{"id":"https://openalex.org/W7207726290","doi":"https://doi.org/10.64898/2026.09.02.749041","title":"Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction","display_name":"Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207726290","doi":"https://doi.org/10.64898/2026.09.02.749041"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.02.749041","doi":"https://doi.org/10.64898/2026.09.02.749041","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.749041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.02.749041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037777087","display_name":"Gautier Follain","orcid":"https://orcid.org/0000-0003-0495-9529","observed_orcids":["https://orcid.org/0000-0003-0495-9529"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I4405259646","display_name":"BoRdeaux Institute of onCology","ror":"https://ror.org/02gezhp66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4405259646"]}],"countries":["FI","FR"],"is_corresponding":false,"raw_author_name":"Gautier Follain","raw_affiliation_strings":["Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","I.CaRe, Bordeaux Institute of Oncology (BRIC), Inserm U1312, Universit\u00e9 de Bordeaux, 146 rue L\u00e9o Saignat, 33076 Bordeaux, France","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Collegium for Science, Medicine and Technology (TCSMT), University of Turku, FI-20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0003-0495-9529","affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899"]},{"raw_affiliation_string":"I.CaRe, Bordeaux Institute of Oncology (BRIC), Inserm U1312, Universit\u00e9 de Bordeaux, 146 rue L\u00e9o Saignat, 33076 Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4405259646"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Collegium for Science, Medicine and Technology (TCSMT), University of Turku, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070431069","display_name":"Sujan Ghimire","orcid":"https://orcid.org/0000-0003-3660-4300","observed_orcids":["https://orcid.org/0000-0003-3660-4300"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sujan Ghimire","raw_affiliation_strings":["Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0003-3660-4300","affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089761345","display_name":"Monika Vaitkevi\u010di\u016bt\u0117","orcid":"https://orcid.org/0000-0003-1803-9571","observed_orcids":["https://orcid.org/0000-0003-1803-9571"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Monika Vaitkevi\u010di\u016bt\u0117","raw_affiliation_strings":["Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0003-1803-9571","affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144975246","display_name":"Helene Helo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Helene Helo","raw_affiliation_strings":["Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016286615","display_name":"Joanna W. Pylv\u00e4n\u00e4inen","orcid":"https://orcid.org/0000-0002-3540-5150","observed_orcids":["https://orcid.org/0000-0002-3540-5150"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Joanna W. Pylv\u00e4n\u00e4inen","raw_affiliation_strings":["Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-3540-5150","affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029133770","display_name":"Fr\u00e9d\u00e9ric Fercoq","orcid":"https://orcid.org/0000-0002-4825-024X","observed_orcids":["https://orcid.org/0000-0002-4825-024X"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Fercoq","raw_affiliation_strings":["Cancer Research UK Scotland Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4825-024X","affiliations":[{"raw_affiliation_string":"Cancer Research UK Scotland Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom","institution_ids":["https://openalex.org/I4210143228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018019760","display_name":"Aleksi Isomursu","orcid":"https://orcid.org/0000-0001-6006-9163","observed_orcids":["https://orcid.org/0000-0001-6006-9163"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aleksi Isomursu","raw_affiliation_strings":["InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0001-6006-9163","affiliations":[{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003041124","display_name":"Megan R. Chastney","orcid":"https://orcid.org/0000-0002-9866-2322","observed_orcids":["https://orcid.org/0000-0002-9866-2322"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Megan R. Chastney","raw_affiliation_strings":["InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-9866-2322","affiliations":[{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078677552","display_name":"Omkar Joshi","orcid":"https://orcid.org/0000-0002-7410-9987","observed_orcids":["https://orcid.org/0000-0002-7410-9987"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Omkar Joshi","raw_affiliation_strings":["InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-7410-9987","affiliations":[{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033264183","display_name":"Marco De Donatis","orcid":"https://orcid.org/0000-0003-2951-5844","observed_orcids":["https://orcid.org/0000-0003-2951-5844"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marco De Donatis","raw_affiliation_strings":["Cancer Research UK Scotland Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom","School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Scotland Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom","institution_ids":["https://openalex.org/I4210143228"]},{"raw_affiliation_string":"School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075882111","display_name":"Ermei M. M\u00e4kil\u00e4","orcid":"https://orcid.org/0000-0002-8300-6533","observed_orcids":["https://orcid.org/0000-0002-8300-6533"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ermei M\u00e4kil\u00e4","raw_affiliation_strings":["Laboratory of Industrial Physics, Department of Physics and Astronomy, Faculty of Science, University of Turku, Vesilinnantie 5, FI-20500 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-8300-6533","affiliations":[{"raw_affiliation_string":"Laboratory of Industrial Physics, Department of Physics and Astronomy, Faculty of Science, University of Turku, Vesilinnantie 5, FI-20500 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035661681","display_name":"James R. W. Conway","orcid":"https://orcid.org/0000-0003-3787-277X","observed_orcids":["https://orcid.org/0000-0003-3787-277X"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"James R.W. Conway","raw_affiliation_strings":["Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland","Faculty of Medicine and Health Technology, Tampere University, Arvo Ylp\u00f6n katu 34, 33520 Tampere, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Collegium for Science, Medicine and Technology (TCSMT), University of Turku, FI-20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0003-3787-277X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Faculty of Medicine and Health Technology, Tampere University, Arvo Ylp\u00f6n katu 34, 33520 Tampere, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Collegium for Science, Medicine and Technology (TCSMT), University of Turku, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079691994","display_name":"Marko Salmi","orcid":"https://orcid.org/0000-0002-1913-7408","observed_orcids":["https://orcid.org/0000-0002-1913-7408"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marko Salmi","raw_affiliation_strings":["InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Institute of Biomedicine, University of Turku, 20520 Turku, Finland","MediCity Research Laboratory, University of Turku, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-1913-7408","affiliations":[{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Institute of Biomedicine, University of Turku, 20520 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"MediCity Research Laboratory, University of Turku, 20520 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039376687","display_name":"Sara A. Wickstr\u00f6m","orcid":"https://orcid.org/0000-0001-6383-6292","observed_orcids":["https://orcid.org/0000-0001-6383-6292"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE","FI"],"is_corresponding":false,"raw_author_name":"Sara A. Wickstr\u00f6m","raw_affiliation_strings":["Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 M\u00fcnster, Germany","Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-6383-6292","affiliations":[{"raw_affiliation_string":"Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]},{"raw_affiliation_string":"Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067662754","display_name":"Leo M. Carlin","orcid":"https://orcid.org/0000-0001-7172-5234","observed_orcids":["https://orcid.org/0000-0001-7172-5234"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Leo M. Carlin","raw_affiliation_strings":["Cancer Research UK Scotland Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom","School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7172-5234","affiliations":[{"raw_affiliation_string":"Cancer Research UK Scotland Institute, Garscube Estate, Glasgow G61 1BD, United Kingdom","institution_ids":["https://openalex.org/I4210143228"]},{"raw_affiliation_string":"School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051981975","display_name":"Johanna Ivaska","orcid":"https://orcid.org/0000-0002-6295-6556","observed_orcids":["https://orcid.org/0000-0002-6295-6556"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johanna Ivaska","raw_affiliation_strings":["Department of Life Technologies, University of Turku, 20520 Turku, Finland","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Western Finnish Cancer Center (FICAN West), University of Turku, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-6295-6556","affiliations":[{"raw_affiliation_string":"Department of Life Technologies, University of Turku, 20520 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Western Finnish Cancer Center (FICAN West), University of Turku, 20520 Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004861283","display_name":"Guillaume Jacquemet","orcid":"https://orcid.org/0000-0002-9286-920X","observed_orcids":["https://orcid.org/0000-0002-9286-920X"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I4405268884","display_name":"Finnish Cancer Institute","ror":"https://ror.org/02cwbja97","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4405268884"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Guillaume Jacquemet","raw_affiliation_strings":["Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","Foundation for the Finnish Cancer Institute, Tukholmankatu 8, 00290 Helsinki, Finland","InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-9286-920X","affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Cell Biology, \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899"]},{"raw_affiliation_string":"Foundation for the Finnish Cancer Institute, Tukholmankatu 8, 00290 Helsinki, Finland","institution_ids":["https://openalex.org/I4405268884"]},{"raw_affiliation_string":"InFLAMES Research Flagship Center, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, 20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5004861283"],"corresponding_institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I4405268884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.1307000070810318,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-cell-extravasation","display_name":"tumor cell extravasation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endothelial-junctions","display_name":"endothelial junctions","score":0.8500000238418579},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/saracatinib","display_name":"saracatinib","score":0.843999981880188},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.921999990940094},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/zebrafish-larvae","display_name":"zebrafish larvae","score":0.6380000114440918},{"id":"https://openalex.org/keywords/aspc-1","display_name":"AsPC-1","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mia-paca-2-cells","display_name":"MIA PaCa-2 cells","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.7366999983787537},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5774000287055969},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5604000091552734},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5375999808311462},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48809999227523804},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4627000093460083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40689998865127563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40400001406669617},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.39070001244544983},{"id":"https://openalex.org/C2781380885","wikidata":"https://www.wikidata.org/wiki/Q17859848","display_name":"VE-cadherin","level":4,"score":0.37389999628067017},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.3328999876976013},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.3057999908924103},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.2563000023365021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25589999556541443},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.02.749041","doi":"https://doi.org/10.64898/2026.09.02.749041","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.749041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.02.749041","doi":"https://doi.org/10.64898/2026.09.02.749041","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.02.749041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2644606476","display_name":"Euro-BioImaging: Research Infrastructure for Imaging\u00a0Technologies in Biological and Biomedical Sciences","funder_award_id":"359073","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4383048128","display_name":"Euro-BioImaging: Research Infrastructure for Imaging\u00a0Technologies in Biological and Biomedical Sciences","funder_award_id":"358879","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4868210545","display_name":"Euro-BioImaging: Research Infrastructure for Imaging\u00a0Technologies in Biological and Biomedical Sciences","funder_award_id":"367577","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G6462026635","display_name":"Euro-BioImaging: Research Infrastructure for Imaging\u00a0Technologies in Biological and Biomedical Sciences","funder_award_id":"367582","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320317353","display_name":"Finnish Cancer Institute","ror":"https://ror.org/02cwbja97"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320326591","display_name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0113k5861"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1495945591","https://openalex.org/W1498712972","https://openalex.org/W1536370890","https://openalex.org/W1774737416","https://openalex.org/W1858855509","https://openalex.org/W1968783143","https://openalex.org/W1972170345","https://openalex.org/W1984474513","https://openalex.org/W2023611910","https://openalex.org/W2024262880","https://openalex.org/W2031409539","https://openalex.org/W2043166238","https://openalex.org/W2054489157","https://openalex.org/W2057711788","https://openalex.org/W2063145866","https://openalex.org/W2064996695","https://openalex.org/W2066651120","https://openalex.org/W2067829376","https://openalex.org/W2089370460","https://openalex.org/W2110432682","https://openalex.org/W2111858177","https://openalex.org/W2121075882","https://openalex.org/W2132770583","https://openalex.org/W2149106868","https://openalex.org/W2150310014","https://openalex.org/W2153429813","https://openalex.org/W2154853638","https://openalex.org/W2158312081","https://openalex.org/W2160318185","https://openalex.org/W2167279371","https://openalex.org/W2175927969","https://openalex.org/W2297415450","https://openalex.org/W2306875942","https://openalex.org/W2480295405","https://openalex.org/W2753779930","https://openalex.org/W2794046880","https://openalex.org/W2806530968","https://openalex.org/W2968350324","https://openalex.org/W2971818215","https://openalex.org/W3021332911","https://openalex.org/W3113331104","https://openalex.org/W3128317116","https://openalex.org/W3132973190","https://openalex.org/W3136129808","https://openalex.org/W3139211629","https://openalex.org/W3156859314","https://openalex.org/W3161073852","https://openalex.org/W3172157145","https://openalex.org/W3174818312","https://openalex.org/W3213380284","https://openalex.org/W3216122825","https://openalex.org/W4220652264","https://openalex.org/W4308803084","https://openalex.org/W4309152025","https://openalex.org/W4318932448","https://openalex.org/W4387730191","https://openalex.org/W4388636059","https://openalex.org/W4397009248","https://openalex.org/W4400675925","https://openalex.org/W4404286038","https://openalex.org/W4405807639","https://openalex.org/W4410755236","https://openalex.org/W7118324054","https://openalex.org/W7120072583","https://openalex.org/W7123452202","https://openalex.org/W7124766821","https://openalex.org/W7136056093","https://openalex.org/W7162768098","https://openalex.org/W7204933211","https://openalex.org/W7208756166"],"related_works":["https://openalex.org/W4402551818","https://openalex.org/W2054489157","https://openalex.org/W4362669695","https://openalex.org/W2039671689","https://openalex.org/W2067829376","https://openalex.org/W7161398805","https://openalex.org/W3185520143","https://openalex.org/W2483773996","https://openalex.org/W2075123115","https://openalex.org/W2095515710"],"abstract_inverted_index":{"Extravasation,":[0],"the":[1,55,67,71,92,103,156],"exit":[2],"of":[3,38,77,186],"circulating":[4],"cancer":[5],"cells":[6,28,42,63,96,126,168],"from":[7,102],"blood":[8],"vessels,":[9],"is":[10],"a":[11,144,192],"critical":[12],"yet":[13],"poorly":[14],"understood":[15],"step":[16],"in":[17,88,155],"metastatic":[18,113,160],"dissemination.":[19],"Here":[20],"we":[21],"show":[22],"that":[23,166,176],"pancreatic":[24],"ductal":[25],"adenocarcinoma":[26],"(PDAC)":[27],"can":[29,169],"breach":[30,43,189],"endothelial":[31,44,79,100,122,129,149,187],"barriers":[32],"through":[33,108],"two":[34],"mechanistically":[35,172],"distinct":[36,82,173],"modes":[37,84,185],"extravasation.":[39],"MIA":[40],"PaCa-2":[41],"junctions":[45],"via":[46,171],"filopodia-like":[47],"protrusions,":[48],"enabling":[49],"access":[50],"to":[51,120,182],"and":[52,69,106,124,158],"spread":[53],"across":[54],"basal":[56,104],"extracellular":[57],"matrix":[58],"(ECM).":[59],"By":[60,139],"contrast,":[61,140],"AsPC-1":[62,95,125],"remain":[64],"rounded":[65],"atop":[66],"endothelium":[68],"cross":[70],"barrier":[72,137,188],"by":[73],"triggering":[74],"rapid":[75],"retraction":[76,110],"neighbouring":[78],"cells.":[80],"These":[81],"extravasation":[83],"were":[85],"also":[86,127],"observed":[87],"zebrafish":[89],"larvae.":[90],"In":[91],"mouse":[93],"lung,":[94,157],"arrest,":[97],"survive,":[98],"induce":[99,128],"detachment":[101],"lamina,":[105],"extravasate":[107,170],"this":[109],"mechanism":[111],"before":[112],"outgrowth.":[114,161],"Mechanistically,":[115],"AsPC-1-secreted":[116],"factors":[117],"are":[118],"sufficient":[119],"destabilise":[121],"monolayers,":[123],"apoptosis;":[130],"however,":[131],"blocking":[132],"apoptosis":[133],"does":[134],"not":[135],"prevent":[136],"disruption.":[138],"treatment":[141],"with":[142],"saracatinib,":[143],"Src-family":[145],"kinase":[146],"inhibitor,":[147],"protects":[148],"barriers,":[150],"limits":[151],"early":[152],"vascular":[153],"disruption":[154],"delays":[159],"Together,":[162],"these":[163],"findings":[164],"reveal":[165],"PDAC":[167],"routes,":[174],"suggesting":[175],"effective":[177],"anti-metastatic":[178],"strategies":[179],"may":[180],"need":[181],"target":[183],"multiple":[184],"rather":[190],"than":[191],"single":[193],"pathway.":[194]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-04T00:00:00"}
