{"id":"https://openalex.org/W7207717255","doi":"https://doi.org/10.1021/acs.nanolett.6c01946","title":"Invasive RNA Programs Optical Switching in DNA Nanoclusters for CRISPR Sensing","display_name":"Invasive RNA Programs Optical Switching in DNA Nanoclusters for CRISPR Sensing","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7207717255","doi":"https://doi.org/10.1021/acs.nanolett.6c01946","pmid":"https://pubmed.ncbi.nlm.nih.gov/42915359","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13587672"},"language":"en","primary_location":{"id":"doi:10.1021/acs.nanolett.6c01946","doi":"https://doi.org/10.1021/acs.nanolett.6c01946","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.6c01946","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.nanolett.6c01946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125537344","display_name":"Reggie Gold","orcid":"https://orcid.org/0009-0001-9836-5715","observed_orcids":["https://orcid.org/0009-0001-9836-5715"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reggie Gold","raw_affiliation_strings":["University at Albany, State University of New York , , 1400 Washington Avenue , , ,"],"raw_orcid":"https://orcid.org/0009-0001-9836-5715","affiliations":[{"raw_affiliation_string":"University at Albany, State University of New York , , 1400 Washington Avenue , , ,","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014514302","display_name":"Yusha Imtiaz","orcid":"https://orcid.org/0000-0001-8997-6461","observed_orcids":["https://orcid.org/0000-0001-8997-6461"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yusha Imtiaz","raw_affiliation_strings":["University at Albany, State University of New York , , 1400 Washington Avenue , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, State University of New York , , 1400 Washington Avenue , , ,","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091705417","display_name":"Vinod Morya","orcid":"https://orcid.org/0000-0002-1539-4108","observed_orcids":["https://orcid.org/0000-0002-1539-4108"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinod Morya","raw_affiliation_strings":["University at Albany, State University of New York , , 1400 Washington Avenue , , ,"],"raw_orcid":"https://orcid.org/0000-0002-1539-4108","affiliations":[{"raw_affiliation_string":"University at Albany, State University of New York , , 1400 Washington Avenue , , ,","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037674579","display_name":"Ken Halvorsen","orcid":"https://orcid.org/0000-0002-2578-1339","observed_orcids":["https://orcid.org/0000-0002-2578-1339"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Halvorsen","raw_affiliation_strings":["University at Albany, State University of New York , , 1400 Washington Avenue , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2578-1339","affiliations":[{"raw_affiliation_string":"University at Albany, State University of New York , , 1400 Washington Avenue , , ,","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125550856","display_name":"Emmett Hanson","orcid":"https://orcid.org/0009-0000-9727-9682","observed_orcids":["https://orcid.org/0009-0000-9727-9682"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmett Hanson","raw_affiliation_strings":["University at Albany, State University of New York , , 1400 Washington Avenue , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University at Albany, State University of New York , , 1400 Washington Avenue , , ,","institution_ids":["https://openalex.org/I392282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055455990","display_name":"Mehmet Veysel Yigit","orcid":"https://orcid.org/0000-0002-4349-3701","observed_orcids":["https://orcid.org/0000-0002-4349-3701"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mehmet V. Yigit","raw_affiliation_strings":["University at Albany, State University of New York , , 1400 Washington Avenue , , ,"],"raw_orcid":"https://orcid.org/0000-0002-4349-3701","affiliations":[{"raw_affiliation_string":"University at Albany, State University of New York , , 1400 Washington Avenue , , ,","institution_ids":["https://openalex.org/I392282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055455990"],"corresponding_institution_ids":["https://openalex.org/I392282"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.9209,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92513755,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"26","issue":"36","first_page":"11988","last_page":"11995"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12149","display_name":"Nanocluster Synthesis and Applications","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-templated-silver-nanoclusters","display_name":"DNA-templated silver nanoclusters","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fluorescence-switching","display_name":"fluorescence switching","score":0.7149999737739563},{"id":"https://openalex.org/keywords/crispr-cas12a","display_name":"CRISPR/Cas12a","score":0.9010000228881836},{"id":"https://openalex.org/keywords/label-free-biosensing","display_name":"label-free biosensing","score":0.7549999952316284},{"id":"https://openalex.org/keywords/listeria-monocytogenes-detection","display_name":"Listeria monocytogenes detection","score":0.9390000104904175},{"id":"https://openalex.org/keywords/foodborne-pathogens","display_name":"foodborne pathogens","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nucleic-acid-hybridization","display_name":"nucleic acid hybridization","score":0.8330000042915344},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.7940000295639038},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778402822","wikidata":"https://www.wikidata.org/wiki/Q22302226","display_name":"Nanoclusters","level":2,"score":0.9075000286102295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5953999757766724},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5866000056266785},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5717999935150146},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.565500020980835},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5489000082015991},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.47760000824928284},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.4472000002861023},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4426000118255615},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3894999921321869},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.35519999265670776},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.3458000123500824},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32499998807907104},{"id":"https://openalex.org/C2778682378","wikidata":"https://www.wikidata.org/wiki/Q746209","display_name":"Listeria","level":4,"score":0.3043999969959259},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C2911215874","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"SELEX Aptamer Technique","level":5,"score":0.2897999882698059},{"id":"https://openalex.org/C130197536","wikidata":"https://www.wikidata.org/wiki/Q418436","display_name":"Hybridization probe","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C32795469","wikidata":"https://www.wikidata.org/wiki/Q5156430","display_name":"Complementary sequences","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000099139","descriptor_name":"DNA Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008089","descriptor_name":"Listeria monocytogenes","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064130","descriptor_name":"CRISPR-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.nanolett.6c01946","doi":"https://doi.org/10.1021/acs.nanolett.6c01946","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.6c01946","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13587672","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13587672/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13587672/pdf/nl6c01946.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Lett","raw_type":"Text"},{"id":"pmid:42915359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42915359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acs.nanolett.6c01946","doi":"https://doi.org/10.1021/acs.nanolett.6c01946","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.6c01946","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1999319973","display_name":null,"funder_award_id":"2022-08596","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G9000879549","display_name":"DNA nanotechnology and synthetic biology for AI-supported detection and precision therapeutics","funder_award_id":"R35GM156250","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000892464","display_name":"Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnology","funder_award_id":"R35GM124720","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207717255.pdf","grobid_xml":"https://content.openalex.org/works/W7207717255.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W2034412692","https://openalex.org/W2077560165","https://openalex.org/W2079081483","https://openalex.org/W2102038510","https://openalex.org/W2164530723","https://openalex.org/W2526824555","https://openalex.org/W2785904295","https://openalex.org/W2787024379","https://openalex.org/W2883124781","https://openalex.org/W2897700601","https://openalex.org/W2973445868","https://openalex.org/W3008807477","https://openalex.org/W3014924238","https://openalex.org/W3031061124","https://openalex.org/W3080536083","https://openalex.org/W3120022585","https://openalex.org/W3171390824","https://openalex.org/W3198035589","https://openalex.org/W4206062492","https://openalex.org/W4295753977","https://openalex.org/W4296773150","https://openalex.org/W4320726276","https://openalex.org/W4377225382","https://openalex.org/W4384935561","https://openalex.org/W4391375745","https://openalex.org/W4391779828","https://openalex.org/W4396230328","https://openalex.org/W4399206609","https://openalex.org/W4408162477","https://openalex.org/W4408346008","https://openalex.org/W4412119838","https://openalex.org/W7117135020","https://openalex.org/W7128504357"],"related_works":["https://openalex.org/W4408162477","https://openalex.org/W7128618380","https://openalex.org/W2531037334","https://openalex.org/W2150352377","https://openalex.org/W4399142710","https://openalex.org/W2982680821","https://openalex.org/W4319986676","https://openalex.org/W4285227456","https://openalex.org/W1977192782","https://openalex.org/W2001671234"],"abstract_inverted_index":{"DNA-templated":[0,22],"silver":[1,23],"nanoclusters":[2],"have":[3],"regained":[4],"attention":[5],"due":[6],"to":[7,79],"recent":[8],"advances":[9],"in":[10],"stability":[11],"and":[12,33,56,67,110,146],"tunable":[13],"optical":[14,70,141],"properties.":[15],"Here,":[16],"we":[17],"report":[18],"a":[19,81,88,93,102,106],"highly":[20],"regulated":[21],"nanocluster":[24,115],"(DFN2)":[25],"that":[26,113],"exhibits":[27,123],"strong":[28],"fluorescence":[29,37,45,116],"at":[30],"561":[31],"nm":[32],"enables":[34],"reversible,":[35],"label-free":[36],"switching":[38],"governed":[39],"by":[40],"nucleic":[41],"acid":[42],"hybridization.":[43],"The":[44],"of":[46,87,108],"DFN2":[47,137],"is":[48],"efficiently":[49],"quenched":[50],"with":[51,77],"complementary":[52],"DNA":[53],"or":[54],"RNA":[55,61],"fully":[57],"restored":[58],"through":[59,117],"invading":[60],"strand":[62],"mediated":[63],"displacement,":[64],"enabling":[65],"robust":[66],"programmable":[68],"ON-OFF-ON":[69],"control.":[71],"We":[72],"integrated":[73],"this":[74],"hybridization-responsive":[75],"platform":[76],"CRISPR-Cas12a":[78],"construct":[80],"target-activated":[82],"biosensing":[83],"system.":[84],"Upon":[85],"recognition":[86],"conserved":[89,127],"genomic":[90,128],"fragment":[91],"from":[92,130],"foodborne":[94,132],"pathogen":[95],"Listeria":[96],"monocytogenes,":[97],"the":[98],"activated":[99],"Cas12a":[100],"cleaves":[101],"regulator":[103],"DNA,":[104],"initiating":[105],"cascade":[107],"hybridization":[109],"strand-displacement":[111],"reactions":[112],"restore":[114],"an":[118],"invasive":[119],"RNA.":[120],"This":[121],"strategy":[122],"high":[124],"specificity":[125],"against":[126],"regions":[129],"other":[131],"pathogens.":[133],"These":[134],"findings":[135],"establish":[136],"as":[138],"programmable,":[139],"enzyme-responsive":[140],"reporters":[142],"for":[143],"rapid,":[144],"sensitive,":[145],"modular":[147],"point-of-care":[148],"biosensing.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-04T00:00:00"}