{"id":"https://openalex.org/W7207737636","doi":"https://doi.org/10.3390/jcm15197700","title":"Comorbidity Burden and Cumulative Anti-HER2 Exposure Associated with Cardiac Dysfunction in Breast Cancer: A Real-World Cardio-Oncology Cohort","display_name":"Comorbidity Burden and Cumulative Anti-HER2 Exposure Associated with Cardiac Dysfunction in Breast Cancer: A Real-World Cardio-Oncology Cohort","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7207737636","doi":"https://doi.org/10.3390/jcm15197700","pmid":"https://pubmed.ncbi.nlm.nih.gov/42882162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13665819"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15197700","doi":"https://doi.org/10.3390/jcm15197700","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15197700","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jcm15197700","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088051972","display_name":"Andrea Sonaglioni","orcid":"https://orcid.org/0000-0001-7641-8831","observed_orcids":["https://orcid.org/0000-0001-7641-8831"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrea Sonaglioni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7641-8831","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021422322","display_name":"Emanuela Fossile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emanuela Fossile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089015373","display_name":"Maria Adelaide Pessi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Adelaide Pessi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135391211","display_name":"Maria Gemelli","orcid":"https://orcid.org/0000-0003-1143-0252","observed_orcids":["https://orcid.org/0000-0003-1143-0252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Gemelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001651127","display_name":"Massimo Baravelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Baravelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103328111","display_name":"Michele Lombardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Lombardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022436940","display_name":"Gian Luigi Nicolosi","orcid":"https://orcid.org/0000-0002-2218-2808","observed_orcids":["https://orcid.org/0000-0002-2218-2808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gian Luigi Nicolosi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2218-2808","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107301137","display_name":"Barbara Bassani","orcid":"https://orcid.org/0000-0002-8002-1607","observed_orcids":["https://orcid.org/0000-0002-8002-1607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Bassani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8002-1607","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023598157","display_name":"Antonino Bruno","orcid":"https://orcid.org/0000-0002-4790-0861","observed_orcids":["https://orcid.org/0000-0002-4790-0861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonino Bruno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056269283","display_name":"Paola C. Muti","orcid":"https://orcid.org/0000-0003-0339-8520","observed_orcids":["https://orcid.org/0000-0003-0339-8520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Muti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088051972"],"corresponding_institution_ids":[],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63950928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"19","first_page":"7700","last_page":"7700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-therapy-related-cardiac-dysfunction","display_name":"cancer therapy-related cardiac dysfunction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7749999761581421},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/comorbidity-burden","display_name":"comorbidity burden","score":0.9700000286102295},{"id":"https://openalex.org/keywords/charlson-comorbidity-index","display_name":"Charlson Comorbidity Index","score":0.9959999918937683},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/left-ventricular-global-longitudinal-strain","display_name":"left ventricular global longitudinal strain","score":0.9760000109672546},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6819999814033508},{"id":"https://openalex.org/keywords/anthracycline-exposure","display_name":"anthracycline exposure","score":0.9430000185966492},{"id":"https://openalex.org/keywords/real-world-cohort","display_name":"real-world cohort","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9228000044822693},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.7890999913215637},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6940000057220459},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6883999705314636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.609000027179718},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.551800012588501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5310999751091003},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4765999913215637},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.42399999499320984},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41110000014305115},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.3294999897480011},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29260000586509705},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2912999987602234},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.272599995136261},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.26570001244544983},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcm15197700","doi":"https://doi.org/10.3390/jcm15197700","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15197700","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202609.0157.v1","doi":"https://doi.org/10.20944/preprints202609.0157.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202609.0157.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13665819","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665819/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665819/pdf/jcm-15-07700.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:42882162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42882162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jcm15197700","doi":"https://doi.org/10.3390/jcm15197700","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15197700","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4743193513","display_name":null,"funder_award_id":"CUP: I43C25000300001","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207737636.pdf","grobid_xml":"https://content.openalex.org/works/W7207737636.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W2000445173","https://openalex.org/W2050477993","https://openalex.org/W2122472092","https://openalex.org/W2123366208","https://openalex.org/W2140512895","https://openalex.org/W2154077173","https://openalex.org/W2160329331","https://openalex.org/W2187887962","https://openalex.org/W2190898938","https://openalex.org/W2307330081","https://openalex.org/W2530921721","https://openalex.org/W2590369252","https://openalex.org/W2760461642","https://openalex.org/W2771620563","https://openalex.org/W2787201390","https://openalex.org/W2899343344","https://openalex.org/W2944602336","https://openalex.org/W2946080087","https://openalex.org/W2951923105","https://openalex.org/W2965296832","https://openalex.org/W3007205432","https://openalex.org/W3017068829","https://openalex.org/W3024954485","https://openalex.org/W3031292493","https://openalex.org/W3093752709","https://openalex.org/W3097490319","https://openalex.org/W3105136620","https://openalex.org/W3126817559","https://openalex.org/W3151108354","https://openalex.org/W3166435635","https://openalex.org/W3171709380","https://openalex.org/W4205594133","https://openalex.org/W4210895659","https://openalex.org/W4221085803","https://openalex.org/W4223455363","https://openalex.org/W4223939326","https://openalex.org/W4249896096","https://openalex.org/W4283259168","https://openalex.org/W4283774226","https://openalex.org/W4289947806","https://openalex.org/W4293101610","https://openalex.org/W4293217929","https://openalex.org/W4300817552","https://openalex.org/W4310022023","https://openalex.org/W4319298030","https://openalex.org/W4323664924","https://openalex.org/W4366813769","https://openalex.org/W4385897980","https://openalex.org/W4386238167","https://openalex.org/W4386644944","https://openalex.org/W4387080183","https://openalex.org/W4387618726","https://openalex.org/W4389379466","https://openalex.org/W4390956294","https://openalex.org/W4391023666","https://openalex.org/W4396730722","https://openalex.org/W4401156563","https://openalex.org/W4402795889","https://openalex.org/W4404076187","https://openalex.org/W4405766167","https://openalex.org/W4406655232","https://openalex.org/W4407028311","https://openalex.org/W4407228747","https://openalex.org/W4408527056","https://openalex.org/W4409430834","https://openalex.org/W4411372797","https://openalex.org/W4412078443","https://openalex.org/W4412493786","https://openalex.org/W4412990566","https://openalex.org/W4413003971","https://openalex.org/W4413677730","https://openalex.org/W4414084334","https://openalex.org/W4414280457","https://openalex.org/W4414618794","https://openalex.org/W4417413225","https://openalex.org/W4417529109","https://openalex.org/W7116044934","https://openalex.org/W7117252976","https://openalex.org/W7124717687","https://openalex.org/W7128068513","https://openalex.org/W7131110185","https://openalex.org/W7155056707","https://openalex.org/W7161251590","https://openalex.org/W7161562116","https://openalex.org/W7164858987","https://openalex.org/W7169799450"],"related_works":["https://openalex.org/W7202360722","https://openalex.org/W7172344469","https://openalex.org/W4392594797","https://openalex.org/W7160616884","https://openalex.org/W7162400527","https://openalex.org/W3087496551","https://openalex.org/W2999294101","https://openalex.org/W4403812939","https://openalex.org/W4210856398","https://openalex.org/W4412965366"],"abstract_inverted_index":{"Background:":[0],"Cancer":[1],"therapy-related":[2],"cardiac":[3,31,128],"dysfunction":[4],"(CTRCD)":[5],"remains":[6,51],"an":[7],"important":[8],"complication":[9],"of":[10,42,70,154,173,290],"human":[11],"epidermal":[12],"growth":[13],"factor":[14],"receptor":[15],"2":[16],"(HER2)-targeted":[17],"therapy":[18,87,181,301],"in":[19,65,186,200],"patients":[20,71,80,175,188,291],"with":[21,63,72,81,159,176,233,268,279,292,308,325],"breast":[22,73,82,177,293],"cancer.":[23],"Although":[24],"conventional":[25],"cardiovascular":[26,216,355],"risk":[27,217,330,356],"factors":[28,61],"and":[29,46,60,88,101,127,165,190,203,208,226,250,278,312,318,339,358],"serial":[30],"imaging":[32],"are":[33],"routinely":[34],"incorporated":[35],"into":[36],"cardio-oncology":[37,91,113,288],"surveillance,":[38],"the":[39,56,138,151,333],"potential":[40],"contribution":[41],"global":[43,123],"comorbidity":[44,133,316],"burden":[45,134,317],"cumulative":[47,144,251,281,319],"anti-HER2":[48,145,180,252,282,320],"treatment":[49,155],"exposure":[50,146,253,321],"incompletely":[52],"characterized.":[53],"We":[54],"investigated":[55,162],"occur-rence,":[57],"clinical":[58],"course,":[59],"associated":[62,158,232,267,307,324],"CTRCD":[64,106,160,184,270,295],"a":[66,94],"large":[67],"real-world":[68],"population":[69],"cancer":[74,83,178],"receiving":[75,179],"HER2-targeted":[76,86,300,364],"therapy.":[77,365],"Methods:":[78],"Adult":[79],"exposed":[84],"to":[85,110,150],"undergoing":[89],"longitudinal":[90,124,354],"surveillance":[92,361],"at":[93,206],"single":[95],"tertiary":[96],"center":[97],"between":[98,335],"January":[99],"2014":[100],"December":[102],"2024":[103],"were":[104,161,182,229,265,322],"included.":[105,183],"was":[107,135,147,191,296,303],"defined":[108],"according":[109,149],"contemporary":[111],"European":[112],"criteria":[114],"integrating":[115],"left":[116,121],"ventricular":[117,122],"ejection":[118],"fraction":[119],"(LVEF),":[120],"strain":[125],"(LV-GLS),":[126],"biomarkers":[129],"when":[130],"available.":[131],"Baseline":[132],"quantified":[136,148],"using":[137,163],"Charlson":[139],"Comorbidity":[140],"Index":[141],"(CCI),":[142],"while":[143],"total":[152,172],"number":[153],"cycles.":[156],"Factors":[157],"univariable":[164],"parsimonious":[166],"multivariable":[167,236],"logistic":[168],"regression.":[169],"Results:":[170],"A":[171],"850":[174],"occurred":[185,199],"179":[187],"(21.1%)":[189],"predominantly":[192,304],"mild,":[193,305],"whereas":[194],"clinically":[195],"overt":[196,309],"heart":[197,310],"failure":[198],"2.9%.":[201],"LVEF":[202],"LV-GLS":[204,228],"deteriorated":[205],"nadir":[207],"subsequently":[209],"showed":[210],"substantial":[211],"recovery":[212],"during":[213,299,362],"follow-up.":[214],"Conventional":[215],"factors,":[218],"previous":[219],"anthracycline":[220],"exposure,":[221],"tumor":[222],"grade,":[223],"baseline":[224,227,336],"LVEF,":[225],"not":[230],"significantly":[231],"CTRCD.":[234,269],"In":[235,285],"analysis,":[237],"increasing":[238,280],"CCI":[239,276],"(adjusted":[240,254],"OR":[241,255],"1.35":[242],"per":[243,257],"one-point":[244],"increase,":[245],"95%":[246,261],"CI":[247,262],"1.12\u20131.63;":[248],"p=0.002)":[249],"1.41":[256],"five":[258],"additional":[259,351],"cycles,":[260],"1.10\u20131.80;":[263],"p=0.006)":[264],"independently":[266,323],"probability":[271],"progressively":[272],"increased":[273],"across":[274],"higher":[275],"categories":[277],"exposure.":[283],"Conclusions:":[284],"this":[286],"10-year":[287],"cohort":[289],"cancer,":[294],"relatively":[297],"frequent":[298],"but":[302],"infrequently":[306],"failure,":[311],"frequently":[313],"reversible.":[314],"Global":[315],"CTRCD,":[326],"suggesting":[327],"that":[328],"cardiotoxic":[329],"may":[331,349],"reflect":[332],"interplay":[334],"patient":[337],"vulnerability":[338],"treatment-related":[340],"bur-den.":[341],"If":[342],"prospectively":[343],"validated,":[344],"these":[345],"readily":[346],"available":[347],"variables":[348],"provide":[350],"information":[352],"for":[353],"assessment":[357],"help":[359],"individualize":[360],"prolonged":[363]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-04T00:00:00"}
