{"id":"https://openalex.org/W7207758682","doi":"https://doi.org/10.17615/cjjf-f440","title":"Pubertal timing and incident ovarian cancer in the Sister Study cohort.","display_name":"Pubertal timing and incident ovarian cancer in the Sister Study cohort.","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207758682","doi":"https://doi.org/10.17615/cjjf-f440"},"language":"en","primary_location":{"id":"doi:10.17615/cjjf-f440","doi":"https://doi.org/10.17615/cjjf-f440","is_oa":true,"landing_page_url":"https://doi.org/10.17615/cjjf-f440","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/cjjf-f440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058634982","display_name":"Dale P. Sandler","orcid":"https://orcid.org/0000-0002-6776-0018","observed_orcids":["https://orcid.org/0000-0002-6776-0018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandler, Dale P","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019411214","display_name":"Sydney A. Lash","orcid":"https://orcid.org/0000-0003-3503-5433","observed_orcids":["https://orcid.org/0000-0003-3503-5433"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lash, Sydney A","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057856727","display_name":"Katie M. O\u2019Brien","orcid":"https://orcid.org/0000-0002-1931-1349","observed_orcids":["https://orcid.org/0000-0002-1931-1349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O'Brien, Katie M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011705257","display_name":"Mandy Goldberg","orcid":"https://orcid.org/0000-0002-6794-1206","observed_orcids":["https://orcid.org/0000-0002-6794-1206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goldberg, Mandy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67446154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.2896000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pubertal-timing","display_name":"pubertal timing","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/age-at-menarche","display_name":"age at menarche","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.800000011920929},{"id":"https://openalex.org/keywords/sister-study","display_name":"Sister Study","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C4258228","wikidata":"https://www.wikidata.org/wiki/Q492514","display_name":"Menarche","level":2,"score":0.902899980545044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8944000005722046},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6988000273704529},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6464999914169312},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5519999861717224},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.531499981880188},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.47119998931884766},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42329999804496765},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27970001101493835},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17615/cjjf-f440","doi":"https://doi.org/10.17615/cjjf-f440","is_oa":true,"landing_page_url":"https://doi.org/10.17615/cjjf-f440","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.17615/cjjf-f440","doi":"https://doi.org/10.17615/cjjf-f440","is_oa":true,"landing_page_url":"https://doi.org/10.17615/cjjf-f440","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7117128939","https://openalex.org/W2041997336","https://openalex.org/W6959058978","https://openalex.org/W6939719889","https://openalex.org/W3097005544","https://openalex.org/W6901905765","https://openalex.org/W2142597742","https://openalex.org/W2104860650","https://openalex.org/W2098122455","https://openalex.org/W3150077228"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pubertal":[1],"milestones":[2],"such":[3],"as":[4],"menarche":[5,38,95,133,167,184,217],"(first":[6],"period)":[7],"and":[8,82,94,102,132,166,183,216],"thelarche":[9,49,93,123,160,182,215],"(onset":[10],"of":[11,16,27,32,35,89,110,118,157,175,202,204,213,221],"breast":[12],"development)":[13],"are":[14],"markers":[15],"hormonal":[17,25],"changes":[18],"that":[19],"may":[20,226],"be":[21],"relevant":[22],"to":[23,56,77],"the":[24,33,67],"etiology":[26],"ovarian":[28,40,57,98,119,146,189,208,222],"cancer.":[29,120],"Prior":[30],"studies":[31],"association":[34,156],"age":[36,47],"at":[37,48,92,122,159,181],"with":[39,96,145,173,188,207,218],"cancer":[41,58,147,190,209],"risk":[42],"have":[43],"been":[44,52],"inconsistent,":[45],"while":[46],"has":[50],"not":[51,143,186,198],"examined":[53],"in":[54,66],"relation":[55],"incidence.":[59],"METHODS:":[60],"With":[61],"data":[62],"from":[63],"40,809":[64],"women":[65,114],"Sister":[68],"Study,":[69],"we":[70],"used":[71],"multivariable-adjusted":[72],"Cox":[73],"proportional":[74],"hazards":[75],"regression":[76],"estimate":[78],"hazard":[79],"ratios":[80],"(HRs)":[81],"95%":[83,126,136,163,170],"confidence":[84],"intervals":[85],"(CIs)":[86],"for":[87],"associations":[88,203,212],"self-reported":[90],"ages":[91,158],"incident":[97],"cancer,":[99],"both":[100],"overall":[101],"by":[103],"histotype.":[104],"RESULTS:":[105],"During":[106],"a":[107,116,153],"median":[108],"follow-up":[109],"13.3":[111],"years,":[112],"291":[113],"reported":[115],"diagnosis":[117],"Ages":[121,180],"(HR":[124,134,161,168],"0.94,":[125],"CI":[127,137,164,171],"0.87-1.02":[128],"per":[129,139],"one-year":[130,140],"older)":[131,141],"0.99,":[135],"0.91-1.07":[138],"were":[142,185],"associated":[144,187],"overall.":[148,192],"Although":[149],"imprecise,":[150],"HRs":[151],"suggested":[152],"possible":[154,211],"inverse":[155],"0.71,":[162],"0.48-1.04)":[165],"0.79,":[169],"0.59-1.04)":[172],"incidence":[174,191,220],"clear":[176,200,223],"cell":[177,224],"tumors.":[178],"CONCLUSIONS:":[179],"IMPACT:":[193],"Though":[194],"our":[195],"results":[196],"do":[197],"provide":[199],"evidence":[201],"pubertal":[205],"timing":[206],"incidence,":[210],"earlier":[214,235],"increased":[219],"carcinoma":[225],"warrant":[227],"further":[228],"investigation,":[229],"especially":[230],"considering":[231],"secular":[232],"trends":[233],"towards":[234],"thelarche.":[236]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-04T00:00:00"}