name":"James B. Y. H. Behrendorff","orcid":"https://orcid.org/0000-0003-4130-6252","observed_orcids":["https://orcid.org/0000-0003-4130-6252"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James Behrendorff","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103536219","display_name":"Alexander S. Beliaev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander S Beliaev","raw_affiliation_strings":["Pacific Northwest National Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018949159","display_name":"Claudia Estelle Vickers","orcid":"https://orcid.org/0000-0002-0792-050X","observed_orcids":["https://orcid.org/0000-0002-0792-050X"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Claudia E Vickers","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013394820","display_name":"Bingyin Peng","orcid":"https://orcid.org/0000-0001-6918-6016","observed_orcids":["https://orcid.org/0000-0001-6918-6016"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Bingyin Peng","raw_affiliation_strings":["Queensland University of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology;","institution_ids":["https://openalex.org/I160993911"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013394820"],"corresponding_institution_ids":["https://openalex.org/I160993911"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.9330000281333923},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.5730000138282776},{"id":"https://openalex.org/keywords/terpene-biosynthesis","display_name":"terpene biosynthesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/strain-degeneration","display_name":"strain degeneration","score":0.7120000123977661},{"id":"https://openalex.org/keywords/biocomputing","display_name":"biocomputing","score":0.7749999761581421},{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amino-acid-biosynthesis","display_name":"amino acid biosynthesis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":1.0},{"id":"https://openalex.org/keywords/on-off-switching","display_name":"on-off switching","score":0.7239999771118164},{"id":"https://openalex.org/keywords/adaptive-evolution","display_name":"adaptive evolution","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.7260000109672546},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.7002000212669373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5774000287055969},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5008999705314636},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.46889999508857727},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.4212999939918518},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.4113999903202057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40619999170303345},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.3937999904155731},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.392300009727478},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.3781000077724457},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3434000015258789},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C2992278830","wikidata":"https://www.wikidata.org/wiki/Q483921","display_name":"Adaptive evolution","level":3,"score":0.32409998774528503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.311599999666214},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29089999198913574},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.26570001244544983},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C3018998897","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Neuronal circuits","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25760000944137573},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.748751","doi":"https://doi.org/10.64898/2026.09.01.748751","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748751","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.09.01.748751.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.748751","doi":"https://doi.org/10.64898/2026.09.01.748751","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748751","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/09/2026.09.01.748751.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320386","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07"},{"id":"https://openalex.org/F4320320591","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89"},{"id":"https://openalex.org/F4320320974","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98"},{"id":"https://openalex.org/F4320320983","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752"},{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207760650.pdf","grobid_xml":"https://content.openalex.org/works/W7207760650.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1204263966","https://openalex.org/W2020726089","https://openalex.org/W2071112606","https://openalex.org/W2092122738","https://openalex.org/W2111993114","https://openalex.org/W2122553662","https://openalex.org/W2132251545","https://openalex.org/W2138207763","https://openalex.org/W2169423549","https://openalex.org/W2196795138","https://openalex.org/W2559864478","https://openalex.org/W2589713488","https://openalex.org/W2789843538","https://openalex.org/W2792972194","https://openalex.org/W2884497523","https://openalex.org/W3026336982","https://openalex.org/W3045105015","https://openalex.org/W3046581440","https://openalex.org/W3087165503","https://openalex.org/W3130820694","https://openalex.org/W3196530061","https://openalex.org/W4213327673","https://openalex.org/W4281391671","https://openalex.org/W4308638148","https://openalex.org/W4310490807","https://openalex.org/W4321601663","https://openalex.org/W4378953426","https://openalex.org/W4381470547","https://openalex.org/W4385638275","https://openalex.org/W4389615493","https://openalex.org/W4391431961","https://openalex.org/W4391543785","https://openalex.org/W4400109764","https://openalex.org/W4404276311","https://openalex.org/W4404926942","https://openalex.org/W4407358258","https://openalex.org/W4409617993","https://openalex.org/W4412392297","https://openalex.org/W4412795238","https://openalex.org/W4412990266","https://openalex.org/W4414085124","https://openalex.org/W4414601652","https://openalex.org/W4414694589","https://openalex.org/W4415518236","https://openalex.org/W7116633381","https://openalex.org/W7117234445","https://openalex.org/W7126265549","https://openalex.org/W7150180639","https://openalex.org/W7160278751","https://openalex.org/W7162095216","https://openalex.org/W7162595763","https://openalex.org/W7163996244","https://openalex.org/W7172490253","https://openalex.org/W7203604542","https://openalex.org/W7204660012"],"related_works":["https://openalex.org/W2885640776","https://openalex.org/W2242085408","https://openalex.org/W4405438396","https://openalex.org/W2249678901","https://openalex.org/W2093469518","https://openalex.org/W3210265068","https://openalex.org/W2515050083","https://openalex.org/W3045105015","https://openalex.org/W6959186735","https://openalex.org/W7001112899"],"abstract_inverted_index":{"Synthetic":[0],"genetic":[1,30,57],"circuits":[2,98],"enable":[3,100,119],"microbial":[4],"differentiation":[5],"from":[6],"growth":[7],"to":[8,28,86],"production,":[9],"yet":[10],"metabolic":[11,43,109,133],"burden,":[12],"imbalance":[13],"and":[14,25,51,74,95,108],"toxicity":[15],"frequently":[16],"drive":[17],"strain":[18],"degeneration.":[19],"Here,":[20],"we":[21],"use":[22],"omics":[23],"analyses":[24],"single-cell":[26],"biosensors":[27],"investigate":[29],"responses":[31],"in":[32],"Saccharomyces":[33],"cerevisiae":[34],"strains":[35],"engineered":[36],"with":[37,68],"stressful":[38],"terpene":[39,90,124],"biosynthetic":[40],"pathways.":[41],"Under":[42],"stress,":[44],"despite":[45],"divergent":[46],"stress":[47],"responses,":[48],"cells":[49],"commonly":[50],"progressively":[52],"lose":[53],"induction":[54,87],"of":[55,70,88,122,128],"synthetic":[56],"circuits.":[58],"In":[59],"the":[60,78],"prenyl":[61],"pyrophosphate-accumulating":[62],"strain,":[63],"this":[64],"loss":[65],"is":[66],"coupled":[67,85],"activation":[69],"amino":[71],"acid":[72],"biosynthesis":[73],"ribosome":[75],"biogenesis.":[76],"Accordingly,":[77],"essential":[79],"glutamine":[80],"synthetase":[81],"gene":[82],"GLN1":[83],"was":[84],"heterologous":[89],"synthesis":[91],"through":[92],"integrated":[93,106],"two-":[94],"three-input":[96],"biocomputing":[97,107],"that":[99],"stringent,":[101],"patterned":[102],"ON/OFF":[103],"switching.":[104],"The":[105],"locking":[110],"systems":[111],"not":[112],"only":[113],"alleviate":[114],"production":[115],"degeneration":[116],"but":[117],"also":[118],"non-degenerative":[120],"adaptation":[121],"toxic":[123],"synthesis,":[125],"allowing":[126],"interrogation":[127],"evolutionary":[129],"shifts":[130],"for":[131],"further":[132],"optimisation.":[134]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-04T00:00:00"}
