{"id":"https://openalex.org/W7207739491","doi":"https://doi.org/10.64898/2026.08.28.747845","title":"Adolescent blockade of complement signaling in the lateral septum increases social novelty seeking behavior in male mice","display_name":"Adolescent blockade of complement signaling in the lateral septum increases social novelty seeking behavior in male mice","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207739491","doi":"https://doi.org/10.64898/2026.08.28.747845","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684662"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747845","doi":"https://doi.org/10.64898/2026.08.28.747845","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747845","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747845.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747845.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024716304","display_name":"Anthony Djerdjaj","orcid":"https://orcid.org/0000-0002-0168-0832","observed_orcids":["https://orcid.org/0000-0002-0168-0832"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Djerdjaj","raw_affiliation_strings":["Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103281793","display_name":"William W. Taylor","orcid":"https://orcid.org/0000-0003-4245-6594","observed_orcids":["https://orcid.org/0000-0003-4245-6594"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William W. Taylor","raw_affiliation_strings":["Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149935954","display_name":"Odette T. Amoakohene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Odette T. Amoakohene","raw_affiliation_strings":["Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020565372","display_name":"Caroline J. W. Smith","orcid":"https://orcid.org/0000-0003-2811-0095","observed_orcids":["https://orcid.org/0000-0003-2811-0095"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caroline J. Smith","raw_affiliation_strings":["Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA","institution_ids":["https://openalex.org/I103531236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020565372"],"corresponding_institution_ids":["https://openalex.org/I103531236"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-signaling","display_name":"complement signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lateral-septum","display_name":"lateral septum","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adolescence","display_name":"adolescence","score":0.890999972820282},{"id":"https://openalex.org/keywords/social-behavior-development","display_name":"social behavior development","score":0.6830000281333923},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.7929999828338623},{"id":"https://openalex.org/keywords/sociability","display_name":"sociability","score":0.8339999914169312},{"id":"https://openalex.org/keywords/immune-related-gene-expression","display_name":"immune gene expression","score":0.6899999976158142},{"id":"https://openalex.org/keywords/synaptic-pruning","display_name":"synaptic pruning","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2778738651","wikidata":"https://www.wikidata.org/wiki/Q16546687","display_name":"Novelty","level":2,"score":0.8855999708175659},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.664900004863739},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5917999744415283},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5489000082015991},{"id":"https://openalex.org/C2778399782","wikidata":"https://www.wikidata.org/wiki/Q2124069","display_name":"Synaptic pruning","level":4,"score":0.5217000246047974},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.49619999527931213},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.47200000286102295},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.41040000319480896},{"id":"https://openalex.org/C2776529864","wikidata":"https://www.wikidata.org/wiki/Q4368945","display_name":"Novelty seeking","level":4,"score":0.3653999865055084},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C2779213276","wikidata":"https://www.wikidata.org/wiki/Q7239824","display_name":"Preference test","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C7033854","wikidata":"https://www.wikidata.org/wiki/Q17130699","display_name":"Neural substrate","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C2781249084","wikidata":"https://www.wikidata.org/wiki/Q908656","display_name":"Preference","level":2,"score":0.3375000059604645},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.3246999979019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3109999895095825},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.257099986076355},{"id":"https://openalex.org/C4727928","wikidata":"https://www.wikidata.org/wiki/Q17164759","display_name":"Social network (sociolinguistics)","level":3,"score":0.2522999942302704},{"id":"https://openalex.org/C2779760398","wikidata":"https://www.wikidata.org/wiki/Q7551043","display_name":"Social defeat","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.28.747845","doi":"https://doi.org/10.64898/2026.08.28.747845","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747845","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747845.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684662","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684662/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684662/pdf/nihpp-2026.08.28.747845v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42922723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747845","doi":"https://doi.org/10.64898/2026.08.28.747845","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747845","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.08.28.747845.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308357","display_name":"Boston College","ror":"https://ror.org/02n2fzt79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207739491.pdf","grobid_xml":"https://content.openalex.org/works/W7207739491.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W110969282","https://openalex.org/W1904307646","https://openalex.org/W1971023423","https://openalex.org/W1985645068","https://openalex.org/W2028338644","https://openalex.org/W2031981320","https://openalex.org/W2033617297","https://openalex.org/W2040073285","https://openalex.org/W2046016307","https://openalex.org/W2052001691","https://openalex.org/W2054275187","https://openalex.org/W2063792498","https://openalex.org/W2071358231","https://openalex.org/W2096327192","https://openalex.org/W2132915420","https://openalex.org/W2140977742","https://openalex.org/W2166045656","https://openalex.org/W2254141494","https://openalex.org/W2462807191","https://openalex.org/W2515320229","https://openalex.org/W2793003989","https://openalex.org/W2891617662","https://openalex.org/W2918315099","https://openalex.org/W2988070260","https://openalex.org/W2990377686","https://openalex.org/W3083835588","https://openalex.org/W3113049055","https://openalex.org/W3199494145","https://openalex.org/W3211953131","https://openalex.org/W3215401653","https://openalex.org/W3216705695","https://openalex.org/W4237542790","https://openalex.org/W4255839518","https://openalex.org/W4281550473","https://openalex.org/W4320495403","https://openalex.org/W4390691795","https://openalex.org/W4391141621","https://openalex.org/W4392372423","https://openalex.org/W4396674584","https://openalex.org/W4402478526","https://openalex.org/W4409498970","https://openalex.org/W4411027489","https://openalex.org/W4413054468","https://openalex.org/W7156873125"],"related_works":["https://openalex.org/W4367849187","https://openalex.org/W4392372423","https://openalex.org/W2891617662","https://openalex.org/W4372349239","https://openalex.org/W7215125734","https://openalex.org/W4367848961","https://openalex.org/W7139087189","https://openalex.org/W4386810500","https://openalex.org/W4409723515","https://openalex.org/W4391888222"],"abstract_inverted_index":{"Social":[0],"behaviors":[1],"are":[2,42],"critical":[3,15,45,205],"for":[4,142,206],"survival":[5],"and":[6,169],"change":[7],"dramatically":[8],"over":[9,147],"the":[10,59,72,80,104,112,120,136,143,148,165,178,184,194,202,207],"lifespan.":[11],"Adolescence":[12,29],"is":[13,30,53,204],"a":[14,32,116],"period":[16],"of":[17,34,50,56,71,82,106,180,210],"development":[18],"during":[19,85,95,138],"which":[20],"social":[21,76,121,124,145,211],"novelty":[22,77,125,212],"seeking":[23],"peaks":[24],"before":[25],"declining":[26],"into":[27,135],"adulthood.":[28],"also":[31,176],"time":[33],"pronounced":[35],"neural":[36,51,73],"circuit":[37],"refinement":[38],"as":[39,150,186],"excess":[40],"synapses":[41,57],"eliminated.":[43],"One":[44],"mechanism":[46],"supporting":[47,75,123],"this":[48,83],"maturation":[49],"circuits":[52],"microglial":[54,69,92,198],"pruning":[55,70,94],"through":[58],"classical":[60],"complement":[61],"signaling":[62],"cascade.":[63],"However,":[64],"it":[65],"remains":[66],"unclear":[67],"how":[68],"circuitry":[74,122],"preference":[78,141],"shapes":[79],"trajectory":[81],"behavior":[84,163],"adolescence.":[86],"To":[87],"address":[88],"this,":[89],"we":[90],"blocked":[91],"complement-dependent":[93,197],"adolescence":[96,139],"by":[97],"injecting":[98],"neutrophil":[99],"inhibitory":[100],"factor":[101],"(NIF;":[102],"blocks":[103],"adhesion":[105],"ligands":[107],"to":[108,152,188],"CD11b/C3":[109],"receptor)":[110],"in":[111,119,127,164,183,201],"lateral":[113],"septum":[114],"(LS),":[115],"key":[117],"node":[118],"preference,":[126],"male":[128],"mice.":[129],"We":[130],"found":[131],"that":[132,196],"NIF":[133],"administration":[134],"LS":[137,185,203],"increased":[140],"novel":[144],"chamber":[146],"familiar":[149],"compared":[151,187],"control":[153],"PBS":[154,189],"administration.":[155],"LS-NIF":[156,174],"treatment":[157,175],"had":[158],"no":[159,170],"impact":[160],"on":[161,172],"anxiety-like":[162],"light-dark":[166],"box":[167],"test":[168],"effect":[171],"sociability.":[173],"decreased":[177],"expression":[179],"immune-related":[181],"genes":[182],"treatment.":[190],"These":[191],"data":[192],"support":[193],"hypothesis":[195],"synaptic":[199],"elimination":[200],"developmental":[208],"progression":[209],"preference.":[213]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-04T00:00:00"}
